CovidResearchTrials by Shray Alag


CovidResearchTrials Covid 19 Research using Clinical Trials (Home Page)


Report for D002294: Carcinoma, Squamous Cell NIH

(Synonyms: Carcinoma, Squ, Carcinoma, Squa, Carcinoma, Squamo, Carcinoma, Squamou, Carcinoma, Squamous, Carcinoma, Squamous Ce, Carcinoma, Squamous Cell)

Developed by Shray Alag
Clinical Trial MeSH HPO Drug Gene SNP Protein Mutation


Correlated Drug Terms (7)


Name (Synonyms) Correlation
drug36 30 Gy over 3 weeks Wiki 1.00
drug1065 F-FMISO PET/CT Scan Wiki 1.00
drug51 5Fluorouracil Wiki 1.00
drug673 Cisplatin Wiki 1.00
drug2262 Proton Therapy Wiki 1.00
drug614 Carboplatin Wiki 0.71
drug752 Convalescent Plasma Wiki 0.20

Correlated MeSH Terms (1)


Name (Synonyms) Correlation
D002277 Carcinoma NIH 0.45

Correlated HPO Terms (2)


Name (Synonyms) Correlation
HP:0002860 Squamous cell carcinoma HPO 1.00
HP:0030731 Carcinoma HPO 0.45

There is one clinical trial.

Clinical Trials


1 A Prospective Single Arm Non-inferiority Trial of Major Radiation Dose De-Escalation Concurrent With Chemotherapy for Human Papilloma Virus Associated Oropharyngeal Carcinoma (Major De-escalation to 30Gy for Select Human Papillomavirus Associated Oropharyngeal Carcinoma)

The purpose of this study is to demonstrate that participants with HPV positive and hypoxia negative T1-2, N1-2c (AJCC, 7th ed.) oropharyngeal squamous cell carcinoma receiving a major de-escalated radiation therapy with 2 cycles of standard chemotherapy is not inferior to comparable subjects treated with the current standard chemoradiation. Given the restrictions of surgery during the COVID19 pandemic, we will start enrolling patients on Cohort B where surgery is not required. Once the COVI19 pandemic is over, we will resume and complete enrollment on Cohort A where surgery is required, prior to continuing enrolling patients on Cohort B. During the COVID-19 pandemic, the research MRIs are optional.

NCT03323463 HPV-Associated Oropharyngeal Squamous Cell Carcinoma Squamous Cell Carcinoma of the Neck Diagnostic Test: F-FMISO PET/CT Scan Radiation: 30 Gy over 3 weeks Drug: Cisplatin Drug: Carboplatin Drug: 5Fluorouracil Radiation: Proton Therapy
MeSH:Carcinoma Carcinoma, Squamous Cell
HPO:Carcinoma Squamous cell carcinoma

Primary Outcomes

Measure: Effectiveness of study treatment for participants receiving de-escalated radiation therapy radiation therapy, comparable to participants treated with the current standard of care chemoradiation by standard CT (or MRI) or tumor site and PET scan

Time: 2 years (+/- 3 months)


HPO Nodes