CovidResearchTrials by Shray Alag


CovidResearchTrials Covid 19 Research using Clinical Trials (Home Page)


Report for D019052: Depression, Postpartum NIH

(Synonyms: Depression, Postpartum)

Developed by Shray Alag
Clinical Trial MeSH HPO Drug Gene SNP Protein Mutation


Correlated Drug Terms (10)


Name (Synonyms) Correlation
drug2353 Standardised questionnaires Wiki 0.45
drug816 EPDS (Edinburgh Postnatal Depression Scale) Wiki 0.45
drug972 GAD-7 (General Anxiety Disorder) scale Wiki 0.45
drug38 38 questions questionnaire Wiki 0.45
drug2793 covid-19 positive pregnant women Wiki 0.45
drug1735 PHQ-9 (Patient Health Questionnaire) Depression Scale Wiki 0.45
drug227 Assessment of postnatal depression using the the Edinburgh questionnaire between 4 and 6 weeks after delivery Wiki 0.45
drug2214 Self-administered questionnaires Wiki 0.45
drug2970 psychological assessment Wiki 0.45
drug387 Blood test Wiki 0.32

Correlated MeSH Terms (4)


Name (Synonyms) Correlation
D003863 Depression, NIH 0.28
D003866 Depressive Disorder NIH 0.21
D013315 Stress, Psychological NIH 0.10
D001008 Anxiety Disorders NIH 0.08

Correlated HPO Terms (1)


Name (Synonyms) Correlation
HP:0000716 Depressivity HPO 0.21

There are 5 clinical trials

Clinical Trials


1 Birth Experience During COVID-19 Confinement (Confinement and Fostering Intrapartum Care)

Different studies have demonstrated that the absence of companionship during labor and childbirth may be responsible for a negative birth experience, an increased risk of postnatal depression and/or post traumatic stress disorders. These situation may also have a negative impact on mother-child interaction, on marital and family relationship and on the rate of maternal suicide in postpartum. However, these previous results cannot be extrapolated in the current context where the absence of the companionship is imposed by the confinement framework. The objective of the CONFINE study is to assess, for the first time, the birth experience of women in the context of limited social support in the immediate post-partum period due to confinement, as well as the associated over-risk of mental disorders, compared to a post-partum without social restriction.

NCT04348929 Postpartum Depression Other: Self-administered questionnaires
MeSH:Depression, Postpartum

Primary Outcomes

Measure: "Labor Agentry Scale questionnaire" score in immediate post-partum (duration of hospital stay)

Time: through study completion, an average of 16 months

Secondary Outcomes

Measure: "Labor Agentry Scale questionnaire" score at two months after birth

Time: through study completion, an average of 16 months

Description: To detect suspicion of Post-Partum Depression

Measure: Edinburg Postnatale Depression Scale questionnaire" score at two months after birth

Time: through study completion, an average of 16 months

Description: To detect suspicion of Post traumatic stress syndrome

Measure: "Impact of Event Scale - Revised questionnaire" score at two months after birth

Time: through study completion, an average of 16 months

Measure: Breastfeeding statement at two months after birth

Time: through study completion, an average of 16 months

Measure: "SF-12 Quality of life questionnaire" score at two months after birth

Time: through study completion, an average of 16 months

Measure: "SF-12 Quality of life questionnaire" score in immediate post-partum

Time: through study completion, an average of 16 months

2 Psychological Impact of the Lockdown on Patients Giving Birth During the COVID-19 Epidemic

The COVID-19 epidemic has a major impact on the organization of hospital structures as a whole. Regarding the functioning of the Maternities, it was decided by the three Maternities of AP-HP. Sorbonne University of the Pitié-Salpêtrière, Trousseau and Tenon sites, from March 20, 2020 to no longer authorize visits during the stay of mothers following childbirth. This prohibition has also been extended to spouses. This measure was guided by a concern to protect both the patients, their newborn and the entire staff of the aftermath. The period surrounding a birth is a period of strong emotional impact with an incidence of postpartum depression estimated at 15% in the general population (1). The separation of women from their spouses during this period could expose them to greater psychological vulnerability. In addition, when they return home, the patients will be isolated from their relatives due to the quarantine, which is an additional risk factor for postpartum depression. The teams of the three maternity units of AP-HP. Sorbonne University have organized themselves to be able to respond to situations of mental vulnerability during their stay with the intervention of maternity psychologists and psychiatrists and child psychiatrists as is done in the treatment usual charge. In addition, anticipating situations of greater vulnerability linked to the health crisis, the Maternity teams decided to set up a follow-up of patients after their return home through a telephone interview with psychologists or student psychologists in Master at D10 - D12 and 6-8 weeks postpartum in order to identify patients at increased risk of postpartum depression and to set up appropriate management if necessary for these patients. We therefore propose through this project to describe the consequences of this separation from the spouse during the postpartum stay and then with the family after returning home within the context of quarantine by assessing the incidence of post-partum depression during this sanitary crisis. A telephone interview of all the patients will be proposed on D10 - D12 and at 6-8 weeks postpartum using specific questionnaire to calculate a score of depression. This early identification will allow the establishment of an adapted psychological follow-up.

NCT04366817 Post Partum Depression Behavioral: psychological assessment
MeSH:Depression, Postpartum Depression

Primary Outcomes

Description: assess the emotional impact of women's separation from their partners following childbirth and then their family isolation when they return home in the context of the health crisis linked to the COVID-19 epidemic

Measure: Proportion of patients with postpartum depression defined by an EPDS score >12

Time: Between week 6 and week 8

Description: assess the emotional impact of women's separation from their partners following childbirth and then their family isolation when they return home in the context of the health crisis linked to the COVID-19 epidemic

Measure: Proportion of patients with postpartum depression defined by an EPDS score >12

Time: Between day 10 and day 12

Secondary Outcomes

Measure: Socio-demographic data

Time: Between day 1 and day 5

Measure: Occurrence of a maternal or fetal pathology in a previous pregnancy

Time: Between day 1 and day 5

Measure: Pregnant maternal pathology (hypertension, diabetes, threat of premature delivery)

Time: Between day 1 and day 5

Description: as above, maternal psychological history as vulnerability factor included : history of perinatal loss, IMG, history of post partum depression.

Measure: Presence of psycological maternal risk factor

Time: Between day 1 and day 5

Measure: Dyadic adjustment scale 16 (DAS-16)

Time: Between day 10 and day 12 and at between week 6 and week 8

Measure: Perinatal post traumatic stress disorder questionnaire (PPQ scale)

Time: Between day 10 and day 12

Measure: Mother to infant bonding scale (MIBS) autoquestionnaire

Time: Between day 10 and day 12 and at between week 6 and week 8

Description: Participants will be asked open-ended questions about their post-partum experience in the context of COVID-19 epidemic lockdown. The interviews will be transcribed and tagged with codes which have been extracted from the data. As more data is collected codes can be regrouped into concepts and then categories. These categories are the basis of the "theory model" that emerge from the narrative of the patients. The verbatim of the interview will be analyzed using NVIVO software which allows a grounded theory approach. Using software package as Nvivo (Hutchison, 2010) with automatic analysis of the verbatim to extract codes and concepts provides a transparent account of the data and enhance study validity. Verbatim are download in the software, that extract repeated lexical fields the categories from the mother's narrative. As this is a qualitative study, there are no expected outcomes. Outcomes will be determined by the themes that arise from the post-partum interview process.

Measure: Measure Qualitative Interviews by Grounded theory

Time: Week 14

3 Impact of Giving Birth During the Covid 19 Pandemia on Postnatal Women's Depression

Postnatal depression is an important problematic in French population with approximatively 10 -20% of women who suffer from postnatal depression. This pathology may have strong negative impact on both women and neonate's health. The women's satisfaction degree in front of childbirth is an important factor associated with postnatal depression since women unsatisfied of their childbirth and/or women with a complicated childbirth are more encline to suffer from postnatal depression. It is likely that the actual context of Covid 19 pandemia and the change in obstetrical cares organization may have a negative impact on women's satisfaction about their childbirth and so a negative impact on the risk of postnatal depression.

NCT04368208 Postnatal Depression Other: Assessment of postnatal depression using the the Edinburgh questionnaire between 4 and 6 weeks after delivery
MeSH:Depression, Postpartum Depression Depressive Disorder
HPO:Depressivity

Primary Outcomes

Description: proportion of women with an Edinburgh score higher than 12 between 4 and 6 weeks postpartum

Measure: Report postnatal depression between 4 of 6 weeks during the covid 19 pandemia

Time: 4-6 weeks postpartum

Secondary Outcomes

Description: Existence of an association with postnatal depression and these factors: socio demographic women's characteristics, modalities of pregnancy management, satisfaction and experience about delivery, postnatal pelvic floor disorders, self rated health for the woman and the child, modalities of delivery, prenatal anxiety

Measure: Report factors associated with postnatal depression between 4 of 6 weeks during the covid 19 pandemia

Time: 4-6 weeks postpartum

Description: Scale from 0 to 10 of satisfaction ; answers to the WOMBLSQ4 questionnaire about childbirth experience and satisfaction

Measure: Describe the experience and the satisfaction about delivery during the covid 19 pandemia

Time: within the week after delivery

4 ''(COVID-19) and Anxiety and Depressive Symptoms in Pregnant Women"

In our study; Anxiety and depression levels, socio-demographic characteristics of the pregnant women who were admitted to our hospital between 25.04.2020-25.07.2020 and treated with the diagnosis of covid 19, and the change in anxiety and depression levelsWİTH Beck Depression and Anxiety Score after the disease regressed are planned. (Beck depression scale contains 10 questions and a total of 1 to 100 points is obtained. High score indicates that depression and anxiety are high.) 0-16 points = mild depressive symptoms 17-29 points = moderate depressive symptoms 30-63 points = severe depressive symptoms

NCT04384887 COVID Anxiety Depression, Postpartum Behavioral: covid-19 positive pregnant women
MeSH:Depression, Postpartum Depression Anxiety Disorders

Primary Outcomes

Description: Evaluation of depression and anxiety score changes of covid-19 positive pregnants Pregnant women are questioned how this period was affected, as the pandemic period loaded with extra stress and caused depression and anxiety.

Measure: Evaluation of depression and anxiety score changes of covid-19 positive pregnants

Time: 4 months

5 Postpartum Depression in the Covid-19 Pandemic and the Impact of Anaesthesia

The aim of this multicenter prospective study is to evaluate the association between the Covid-19 pandemic maternal psychological distress with the postpartum depression, demographic and anaesthesiologic variables

NCT04437342 Postpartum Depression Psychological Stress Maternal Distress Other: PHQ-9 (Patient Health Questionnaire) Depression Scale Other: GAD-7 (General Anxiety Disorder) scale Other: 38 questions questionnaire Other: EPDS (Edinburgh Postnatal Depression Scale)
MeSH:Depression, Postpartum Depression Depressive Disorder Stress, Psychological
HPO:Depressivity

Primary Outcomes

Description: Prevalence of postpartum depression during the Covid-19 pandemic with EPDS scale (Edinburgh postnatal depression scale)

Measure: Correlation between the Covid-19 pandemic and postpartum depression with EPDS scale (Edinburgh postnatal depression scale)

Time: 40 days postpartum

Secondary Outcomes

Description: Association between the Covid-19 pandemic, postpartum depression and type of anaesthesia (general, epidural, spinal, combined, epidural analgesia for vaginal delivery)

Measure: Correlation between the Covid-19 pandemic, postpartum depression and type of anaesthesia (general, epidural, spinal, combined, epidural analgesia for vaginal delivery)

Time: 10 minutes postpartum

Description: Association between the Covid-19 pandemic, postpartum depression and postpartum pain assessed during postanesthesia care unit stay assessed by Numeric Pain Rating Scale (Scale 0-10 where 0 equals no pain and 10 maximum possible pain)

Measure: Correlation between the Covid-19 pandemic, postpartum depression and postpartum pain

Time: 2 minutes prior to discharge from the Postanaesthesia care unit

Description: Association between the Covid-19 pandemic, postpartum depression and postpartum pain assessed during postanesthesia care unit stay assessed by Numeric Pain Rating Scale (Scale 0-10 where 0 equals no pain and 10 maximum possible pain)

Measure: Correlation between the Covid-19 pandemic, postpartum depression and postpartum pain

Time: 2 minutes after admission to the Postanaesthesia care unit


HPO Nodes