CovidResearchTrials by Shray Alag


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Report for D006976: Hypertension, Pulmonary NIH

(Synonyms: Hypertension, Pul, Hypertension, Pulmon, Hypertension, Pulmonary)

Developed by Shray Alag
Clinical Trial MeSH HPO Drug Gene SNP Protein Mutation


Correlated Drug Terms (1)


Name (Synonyms) Correlation
drug3256 echocardiogram 2D Wiki 0.71

Correlated MeSH Terms (1)


Name (Synonyms) Correlation
D006973 Hypertension NIH 0.37

Correlated HPO Terms (2)


Name (Synonyms) Correlation
HP:0002092 Pulmonary arterial hypertension HPO 1.00
HP:0000822 Hypertension HPO 0.37

There are 2 clinical trials

Clinical Trials


1 The Prevalence of Pulmonary Hypertension, With or Without Right Ventricular Loading, in Patients With COVID-19 Who Are Being Treated With a Respirator in the Intensive Care Unit.

The virus infection Covid-19 fills our hospitals and intensive care departments in a very unique way and there is a lack of essential insight into the pathophysiology of the disease. As a result, very specific treatment options are missing. The US Medicines Agency (FDA) has in the last days given a general license for treatment with inhaled nitric oxide (iNO). Inhaled NO in Sweden (and Europe) is approved for the indication of pulmonary hypertension in adults. However, no one has yet described the occurrence of pulmonary hypertension, with or without right ventricular loading, in the Covid-19 patients who become so seriously ill that they need to be treated at an IVA ward. Knowledge of this is, of course, a prerequisite for determining the need for pulmonary artery catheterization (PA catheter, Swan-Ganz catheter) and also to better understand whether iNO treatment or other forms of lung selective vasodilation therapy may be of benefit to this patient group.

NCT04459364 Hypertension, Pulmonary Right Ventricular Overload COVID
MeSH:Hypertension, Pulmonary Hypertension
HPO:Hypertension Pulmonary arterial hypertension

Primary Outcomes

Description: To determine the prevalence of pulmonary hypertension and right ventricular load in patients with COVID-19 treated in intensive care unit evaluated by routine echocardiography.

Measure: Prevalence

Time: Day 1

2 Stress Echocardiography in Patients Recovery From Mild COVID-19 Illness

With the appearance of the new SARS-COV2 virus, additional challenges are being imposed on the medical community after the resolution of acute COVID-19 illness, resulting in specific pathophysiologic mechanisms that while acutely damage the lung parenchyma might chronically impact the cardiopulmonary system. This study aims to investigate changes after mild COVID-19 illness in echocardiographic indices at rest and stress.

NCT04498299 Echocardiography, Stress COVID-19 Hypertension, Pulmonary Diagnostic Test: echocardiogram 2D
MeSH:Hypertension, Pulmonary Hypertension
HPO:Hypertension Pulmonary arterial hypertension

Primary Outcomes

Description: Left atrium volume index

Measure: • LA volume index

Time: 3 minutes

Description: Left ventricle telediastolic diameter

Measure: • LV telediastolic diameter

Time: 3 minutes

Description: Left ventricle telesystolic diameter

Measure: • LV telesystolic diameter

Time: 3 minutes

Description: Left ventricle posterior wall

Measure: • LV posterior wall

Time: 3 minutes

Description: Right atrium area

Measure: • RA area

Time: 3 minutes

Description: Right ventricle basal dimensión

Measure: • RV basal dimensión

Time: 3 minutes

Description: Right ventricle cavity dimensión

Measure: • RV mid cavity dimension;

Time: 3 minutes

Description: Right ventricle longitudinal dimension

Measure: • RV longitudinal dimension

Time: 3 minutes

Description: Distal, right ventricle outflow tract dimension at the distal or pulmonic valve level

Measure: • Distal, RV outflow tract dimension at the distal or pulmonic valve level

Time: 3 minutes

Description: Proximal right ventricle outflow tract dimension at the proximal subvalvular level

Measure: • Proximal RV outflow tract dimension at the proximal subvalvular level

Time: 3 minutes

Description: • Tricuspid annular plane systolic excursion

Measure: • TAPSE

Time: 3 minutes

Description: Right ventricle free Wall strain

Measure: • RV free Wall strain

Time: 3 minutes

Description: Inferior cava vein PW Doppler

Measure: • Inferior cava vein PW Doppler

Time: 3 minutes

Description: E wave mitral

Measure: • E wave mitral

Time: 3 minutes

Description: A wave mitral

Measure: • A wave mitral

Time: 3 minutes

Description: E wave /A wave mitral

Measure: • E wave /A wave mitral

Time: 3 minutes

Description: E-wave at mitral annulus

Measure: • E-wave at mitral annulus

Time: 3 minutes

Description: E-wave at mitral annulus / A-wave at the mitral annulus

Measure: • E-wave at mitral annulus / A-wave at the mitral annulus

Time: 3 minutes

Description: E wave/ E-wave at the mitral annulus

Measure: • E wave/ E-wave at the mitral annulus

Time: 3 minutes

Description: E tricuspid (E)

Measure: • E tricuspid (E)

Time: 3 minutes

Description: A triuspid (A)

Measure: • A tricuspid (A)

Time: 3 minutes

Description: E/A

Measure: • E/A

Time: 3 minutes

Description: Systolic pulmonary artery pressure

Measure: • Systolic pulmonary artery pressure

Time: 3 minutes

Description: E-wave at the tricuspid annulus

Measure: • E-wave at the tricuspid annulus

Time: 3 minutes

Description: Mean pulmonary artery pressure

Measure: • Mean pulmonary artery pressure

Time: 3 minutes

Description: Stroke volume

Measure: • Stroke volume

Time: 3 minutes

Description: Cardiac output

Measure: • Cardiac output

Time: 3 minutes


HPO Nodes