Covid 19 Research using Clinical Trials (Home Page)
Report for D020022: Genetic Predisposition to Disease NIH
(Synonyms: Genetic Predispositio, Genetic Predisposition , Genetic Predisposition to Disease)
Developed by Shray Alag
Clinical Trial MeSH HPO Drug Gene SNP Protein Mutation
Correlated Drug Terms (0)
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Correlated HPO Terms (0)
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There is one clinical trial.
Clinical Trials
1 Various Molecular Markers With Predictive and Prognostic Significance in COVID-19 Outcome
Background: There is a current worldwide outbreak of the novel coronavirus Covid-19 which originated from Wuhan in China and has now spread to 6 continents including 210 countries. There is still a lack of any report about severe acute respiratory syndromes (SARS-CoV-2) genetic polymorphisms which are associated with the susceptibility to infection. In addition, gene polymorphisms of MBL (mannose-binding lectin) associated with antigen presentation are related to the risk of SARS-CoV infection. Aim: To investigate the association of different genetic markers of different mechanisms of viral pathogenesis with the outcome of COVID-19. Methods: The study will include one hundred patients diagnosed as COVID-19. Biological blood samples will be taken for routine diagnostic analysis, routine molecular testing using Real-time polymerase chain reaction (PCR), Allelic discrimination and genotyping analysis. Outcome: Different genetic markers could play a role in the outcome and prognosis of COVID-19 viral infection.
NCT04390269 Genetic Predisposition to Disease MeSH:Disease Susceptibility Genetic Predisposition to Disease
Primary Outcomes
Description: To assess genetic mutation via detection of genetic polymorphisms of ACE2 in patients and control to detect what alleles will be associated with the susceptibility to COVID-19 and what alleles will be associated with clearance or protection from infections. using allelic discrimination SSCP (i.e Real-time PCR and genetic sequencer).
Measure: for the patients Time: 2 years