Covid 19 Research using Clinical Trials (Home Page)
Report for D000073397: Occupational Stress NIH
(Synonyms: Occupational Stress)
Developed by Shray Alag
Clinical Trial MeSH HPO Drug Gene SNP Protein Mutation
Correlated Drug Terms (9)
| Name (Synonyms) | Correlation | |
|---|---|---|
| drug643 | Control swab Wiki | 0.71 |
| drug1195 | Infectious Disease and Cardiology Clinical Consultations Wiki | 0.71 |
| drug2188 | Saliva sample collection Wiki | 0.71 |
| drug523 | Cardiac and electrodermal recordings Wiki | 0.71 |
| drug229 | Assessment of work-related stress Wiki | 0.71 |
| drug2374 | Sudarshan Kriya Yoga (SKY) Wiki | 0.71 |
| drug225 | Assessment of behavioral response to emotional stimulation Wiki | 0.71 |
| drug1038 | Health Enhancement Program Wiki | 0.71 |
| drug1934 | Prototype swab Wiki | 0.71 |
Correlated MeSH Terms (3)
| Name (Synonyms) | Correlation | |
|---|---|---|
| D000068376 | Compassion Fatigue NIH | 0.50 |
| D000067073 | Psychological Trauma NIH | 0.41 |
| D002055 | Burnout, Professional NIH | 0.32 |
Correlated HPO Terms (0)
| Name (Synonyms) | Correlation |
|---|
There are 2 clinical trials
Clinical Trials
1 Stress Biomarkers Leading to Professional Burnout Among People Involved in a Mobile Intensive Care Unit During the COVID-19 Pandemic
This study is aiming at investigating whether professional burnout in people involved in the mobile intensive care unit (in French: Element Mobile de Réanimation, EMR) in Mulhouse (France) can be predicted upstream by a low mindfulness level (as a protective factor) or by a dysregulation of stress pathways with a high level of perceived stress towards an emotional event (psychological index of allostatic load), i.e. an early and silent dysfunctional physiological response (measured by the electrophysiological and biological measurements of allostasis load and parasympathetic brake). It is part of a global approach aiming at identifying levers to prevent the allostatic load of occupational stress related to large-scale health crises.
NCT04365335 Occupational Stress Behavioral: Assessment of work-related stress Biological: Saliva sample collection Other: Cardiac and electrodermal recordings Behavioral: Assessment of behavioral response to emotional stimulation MeSH:Occupational Stress Burnout, Professional
Primary Outcomes
Description: Professional burnout is measured at D21 by the Burnout Measure Short Version (BMS) questionnaire It is a 10-item questionnaire used to assess burnout regardless of the occupational category. Each item is rated from 0 to 6 ("never" to "always"). An average score (sum/10) below 2.4 indicates a very low degree of burnout exposure; a score between 2.5 and 3.4 indicates a low degree of burnout exposure; a score between 3.5 and 4.4 indicates the presence of burnout; a score between 4.5 and 5.4 indicates a high degree of burnout exposure; a score above 5.5 indicates a very high degree of burnout exposure.
Measure: Professional burnout Time: 21 days after enrollment (Day 21)Description: Mindfulness level is assessed at D0 thanks to the Freiburg Mindfulness Inventory. It is a 14 item scale. Each item is rated from 1 to 4 ("almost never" to "almost always"). The total score is between 14 and 56. The mean value in a population of young adults under 36 years of age is 38.5 (+/- 5.1 standard deviation).
Measure: Mindfulness level Time: Day 1Secondary Outcomes
Description: Perceived stress level is assessed with the Perceived Stress Scale (PSS). It is a 14 item scale. Each item is rated from 0 to 5 ("never" to "very often"). The total score ranges from 0 to 56 with higher scores indicating greater perceived stress.
Measure: Perceived stress level following the emotional stimulation Time: Day 1Description: Parasympathetic flexibility is assessed through dynamic electro-physiological analysis of cardiac and electrodermal conductance recordings. Physiological and cognitive reserve of emotional regulation is assessed through the analysis of the spectral power of the 0.1 Hz frequency band at emotional recall.
Measure: Parasympathetic flexibility evolution during emotional recall Time: Day 1Description: The activity of the sympathetic tone is assessed by the measurement of the resting state salivary Chromogranin A. Physiological and cognitive reserve of emotional regulation is assessed through the analysis of the spectral power of the 0.1 Hz frequency band at emotional recall. The activity of the sympathetic tone is assessed by the measurement of the resting salivary Chromogranin A.
Measure: Sympathetic tone at rest Time: Day 1Description: Corticotropic activation at rest is assessed through the DHEA/cortisol level ratio
Measure: Corticotropic activation at rest Time: Day 1Description: The Hospital Anxiety and Depression Scale (HAD-s32) is used to assess mood disorders in the general non-psychiatric population. It is used to discriminate between anxiety and depression. Scores greater than 11 are indicative of charcaterized anxiety/depression.
Measure: Mood disorders (anxiety / depression) Time: Day 1Description: Post-traumatic disorder is assessed with the PCL-5. It is a 20-item self-administered questionnaire representing DSM-5 PTSD diagnosis symptoms rated by the subject on a scale from 0 ("not at all") to 4 ("extremely") during the past month. Scores range from 0 to 80. A score greater than of 33 evokes the presence of post-traumatic stress disorder.
Measure: Post-traumatic stress disorder Time: Day 1Description: Sleep quality is assesses thanks to the Leeds Sleep Evaluation questionnaire (LEEDS). It consists of ten visual analogue scales assessing four aspects of sleep: (i) quality of falling asleep and degree of drowsiness, (ii) quality of sleep, (iii) quality of wakefulness, and (iv) quality of post-wakefulness and performance.
Measure: Sleep quality Time: Day 12 Breath Regulation and Yogic Exercise An Online Therapy for Calm and Happiness (BREATH): an RCT for Frontline Hospital and Long-term Care Home Staff Managing the COVID-19 Pandemic
This study will examine the feasibility of conducting an online Randomized Controlled Trial (RCT) in frontline hospital and long term care healthcare staff in managing COVID-19 patients in London, ON. The study will randomize participants to Sudarshan Kriya Yoga (SKY) or a Health Enhancement Program (HEP).
NCT04368676 Job St Job Stress Workplace Stress Compassion Fatigue Psychological Trauma Healthcare Workers Healthcare Providers Other: Sudarshan Kriya Yoga (SKY) Other: Health Enhancement Program MeSH:Compassion Fatigue Occupational Stress Psychological Trauma
Primary Outcomes
Description: The number of participants recruited per month will be calculated as a feasibility measure.
Measure: Rate of participant recruitment Time: 1 yearDescription: The retention rate of participants will be calculated as a feasibility measure.
Measure: Rate of retention Time: 1 yearDescription: The completeness of study assessments will be assessed as a feasibility measure by calculating the missing percentage of data in case report forms.
Measure: Completeness of data entry Time: 1 yearDescription: The cost of both study interventions will be calculated to assess the total study cost for interventions and the cost per participant. This information will be used as a feasibility measure.
Measure: Cost of interventions Time: 1 yearDescription: The total of unexpected costs will be calculated as a feasibility measure.
Measure: Unexpected costs Time: 1 yearSecondary Outcomes
Description: The Athens Insomnia Scale will be used to assess insomnia. This scale is an 8-item, self-rated measure of the extent of sleep difficulties over the last 30 days with each item representing a different aspect of sleep (e.g. "Overall Quality of Sleep"). Ratings are from 0 to 4, with 0 being no difficulty with the item and 4 being the most difficulty with the item. Higher overall scores on this scale indicate higher difficulties with sleep.
Measure: Change in Athens Insomnia Scale Time: Change from Week 0 to week 3 and to week 5Description: The Generalized Anxiety Disorder 7-item scale (each scored 0-3) is a self-rated measure of anxiety and has been validated for the diagnosis of Generalized Anxiety Disorder in the adult population. Scores range from 0 to 21. Higher scores indicate greater anxiety symptoms (5-9, mild anxiety; 10-14, moderate anxiety; 15-21 severe anxiety).
Measure: Change in Generalized Anxiety Disorder 7-item scale Time: Change from Week 0 to week 3 and to week 5Description: The Patient Health Questionnaire (PHQ-9) is a 9-item, self-rated measure of depression which has been validated for screening a major depressive episode in adults. Total scores indicate various levels of depression: 0-4, no depression; 5-9, mild depression; 10-14, moderate depression; 15-19, moderately severe depression; 20-27, severe depression.
Measure: Change in Patient Health Questionnaire 9 Time: Change from Week 0 to week 3 and to week 5Description: The Connor-Davidson Resilience Scale (CD-RISC) is a brief self-rated assessment tool that comprises of 10 items, each rated on a 5-point Likert scale (0 = not true at all to 4 = true nearly all the time). Higher scores reflect greater resilience, which is a measure of one's ability to cope with stress. The scale demonstrated strong reliability and validity and has been studied in a variety of populations including medical personnel, nurses, social workers and physicians).
Measure: Change in Connor-Davidson Resilience Scale Time: Change from Week 0 to week 3 and to week 5