Covid 19 Research using Clinical Trials (Home Page)
Report for D001416: Back Pain NIH
(Synonyms: Back P, Back Pa, Back Pain)
Developed by Shray Alag
Clinical Trial MeSH HPO Drug Gene SNP Protein Mutation
Correlated Drug Terms (2)
| Name (Synonyms) | Correlation | |
|---|---|---|
| drug633 | Cerebrospinal fluid sampling, meningeal and brain parenchyma biopsies Wiki | 1.00 |
| drug3374 | non interventional Wiki | 1.00 |
Correlated MeSH Terms (2)
| Name (Synonyms) | Correlation | |
|---|---|---|
| D010146 | Pain NIH | 1.00 |
| D017116 | Low Back Pain NIH | 1.00 |
Correlated HPO Terms (3)
| Name (Synonyms) | Correlation | |
|---|---|---|
| HP:0003418 | Back pain HPO | 1.00 |
| HP:0012531 | Pain HPO | 1.00 |
| HP:0003419 | Low back pain HPO | 1.00 |
There is one clinical trial.
Clinical Trials
1 Confinement Effect on Low Back Pain Intensity in Chronic Low Back Pain Patients
The current situation, linked to the pandemic of the new coronavirus SARS-CoV-2 generates health concerns, but is also accompanied by many other psychological, social, economic, professional, etc. consequences as well as numerous changes in behavior and lifestyles, notably due to confinement. While the prevention of chronic low back pain and its management are primarily based on the practice of regular physical and sports activity, other psychological factors (stress, anxiety, depression), socioeconomic (low level of education, resources), professionals (physical workload, job dissatisfaction), etc. also have a major role in the onset and the persitence of low back pain. Thus, it is to be supposed that the current context, and more particularly the confinement to which the population has been constrained for almost 2 months, have and will have notable consequences on the evolution of lumbar symptoms in chronic low back pain patients. However, the entanglement of different factors related to containment will potentially have different consequences depending on the individual. It therefore seems difficult to predict how the lumbar symptoms will develop in this population. Indeed, if it can imagined that the decrease in regular physical activity and the increase in anxiety in this context of insecurity could lead to an increase in pain, it could just as well consider that the decrease in stress work, strenuous physical work or travel time from work to home can, on the contrary, have a favorable effect. The objective of this study is to assess the confinement effect on low back pain intensity in chronic low back pain patients. This is an observational, descriptive, transversal and pluricentric study conducted by a single questionnaire.
NCT04406363 Chronic Low-back Pain Other: non interventional MeSH:Back Pain Low Back Pain Pain
HPO:Back pain Low back pain Pain
Primary Outcomes
Description: Proportion of subjects having a significant change in their low back pain intensity during confinement, defined by the items "much worse" and "moderately worse", or "much improved" and "moderately improved" respectively.The meaning of this significant change (worsening or improvement) will also be described.
Measure: Impact of confinement on the low back pain intensity Time: at inclusion
Secondary Outcomes
Description: Change in low back pain intensity between before and during confinement evaluated by a numerical pain scale rated from 0 to 10 (0 = no pain ; 10 = worst imaginable pain). Confinement conditions (alone or in a group, space, etc.) and the practice of physical and sporting activities during confinement (weekly duration, etc.)
Measure: Correlation between confinement conditions and low back pain intensity Time: at inclusion
Description: Disability measured by the "incapacity" sub-score of the "Core Outcome Measures Index" (COMI) questionnaire
Measure: Correlation between confinement conditions and disability related to low back pain Time: at inclusion
Description: Occurrence of a SARS-CoV-2 infection and its level of severity (confirmed diagnosis, few or no symptoms, symptoms severely limiting daily activities, hospitalization in a conventional service or in intensive care)
Measure: Correlation between infection with the new SARS-CoV-2 coronavirus and change in low back pain intensity Time: at inclusion
Description: Quality of life and levels of anxiety and depression evaluated with the COMI-AD sub-score (modified version of the COMI integrating the state of psychological health);
Measure: Correlation between confinement conditions and quality of life as well as psychological health Time: at inclusion
Description: Use of care, drug consumption and psychoactive substances (tobacco, cannabis, alcohol, anxiolytics) for low back pain
Measure: Impact of confinement on the use of care and the consumption of medication and psychoactive substances for low back pain Time: at inclusion
Description: Modalities of the the ocupational activity continuation (continuation of the activity, evolution of the working time, telework and modalities of establishment)
Measure: Correlation between working conditions and / or teleworking and low back pain intensity Time: at inclusion
Description: Experience of confinement. Socio-economic characteristics of the participants (age, sex, department, job and socio-professional category).
Measure: Correlation between socio-economic factors and modalities as well as the experience of confinement Time: at inclusion
HPO Nodes
HP:0003418: Back pain
Genes 56
DLL3 CAPN3 BAP1 BRCA2 TBX6 TERT SMO NAB2 PALB2 SEC63 HTRA1 EMD KRAS FLI1 FHL1 SMAD4 VANGL1 BAP1 TMEM43 ATP7B HELLPAR ALDH18A1 LMX1B TCIRG1 SYNE2 VCP PLEKHM1 PDGFB PIK3CA STAT6 CFH MESP2 PRKCSH VCP CLCN7 SMARCE1 CD46 HLA-B BRCA1 TP53 PRKCSH LRP5 TRAF7 LMNA SMARCB1 FHL1 SUFU PALLD CDKN2A AKT1 SPAST NF2 LMNA CFI HGD SYNE1
Primary Outcomes
Description: Proportion of subjects having a significant change in their low back pain intensity during confinement, defined by the items "much worse" and "moderately worse", or "much improved" and "moderately improved" respectively.The meaning of this significant change (worsening or improvement) will also be described.
Measure: Impact of confinement on the low back pain intensity Time: at inclusionSecondary Outcomes
Description: Change in low back pain intensity between before and during confinement evaluated by a numerical pain scale rated from 0 to 10 (0 = no pain ; 10 = worst imaginable pain). Confinement conditions (alone or in a group, space, etc.) and the practice of physical and sporting activities during confinement (weekly duration, etc.)
Measure: Correlation between confinement conditions and low back pain intensity Time: at inclusionDescription: Disability measured by the "incapacity" sub-score of the "Core Outcome Measures Index" (COMI) questionnaire
Measure: Correlation between confinement conditions and disability related to low back pain Time: at inclusionDescription: Occurrence of a SARS-CoV-2 infection and its level of severity (confirmed diagnosis, few or no symptoms, symptoms severely limiting daily activities, hospitalization in a conventional service or in intensive care)
Measure: Correlation between infection with the new SARS-CoV-2 coronavirus and change in low back pain intensity Time: at inclusionDescription: Quality of life and levels of anxiety and depression evaluated with the COMI-AD sub-score (modified version of the COMI integrating the state of psychological health);
Measure: Correlation between confinement conditions and quality of life as well as psychological health Time: at inclusionDescription: Use of care, drug consumption and psychoactive substances (tobacco, cannabis, alcohol, anxiolytics) for low back pain
Measure: Impact of confinement on the use of care and the consumption of medication and psychoactive substances for low back pain Time: at inclusionDescription: Modalities of the the ocupational activity continuation (continuation of the activity, evolution of the working time, telework and modalities of establishment)
Measure: Correlation between working conditions and / or teleworking and low back pain intensity Time: at inclusionDescription: Experience of confinement. Socio-economic characteristics of the participants (age, sex, department, job and socio-professional category).
Measure: Correlation between socio-economic factors and modalities as well as the experience of confinement Time: at inclusion