Covid 19 Research using Clinical Trials (Home Page)
Report for D007040: Hypoventilation NIH
(Synonyms: Hypoventilation)
Developed by Shray Alag
Clinical Trial MeSH HPO Drug Gene SNP Protein Mutation
Correlated Drug Terms (4)
| Name (Synonyms) | Correlation | |
|---|---|---|
| drug903 | Direct laryngoscope Wiki | 0.71 |
| drug166 | AirGo Respiratory Monitor Wiki | 0.71 |
| drug1694 | McGrath videolaryngoscope Wiki | 0.71 |
| drug2860 | Telerehabilitation Wiki | 0.35 |
Correlated MeSH Terms (4)
| Name (Synonyms) | Correlation | |
|---|---|---|
| D012128 | Respiratory Distress Syndrome, Adult NIH | 0.06 |
| D011014 | Pneumonia NIH | 0.04 |
| D045169 | Severe Acute Respiratory Syndrome NIH | 0.03 |
| D018352 | Coronavirus Infections NIH | 0.03 |
Correlated HPO Terms (2)
| Name (Synonyms) | Correlation | |
|---|---|---|
| HP:0002791 | Hypoventilation HPO | 1.00 |
| HP:0002090 | Pneumonia HPO | 0.04 |
There are 2 clinical trials
Clinical Trials
1 Non-Invasive Monitoring of Respiratory Function in Spontaneously Breathing Patients With COVID-19 Infection
This study uses the AirGo band to monitor changes in tidal ventilation in spontaneously breathing patients with COVID-19 associated respiratory failure. It aims to recognize patterns of ventilation associated with worsening respiratory failure in this patient population. If successful, this study will lead to the development of new robust methods for real-time, continuous monitoring of respiratory function in patients with respiratory failure. In turn, such monitoring methods may enable improvements in the medical management of respiratory failure and timing of interventions.
NCT04356443 Respiratory Failure Ventilatory Failure COVID-19 Pneumonia ARDS, Human Device: AirGo Respiratory Monitor MeSH:Pneumonia Respiratory Insufficiency Respiratory Distress Syndrome, Adult Hypoventilation
HPO:Hypoventilation Pneumonia
Primary Outcomes
Description: Progression of respiratory failure to require endotracheal intubation (and mechanical ventilation)
Measure: Endotracheal intubation during present hospitalization, recorded through chart review Time: Up to three weeks
Secondary Outcomes
Description: Maintenance of SpO2 >=90% on no or low flow supplemental oxygen (=< 1 liter by nasal cannula or CPAP, or return of supplemental oxygen to baseline if required supplemental O2 for another indication, prior to onset of COVID-19 infection)
Measure: Improvement in hypoxemia as indicated by oxygen saturation and requirement for supplemental oxygen, recorded through chart review Time: Up to three weeks
Description: Patient or care provider may request removal of the band for any reason prior to the patient reaching the outcome
Measure: Premature need for removal of the band, recorded through investigator report Time: Up to three weeks
Description: Death from any cause while in the hospital
Measure: In-hospital mortality, recorded through chart review Time: Up to 24 weeks
2 A Randomised Controlled Trial to Compare McGrath Videolaryngoscope Against Direct Laryngoscope for Endotracheal Intubation When Powered Air Purifying Respirator is Worn During the Current Coronavirus Disease 2019 Pandemic
Primary Outcomes
Description: Progression of respiratory failure to require endotracheal intubation (and mechanical ventilation)
Measure: Endotracheal intubation during present hospitalization, recorded through chart review Time: Up to three weeksSecondary Outcomes
Description: Maintenance of SpO2 >=90% on no or low flow supplemental oxygen (=< 1 liter by nasal cannula or CPAP, or return of supplemental oxygen to baseline if required supplemental O2 for another indication, prior to onset of COVID-19 infection)
Measure: Improvement in hypoxemia as indicated by oxygen saturation and requirement for supplemental oxygen, recorded through chart review Time: Up to three weeksDescription: Patient or care provider may request removal of the band for any reason prior to the patient reaching the outcome
Measure: Premature need for removal of the band, recorded through investigator report Time: Up to three weeksDescription: Death from any cause while in the hospital
Measure: In-hospital mortality, recorded through chart review Time: Up to 24 weeksVarious guidelines for endotracheal intubation (insertion of breathing tube for mechanical ventilation) of Coronavirus Disease 2019 (COVID-19) patients recommend the use of videolaryngoscope (medical device used for intubation that has a camera to visualize the vocal cords between which the breathing tube will pass) over direct laryngoscope (conventionally-used medical device for intubation that depends on anesthetist's direct visualization of vocal cords). The reasons for this recommendation are to maximize the distance between the medical personnel and the patient's face during intubation to decrease the risk of viral particles transmission and to improve intubation success. For patients infected with COVID-19, Powered Air Purifying Respirator (PAPR) is recommended as an alternative to N95 masks during aerosol-generating procedures such as intubation because N95 masks may not fully protect medical personnel from viral transmission during intubation. There is no evidence to suggest that videolaryngoscope (VL) is superior to direct laryngoscope (DL) for intubation when PAPR is donned. The purpose of this study is to determine if McGrath VL is superior to DL for intubation when the anesthetist is wearing a PAPR. The investigators' hypothesis is that McGrath VL will decrease the time to intubation by 20 seconds and more compared to DL when PAPR is donned. The investigators also hope to learn if there is any difference in the difficulties encountered between the use of VL and DL.
NCT04424953 Coronavirus Infection Ventilatory Failure Anesthesia Intubation Complication Device: McGrath videolaryngoscope Device: Direct laryngoscope MeSH:Coronavirus Infections Severe Acute Respiratory Syndrome Hypoventilation
HPO:Hypoventilation
Primary Outcomes
Description: The time to intubation starts from the time the anesthetist takes over the laryngoscope till the first appearance of consecutive capnography tracings. The time to intubation will be assessed via a retrospective playback of the video-recording of the intubation process. Compares the time to intubation for McGrath videolaryngoscope against direct laryngoscope.
Measure: Time to intubation for McGrath videolaryngoscope versus direct laryngoscope Time: During the intubation process
Secondary Outcomes
Description: Compares the incidence of success at first intubation attempt using McGrath videolaryngoscope against direct laryngoscope. To be assessed via a retrospective playback of the video-recording of the intubation process.
Measure: Incidence of success at first intubation attempt with McGrath videolaryngoscope versus direct laryngoscope Time: During the intubation process
Description: Compares the incidence of the use of adjuncts (bougie, stylet, external laryngeal pressure, hyper-angulated blades) at first attempt with McGrath videolaryngoscope against direct laryngoscope. To be assessed via a retrospective playback of the video-recording of the intubation process
Measure: Incidence of the use of adjuncts at first attempt with McGrath videolaryngoscope versus direct laryngoscope Time: During the intubation process
Description: Compares the incidence of the use of adjuncts (bougie, stylet, external laryngeal pressure, hyper-angulated blades) at subsequent attempts (after first attempt) with McGrath videolaryngoscope against direct laryngoscope. To be assessed via a retrospective playback of the video-recording of the intubation process
Measure: Incidence of the use of adjuncts at subsequent attempts with McGrath videolaryngoscope versus direct laryngoscope Time: During the intubation process
Description: Compares the incidence of success and failure at intubation using the initial laryngoscope that the anesthetist is randomised to. To be assessed via a retrospective playback of the video-recording of the intubation process.
Measure: Incidence of success and failure at intubation using initial laryngoscope Time: During the intubation process
Description: Compares the Intubation Difficulty Scale between using McGrath videolaryngoscope and direct laryngoscope for intubation. The scale is the sum of score from 7 variables. Ranges from 0 ("ideal" intubation, that is one performed without effort, on the first attempt, practiced by one operator, using one technique, full visualization of laryngeal aperture and vocal cords abducted) to infinity (impossible intubation). The higher the scale, the more difficulty the intubation process. To be assessed via a retrospective playback of the video-recording of the intubation process and also by interviewing the anesthetist who carried out the intubation.
Measure: Intubation Difficulty Scale with McGrath videolaryngoscope versus direct laryngoscope Time: During the intubation process
Description: Compares the incidence of oxygen desaturation to less than 88% and oro-dental injuries between the McGrath videolaryngoscope and direct laryngoscope. To be assessed during the playback of the video-recording of the intubation process and by intereviewing the anesthetist.
Measure: Incidence of oxygen desaturation to less than 88% and oro-dental injuries with McGrath videolaryngoscope versus direct laryngoscope. Time: During the intubation process.
Description: Compares the incidence of inability to intubate despite all efforts by the anesthetist between the McGrath videolaryngoscope and the direct laryngoscope. To be assessed during the playback of the video-recording of the intubation process.
Measure: Incidence of inability to intubate despite all efforts by the anesthetist with McGrath videolaryngoscope versus direct laryngoscope Time: During the intubation process
HPO Nodes
HP:0002791: Hypoventilation
Genes 56
MKRN3-AS1 KLHL41 MECP2 ACTA1 DCTN1 SNORD116-1 FKRP NDUFB8 COL6A3 GDNF SELENON TTN DCTN1 SLC5A7 MYH7 SNRPN PWAR1 SURF1 PHOX2B MOGS SLC52A3 PWRN1 CFL2 DMD COL6A2 NDN SELENON LAMA2 LMOD3 NDUFS6 NDUFAF3 TPM2 TPM2 ASCL1 MYPN RET ASCL1 NEB IPW TPM3 HERC2 COLQ LAMB2 NPAP1 TTN MKRN3 MAGEL2 EDN3 PHOX2B COL6A1 P4HTM SNORD115-1 SCO2 NDUFS2 RET NDUFAF2 Protein Mutations 0
SNP 0
Primary Outcomes
Description: The time to intubation starts from the time the anesthetist takes over the laryngoscope till the first appearance of consecutive capnography tracings. The time to intubation will be assessed via a retrospective playback of the video-recording of the intubation process. Compares the time to intubation for McGrath videolaryngoscope against direct laryngoscope.
Measure: Time to intubation for McGrath videolaryngoscope versus direct laryngoscope Time: During the intubation processSecondary Outcomes
Description: Compares the incidence of success at first intubation attempt using McGrath videolaryngoscope against direct laryngoscope. To be assessed via a retrospective playback of the video-recording of the intubation process.
Measure: Incidence of success at first intubation attempt with McGrath videolaryngoscope versus direct laryngoscope Time: During the intubation processDescription: Compares the incidence of the use of adjuncts (bougie, stylet, external laryngeal pressure, hyper-angulated blades) at first attempt with McGrath videolaryngoscope against direct laryngoscope. To be assessed via a retrospective playback of the video-recording of the intubation process
Measure: Incidence of the use of adjuncts at first attempt with McGrath videolaryngoscope versus direct laryngoscope Time: During the intubation processDescription: Compares the incidence of the use of adjuncts (bougie, stylet, external laryngeal pressure, hyper-angulated blades) at subsequent attempts (after first attempt) with McGrath videolaryngoscope against direct laryngoscope. To be assessed via a retrospective playback of the video-recording of the intubation process
Measure: Incidence of the use of adjuncts at subsequent attempts with McGrath videolaryngoscope versus direct laryngoscope Time: During the intubation processDescription: Compares the incidence of success and failure at intubation using the initial laryngoscope that the anesthetist is randomised to. To be assessed via a retrospective playback of the video-recording of the intubation process.
Measure: Incidence of success and failure at intubation using initial laryngoscope Time: During the intubation processDescription: Compares the Intubation Difficulty Scale between using McGrath videolaryngoscope and direct laryngoscope for intubation. The scale is the sum of score from 7 variables. Ranges from 0 ("ideal" intubation, that is one performed without effort, on the first attempt, practiced by one operator, using one technique, full visualization of laryngeal aperture and vocal cords abducted) to infinity (impossible intubation). The higher the scale, the more difficulty the intubation process. To be assessed via a retrospective playback of the video-recording of the intubation process and also by interviewing the anesthetist who carried out the intubation.
Measure: Intubation Difficulty Scale with McGrath videolaryngoscope versus direct laryngoscope Time: During the intubation processDescription: Compares the incidence of oxygen desaturation to less than 88% and oro-dental injuries between the McGrath videolaryngoscope and direct laryngoscope. To be assessed during the playback of the video-recording of the intubation process and by intereviewing the anesthetist.
Measure: Incidence of oxygen desaturation to less than 88% and oro-dental injuries with McGrath videolaryngoscope versus direct laryngoscope. Time: During the intubation process.Description: Compares the incidence of inability to intubate despite all efforts by the anesthetist between the McGrath videolaryngoscope and the direct laryngoscope. To be assessed during the playback of the video-recording of the intubation process.
Measure: Incidence of inability to intubate despite all efforts by the anesthetist with McGrath videolaryngoscope versus direct laryngoscope Time: During the intubation process