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Name (Synonyms) | Correlation |
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There is one clinical trial.
Osteosarcopenia designates the simultaneous presence of sarcopenia and osteopenia; both chronic conditions of advanced age. Dynamic-resistance exercise (DRT) might be the most powerful agent to fight osteosarcopenia. Indeed, in the present FrOST study, we clearly determine the positive effect of slightly adapted 18 month high-intensity (HIT)-DRT on bone mineral density (BMD), sarcopenia and other health related parameters in osteosarcopenic men. However, after a short training break, COVID-19 induced lock down prevented a re-start of the HIT resistance exercise training in the FrOST cohort. The aim of the present observational study is thus to determine the effects of 6 months of deconditioning on health related parameters under special regard of osteosarcopenia in this cohort of older men with osteosarcopenia.
Description: Skeletal muscle mass index (appendicular skeletal muscle mass / body height; kg/m2) as determined by Dual Energy x-Ray Absorptiometry
Measure: SMI Time: Change from Baseline to 26 weeksDescription: Bone Mineral Density at the Lumbar Spine as determined by Dual Energy x-Ray Absorptiometry
Measure: BMD-LS Time: Change from Baseline to 26 weeksDescription: Bone Mineral Density at the total hip as determined by Dual Energy x-Ray Absorptiometry
Measure: BMD-hip Time: Change from Baseline to 26 weeksDescription: Z-Score of parameters constituting the metabolic syndrome (i.e. SMI, hand-grip strength, gait velocity)
Measure: Sarcopenia-Z-Score Time: Change from Baseline to 26 weeksDescription: Intramuscular adipose tissue at the mid thigh as determined by Magnetic Resonance Imaging
Measure: Fat infiltration thigh muscles Time: Change from Baseline to 26 weeksDescription: Intramuscular adipose tissue at the mid thigh as determined by Magnetic Resonance Imaging
Measure: Fat infiltration para-vertebral muscles Time: Change from Baseline to 26 weeksDescription: Maximum hip-/leg extensor strength as determined by an isokinetic leg press
Measure: Maximum hip-/leg extensor strength Time: Change from Baseline to 26 weeksDescription: Metabolic Syndrome Z-Score based on the definition of the International Diabetes Federation including waist circumference, resting glucose, HDL-cholesterol, triglyzerides, mean arterial blood pressure)
Measure: Metabolic Syndrome Z-Score Time: Change from Baseline to 26 weeksDescription: Late-Life Function and Disability Index of McAuley et al.
Measure: Self rated physical performance Time: Change from Baseline to 26 weeks