Covid 19 Research using Clinical Trials (Home Page)
Report for D009765: Obesity NIH
(Synonyms: Ob, Obe, Obes, Obesi, Obesity)
Developed by Shray Alag
Clinical Trial MeSH HPO Drug Gene SNP Protein Mutation
Correlated Drug Terms (9)
| Name (Synonyms) | Correlation | |
|---|---|---|
| drug2085 | Response and Attention Training Wiki | 0.41 |
| drug997 | Generic Response Training Control Intervention Wiki | 0.41 |
| drug910 | FBT+Variety Wiki | 0.41 |
| drug626 | Computer Based Response Training Weight Loss Intervention Wiki | 0.41 |
| drug909 | FBT Wiki | 0.41 |
| drug2459 | Telemedicine to remote outpatient visit in bariatric patient Wiki | 0.41 |
| drug894 | Exposure to the Dutch measures due to the Covid-19 pandemic. Wiki | 0.41 |
| drug2768 | blood sampling for biobank Wiki | 0.41 |
| drug1915 | Project Health Wiki | 0.41 |
Correlated MeSH Terms (7)
| Name (Synonyms) | Correlation | |
|---|---|---|
| D050177 | Overweight NIH | 0.37 |
| D063766 | Pediatric Obesity NIH | 0.37 |
| D006963 | Hyperphagia NIH | 0.29 |
| D001068 | Feeding and Eating Disorders NIH | 0.20 |
| D016638 | Critical Illness NIH | 0.06 |
| D045169 | Severe Acute Respiratory Syndrome NIH | 0.02 |
| D018352 | Coronavirus Infections NIH | 0.02 |
Correlated HPO Terms (2)
| Name (Synonyms) | Correlation | |
|---|---|---|
| HP:0001513 | Obesity HPO | 1.00 |
| HP:0002591 | Polyphagia HPO | 0.29 |
There are 6 clinical trials
Clinical Trials
1 Translational Neuroscience: Response Training for Obesity Treatment
This project will test whether a food response training intervention produces lasting body fat loss, use objective brain imaging to examine the mechanism of effect of this treatment and investigate the generalizability of the training to non-training foods, and examine factors that should amplify intervention effects to provide a test of the intervention theory. This novel treatment represents a bottom-up implicit training intervention that does not rely on executive control, prolonged caloric deprivation, and expensive clinicians to deliver, like behavioral weight loss treatments that have not produced lasting weight loss. If this computer-based response training intervention produces sustained body fat loss in overweight individuals, it could be easily implemented very broadly at almost no expense, addressing a leading public health problem.
NCT03375853 Obesity Hyperphagia Feeding and Eating Disorders Behavioral: Computer Based Response Training Weight Loss Intervention Behavioral: Generic Response Training Control Intervention MeSH:Obesity Hyperphagia Feeding and Eating Disorders
HPO:Obesity Polyphagia
Primary Outcomes
Description: Change in participant's body fat percentage
Measure: Body Fat Change Time: Baseline, 1 month, 3 months, 6 months, 12 months
Secondary Outcomes
Description: Eating disorder symptoms as measured with the Eating Disorder Diagnostic Interview
Measure: Change in Eating Disorder Symptoms Time: Baseline, 1 month, 3 months, 6 months, 12 months
Description: Change in Dietary Restraint, Emotional Eating, and External Eating (aggregate score) as measured by the Dutch Eating Behavior Questionnaire
Measure: Dietary Restraint, Emotional Eating, and External Eating Time: Baseline, 1 month, 3 months, 6 months, 12 months
Description: Chang in Disinhibited Eating as measured by the Three Factor Eating Questionnaire
Measure: Change in Disinhibited Eating Behavior Time: Baseline, 1 month, 3 months, 6 months, 12 months
Description: Change in Eating When Not Hungry as measured by the Eating in the Absence of Hunger Questionnaire
Measure: Change in Eating in the Absence of Hunger Behavior Time: Baseline, 1 month, 3 months, 6 months, 12 months
Description: Change in Problematic eating patterns associated with symptoms of addictive behaviors as measured by the Yale Food Addiction Scale
Measure: Change in Food Addiction Behavior Time: Baseline, 1 month, 3 months, 6 months, 12 months
Description: Change in Physical Activity as measured by the Paffenberger Questionnaire
Measure: Change in Physical Activity Time: Baseline, 1 month, 3 months, 6 months, 12 months
Description: Change in Substance use frequency (i.e., number of times per day) for alcohol of participants as measured by the Daily Drinking Questionnaire
Measure: Change in Alcohol Use Behavior Time: Baseline, 1 month, 3 months, 6 months, 12 months
Description: Change in Substance use frequency (i.e., number of times per day) for common recreational drugs of participants as measured by the Daily Drug Taking Questionnaire
Measure: Change in Substance Use Behavior Time: Baseline, 1 month, 3 months, 6 months, 12 months
Description: Change in Participant behavioral response to food pictures, and subjective palatability rating
Measure: Change in Participant Ratings of Unhealthy Food Palatability Time: Baseline, 1 month
Description: Change in Participant behavioral response to food pictures, and willingness to pay given dollar amounts (aggregate score) for the pictured food
Measure: Change in Participant Ratings of Food Monetary Value Time: Baseline, 1 month
Description: Change Participant food craving behaviors as measured by the Food Craving and Liking Scale
Measure: Change in Food Craving and Liking Behavior Time: Baseline, 1 month, 3 months, 6 months, 12 months
Description: Change in Participant BMI using standard methods of calculation
Measure: Change in Body Mass Index Time: Baseline, 1 month, 3 months, 6 months, 12 months
Description: Change in mean R-Peak Amplitude measured using three-lead ECG using PowerLab 8 Diagnostic Suite
Measure: Change in mean R-Peak Amplitude Time: Baseline, 1 month, 3 months, 6 months, 12 months
Description: Change in Heart Rate Variability measured using three-lead ECG using PowerLab 8 Diagnostic Suite
Measure: Change in Heart Rate Variability Time: Baseline, 1 month, 3 months, 6 months, 12 months
2 Enhancing Effectiveness of a Dissonance-Based Obesity Prevention Program
Primary Outcomes
Description: Change in participant's body fat percentage
Measure: Body Fat Change Time: Baseline, 1 month, 3 months, 6 months, 12 monthsSecondary Outcomes
Description: Eating disorder symptoms as measured with the Eating Disorder Diagnostic Interview
Measure: Change in Eating Disorder Symptoms Time: Baseline, 1 month, 3 months, 6 months, 12 monthsDescription: Change in Dietary Restraint, Emotional Eating, and External Eating (aggregate score) as measured by the Dutch Eating Behavior Questionnaire
Measure: Dietary Restraint, Emotional Eating, and External Eating Time: Baseline, 1 month, 3 months, 6 months, 12 monthsDescription: Chang in Disinhibited Eating as measured by the Three Factor Eating Questionnaire
Measure: Change in Disinhibited Eating Behavior Time: Baseline, 1 month, 3 months, 6 months, 12 monthsDescription: Change in Eating When Not Hungry as measured by the Eating in the Absence of Hunger Questionnaire
Measure: Change in Eating in the Absence of Hunger Behavior Time: Baseline, 1 month, 3 months, 6 months, 12 monthsDescription: Change in Problematic eating patterns associated with symptoms of addictive behaviors as measured by the Yale Food Addiction Scale
Measure: Change in Food Addiction Behavior Time: Baseline, 1 month, 3 months, 6 months, 12 monthsDescription: Change in Physical Activity as measured by the Paffenberger Questionnaire
Measure: Change in Physical Activity Time: Baseline, 1 month, 3 months, 6 months, 12 monthsDescription: Change in Substance use frequency (i.e., number of times per day) for alcohol of participants as measured by the Daily Drinking Questionnaire
Measure: Change in Alcohol Use Behavior Time: Baseline, 1 month, 3 months, 6 months, 12 monthsDescription: Change in Substance use frequency (i.e., number of times per day) for common recreational drugs of participants as measured by the Daily Drug Taking Questionnaire
Measure: Change in Substance Use Behavior Time: Baseline, 1 month, 3 months, 6 months, 12 monthsDescription: Change in Participant behavioral response to food pictures, and subjective palatability rating
Measure: Change in Participant Ratings of Unhealthy Food Palatability Time: Baseline, 1 monthDescription: Change in Participant behavioral response to food pictures, and willingness to pay given dollar amounts (aggregate score) for the pictured food
Measure: Change in Participant Ratings of Food Monetary Value Time: Baseline, 1 monthDescription: Change Participant food craving behaviors as measured by the Food Craving and Liking Scale
Measure: Change in Food Craving and Liking Behavior Time: Baseline, 1 month, 3 months, 6 months, 12 monthsDescription: Change in Participant BMI using standard methods of calculation
Measure: Change in Body Mass Index Time: Baseline, 1 month, 3 months, 6 months, 12 monthsDescription: Change in mean R-Peak Amplitude measured using three-lead ECG using PowerLab 8 Diagnostic Suite
Measure: Change in mean R-Peak Amplitude Time: Baseline, 1 month, 3 months, 6 months, 12 monthsDescription: Change in Heart Rate Variability measured using three-lead ECG using PowerLab 8 Diagnostic Suite
Measure: Change in Heart Rate Variability Time: Baseline, 1 month, 3 months, 6 months, 12 monthsThis project seeks to improve the effectiveness of a novel dissonance-based obesity prevention program that has reduced future BMI gain and overweight/obesity onset by (a) experimentally testing whether implementing it in single- versus mixed-sex groups, which should increase dissonance-induction that contributes to weight gain prevention effects, and (b) experimentally testing whether adding food response and attention training, which theoretically reduces valuation of and attention for high-calorie foods, increases weight gain prevention effects. This randomized trial would be the first to experimentally manipulate these two factors in an effort to produce superior weight gain prevention effects. A brief effective obesity prevention program that can be easily, inexpensively, and broadly implemented to late adolescents at risk for excess weight gain, as has been the case with another dissonance-based prevention program, could markedly reduce the prevalence of obesity and associated morbidity and mortality.
NCT03710746 Overweight and Obesity Behavioral: Project Health Behavioral: Response and Attention Training MeSH:Obesity Overweight
HPO:Obesity
Primary Outcomes
Description: Change in percentage of body fat (Not collected during COVID-19 shelter-at-home order)
Measure: Body Fat Time: Baseline, 2 months, 8 months, 14 months, 26 months, and 38 months
Description: Change in BMI (Not collected during COVID-19 shelter-at-home order)
Measure: Body Mass Index (BMI) Time: Baseline, 2 months, 8 months, 14 months, 26 months, and 38 months
Secondary Outcomes
Description: Change in weight concerns. Scale scores range from 0 to 42 with higher scores being indicative of higher weight concerns.
Measure: Weight Concerns Scale from the Eating Disorder Examination Questionnaire (EDE-Q) Time: Baseline, 2 months, 8 months, 14 months, 26 months, and 38 months
Description: Change in depressive symptoms
Measure: Beck Depression Index (BDI) Time: Baseline, 2 months, 8 months, 14 months, 26 months, and 38 months
Description: Change in eating disorder symptoms
Measure: Eating Disorder Interview (EDDI) Time: Baseline, 2 months, 8 months, 14 months, 26 months, and 38 months
3 Families Becoming Healthy Together
Primary Outcomes
Description: Change in percentage of body fat (Not collected during COVID-19 shelter-at-home order)
Measure: Body Fat Time: Baseline, 2 months, 8 months, 14 months, 26 months, and 38 monthsDescription: Change in BMI (Not collected during COVID-19 shelter-at-home order)
Measure: Body Mass Index (BMI) Time: Baseline, 2 months, 8 months, 14 months, 26 months, and 38 monthsSecondary Outcomes
Description: Change in weight concerns. Scale scores range from 0 to 42 with higher scores being indicative of higher weight concerns.
Measure: Weight Concerns Scale from the Eating Disorder Examination Questionnaire (EDE-Q) Time: Baseline, 2 months, 8 months, 14 months, 26 months, and 38 monthsDescription: Change in depressive symptoms
Measure: Beck Depression Index (BDI) Time: Baseline, 2 months, 8 months, 14 months, 26 months, and 38 monthsDescription: Change in eating disorder symptoms
Measure: Eating Disorder Interview (EDDI) Time: Baseline, 2 months, 8 months, 14 months, 26 months, and 38 monthsThe investigators plan to implement a novel limited RED (high-energy-dense) food variety prescription within a 18-month FBT to examine its effect on 18-month body mass index (BMI). This will be the first randomized control trial to examine how habituation rate, assessed via salivary habituation, mediates reduction in RED food intake, overall energy intake, and reductions in BMI over time, as well as if baseline habituation rate is a behavioral phenotype that moderates BMI outcomes. One hundred fifty-six children aged 8 to 12 years at > 85th percentile BMI will be randomized to one of two, 18-month interventions compared in our 6-month pilot study: FBT (family-based behavioral obesity treatment) or FBT+Variety. Child and adult caregiver assessments will occur at 0, 6, 12, and 18 months on anthropometrics, dietary intake (RED food variety, energy, and diet quality), habituation, and physical activity.
NCT04027426 Obesity Childhood Obesity Behavioral: FBT Behavioral: FBT+Variety MeSH:Obesity Pediatric Obesity
HPO:Obesity
Primary Outcomes
Description: Child's and adult caregiver's weight will be assessed by an electronic scale and height will be measured by a stadiometer.
Measure: Child and adult body mass index Time: Change from 0 to 6, and 6 to 18 months
Description: To assess habituation of salivary responses to food cues, whole mouth parotid salivary flow will be measured using the Strongin-Hinsie Peck method. Two measures will be taken, one with juice and one with food.
Measure: Child and adult salivary habituation Time: Change from 0 to 6, and 6 to 18 months
Secondary Outcomes
Description: Dietary intake for both the child and adult caregiver will be assessed by 3 (2 weekdays and 1 weekend day) 24-hour dietary phone recalls, using the five-step, multiple-pass method. Variables of interest will be the variety of RED foods consumed over the three days; and the mean over the three days of daily servings and kcal from RED foods, kcal, energy density (kcal/g), and Healthy Eating Index (HEI)-2015. Adherence to the prescriptions in the two conditions will be examined. At 6, 12, and 18 months, the percentage of goals met each day will be calculated, with a mean percentage calculated. We will also provide a detailed list of snack foods to participants, and they will be asked to indicate which of the foods on the list were eaten during the previous month, regardless of quantity consumed.
Measure: Child and adult dietary Intake Time: Change from 0 to 6, and 6 to 18 months
Description: The wGT9x (ActiGraph, LLC, Pensacola, FL) will objectively measure time spent in MVPA (physical activity at > 3.0 metabolic equivalents units).
Measure: Child and adult physical activity via wGT3X-BT Time: Change from 0 to 6, and 6 to 18 months
Description: Percent overweight (%OW) will also be calculated (100*[BMI/50th percentile BMI for child age and sex]).
Measure: Child percent overweight Time: Change from 0 to 6, and 6 to 18 months
Description: Waist circumference (WC) will be measured using standard procedures.
Measure: Child and adult waist circumference Time: Change from 0 to 6, and 6 to 18 months
Description: Parent time scarcity and fatigue as barriers to planning and preparing meals will measure frequency of occurrence of these barriers.
Measure: Meal planning, preparation, and grocery shopping Time: Change from 0 to 6, and 6 to 18 months
Description: Child eating pathology will be assessed using the Kid's Eating Disorder Survey
Measure: Child eating pathology Time: Change from 0 to 6, and 6 to 18 months
Description: Self-reported inventory of foods available in the household will be assessed
Measure: Home Food Inventory Time: Change from 0 to 6, and 6 to 18 months
Description: Usual sleeping and waking time will be collected
Measure: Child and Adult Sleep Habits Time: Change from 0 to 6, and 6 to 18 months
Description: Parent-report measure of commonly occurring routines in school-aged children will measure the frequency of occurrence of routines in children.
Measure: Child Routines Time: Change from 0 to 6, and 6 to 18 months
Description: Total number of weekly, and type, of self-monitoring records (hard copy or electronic) completed will be assessed. Number of treatment sessions attended will be recorded.
Measure: Compliance and process data Time: 6, 12, and 18 months
4 Outpatient Clinic in Obesity Care During COVID-19 Outbreak: Physically Far, Virtually Near. Brief Correspondence on a Single Center Experience. Cohort Study
Primary Outcomes
Description: Child's and adult caregiver's weight will be assessed by an electronic scale and height will be measured by a stadiometer.
Measure: Child and adult body mass index Time: Change from 0 to 6, and 6 to 18 monthsDescription: To assess habituation of salivary responses to food cues, whole mouth parotid salivary flow will be measured using the Strongin-Hinsie Peck method. Two measures will be taken, one with juice and one with food.
Measure: Child and adult salivary habituation Time: Change from 0 to 6, and 6 to 18 monthsSecondary Outcomes
Description: Dietary intake for both the child and adult caregiver will be assessed by 3 (2 weekdays and 1 weekend day) 24-hour dietary phone recalls, using the five-step, multiple-pass method. Variables of interest will be the variety of RED foods consumed over the three days; and the mean over the three days of daily servings and kcal from RED foods, kcal, energy density (kcal/g), and Healthy Eating Index (HEI)-2015. Adherence to the prescriptions in the two conditions will be examined. At 6, 12, and 18 months, the percentage of goals met each day will be calculated, with a mean percentage calculated. We will also provide a detailed list of snack foods to participants, and they will be asked to indicate which of the foods on the list were eaten during the previous month, regardless of quantity consumed.
Measure: Child and adult dietary Intake Time: Change from 0 to 6, and 6 to 18 monthsDescription: The wGT9x (ActiGraph, LLC, Pensacola, FL) will objectively measure time spent in MVPA (physical activity at > 3.0 metabolic equivalents units).
Measure: Child and adult physical activity via wGT3X-BT Time: Change from 0 to 6, and 6 to 18 monthsDescription: Percent overweight (%OW) will also be calculated (100*[BMI/50th percentile BMI for child age and sex]).
Measure: Child percent overweight Time: Change from 0 to 6, and 6 to 18 monthsDescription: Waist circumference (WC) will be measured using standard procedures.
Measure: Child and adult waist circumference Time: Change from 0 to 6, and 6 to 18 monthsDescription: Parent time scarcity and fatigue as barriers to planning and preparing meals will measure frequency of occurrence of these barriers.
Measure: Meal planning, preparation, and grocery shopping Time: Change from 0 to 6, and 6 to 18 monthsDescription: Child eating pathology will be assessed using the Kid's Eating Disorder Survey
Measure: Child eating pathology Time: Change from 0 to 6, and 6 to 18 monthsDescription: Self-reported inventory of foods available in the household will be assessed
Measure: Home Food Inventory Time: Change from 0 to 6, and 6 to 18 monthsDescription: Usual sleeping and waking time will be collected
Measure: Child and Adult Sleep Habits Time: Change from 0 to 6, and 6 to 18 monthsDescription: Parent-report measure of commonly occurring routines in school-aged children will measure the frequency of occurrence of routines in children.
Measure: Child Routines Time: Change from 0 to 6, and 6 to 18 monthsDescription: Total number of weekly, and type, of self-monitoring records (hard copy or electronic) completed will be assessed. Number of treatment sessions attended will be recorded.
Measure: Compliance and process data Time: 6, 12, and 18 monthsBariatric patients represent a peculiar and frail subset of subjects, constantly increasing. During the novel coronavirus disease outbreak, for the lockdown of any non-urgent and non-oncological activity, the access to healthcare services was severely limited, according to the International Federation for the Surgery of Obesity and Metabolic Disorders.
NCT04407663 Bariatric Surgery Candidate Patient Underwent Bariatric Surgery Other: Telemedicine to remote outpatient visit in bariatric patient MeSH:Obesity
HPO:Obesity
Primary Outcomes
Description: Telemedicine to follow-up and identify sing or symptom of alarm in patient undergoing bariatric surgery or in established bariatric patients during COVID-19 outbreak
Measure: Evaluation of feasibility of telemedicine in outpatient visit in bariatric patients Time: 2 months
5 The Influence of the Covid-19 Pandemia on the Health Behaviour of Primary School Children (and Their Parents) - COVID-19, Obesity and Lifestyle in Children
Primary Outcomes
Description: Telemedicine to follow-up and identify sing or symptom of alarm in patient undergoing bariatric surgery or in established bariatric patients during COVID-19 outbreak
Measure: Evaluation of feasibility of telemedicine in outpatient visit in bariatric patients Time: 2 monthsThis study aims to evaluate the impact of the COVID-19 pandemic and its measures on lifestyle in Dutch children between 4 - 18 years.
NCT04411511 Covid-19 Obesity, Childhood Lifestyle Lifestyle, Healthy Overweight, Childhood Children, Only Family Other: Exposure to the Dutch measures due to the Covid-19 pandemic. MeSH:Obesity Pediatric Obesity Overweig Overweight
HPO:Obesity
Primary Outcomes
Description: Weight development of the child. Weight (in kg) will be measured using scales at home, with clear instructions.
Measure: Change in weight child Time: Every 2 weeks until end of the Dutch governement measures affecting children (e.g. fully opening of the schools and sportclubs). Three months after the "measures"-period, 1 follow-up moment.
Description: Weight development of the parents. Weight (in kg) will be measured using scales at home, with clear instructions.
Measure: Change in weight parents Time: Every 2 weeks until end of the Dutch governement measures affecting children (e.g. fully opening of the schools and sportclubs, hereafter: "coronacrisis-period"). Three months after the "measures"-period, 1 follow-up moment.
Secondary Outcomes
Description: eating behaviour during measures due to the coronacrisis, measured with an online questionnaire.
Measure: Eating behaviour Time: Every month until end of the Dutch governement measures affecting children (e.g. fully opening of the schools and sportclubs). Three months after the "measures"-period, 1 follow-up moment.
Description: COVID-19 related symptoms and adherence to governmental measures, measured with an online questionnaire.
Measure: Symptoms Time: Every 2 weeks until end of the Dutch governement measures affecting children (e.g. fully opening of the schools and sportclubs). Three months after the "measures"-period, 1 follow-up moment.
Description: Daystructure of children during the coronacrisis, measured with an online questionnaire.
Measure: Day structure Time: Every month until end of the Dutch governement measures affecting children (e.g. fully opening of the schools and sportclubs). Three months after the "measures"-period, 1 follow-up moment.
Description: Physical activity behaviour children during the coronacrisis, measured with the Baecke questionnaire.
Measure: Physical activity Time: Every month until end of the Dutch governement measures affecting children (e.g. fully opening of the schools and sportclubs). Three months after the "measures"-period, 1 follow-up moment.
Description: Screentime during the the coronacrisis, measured with an online questionnaire.
Measure: Screentime Time: Every month until end of the Dutch governement measures affecting children (e.g. fully opening of the schools and sportclubs). Three months after the "measures"-period, 1 follow-up moment.
Description: Online possibilities for working on a healthy lifestyle, such as challenges regarding nutrition and physical activity, measured with an online questionnaire.
Measure: Online possibilities Time: Every month until end of the Dutch governement measures affecting children (e.g. fully opening of the schools and sportclubs). Three months after the "measures"-period, 1 follow-up moment.
Description: Quality of life during the coronacrisis, measured with the Kidscreen-27.
Measure: Quality of life in children Time: Once in first month of the study and once within three months after COVID-19 measures are scaled down.
Description: Parenting practices regarding eating behaviour and physical activity, measured with a questionnaire.
Measure: Parenting practices Time: Once in first month of the study and once within three months after COVID-19 measures are scaled down.
Other Outcomes
Description: Qualitative data on lifestyle in children during the coronacrisis, by semi-structured interviews.
Measure: Qualitative data on lifestyle in children Time: Up to approximately 1 year
6 Obesity as a Risk Factor for Mortality of Critically Ill Patients With Coronavirus Disease 2019 (COVID-19): a Cohort Study of the First Wave in Nancy, France
Primary Outcomes
Description: Weight development of the child. Weight (in kg) will be measured using scales at home, with clear instructions.
Measure: Change in weight child Time: Every 2 weeks until end of the Dutch governement measures affecting children (e.g. fully opening of the schools and sportclubs). Three months after the "measures"-period, 1 follow-up moment.Description: Weight development of the parents. Weight (in kg) will be measured using scales at home, with clear instructions.
Measure: Change in weight parents Time: Every 2 weeks until end of the Dutch governement measures affecting children (e.g. fully opening of the schools and sportclubs, hereafter: "coronacrisis-period"). Three months after the "measures"-period, 1 follow-up moment.Secondary Outcomes
Description: eating behaviour during measures due to the coronacrisis, measured with an online questionnaire.
Measure: Eating behaviour Time: Every month until end of the Dutch governement measures affecting children (e.g. fully opening of the schools and sportclubs). Three months after the "measures"-period, 1 follow-up moment.Description: COVID-19 related symptoms and adherence to governmental measures, measured with an online questionnaire.
Measure: Symptoms Time: Every 2 weeks until end of the Dutch governement measures affecting children (e.g. fully opening of the schools and sportclubs). Three months after the "measures"-period, 1 follow-up moment.Description: Daystructure of children during the coronacrisis, measured with an online questionnaire.
Measure: Day structure Time: Every month until end of the Dutch governement measures affecting children (e.g. fully opening of the schools and sportclubs). Three months after the "measures"-period, 1 follow-up moment.Description: Physical activity behaviour children during the coronacrisis, measured with the Baecke questionnaire.
Measure: Physical activity Time: Every month until end of the Dutch governement measures affecting children (e.g. fully opening of the schools and sportclubs). Three months after the "measures"-period, 1 follow-up moment.Description: Screentime during the the coronacrisis, measured with an online questionnaire.
Measure: Screentime Time: Every month until end of the Dutch governement measures affecting children (e.g. fully opening of the schools and sportclubs). Three months after the "measures"-period, 1 follow-up moment.Description: Online possibilities for working on a healthy lifestyle, such as challenges regarding nutrition and physical activity, measured with an online questionnaire.
Measure: Online possibilities Time: Every month until end of the Dutch governement measures affecting children (e.g. fully opening of the schools and sportclubs). Three months after the "measures"-period, 1 follow-up moment.Description: Quality of life during the coronacrisis, measured with the Kidscreen-27.
Measure: Quality of life in children Time: Once in first month of the study and once within three months after COVID-19 measures are scaled down.Description: Parenting practices regarding eating behaviour and physical activity, measured with a questionnaire.
Measure: Parenting practices Time: Once in first month of the study and once within three months after COVID-19 measures are scaled down.Other Outcomes
Description: Qualitative data on lifestyle in children during the coronacrisis, by semi-structured interviews.
Measure: Qualitative data on lifestyle in children Time: Up to approximately 1 yearDisproportionate impact of COVID-19 in patients with obesity is now well established. Obesity is associated with severe forms of COVID-19 and may be a risk factor of intensive care unit (ICU) admission. Obesity is associated with COVID-19 related hospital death in a large United Kingdom cohort study. However, there is a gap of knowledge on assessment of outcomes such as severity of Acute Respiratory Distress syndrome (ARDS), duration of hospitalisation and mortality in ICU. Moreover, an obesity survival paradox has been observed in patients with ARDS. This raises the question whether the obesity paradox has been broken by COVID-19. The investigators aim to explore risk factors of in-ICU death for patient with COVID-19, including obesity and other chronic diseases and to describe the clinical course and outcomes, including the management of acute respiratory failure and other intensive care management.
NCT04425213 COVID Severe Acute Respiratory Syndrome Obesity Comorbidities and Coexisting Conditions MeSH:Severe Acute Respiratory Syndrome Coronavirus Infections Obesity Critical Illness
HPO:Obesity
Primary Outcomes
Description: number of fatal cases
Measure: ICU mortality Time: through study completion, an average of 14 days
Secondary Outcomes
Description: number of patients with invasive mechanical ventilation
Measure: Invasive mechanical ventilation Time: through study completion, an average of 14 days
Description: number of fatal cases
Measure: In-hospital mortality Time: through study completion, an average of 21 days
HPO Nodes
HP:0001513: Obesity
Genes 477
SHOX HACE1 THOC2 LIMK1 FMR1 SOX3 PHF6 CLCN4 IFT172 TNFSF4 PDX1 KCNAB2 AGRP GNAS ADCY3 HLA-DRB1 AFF4 REEP6 PRPF6 KLF11 KIAA1549 ARL6 ELN MKS1 PWAR1 IFT27 SDC3 LIPE SYNE2 RAB39B FGF8 ARHGEF6 RDH12 ZNF408 BRAF SH2B1 BPTF HLA-DQB1 ANOS1 LMNA TRIM32 ARX AKT1 KIF7 TRIP12 SLC7A7 IL1RAPL1 SHANK3 INS EGF RAI1 SYNE1 GNAS ATP6AP2 XRCC4 SLC7A14 GNAS HDAC8 BBS2 HSD11B1 MC4R AGBL5 KMT2D ACADVL BBS4 MEGF8 CYP7A1 RAD21 ARVCF BEST1 RPS6KA3 ZNF365 ADRB3 CRX MID2 ATRX NDN UCP3 IQSEC2 SKI RBP3 CNGB1 RAB23 ZNF513 SLC25A4 FLRT3 KISS1R CCDC141 IFT140 TSPAN7 CCDC141 ARMC5 TRAF3IP1 LZTFL1 SUFU OFD1 MAGEL2 SMC1A AKT2 GNAS ARL6 GTF2IRD1 UFD1 TRIM32 CDHR1 NF2 MEGF8 SNORD115-1 WT1 HACE1 SH2B1 CNGA1 DHDDS RFC2 PSMD12 SMO KIZ NTRK2 BBS10 DCC PRPF8 EP300 SOX10 POU3F4 BAP1 TMEM43 NEK2 DEAF1 GNAS-AS1 BBS9 SIN3A SNRPN MAK FGFR1 PHF6 CLIP2 BBS2 COMT BBS2 HESX1 HESX1 GNAS JMJD1C TCF20 MCM3AP NEUROD1 LZTFL1 ARL6 ABCA4 C8ORF37 GHR TMEM67 USP8 HIRA LEP IQSEC2 CERKL NRL PAX6 TBX1 SRY H6PD CREBBP PRKAR1A PROM1 ZNF41 PCSK1 PCSK1 EHMT1 IMPDH1 CNNM2 RNPC3 C8ORF37 ZNF711 LEPR TTC8 ALMS1 PRCD PROKR2 ELN PNPLA6 PAX4 MKKS GATA4 SYP VPS13B FGF17 PRPF4 HNF1A CA4 GDI1 TUB POMC AIP TTC8 ENPP1 KIDINS220 SLC9A7 CEP164 NSD1 NR2E3 TBX1 HNF4A PWRN1 MC3R KIDINS220 KMT2A BDNF MTTP PCARE ARL6 POMC P2RY11 IQSEC2 BBS10 RAB23 KCNJ18 PDE4D BBS9 HDAC4 TUB XYLT1 SEC24C PDSS1 HGSNAT EIF2S3 IGF1R MAGEL2 IPW FTO GCK SPRY4 PRMT7 ARHGEF18 DYRK1B XYLT1 RP1 GNAS CLRN1 AHR MED12 HDAC8 CTSH TTC8 PNKP IFT172 FGFR1 SIM1 MKKS FTSJ1 MAPK8IP3 ALB IFT74 ALMS1 GUCA1B UPF3B ATRX PDE6G CTNNB1 CCDC28B SETD2 SLC10A7 APOE NIPBL BBS7 RAI1 HCFC1 PRDM16 TOPORS WDR11 BBS5 IDH3B PIK3CA SCAPER ARL2BP SPG11 CXORF56 ADRB2 HS6ST1 RREB1 LAS1L PDE6B BLK IL17RD ADNP TBX3 NPAP1 P4HTM EIF2S3 PRPF3 CARTPT SMC3 POMC SPATA7 SH3KBP1 MECP2 CYP19A1 BBS12 MKS1 NKAP HDAC8 RERE PRKAR1A TAF1 UBE3A MLXIPL KCNJ11 INPP5E HCRT IGF1 RPGR APC2 CNKSR2 BLK PRMT7 MC4R PPARG RPS6KA3 HUWE1 BAZ1B PDGFB PROKR2 NIN AHI1 RBMX SOX2 SAG MECP2 TRAF7 WDPCP HERC2 ABCC8 GP1BB TRAPPC9 BBS12 CEP290 ADNP MKRN3-AS1 PTCHD1 ACSL4 CUL4B BAP1 NR0B2 PROK2 TERT PCNT PCNT EYS WT1 FGFR3 IFT27 RGR GTF2I ZNF711 SDCCAG8 EMD LAS1L CACNA1S GNAS DHX38 IDH3A USP27X DYNC2I2 PIGT PDE4D TACR3 LEPR RHO POGZ MRAP2 EXOC6B BBS5 ZBTB20 FOXP1 RP9 BBS7 SH2B1 KLHL7 EHMT1 DNMT3A ARMC5 RLBP1 ALG13 AGTR2 MYT1L VPS13B CDH23 PAX6 PAK3 SMARCB1 LEP BBS4 ARL13B DUSP6 MKRN3 TRAPPC9 AFF4 SDCCAG8 TBX1 GHRL BBS1 STX16 BBIP1 USH2A MOG LMNA PROK2 OFD1 SIM1 FLII RP2 SETD5 MOG FRMPD4 DPYD IFT172 APPL1 ARNT2 SNORD116-1 NSMF BBS1 DLG3 FAM161A RPE65 PDE4D PRPH2 ROM1 TBL2 OTX2 FHL1 ERMARD C8ORF37 NPHP1 CEP19 DMD SEMA4A ARL3 PHIP CEL MAN1B1 LRAT CANT1 GABRD TULP1 SNRNP200 IFT88 MTFMT AKT2 FSCN2 CEP290 MERTK SEMA3A BBIP1 PDE11A CHD7 IMPG2 POMGNT1 SMARCE1 SMAD4 IFT172 MAN1B1 CUL4B USP9X PRPF31 PTEN KDM6A IGFALS WNT4 SETD2 GNAS TBX3 PDE6A FEZF1 USP8 CRB1 ZNF81 GABRA3
Primary Outcomes
Description: number of fatal cases
Measure: ICU mortality Time: through study completion, an average of 14 daysSecondary Outcomes
Description: number of patients with invasive mechanical ventilation
Measure: Invasive mechanical ventilation Time: through study completion, an average of 14 daysDescription: number of fatal cases
Measure: In-hospital mortality Time: through study completion, an average of 21 days