SNPMiner Trials by Shray Alag

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Report for SNP rs3765467

Developed by Shray Alag, 2020.
SNP Clinical Trial Gene

There is one clinical trial.

Clinical Trials

1 Effect of Genetic Variation in the GLP-1 Receptor on Beta-cell Function During Fasting and Hyperglycemia in Nondiabetic Humans

The GLP-1 receptor (GLP1R) gene is found on the beta cells of the pancreas. Its role is in the control of blood sugar level by enhancing insulin secretion from the pancreas after eating a meal. The purpose of this research study to find out how genetic variations in GLP1R alter insulin secretion, in the fasting state and when blood sugars levels are elevated.

NCT04466566 Healthy Other: Saline Biological: Exendin-9,39
MeSH:Hyperglycemia
HPO:Hyperglycemia Postprandial hyperglycemia

- 20 subjects with the AA genotype at rs3765467 and remainder will have the GG genotype.

Primary Outcomes

Measure: Insulin secretion quantified using the minimal model to generate an index of beta-cell responsivity (Φ)

Time: This will be calculated from the 0-180 minute data of the study

Secondary Outcomes

Measure: Glucagon secretion measured by immunoassay

Time: This will be averaged over the 0-180 minute data of the study

HPO Nodes