Name (Synonyms) | Correlation | |
---|---|---|
drug65 | ACT-541478 dose E1 Wiki | 0.22 |
drug60 | ACT-541478 10 mg Wiki | 0.22 |
drug94 | AVIGAN 200 mg FT Wiki | 0.22 |
drug61 | ACT-541478 100 mg Wiki | 0.22 |
drug66 | ACT-541478 high or low dose (or placebo) Wiki | 0.22 |
drug622 | Completion of pre-pandemic survey Wiki | 0.22 |
drug907 | FAVIR 200 MG FT Wiki | 0.22 |
drug621 | Completion of post telemedicine encounter survey Wiki | 0.22 |
drug93 | AVIGAN 200 MG Film Tablets Wiki | 0.22 |
drug623 | Completion of survey after peak of pandemic Wiki | 0.22 |
drug2879 | mRNA in urine test Wiki | 0.22 |
drug2438 | Tacrolimus Wiki | 0.22 |
drug62 | ACT-541478 1000 mg Wiki | 0.22 |
drug1841 | Placebo for Hydroxychloroquine Wiki | 0.22 |
drug720 | Data collection and clinical testing of subjects Wiki | 0.22 |
drug2148 | SBI-101 Wiki | 0.22 |
drug1313 | LSALT peptide Wiki | 0.22 |
drug88 | AT-527 Wiki | 0.22 |
drug64 | ACT-541478 300 mg Wiki | 0.22 |
drug1839 | Placebo capsules Wiki | 0.22 |
drug63 | ACT-541478 30 mg Wiki | 0.22 |
drug2587 | Ultrasound lung imaging as part of FAST+ evaluation Wiki | 0.22 |
drug2658 | Visiospatial Interference Wiki | 0.22 |
drug432 | CERC-002 Wiki | 0.22 |
drug1182 | Immunofluorescence Imaging Wiki | 0.22 |
drug1837 | Placebo Tablet Wiki | 0.22 |
drug1625 | Non interventional study Wiki | 0.22 |
drug1350 | Liver injury Wiki | 0.22 |
drug1840 | Placebo for Azithromycin Wiki | 0.22 |
drug137 | Airway pressure release ventilation Wiki | 0.22 |
drug908 | FAVIRA 200 MG Film Tablet Wiki | 0.22 |
drug92 | AV-COVID-19 Wiki | 0.22 |
drug263 | Azithromycin (Azithro) Wiki | 0.22 |
drug8 | 0.9% Sodium-chloride Wiki | 0.22 |
drug1442 | Matching placebo Wiki | 0.16 |
drug1047 | Heparin Wiki | 0.16 |
drug1303 | L-ascorbic acid Wiki | 0.16 |
drug403 | Brief cognitive intervention Wiki | 0.16 |
drug70 | AG0301-COVID19 Wiki | 0.16 |
drug41 | 3D Telemedicine Wiki | 0.13 |
drug1087 | Hydroxychloroquine (HCQ) Wiki | 0.11 |
drug1484 | Methylprednisolone Wiki | 0.07 |
drug1822 | Placebo Wiki | 0.05 |
drug262 | Azithromycin Wiki | 0.04 |
drug1086 | Hydroxychloroquine Wiki | 0.02 |
Name (Synonyms) | Correlation | |
---|---|---|
D058186 | Acute Kidney Injury NIH | 0.38 |
D013119 | Spinal Cord Injuries NIH | 0.22 |
D015428 | Myocardial Reperfusion Injury NIH | 0.22 |
D015427 | Reperfusion Injury NIH | 0.22 |
D055370 | Lung Injury NIH | 0.19 |
D000068099 | Trauma and Stressor Related Disorders NIH | 0.16 |
D000067073 | Psychological Trauma NIH | 0.13 |
D001930 | Brain Injuries, NIH | 0.08 |
D055371 | Acute Lung Injury NIH | 0.07 |
D012128 | Respiratory Distress Syndrome, Adult NIH | 0.06 |
D040921 | Stress Disorders, Traumatic NIH | 0.05 |
D002318 | Cardiovascular Diseases NIH | 0.05 |
D001523 | Mental Disorders NIH | 0.05 |
D013313 | Stress Disorders, Post-Traumatic NIH | 0.05 |
D004194 | Disease NIH | 0.04 |
D016638 | Critical Illness NIH | 0.03 |
D013577 | Syndrome NIH | 0.02 |
D011014 | Pneumonia NIH | 0.01 |
D045169 | Severe Acute Respiratory Syndrome NIH | 0.01 |
D018352 | Coronavirus Infections NIH | 0.01 |
Name (Synonyms) | Correlation | |
---|---|---|
HP:0001919 | Acute kidney injury HPO | 0.38 |
HP:0001626 | Abnormality of the cardiovascular system HPO | 0.05 |
HP:0002090 | Pneumonia HPO | 0.01 |
There are 20 clinical trials
This will be a prospective observational trial to better understand the range and variation associated with bone/soft tissue perfusion in fracture patients and examine the relationship between perfusion, measured using quantitative Indocyanine green (ICG) fluorescence and complications such as surgical site infection (SSI), persistent SSI, and fracture nonunion.
Description: Post-procedure surgical site infection using CDC criteria will be documented at each follow-up appointment up to six months
Measure: Post procedure surgical site infection Time: six monthsDescription: All unplanned reoperations will be documented
Measure: Unplanned fracture-related reoperation Time: six monthsThe kidney may be affected in coronavirus-2019 disease (COVID-19). This study assessed the predictors and outcomes of acute kidney injury (AKI) among individuals with COVID-19.
Description: the incidence of Acute Kidney Injury
Measure: Rate of Acute Kidney Injury Time: From date of admission until the date of discharge or death from any cause, up to 60 daysDescription: death from any cause in the hospital
Measure: Rate of Death Time: From date of admission until the date of death from any cause, up to 60 daysDescription: days from admission to discharge or death
Measure: the length of hospital stay Time: From date of admission until the date of discharge or death from any cause, up to 60 daysThe current COVID-19 pandemic is providing healthcare organizations with considerable challenges and opportunities for rapid cycle improvement efforts, in diagnostic and patient management arenas. Healthcare providers are tasked with limiting the use of personal protective equipment while minimizing unnecessary exposures to the virus. Results from real-time PCR tests to detect active COVID-19 infections may not be available in a timely fashion during emergent trauma assessments. Since the start of the COVID-19 pandemic, a rapidly expanding body of literature has identified a pattern of imaged lung abnormalities with CT and ultrasound (US) characteristic of an active viral infection. US evaluation provides a reliable, portable, and reproducible way of evaluating acute patients in a real time setting. During initial trauma evaluations, patients may also receive adjunct imaging modalities like the Focused Assessment with Sonography in Trauma (FAST) exam designed to discover life threatening findings that may require urgent interventions. We therefore propose a study expanding on the current FAST adjunct evaluation in the trauma bay that may include lung parenchyma imaging at the initial assessment to help stratify patients into low or high-risk groups for active COVID-19 infections. We believe the use of point of care US in the initial assessment of the trauma patient may help identify potentially infected individuals and aid ED providers to best directing subsequent laboratory and imaging evaluations for these patients, while further directing the necessary protective measures for additional team members involved in the care of the injured patient.
Description: Will correlate FAST+ pulmonary findings and published CT findings noted in active COVID infection to determine if FAST+ is a suitable diagnostic tool in detecting active COVID infection. Plan to use FAST+ imaging findings to stratify patients into low or high-risk COVID-19 infection groups.
Measure: Correlation of FAST+ pulmonary findings with active COVID infection Time: 12 monthsDescription: Exploratory outcomes will focus on description of additional ancillary findings of the FAST+ examination in those patients who later are determined to be COVID-19 positive compared to those determined to be COVID-19 negative (e.g., patterns of pleural space disease).
Measure: Description of additional ancillary findings of the FAST+ examination among infected and non-infected patients Time: 12 monthsThe primary objective of the study is to evaluate the days until reaching clinical stability after starting randomization in hospitalized patients with elevated inflammatory parameters and severe COVID-19 lung injury.
Description: Assess the days until clinical stability is achieved after initiating randomization in hospitalized patients with elevated inflammatory parameters and severe COVID-19 lung injury. Clinical stability is defined if all the following criteria are met for 48 consecutive hours: Body temperature ≤ 37.0ºC; PaO2 / FiO2> 400 and / or SatO2 / FiO2> 300; Respiratory rate ≤ 24 rpm
Measure: Time to reach clinical stability Time: 28 daysDescription: days
Measure: Time to reach an afebrile state for 48 hours. Time: 56 daysDescription: days
Measure: Time to reach PaO2 / FiO2> 400 and / or SatO2 / FiO2> 300 Time: 56 daysDescription: days
Measure: Time to reach FR ≤ 24 rpm for 48 hours Time: 56 daysDescription: days
Measure: Time to normalization of D-dimer (<250 ug / L) Time: 56 daysDescription: days
Measure: Time until PCR normalization (<5mg / L). Time: 56 daysDescription: days
Measure: Time until normalization of ferritin (<400ug / L) Time: 56 daysDescription: viral load
Measure: Study the impact of immunosuppressive treatment on viral load using quantitative PCR Time: 56 daysDescription: days
Measure: Time until hospital discharge Time: 56 daysDescription: days
Measure: Need for ventilatory support devices Time: 56 daysDescription: days
Measure: Duration that it is necessary to maintain ventilatory support. Time: 56 daysDescription: days
Measure: COVID-19 mortality Time: 56 daysDescription: days
Measure: all-cause mortality Time: 56 daysDescription: cytokines quantification technique by Luminex
Measure: Analyze the expanded cytokine profile before the start of treatment and their evolution every 7 days after admission Time: 56 daysDescription: IDIBELL Clinical Research and Clinical Trials Unit will oversee the monitoring and pharmacovigilance
Measure: Describe the side effects and their severity attributed to tacrolimus and / or methylprednisolone. Time: 56 daysThis research study is an extension on a study already preregistered NCT04209283 and is designed to investigate the use of a simple cognitive task (a memory cue followed by playing the computer game "Tetris") for decreasing the number of intrusive memories of trauma among trauma-exposed women in Iceland. This is a single case series using a within subject multiple baseline AB design. Participants will aim to complete a no-intervention phase ('A': baseline phase) of one week followed by a one-week intervention phase ('B'), including a one-session intervention with a researcher comprising the simple cognitive task, followed by instructions to continue using the technique self-guided in subsequent weeks. Participants will be asked to monitor the occurrence of intrusive memories of trauma in a daily diary. It is predicted that participants will report fewer intrusive memories during the intervention phase than during the preceding baseline phase and that the frequency of targeted intrusive memories is going to decrease relative to non-targeted intrusive memories. Furthermore, the investigators will explore whether having fewer intrusive memories has an impact on function and/or PTSD, depressive or anxiety symptoms.
Description: Number of intrusive memories of traumatic event recorded by participants in a diary daily (morning, afternoon, evening and night) for one week during the baseline phase and each week during the intervention phase (week 1-6) and during one week at one month follow-up and three month follow-up.
Measure: Change in the number of intrusive memories of trauma Time: Baseline week 1; Intervention week 1-6; 1 month follow-up and 3 month follow-upDescription: How often did you manage to play Tetris after you experienced an intrusive memory? (11-point scale; 0 = not at all; 10 = every time).
Measure: Self-guided intervention adherence - usage of the gameplay intervention in daily life Time: Intervention week 2-6Description: Feasibility and Acceptability of the intervention assessed with two self-rated items, "Would you recommend playing Tetris to a friend?" and "Do you consider gameplay to be an acceptable way to reduce the daily frequency of intrusive memories?". Scores could range from 0 - 10 with higher scores indicating greater acceptability/feasibility.
Measure: Feasibility and acceptability ratings for using a smartphone game-play intervention Time: Post intervention up to week 7Description: Two open-ended questions: 1. "How did you feel about playing Tetris after you had an intrusive memory?" 2. "Did you find the intervention helpful? If yes, how?"
Measure: Feasibility and acceptability - open ended questions Time: Post intervention up to week 7Description: Six self-rated items to assess the impact of intrusive memories on concentration, sleep, and stress in the past week. 2 items assessing concentration difficulties in general and due to intrusive memories (11-point scale; high scores indicating more difficulties). 2 items assessing sleep disturbances due to intrusive memories (11-point scale; higher scores indicating more sleep disturbance); and 1 item assessing to what degree intrusive memories affected stress levels (0 = not at all; 10 = affected very much).
Measure: Impact of intrusive memories on concentration, sleep and stress - ratings Time: Baseline week 1; Post intervention up to week 7; 1 month follow-up and 3 month follow-upDescription: 1 item assessing for how long intrusive memories disrupted concentration on average on a 6-point scale (0 = <1 minute - 6 = > 60 minutes)
Measure: Rating of how long intrusive memories disrupted concentration on average Time: Baseline week 1; Post intervention up to week 7; 1 month follow-up and 3 month follow-upDescription: Two items both rated on an 11-point scale: 1. "During the last week, how distressing were your intrusive memories (0 = not at all; 10 = very distressing). 2. During the last week, how vivid were your intrusive memories (0 = not at all; 10= very vivid)
Measure: General impact of intrusive memories - ratings Time: Baseline week 1; Intervention week 1-6; 1 month follow-up and 3 month follow-upDescription: Adherence to the intrusion diary assessed with 1 item: "How accurately did you fill out the diary?" (0= not at all; 10 = very accurately)
Measure: Intrusion diary adherence Time: Baseline phase week 1; Intervention week 1-6; 1 month follow-up and 3 month follow-upDescription: The PCL-5 is a short 20-item self-report scale used to assess the severity of PTSD symptoms corresponding to the DSM-5 criteria for PTSD. Symptoms are rated from 0-4. Higher scores indicate greater severity.
Measure: The Posttraumatic Stress Disorder Checklist 5 (PCL-5) Time: Baseline week 1; Post intervention up to week 7; 1 month follow-up and 3 month follow-upDescription: The PHQ-9 is a 9-item self-report measure of depression symptoms and the severity of those symptoms. Each item can be scored from 0 (i.e., not at all) to 3 (i.e., nearly every day).
Measure: The Patient Health Questionnaire-9 (PHQ-9) Time: Baseline week 1; Post intervention up to week 7; 1 month follow-up and 3 month follow-upDescription: The GAD-7 is a brief self-report questionnaire designed as a screening tool for symptoms of general anxiety disorder and their severity. Each item can be scored from 0 (i.e., not at all) to 3 (i.e., nearly every day).
Measure: The Generalized Anxiety Disorder-7 scale (GAD-7) Time: Baseline week 1; Post intervention up to week 7; 1 month follow-up and 3 month follow-upDescription: The SDS is a self-report questionnaire which is designed to assess functional impairment across three domains: (1) Work/school, (2) social, and (3) family life. These domains are measured on an 11-point scale which ranges from 0 (i.e., not at all) to 10 (i.e., extremely). The scale will be adjusted to assess impairment associated with intrusive memories.
Measure: The Sheehan Disability Scale (SDS) Time: Baseline week 1; Post intervention up to week 7; 1 month follow-up and 3 month follow-upDescription: Two questions assessing the impact intrusive memories have on functioning in daily life. One question is open-ended: "Have the intrusive memories affected your ability to function in your daily life in the past week? If yes, how?" and one question is self-rated: "Have the intrusive memories affected your ability to function in your daily life?" (11-point scale, higher score indicate greater impact on functioning.)
Measure: Impact of intrusive memories on functioning Time: Baseline week 1; Post intervention up to week 7, 1 month follow-up and 3 month follow-upThis study will test to see if a 72-hour intravenous vitamin C infusion protocol (100 mg/kg every 8 hours) in patients with hypoxemia and suspected COVID-19 will reduce the lung injury caused by the SARS-Cov-2.
Description: Documented days free off mechanical ventilation the first 28 days post enrollment
Measure: Number of ventilator-free days Time: Up to 28 daysDescription: Mortality at 28-days by all causes
Measure: All-cause-mortality Time: Up to 28 daysDescription: Number of days free of acute inflammation (defined as CRP >= 10 mg/L)
Measure: Acute-inflammation-free days Time: Up to 28 daysDescription: Number of days that the participant is free of organ failure in ALL of the following organ systems: Cardiovascular, Respiratory, Neurological, Liver, Bone marrow organ, Renal
Measure: Organ-failure-free days Time: Up to 1 yearCoronavirus disease was first diagnosed in December 2019, in the city of Wuhan, China. The World Health Organization recently declared coronavirus disease 2019 (COVID-19) as a pandemic. The infection is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). It is a single-stranded RNA virus, which in humans causes mild respiratory symptoms and generally has a good prognosis. However, in a certain group of patients it manifests as severe pneumonia, respiratory distress syndrome, multiple organ dysfunction and death. The factors associated with a worse prognosis are older than 60 years, the presence of diabetes, cardiovascular disease and obesity. According to studies carried out in the Eastern world, the prevalence of liver injury in patients with COVID-19 disease varies between 14% and 53%, being more prevalent in patients with severe symptoms of COVID-19 disease. It is not really known whether the liver involvement of patients with SARS-CoV-2 infection is secondary to the direct effect of the virus on the liver. One of the mechanisms of action of SARS-CoV-2 is through the binding to the angiotensin-converting enzyme receptor, which is present in cholangiocytes, this could explain its excretion in faeces. However, liver injury could be due to the immune response generated in the body by the virus with systemic inflammatory response syndrome and the release of inflammatory cytokines such as IL6, generating direct cytopathic damage to the liver. On the other hand, it could be the product of hepatotoxic drugs administered during hospitalization, such as antibiotics, antivirals or non-steroidal anti-inflammatory drugs. Liver biopsy described microvacuolar steatosis, and a mild portal and lobular inflammatory infiltrate . Therefore, the aim this study is to assess the prevalence of liver complications (liver injury, decompensation of cirrhosis) in patients diagnosed with COVID-19 in Latin America. As secondary objectives, the investigators will describe the clinical characteristics of COVID-19 disease and identify risk factors associated with poor prognosis,
Description: Hospitalized patients with COVD-19 who developed liver injury
Measure: Liver injury in patients with COVID-19 Time: through study completion, an average of 6 monthsDescription: Factors associated with worse outcome
Measure: Prognostic factors associated with death Time: through study completion, an average of 6 monthsDescription: Description of patients hospitalized with COVID-19
Measure: Clinical characteristics of patients who developed liver injury Time: through study completion, an average of 6 monthsThe authors hypothesize that the SARS-CoV-2 virus can affect the kidneys, causing them to be damaged. The present study aims to explain the mechanisms of kidney injury in patients diagnosed with COVID-19.
Description: estimated glomerular filtration rate (eGFR), ml/min, in groups with mild, moderate and severe COVID-19
Measure: The effect of COVID-19 severity on the severity of renal failure Time: 2 monthsDescription: viral RNA concentration in urine, ME/ml
Measure: The expression of viral RNA in the urine with the severity of renal failure Time: 2 monthsDescription: albumine excretion with urine, g/ml
Measure: The severity of microalbuminuria in patients with COVID-19 of different conditions and renal failure Time: 2 monthsDescription: estimated glomerular filtration rate (eGFR), ml/min
Measure: Assessment of the severity of renal impairment in patients who died from COVID-19 Time: 2 monthsDescription: Duration of viral RNA detection in urine by PCR, weeks
Measure: Estimation of the duration of urinary viral RNA isolation in patients undergoing COVID-19 Time: 2 monthsDescription: expression of ACE-2 by imminohistochemistry at autopsy specimen
Measure: Expression of ACE-2 receptors in the kidneys of patients with renal failure who died from COVID-19 Time: 2 monthsThis research study is designed to investigate the use of a simple cognitive task for decreasing the number of intrusive memories of traumatic events experienced by refugees and asylum seekers with a diagnosis of Post-traumatic Stress Disorder (PTSD) currently living in the UK. The intervention includes a memory reminder cue, a 10-minute time gap and then around 20 minutes playing the mobile phone game Tetris, using mental rotation instructions. The study will have a multiple baseline case-series design (AB), with a randomised duration of baseline length up to three weeks. Thus, participants will complete a no-intervention phase of up to three weeks, followed by an intervention phase. Please see the intervention section for more details about the intervention sessions. Follow ups are conducted after each week to monitor the frequency of intrusive memories of trauma in a pen-and-paper diary. It is predicted that participants will report fewer intrusive memories after receiving the intervention than in the preceding baseline phase.
Description: Number of intrusive memories of traumatic events recorded by participants in a daily pen and and paper diary.
Measure: Frequency of intrusive memories Time: Baseline weeks 1-3, throughout the duration of the intervention phase (approximately 5 weeks), post-intervention weeks 1-2 and for 1 week 2 months post-intervention. Change is assessed from baseline to post-intervention.Description: A brief bespoke measure of concentration adapted from that used previously with refugees (Holmes et al., 2017). It has three questions about disruption to concentration from intrusive memories. A higher score on each question means a worse outcome.
Measure: Concentration Time: Baseline, 2-weeks post-intervention and 2-months post-interventionDescription: Developed by Woodfield Trauma Service. The measure asks how many hours the person has spent doing various activities in the past two weeks (for example, domestic chores, exercise, cultural activities). A higher score means a better outcome.
Measure: Social and Occupational Activity Tally (SOAT) Time: Baseline, 2-weeks post-intervention and 2-months post-interventionDescription: Four items from the Dissociative Experiences Scale II - items two, three, 14 and 20 (DES II; Carlson, & Putnam, 1993). Each item asks how often (from 0% to 100% of the time) the dissociative experience described happens to the individual. A higher score on each question means a worse outcome.
Measure: Dissociation Time: Baseline, 2-weeks post-intervention and 2-months post-interventionDescription: The PCL-5 (Weathers, Litz, Keane, Palmieri, Marx, & Schnurr, 2013) is a 20-item self-report measure that assesses the 20 DSM-5 symptoms of PTSD. Total scores can range from 0 to 80, with higher scores meaning a worse outcome.
Measure: Post-Traumatic Stress Disorder (PTSD) Checklist for Diagnostic and Statistical Manual of Mental Disorders, 5th Edition (DSM-5) (PCL-5) Time: Baseline and 2-weeks post-interventionDescription: The PHQ-9 (Kroenke, Spitzer & Williams, 2001) is a nine-item self-report measure that assesses the nine DSM-IV symptoms of depression. Total scores can range from 0 to 27, with higher scores meaning a worse outcome.
Measure: Patient Health Questionnaire (PHQ-9) Time: Baseline and 2-weeks post-interventionDescription: The WHO DAS 2.0 (World Health Organisation, 2010) is a measure of health and disability. Total scores can range from 0 to 48, with higher scores meaning a worse outcome.
Measure: World Health Organisation Disability Assessment Schedule 2.0 (WHO DAS 2.0) 12 item version Time: Baseline and 2-weeks post-interventionDescription: A bespoke measure to assess adherence to self-guided practice of the intervention. It includes four questions to assess how often, and for how long, the person played Tetris after experiencing intrusive memories during the previous week.
Measure: Self-Guided Intervention Adherence Questionnaire Time: Time Frame: Intervention sessions 2-5, 1 week post-intervention, 2 weeks post-intervention and 2 months post-intervention.Description: A bespoke questionnaire to gain feedback on the intervention. It includes 16 questions to assess acceptability and usefulness of the intervention with a variety of response options including yes/no, visual analogue scales and open responses.
Measure: Feedback Questionnaire Time: 1-week post-intervention.Randomized, placebo controlled study to determine if nebulized heparin may reduce the severity of lung injury caused by the novel coronavirus, also known as COVID-19
The study will analyze the incidence, clinical outcomes and predictors of myocardial injury in a large patient population with COVID-19 treated in Mount Sinai Hospital (MSH) system. In addition, the study team will explore the association between high-sensitivity troponin I (TnI) levels and clinical characteristics, biomarkers, cardiac tests data and treatment approaches to uncover the potential mechanisms responsible for COVID-19 induced myocardial injury.
Description: Number of death during hospitalization
Measure: Number of In-Hospital Death Time: During hospitalization, average 2-3 weeksDescription: Length of stay in the hospital
Measure: Length of Stay Time: During hospitalization, average 2-3 weeksDescription: Successful treatment will be defined by two consecutive negative tests for COVID-19
Measure: Number of Successful Treatment Time: During hospitalization, average 2-3 weeksTo evaluate the proportion of subjects alive and free of respiratory failure (e.g. need for non-invasive or invasive mechanical ventilation, high flow oxygen, or ECMO) and free of the need for continued renal replacement therapy (RRT) on Day 28. The need for continued RRT at Day 28 will be defined as either dialysis in the past 3 days (Day 26, 27, or 28) or an eGFR on Day 28 <10 mL/min/1.73 m2.
Description: To evaluate the efficacy of intravenous LSALT peptide plus standard of care to prevent the progression of COVID-19 to mild, moderate or severe ARDS, acute kidney injury, cardiomyopathy, acute liver injury, coagulopathy, or death in patients infected with SARS-CoV-2 compared with placebo plus standard of care.
Measure: Development of Acute Respiratory Distress Syndrome (ARDS) and Other Organ Injuries Time: 28 daysDescription: High-frequency oscillatory ventilation, with its rapid delivery of low tidal volumes and a respiratory rate in the range of 60 to 900 breaths/minute, has also been utilized in ARDS patients.
Measure: Ventilation-free days Time: 28 daysDescription: Oxygen therapy provided as non-invasive therapy for ARDS patients.
Measure: Time on nasal cannula or oxygen masks Time: 28 daysDescription: 28 day mortality - all cause and attributable
Measure: 28 day mortality - all cause and attributable Time: 28 daysDescription: ICU and hospitalization length of stay (days)
Measure: ICU and hospitalization length of stay (days) Time: 28 daysDescription: Swab (nasopharyngeal, nasal, throat, sputum, or lower respiratory tract) at baseline (Day 1) and every 3 days thereafter until eradication → virologic clearance rate
Measure: SARS-CoV2 testing Time: 28 daysDescription: Extracorporeal membrane oxygenation (ECMO) is often used for severe ARDS to allow lung healing/repair and reverse respiratory failure.
Measure: Need and duration for extracorporeal membrane oxygenation (ECMO) Time: 28 daysDescription: Vasopressor free days
Measure: Vasopressor free days Time: 28 daysDescription: Chest X-rays performed at Baseline, Day 3, at clinical improvement, and end-of-treatment (EOT) and study (EOS) to determine presence of bilateral opacities.
Measure: Radiographic pulmonary assessments Time: 28 daysDescription: Change in daily mMRC dyspnea and SOFA scores (0 to 4) with 4 being the most severe outcome
Measure: Change in modified Medical Research Council (mMRC) dyspnea and Sequential Organ Failure Assessment (SOFA) scores Time: 28 daysDescription: Incidence of other organ (non-lung) disorders
Measure: Incidence of non-lung disorders Time: 28 daysDescription: Change in liver function tests (ALT, AST, and total bilirubin levels) from baseline
Measure: Measures of liver dysfunction Time: 28 daysDescription: Change in SCr and eGFR from baseline
Measure: Measures of kidney dysfunction Time: 28 daysDescription: Change in highly-sensitive troponin (hs-troponin) from baseline
Measure: Measures of cardiac dysfunction Time: 28 daysDescription: Change from baseline ACT, aPTT, and/or PT/INR levels
Measure: Measures of coagulopathies Time: 28 daysDescription: Change in baseline antiviral immunoglobulins (IgG, IgM) at EOS.
Measure: Changes in immunogenic responses Time: 28 daysDescription: Changes in total healthcare costs from admission to discharge between treatment groups.
Measure: Healthcare outcomes Time: 28 daysDescription: Change in serum cytokines including IL-1α, IL-1ß, IL-1ra, IL-5, IL-6, IL-8, IL-12, TNFα, CXCL10/IP10, MCP-3, and ferritin drawn at the same time as LSALT peptide levels
Measure: Molecular changes in pro-inflammatory pathways Time: 28 daysDescription: Pharmacokinetics of LSALT peptide over the study period.
Measure: Pharmacokinetics of LSALT peptide Time: 28 daysThe two biomarkers determined in urine, "Tissue Inhibitor of Metalloproteinases 2 (TIMP-2)" and "Insulin-like Growth Factor-Binding Protein 7 (IGFBP7)", can indicate the occurrence of Acute kidney injury (AKI) in cardiac surgery and critically ill patients at an early stage. However, no data are available whether these parameters can also predict the occurrence of AKI in the context of COVID-19 infection. An early prediction of AKI can be helpful for the optimisation of therapeutic management to improve patient outcome and for the triage of patients. The aim of this observational study is to evaluate whether the biomarker [TIMP- 2]*[IGFBP7] can predict the occurrence of AKI in critically ill patients suffering from SARS-CoV2 associated acute respiratory distress syndrome.
Description: Occurence of moderate or severe AKI
Measure: Occurence of acute kidney injury (AKI) Time: within 7 days after beginning of moderate or severe ARDSDescription: e.g., Analysis of interleukin (IL) 6, IL8
Measure: Add-on analysis: pro- and antiinflammatory mediators Time: within 7 days after beginning of moderate or severe ARDSThe study is a prospective, randomized, placebo-controlled, single-blind phase 2 clinical study of the efficacy and safety of CERC-002, a potent inhibitor of LIGHT, for the treatment of patients with COVID-19 pneumonia who have mild to moderate ARDS. LIGHT is a cytokine in the TNF super family (TNFSF14) which drives inflammation and induces many other cytokines including IL-1, IL-6 and GM-CSF. LIGHT levels have been shown to be elevated in COVID-19 infected patients and inhibiting LIGHT is hypothesized to ameliorate the cytokine storm which has shown to be a major factor in progression of ARDS. The study will assess the efficacy and safety of CERC-002 in patients with severe COVID-19 over a 28 day period as single dose on top of standard of care.
Description: Respiratory failure defined based on resource utilization requiring at least one of the following: Endotracheal intubation and mechanical ventilation Oxygen delivered by high-flow nasal cannula (heated, humidified oxygen delivered via reinforced nasal cannula at flow rates >20L/min with fraction of delivered oxygen ≥0.5) Noninvasive positive pressure ventilation, Extracorporeal membrane oxygenation
Measure: Proportion of patient alive and free of respiratory failure Time: Baseline to Day 28Description: 1-month mortality
Measure: Proportion of subjects who are alive Time: Baseline to Day 28Persons with spinal cord injury (PwSCI) are at a greater risk for major health conditions and poorer health outcomes than persons without spinal cord injury (SCI). They often experience a great deal of health needs both on a physiological level as well as a psychosocial level. PwSCI frequently require supports and services to be able to live independently within the community. These services and supports are sometimes difficult to access within the community when the country is operating under regular capacity, in current times with the global COVID-19 pandemic, the challenges for obtaining and accessing supports and services will become much greater. The proposed project aims to identify the specific needs during this time of crisis and to provide referrals and resources to ameliorate those needs by surveying PwSCI in the St. Louis region. The project also hopes to determine if these persons experience isolation during shelter at home orders. PwSCI, who the investigators serve or have served in the past, will be contacted via phone or e-mail once a month for six months and asked to complete a questionnaire that will allow the investigators to track the participant's needs during the COVID-19 pandemic.
Description: Instrumental Support refers to the perception that people in one's social network are available to provide material or functional aid in completing daily tasks (such as making meals or providing transportation) if needed. This self-report measure for adults (ages 18 and above) is an 8-item calibrated scale.This study will use the measure to determine if people's instrumental support changes during a pandemic.
Measure: NIH Toolbox Instrumental Support Survey - change in instrumental support Time: Initial, 3 month and 6 monthDescription: A scale designed to measure one's subjective feelings of loneliness as well as feelings of social isolation. Participants rate each of the 3 items as hardly ever, some of the time, or often. This study will use the measure to determine if people feel socially isolated during a pandemic.
Measure: UCLA 3-item Loneliness Scale - change in social isolation Time: Initial, 3 month and 6 monthDocument and evaluate the impact of societal restrictions due to the pandemic on SCI- and ABI-related disability and functional impairments, and the resultant effects on psychological wellbeing, physical wellbeing and quality of life for those with SCI/ABI.
Description: Fear of COVID-19 Questionnaire
Measure: Change in Fear of COVID-19 Time: baseline, 3 months, 6 monthsDescription: NeuroQol SF v1.0 - Ability to Part. in SRA
Measure: Change in ability to participate in social roles and activities Time: baseline, 3 months, 6 monthsDescription: NeuroQol SF v1.0 - Depression
Measure: Change in depressive symptoms Time: baseline, 3 months, 6 monthsDescription: NeuroQol SF v1.0 - Pos. Affect & Well-Being
Measure: Change in positive affect and well-being Time: baseline, 3 months, 6 monthsDescription: NeuroQol SF v1.0 - Anxiety
Measure: Change in anxiety Time: baseline, 3 months, 6 monthsDescription: NeuroQol SF v1.0 - Fatigue
Measure: Change in fatigue Time: baseline, 3 months, 6 monthsDescription: NeuroQol SF v1.0 - Emotional & Beh. Dyscontrol
Measure: Change in emotional and behavioural dyscontrol Time: baseline, 3 months, 6 monthsDescription: NeuroQol SF v1.0 - Satisfaction w SRA
Measure: Change in satisfaction with social roles and activities Time: baseline, 3 months, 6 monthsDescription: NeuroQol SF v1.0 - Sleep Disturbance
Measure: Change in sleep disturbance Time: baseline, 3 months, 6 monthsDescription: NeuroQol SF v1.0 - Stigma
Measure: Change in stigma Time: baseline, 3 months, 6 monthsDescription: NeuroQol SF v1.0 - Cognitive Function
Measure: Change in cognitive function Time: baseline, 3 months, 6 monthsDescription: 23 questions about strategies to social distance
Measure: Change in social distancing strategies used Time: baseline, 3 months, 6 monthsDescription: 22 questions about social distancing
Measure: Change in thoughts and feelings about social distancing Time: baseline, 3 months, 6 monthsThe purpose of this study is to assess the safety and tolerability of the investigational product, SBI-101, in COVID-19 subjects with Acute Kidney Injury (AKI). SBI-101 is a biologic/device combination product designed to regulate inflammation and promote repair of injured tissue using allogeneic human mesenchymal stromal cells. SBI-101 will be integrated into the renal replacement circuit and patients will be treated for up to 24 hours.
The aim is to describe the epidemiology and determine the independent risk factors for mortality and acute organ injury in AKI and to assess the impact of different treatment strategies on survival. This will allow the development of prevention strategies and design of appropriately powered intervention studies.
Description: As defined by Kidney Diseases: Improving Global Outcomes (KDIGO) criteria
Measure: Incidence of any stage of acute kidney injury Time: 14 daysDescription: Mortality
Measure: Mortality Time: 14-day, hospital, and intensive care unit (ICU) mortalityDescription: Defined by return of creatinine to < 1.5 times of baseline
Measure: Renal recovery Time: 14 daysDescription: Percentage
Measure: Percentage of patients who receive renal replacement therapy Time: 14 daysDescription: Percentage of participants who are dialysis dependent
Measure: Percentage of participants who are dialysis dependent Time: Through study completion, an average of 90 daysDescription: Days without vasoactive medications and mechanical ventilation
Measure: Free-days of vasoactive medications and mechanical ventilation Time: Day 30Description: Length of intensive care unit and hospital stay
Measure: Length of intensive care unit and hospital stay Time: Through study completion, an average of 90 daysDescription: Congestive heart failure, Arrhythmia, Acute respiratory distress syndrome, Septic shock, Acute cardiac injury, pneumonia
Measure: Number of participants with consequences following AKI Time: Through study completion, an average of 90 daysDescription: Time from illness onset to need for mechanical ventilator support
Measure: Time from illness onset to need for mechanical ventilator support Time: Through study completion, an average of 30 daysThe actual COVID-19 epidemy is an unprecedented healthcare problem. Although acute respiratory distress syndrome is the main organ failure, acute kidney injury (AKI) has appeared to be more frequent and more severe than expected. Some data suggested a potential direct renal tropism of the virus, or undirect injury by "cytokine storm". The aims of this study are: 1. To describe incidence, severity and mortality associated with AKI during covid-19 infection in ICU 2. To identify specific risk factors for AKI 3. To explore pathophysiologic mechanism of AKI during COVID-19 infection
Description: AKI will be defined according with KDIGO guidelines: increase in creatinine of more than 1,5 fold compared to baseline Severe CVOID-19 infection is defined as 1/ confirm COVID-19 infection (by TDM and/or qRT-PCR) 2/ Requirement of ICU support during more than 72h
Measure: Primary endpoint is the incidence, the severity and the mortality associated with AKI during COVID-19 severe infection Time: 7 monthsThis study is an observational registry of children with or suspected to have SARS CoV2 (COVID-19) admitted to pediatric intensive care units (PICU). This registry will help describe the prevalence, rate and severity of acute kidney injury (AKI) in children with Severe Acute Respiratory Syndrome Coronavirus-2(SARS CoV2) across the world. The registry will be developed using a point prevalence methodology and then full retrospective review. Once a week, from April through June 2020, data collection will occur in "real-time" to estimate a weekly point prevalence of AKI and renal replacement therapy (RRT). The operational definition of "patients under investigation" (PUIs) will be used to identify the denominator of patients to be studied. The PUIs will be cohorted into SARS CoV2 test positive, test negative, test pending, or test unavailable. The primary aim of this study is to deliver a global, objective data driven analysis of the burden of AKI in virus positive patients or patients under investigation (PUI) who are admitted to the pediatric intensive care unit.
Description: Kidney Disease Improving Global Outcomes (KDIGO) Staged AKI by serum creatinine or urine output
Measure: Acute Kidney Injury (AKI) Time: 14 daysDescription: Survival to ICU discharge or Day 14
Measure: Survival Time: 14 daysDescription: The use of extracorporeal membrane oxygenation (ECMO) and/or renal replacement therapy
Measure: Rate of Extracorporeal Therapy Requirement Time: 14 daysDescription: >20% fluid overload as defined as the net fluid balance since ICU admission (in liters) divided by ICU admission weight
Measure: Fluid overload Time: Day of EnrollmentDescription: The exposure of enrolled patients to known nephrotoxic medications, including diuretics
Measure: Rate of nephrotoxic medication exposure Time: Day of Enrollment