Covid 19 Clinical Trials

	Name (Synonyms)	Correlation
drug622	Completion of pre-pandemic survey Wiki	0.50
drug621	Completion of post telemedicine encounter survey Wiki	0.50
drug2689	WebEx Physical Activity Program Wiki	0.50
drug623	Completion of survey after peak of pandemic Wiki	0.50
drug2032	ReWalk 6.0 Wiki	0.50

Correlated MeSH Terms (2)

	Name (Synonyms)	Correlation
D014947	Wounds and Injuries NIH	0.22
D001930	Brain Injuries, NIH	0.19

Correlated HPO Terms (0)

	Name (Synonyms)	Correlation

There are 4 clinical trials

Clinical Trials

1 CSP #2003 - Exoskeleton Assisted-Walking in Persons With SCI: Impact on Quality of Life

Background Veterans with spinal cord injury (SCI) have many adverse secondary medical and quality of life (QOL) changes as a result of immobilization. Veterans with SCI who have completed rehabilitation after injury and are unable to ambulate receive a wheelchair as standard of care (SOC) for mobility. Powered exoskeletons are a technology that has recently become available as an alternate form of mobility by providing an external framework for support and computer controlled motorized hip and knee joints to assist with over ground ambulation.

NCT02658656 Spinal Cord Injury Device: ReWalk 6.0

MeSH:Spinal Cord Injuries

Primary Outcomes

Description: The Veterans RAND 36 Item Health Survey (VR-36) is a brief, generic, multi-use, self-administered health survey comprised of 36 items. The instrument is primarily used to measure health related quality of life, to estimate disease burden and to evaluate disease-specific impact on general and selected populations. The items on the questionnaire correspond to eight principal health domains including general health perceptions, physical functioning, role limitations due to physical and emotional problems, bodily pain, energy-fatigue, social functioning and mental health. The outcome in this study is the score from the Mental Health Component Summary (MCS) of the VR-36, which measures the vitality, social functioning, role-emotional, and mental health of the participant.

Measure: Mental Health Component Summary (MCS) of the Veterans Rand-36 (VR-36)

Time: Change from Baseline Assessment to 4 Months Post Intervention

Description: The Spinal Cord Injury - Quality of Life (SCI-QOL) measurement tool was developed to assess patient reported outcome measures in persons with SCI. It is comprised of four broad domains of physical-medical health, emotional health, social participation, and physical functioning. Primary Outcome #2 will be a sum of the scores on the Bladder Management Difficulties, Bowel Management Difficulties, and Pain Interference item banks within the Physical-Medical Health domain.

Measure: The sum T-score for the SCI-QOL Physical Medical Health domain (three item banks of Bladder Management Difficulties, Bowel Management Difficulties, and Pain Interference)

Time: Change from Baseline Assessment to 4 Months Post Intervention

Secondary Outcomes

Description: Total body fat mass as measured by DXA (Dual energy X-Absorptiometry) scan.

Measure: Total Body Fat Mass (Kg)

Time: Change from Baseline Assessment to 4 Months Post Intervention

2 Improving Activity Engagement Among Persons With SCI During COVID-19

During the current COVID-19 pandemic many spinal cord injury (SCI) rehabilitation services are limited to emergency management, leaving those living in the community without access to services. Unfortunately, this can lead to negative effects including increase in emotional distress, feelings of isolation, and decreased activity engagement. Due to their limited mobility and greater likelihood of respiratory illness it is imperative to provide alternative forms of activity engagement to reduce their risk for secondary complications. Physical activity has been demonstrate to have numerous benefits for individuals with SCI ranging from enhanced health through prevention of secondary complications to improved subjective well-being. The current study proposes to provide an online physical activity program through web-based videoconferencing to person with SCI to improve overall wellbeing and activity engagement. The program will consist of six weeks of twice-weekly, 45-minute sessions in which an experienced fitness instructor (i.e., wheelchair aerobics) with lived experience and a Kinesiology graduate student will lead online sessions. The sessions will be comprised of a 10-minute warm-up phase, a 25-minute aerobic phase and a 10-minute cool-down phase that will incorporate upper-extremity flexibility exercises and guided meditation. In all cases, remote (i.e., in-home) participant monitoring of physiological signals will be conducted by the instructor to ensure safety of participants. Once the program has been completed, participants will be asked to complete self-report questionnaires related to acceptability, feasibility, and limited effectiveness. Participants will also be asked to complete a brief semi-structured interview examining barriers and facilitators of the program. Participant feedback from the interviews will be used to further develop of the program to meet the needs of the population and develop sustainable approaches for access to care in the community setting through collaborations with community partners (SCI Ontario, National SCI Alliance, Ontario Neurotrauma Foundation). Ultimately, the proposed project aims to improve overall wellbeing and access to health care service for those with SCI during the COVID-19 quarantine.

NCT04408287 Spinal Cord Injuries Other: WebEx Physical Activity Program

MeSH:Spinal Cord Injuries

Primary Outcomes

Description: Treatment Satisfaction Questionnaire

Measure: Treatment Satisfaction

Time: 6 weeks

Secondary Outcomes

Description: Spinal Cord Injury - Quality of Life Short Form

Measure: Ability to Participate in Social Roles and Activities

Time: Baseline, 6 weeks, and at 3 month follow-up

Description: Spinal Cord Injury - Quality of Life Short Form

Measure: Fatigue

Time: Baseline, 6 weeks, and at 3 month follow-up

Description: Spinal Cord Injury - Quality of Life Short Form

Measure: Satisfaction with Social Roles and Activities

Time: Baseline, 6 weeks, and at 3 month follow-up

Description: Spinal Cord Injury - Quality of Life Short Form

Measure: Positive Affect and Well-Being

Time: Baseline, 6 weeks, and at 3 month follow-up

Description: Spinal Cord Injury - Quality of Life Short Form

Measure: Pain Interference

Time: Baseline, 6 weeks, and at 3 month follow-up

Description: Spinal Cord Injury - Quality of Life Short Form

Measure: Resilience

Time: Baseline, 6 weeks, and at 3 month follow-up

Description: Spinal Cord Injury - Quality of Life Short Form

Measure: Self-Esteem

Time: Baseline, 6 weeks, and at 3 month follow-up

Other Outcomes

Description: Fear of COVID-19 Scale

Measure: Fear of COVID-19 Scale

Time: Baseline, 6 weeks, and at 3 month follow-up

3 Tracking Needs of Persons With a Spinal Cord Injury (SCI) During the COVID-19 Pandemic

Persons with spinal cord injury (PwSCI) are at a greater risk for major health conditions and poorer health outcomes than persons without spinal cord injury (SCI). They often experience a great deal of health needs both on a physiological level as well as a psychosocial level. PwSCI frequently require supports and services to be able to live independently within the community. These services and supports are sometimes difficult to access within the community when the country is operating under regular capacity, in current times with the global COVID-19 pandemic, the challenges for obtaining and accessing supports and services will become much greater. The proposed project aims to identify the specific needs during this time of crisis and to provide referrals and resources to ameliorate those needs by surveying PwSCI in the St. Louis region. The project also hopes to determine if these persons experience isolation during shelter at home orders. PwSCI, who the investigators serve or have served in the past, will be contacted via phone or e-mail once a month for six months and asked to complete a questionnaire that will allow the investigators to track the participant's needs during the COVID-19 pandemic.

NCT04422769 Spinal Cord Injuries

MeSH:Spinal Cord Injuries Wounds and Injuries

Primary Outcomes

Description: Instrumental Support refers to the perception that people in one's social network are available to provide material or functional aid in completing daily tasks (such as making meals or providing transportation) if needed. This self-report measure for adults (ages 18 and above) is an 8-item calibrated scale.This study will use the measure to determine if people's instrumental support changes during a pandemic.

Measure: NIH Toolbox Instrumental Support Survey - change in instrumental support

Time: Initial, 3 month and 6 month

Secondary Outcomes

Description: A scale designed to measure one's subjective feelings of loneliness as well as feelings of social isolation. Participants rate each of the 3 items as hardly ever, some of the time, or often. This study will use the measure to determine if people feel socially isolated during a pandemic.

Measure: UCLA 3-item Loneliness Scale - change in social isolation

Time: Initial, 3 month and 6 month

4 COVID-19 and Disability: The Impact of a Societal Lockdown on Those With Spinal Cord and Brain Injuries

Document and evaluate the impact of societal restrictions due to the pandemic on SCI- and ABI-related disability and functional impairments, and the resultant effects on psychological wellbeing, physical wellbeing and quality of life for those with SCI/ABI.

NCT04426071 Brain Injuries Stroke Spinal Cord Injuries