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Report for D009771: Obsessive-Compulsive Disorder NIH

(Synonyms: Obsessive-C, Obsessive-Compulsi, Obsessive-Compulsiv, Obsessive-Compulsive Di, Obsessive-Compulsive Disorder)

Developed by Shray Alag
Clinical Trial MeSH HPO Drug Gene SNP Protein Mutation


Correlated Drug Terms (3)


Name (Synonyms) Correlation
drug616 Community Referral as appropriate Wiki 1.00
drug1196 Inflammatory cytokines and chemokines profiles of patients with dexmedetomidine administration Wiki 1.00
drug595 Cognitive Behavioral Therapy Wiki 0.71

Correlated MeSH Terms (2)


Name (Synonyms) Correlation
D003193 Compulsive Personality Disorder NIH 1.00
D003192 Compulsive Behavior NIH 1.00

Correlated HPO Terms (1)


Name (Synonyms) Correlation
HP:0000722 Obsessive-compulsive behavior HPO 0.71

There is one clinical trial.

Clinical Trials


1 Task Control Circuit Targets for Obsessive Compulsive Behaviors in Children

This study will use magnetic resonance imaging (MRI) to assess the function and structure of overlapping task control circuits in children with a range of Obsessive-Compulsive symptoms (OCS). The functioning of task control circuits will be assessed using the well-validated Multisource interference task (MSIT). This study will also assess functional and anatomical connectivity within task control circuits in the same children, and determine whether disturbances in these overlapping circuits are associated with Obsessive-Compulsive Disorder (OCD) symptom severity. Behavioral measures will be administered to further assess regulatory, learning and memory functions. Children with OCD will then be offered a standard course of cognitive behavioral therapy (CBT) before rescanning (along with age-and gender-matched control participants) in order to assess how these circuits may change with treatment. Children with subclinical OC symptoms will be offered referral for treatment on an as-needed basis. In addition, de-identified data may be used in the future to conduct secondary data analyses. As more about OC symptoms and neurobiological mechanisms of interest in the current study are understood, data may be used to answer questions beyond those described in this protocol. All study procedures will be conducted on-site at Columbia University/the New York State Psychiatric Institute (New York, NY) and the University of Michigan's outpatient Child and Adolescent Psychiatry (Ann Arbor, Michigan).

NCT03584945 Obsessive-compulsive Disorders and Symptoms in Children Behavioral: Cognitive Behavioral Therapy Other: Community Referral as appropriate
MeSH:Compulsive Personality Disorder Obsessive-Compulsive Disorder Compulsive Behavior
HPO:Obsessive-compulsive behavior

Primary Outcomes

Measure: Blood oxygen-level dependent (BOLD) functional MRI signal during a cognitive conflict task

Time: approximately 15-20 minutes

Description: Child Yale-Brown Obsessive Compulsive Scale (CYBOCS) is scored on a scale of 0 to 40, with 40 being the most severe.

Measure: Child Yale-Brown Obsessive Compulsive Scale

Time: approximately 1 hour

Secondary Outcomes

Measure: Blood oxygen-level dependent (BOLD) functional connectivity MRI of task control circuits

Time: approximately 10 minutes

Measure: Diffusion tensor imaging (fractional anisotropy, FA) in task control circuit regions

Time: approximately 10 minutes


HPO Nodes