Covid 19 Research using Clinical Trials (Home Page)
Report for D019586: Intracranial Hypertension NIH
(Synonyms: Intracranial Hypertension)
Developed by Shray Alag
Clinical Trial MeSH HPO Drug Gene SNP Protein Mutation
Correlated Drug Terms (1)
| Name (Synonyms) | Correlation | |
|---|---|---|
| drug538 | Cerebral compliance and hemodynamics monitoring Wiki | 1.00 |
Correlated HPO Terms (1)
| Name (Synonyms) | Correlation | |
|---|---|---|
| HP:0002516 | Increased intracranial pressure HPO | 1.00 |
There is one clinical trial.
Clinical Trials
1 Assessment of Cerebral Compliance and Hemodynamics in Severe COVID-19
Several recent studies point to the possibility of the new coronavirus (SARS-Cov2), which currently causes pandemic COVID-19, to infiltrate the central nervous system (CNS) and cause primary damage to neural tissues, increasing the morbidity and mortality of these patients. A pathophysiological hypothesis for insulting the CNS would be the impairment of cerebral compliance (CC), because elevation of intracranial pressure (ICP), but due to the invasive nature of the methods available for ICP evaluation, this hypothesis has so far not been verified. Recently, a noninvasive technique was developed to evaluate CC (B4C sensor), making it possible to analyse CC in patients outside the neurosurgical environment. Therefore, the main objective of this study was to assess the presence of CC impairment in patients with COVID-19, and observe potential influences of this syndrome on cerebral hemodynamics.
NCT04429477 Intracranial Hypertension Cerebral Circulatory Failure Device: Cerebral compliance and hemodynamics monitoring MeSH:Intracranial Hypertension Shock
HPO:Increased intracranial pressure
Primary Outcomes
Description: Observe alteration in cerebral compliance due to potential intracranial hypertension during severe COVID-19. This situation is indicated when the relation P2/P1 given by the B4C sensor is >1.
Measure: Detection of cerebral compliance impairment by the B4C sensor Time: During critical care, around 15 days/patient
Description: Observe disturbances in cerebral circulation during severe COVID-19, given by blood flow velocities in middle cerebral arteries (with normal range 40-70 cm/s) and the pulsatility index (normal <1.2) calculated by transcranial Doppler.
Measure: Detection of cerebral hemodynamics impairment by transcranial Doppler Time: During critical care, around 15 days/patient
Secondary Outcomes
Description: Observe whether disturbances in cerebral compliance and hemodynamics assessed in this population is significantly associated with higher mortality.
Measure: Calculate mortality in this population Time: 3 months
HPO Nodes
HP:0002516: Increased intracranial pressure
Genes 95
TWIST1 AKT1 ERF PIK3CA BAP1 IL12A PRF1 HLA-B KRAS PRKAR1A TERT KLLN SMO NF2 PDE4D PMS2 TGFBR2 BMPR1A NLRP3 FGFR2 FGFR2 EPCAM SDHB FGFR3 MEFV C4A IL12A-AS1 BAP1 UBAC2 CTNNB1 PDE4D GALK1 FGFR3 IL10 KIAA0586 RPS20 FGFR2 USF3 PTEN TWIST1 TCF12 STAT4 FGFR2 CSPP1 IL23R FGFR3 SEMA4A PTEN ERF SDHC GNA11 PDCD10 ALX4 PDE4D ERAP1 PDGFB CCM2 VHL PIK3CA PSAP GALC CCR1 BRAF L1CAM MLH3 SMARCE1 MSH2 APC KLRC4 DKK1 TRAF7 TWIST1 SMARCB1 KRIT1 LRP5 MSH6 SUFU PMS1 TLR4 ELMO2 AKT1 SEC23B PIK3CA ANTXR1 SOST FGFR3 SOST ZIC1 FAN1 NF2 ZIC1 FAS SDHD CASR MLH1 Protein Mutations 0
SNP 0
Primary Outcomes
Description: Observe alteration in cerebral compliance due to potential intracranial hypertension during severe COVID-19. This situation is indicated when the relation P2/P1 given by the B4C sensor is >1.
Measure: Detection of cerebral compliance impairment by the B4C sensor Time: During critical care, around 15 days/patientDescription: Observe disturbances in cerebral circulation during severe COVID-19, given by blood flow velocities in middle cerebral arteries (with normal range 40-70 cm/s) and the pulsatility index (normal <1.2) calculated by transcranial Doppler.
Measure: Detection of cerebral hemodynamics impairment by transcranial Doppler Time: During critical care, around 15 days/patientSecondary Outcomes
Description: Observe whether disturbances in cerebral compliance and hemodynamics assessed in this population is significantly associated with higher mortality.
Measure: Calculate mortality in this population Time: 3 months