Name (Synonyms) | Correlation | |
---|---|---|
drug1455 | Interpersonal Therapy Wiki | 0.45 |
drug736 | Continuation of ACEi/ARB Wiki | 0.45 |
drug729 | Computer Based Response Training Weight Loss Intervention Wiki | 0.45 |
drug782 | Counter Attitudinal Therapy Wiki | 0.45 |
drug905 | Discontinuation of ACEi/ARB Wiki | 0.45 |
drug1178 | Generic Response Training Control Intervention Wiki | 0.45 |
drug2322 | Questionnaires Wiki | 0.18 |
Name (Synonyms) | Correlation | |
---|---|---|
D002032 | Bulimia NIH | 0.45 |
D006963 | Hyperphagia NIH | 0.32 |
D009765 | Obesity NIH | 0.16 |
D004194 | Disease NIH | 0.08 |
Name (Synonyms) | Correlation | |
---|---|---|
HP:0100739 | Bulimia HPO | 0.45 |
HP:0002591 | Polyphagia HPO | 0.32 |
HP:0001513 | Obesity HPO | 0.16 |
There are 5 clinical trials
Most people with an eating disorder (ED) do not receive good treatment. The investigators have developed a new brief group treatment that is supposed to work by reducing how much women with an ED value the impossible thinness standard promoted by the media and how much they value/crave binge foods. The investigators want to test whether the treatment actually changes those two mechanisms using brain scan data, which is more objective than completing questionnaires and even interviews. In the first phase of the study (R61), the investigators will compare women in the treatment versus those on a wait-list. If the investigators can show that the treatment "works" (does what the investigators think it does) compared to no active treatment (women will be allowed to seek and receive outside help but investigators will not provide it until after the wait-list), investigators will conduct the second phase of study (R33),where they will randomly assign women with an ED to either the new treatment or to a group treatment that represents what many college mental health clinics provide to their clients with ED.
Description: Interviewer assesses frequency in binge eating episodes
Measure: Change in occurrences of binge eating episodes using Eating Disorder Diagnostic Interview Time: Week 8; R33 also reviews at 6-month follow-upDescription: Interviewer assesses frequency of compensatory weight control behaviors
Measure: Change in occurrences of compensatory weight control behavior using Eating Disorder Diagnostic Interview Time: Week 8; R33 also reviews at 6-month follow-upDescription: Interviewer assesses change in psychosocial impairment
Measure: Change in psychosocial impairment due to eating disorder symptoms using the Clinical Impairment Assessment Questionnaire Time: Week 8; R33 also reviews at 6-month follow-upDescription: Assess if CAT produces larger pre-post reductions in reward region in response to thin models and binge food (Not collected during COVID-19 shelter-at-home order)
Measure: Change in reward region of the brain using fMRI Time: Week 1 and Week 8Description: Assess if there are any changes in suicide ideation/attempts
Measure: Change in suicidal ideation/attempts using the Patient Health Questionnaire version 9 (PHQ-9) Time: Weeks 2, 4 and 6Description: Assess if there are any changes in negative affect
Measure: Change in negative affect using the Positive Affect and Negative Affect Scale-Revised Time: Weeks 2, 4, and 6Description: Assess if there are any changes in body dissatisfaction
Measure: Change in body dissatisfaction using the Body Dissatisfaction Scale Time: Weeks 2, 4 and 6Description: Assess if there are any changes in food addiction (Only collected during R61 phase)
Measure: Change in food addiction using the Yale Food Addiction Scale version 2.0 Time: Weeks 2, 4, and 6Description: Assess if there are any changes in valuation of the thin beauty ideal
Measure: Change in valuation of thin ideal using the Thin Ideal Valuation Scale Time: Weeks 2, 4, 6, and 8; R33 also reviews at 6-month follow-upDescription: Assess if there are any changes in dietary restraint
Measure: Change in dietary restraint using the 10-item Dutch Restrained Eating Scale Time: Week 8; R33 also reviews at 6-month follow-upDescription: Three implicit association tasks will assess response to binge foods, thin models, and eating disorder behavior words at pre- and post-test (Not collected during COVID-19 shelter-at-home order)
Measure: Change in implicit associations of binge foods, thin models, and eating disorder behavior words Time: Week 8; R33 also reviews at 6-month follow-upThis project will test whether a food response training intervention produces lasting body fat loss, use objective brain imaging to examine the mechanism of effect of this treatment and investigate the generalizability of the training to non-training foods, and examine factors that should amplify intervention effects to provide a test of the intervention theory. This novel treatment represents a bottom-up implicit training intervention that does not rely on executive control, prolonged caloric deprivation, and expensive clinicians to deliver, like behavioral weight loss treatments that have not produced lasting weight loss. If this computer-based response training intervention produces sustained body fat loss in overweight individuals, it could be easily implemented very broadly at almost no expense, addressing a leading public health problem.
Description: Change in participant's body fat percentage
Measure: Body Fat Change Time: Baseline, 1 month, 3 months, 6 months, 12 monthsDescription: Eating disorder symptoms as measured with the Eating Disorder Diagnostic Interview
Measure: Change in Eating Disorder Symptoms Time: Baseline, 1 month, 3 months, 6 months, 12 monthsDescription: Change in Dietary Restraint, Emotional Eating, and External Eating (aggregate score) as measured by the Dutch Eating Behavior Questionnaire
Measure: Dietary Restraint, Emotional Eating, and External Eating Time: Baseline, 1 month, 3 months, 6 months, 12 monthsDescription: Chang in Disinhibited Eating as measured by the Three Factor Eating Questionnaire
Measure: Change in Disinhibited Eating Behavior Time: Baseline, 1 month, 3 months, 6 months, 12 monthsDescription: Change in Eating When Not Hungry as measured by the Eating in the Absence of Hunger Questionnaire
Measure: Change in Eating in the Absence of Hunger Behavior Time: Baseline, 1 month, 3 months, 6 months, 12 monthsDescription: Change in Problematic eating patterns associated with symptoms of addictive behaviors as measured by the Yale Food Addiction Scale
Measure: Change in Food Addiction Behavior Time: Baseline, 1 month, 3 months, 6 months, 12 monthsDescription: Change in Physical Activity as measured by the Paffenberger Questionnaire
Measure: Change in Physical Activity Time: Baseline, 1 month, 3 months, 6 months, 12 monthsDescription: Change in Substance use frequency (i.e., number of times per day) for alcohol of participants as measured by the Daily Drinking Questionnaire
Measure: Change in Alcohol Use Behavior Time: Baseline, 1 month, 3 months, 6 months, 12 monthsDescription: Change in Substance use frequency (i.e., number of times per day) for common recreational drugs of participants as measured by the Daily Drug Taking Questionnaire
Measure: Change in Substance Use Behavior Time: Baseline, 1 month, 3 months, 6 months, 12 monthsDescription: Change in Participant behavioral response to food pictures, and subjective palatability rating
Measure: Change in Participant Ratings of Unhealthy Food Palatability Time: Baseline, 1 monthDescription: Change in Participant behavioral response to food pictures, and willingness to pay given dollar amounts (aggregate score) for the pictured food
Measure: Change in Participant Ratings of Food Monetary Value Time: Baseline, 1 monthDescription: Change Participant food craving behaviors as measured by the Food Craving and Liking Scale
Measure: Change in Food Craving and Liking Behavior Time: Baseline, 1 month, 3 months, 6 months, 12 monthsDescription: Change in Participant BMI using standard methods of calculation
Measure: Change in Body Mass Index Time: Baseline, 1 month, 3 months, 6 months, 12 monthsDescription: Change in mean R-Peak Amplitude measured using three-lead ECG using PowerLab 8 Diagnostic Suite
Measure: Change in mean R-Peak Amplitude Time: Baseline, 1 month, 3 months, 6 months, 12 monthsDescription: Change in Heart Rate Variability measured using three-lead ECG using PowerLab 8 Diagnostic Suite
Measure: Change in Heart Rate Variability Time: Baseline, 1 month, 3 months, 6 months, 12 monthsThe purpose of this proposed project is to test whether several biological factors (such as elevated brain reward region and attention region response to high-calorie foods, weaker inhibitory region response to high-calorie foods, habitual caloric deprivation, and elevated limbic region responsivity) increase the risk of problematic eating (bingeing and purging) in female adolescents.
Description: Eating Disorder Diagnostic Interview (EDDI)
Measure: Change in binge eating behaviors using the EDDI Time: 6 months, 1 year, 2 year, and 3 year follow-upDescription: Eating Disorder Diagnostic Interview (EDDI)
Measure: Change in compensatory behaviors using the EDDI Time: 6 months, 1 year, 2 year, and 3 year follow-upCOVID-19 lockdown presents particular challenges for people living with obesity. Indeed during this period, the lifestyle was deeply modified: diet, activity, and sleep behaviours, home office, take care of child, social distancing... All of these modifications may have led to stress and anxiety. It has been previously demonstrated that high perceived stress levels are correlated with high preference for sweet and fat foods . In this context caution would be exercised in obese patients especially those with binge eating disorders. Indeed binge eating disorder is characterized by compulsive overeating or consuming abnormal amounts of food while feeling unable to stop and a loss of control. And one key trigger of binge eating disorder is stress and anxiety. Thus, patients with binge eating disorders may have been more sensitive to the impact of lockdown and thus urgently would require appropriated care management. The main objective is to compare the eating behaviour between obese patients with or without binge eating disorders. The second objective is to compare the weight evolution between the two groups before and after the lockdown. To reach these objectives, the scientific team of the CIO project proposes to contact by phone and e-mail obese patients (with or without binge eating disorders) who have been hospitalized for their obesity disease before the start of the lockdown in the Endocrinology department of the Lyon Hospital. The patients will be asked to fill in several questionnaires (using an online tool) allowing to evaluate their mood, anxiety, eating behaviour, binge eating disorders… during the lockdown. The results of these questionnaires will be compared to those collected during their hospitalisation before the lockdown. The hypothesis is that participants suffering from binge eating disorder will have more sever eating behaviour perturbations as higher level of stress, anxiety, depressive symptoms.
Since March 17, 2020, the French government has implemented national containment measures due to the COVID-19 epidemic. Quarantine is an unpleasant experience : Separation from relatives, loss of liberty, concern about the infectious status, boredom, can negatively affect mental health, with the emergence of anxiety and depressive symptoms. In addition, confinement can disrupt usual physical activity, a major destabilization criterion for patients suffering from eating disorders (ED). Finally, conditions of confinement can harm social support, yet identified as a protective and resilience factor in stress contexts. Thus, the current context of confinement and social distances could be source of an increase in eating behavior disorders symptoms in people suffering from ED.
Description: the investigators aim to investigate the link between containment measures
Measure: Variation in eating disorders Time: 1 monthDescription: the investigators aim to investigate the link between ED symptomatology with EDE-Q (eating disorder evaluation, caractéristiques du TCA)
Measure: Variation in eating disorders Time: 1 monthDescription: The investigators aim to investigate the link between containment measures
Measure: Vision of the bodily aspect Time: 1 monthDescription: The investigators aim to investigate the link between body dissatisfaction
Measure: Vision of the bodily aspect Time: 1 monthDescription: the investigators aim to investigate the link between containment measures
Measure: Variation in physical activity Time: 1 monthDescription: the investigators aim to investigate the link between physical activity
Measure: Variation in physical activity Time: 1 monthDescription: the investigators aim to investigate the link between containment measures
Measure: Identify the clinical factors modulating the psychological state during confinement Time: 1 monthDescription: the investigators aim to investigate the link between emotional eating
Measure: Identify the clinical factors modulating the psychological state during confinement Time: 1 month