CovidResearchTrials by Shray Alag


CovidResearchTrials Covid 19 Research using Clinical Trials (Home Page)


Report for D059352: Musculoskeletal Pain NIH

(Synonyms: Musculoskeletal Pain)

Developed by Shray Alag
Clinical Trial MeSH HPO Drug Gene SNP Protein Mutation


Correlated Drug Terms (5)


Name (Synonyms) Correlation
drug3115 Web-based self-report questionnaires Wiki 0.45
drug2231 Primary care Wiki 0.45
drug992 Emotion- and Relationship-Focused Therapeutic Interview Wiki 0.45
drug1127 Focus Group Interviews Wiki 0.45
drug2843 Tele-yoga therapy Wiki 0.45

Correlated MeSH Terms (0)


Name (Synonyms) Correlation

Correlated HPO Terms (0)


Name (Synonyms) Correlation

There are 5 clinical trials

Clinical Trials


1 Effects of Chronic Pain, Dyspnea, and Physical Activity Promotion on Functional Connectivity of the Brain in COPD

Persons with COPD have both chronic musculoskeletal pain and dyspnea that require accurate diagnosis and treatment, ultimately to optimize functional status. The investigators propose to use advanced neuroimaging techniques to understand central mechanisms of chronic pain, dyspnea, and physical activity promotion in COPD. The investigators' novel proposal to correlate subjective symptoms (chronic pain and dyspnea) with an objective central biomarker (resting state functional connectivity) and examine their changes in response to a non-pharmacological, non-addictive physical activity intervention will personalize the care of Veterans with COPD.

NCT04291131 COPD Chronic Musculoskeletal Pain
MeSH:Musculoskeletal Pain

Primary Outcomes

Description: Cortical thickness will be measured by brain MRIs that will assess functional connectivity and structural variables. Cortical thickness will be reported in millimeters.

Measure: Cortical thickness

Time: 3 months

Other Outcomes

Description: Pain intensity will be measured with the Brief Pain Index.

Measure: Pain Intensity

Time: 3 months

Description: Dyspnea will be measured with the modified Medical Research Council scale

Measure: Dyspnea

Time: 3 months

2 Evaluate the Working Environments of Individuals Working From Home During Covid-19 Outbreak

The study aims to evaluate the working environments of individuals working from home during the covid-19 outbreak and the effect of the working environments on their musculoskeletal system. The study will include 500 people between the ages of 18-65 who works from home (works in the office before isolation) as a part of Covid-19 isolation measure. The working environment of the individuals participating in the study will be evaluated with The Rapid Office Strain Assessment (ROSA). Musculoskeletal symptoms will be analysed by using the Standardised Nordic Questionnaries (NMQ). Pain will be analysed by using Visual Analogue Scale (VAS)

NCT04342208 Musculoskeletal Pain
MeSH:Musculoskeletal Pain

Primary Outcomes

Description: The working environment of the individuals participating in the study will be evaluated with The Rapid Office Strain Assessment (ROSA).

Measure: The Rapid Office Strain Assessment (ROSA)

Time: 30 minutes

Secondary Outcomes

Description: The NMQ can be used as a questionnaire or as a structured interview

Measure: The Standardised Nordic Questionnaries (NMQ)

Time: 15 minutes

Other Outcomes

Description: Pain will be analysed by using Visual Analogue Scale (VAS)

Measure: Visual Analog Scale (VAS)

Time: 2 minutes

3 Sustainable UNiversity Life (SUN): Mental Illness and Pain Conditions Among Students - a Cohort Study to Identify Modifiable Risk and Prognostic Factors

In 2017, Socialstyrelsen reported that mental ill-health in young adults had increased by almost 70% in the previous10 years. A 2014 report showed that 5% of men and 11% of women 18-24 years were diagnosed with depression or anxiety in Stockholm County. Furthermore, 41% of women 21-24 years have self reported psychological distress. Regarding pain, 28% of men and 36% of women 16-24 years have disabling neck pain. Little is known about the etiology and prognosis of poor mental health in university students. The aim is to advance knowledge about the etiology of depression, anxiety, stress and pain in undergraduate university students. The investigators will study a cohort of students at full-year programs at universities in the Stockholm area. Primary research questions are whether modifiable factors such as sleep quality, lifestyle, screen time and work environment are independent risk factors for incident episodes or unfavorable trajectories of depression, anxiety and pain in men and women? To be able to answer these research questions we designed a prospective cohort study targeting 5000 university students.

NCT04465435 Mental Health Issue Musculoskeletal Pain Other: Web-based self-report questionnaires Other: Focus Group Interviews
MeSH:Musculoskeletal Pain

Primary Outcomes

Description: Repeated measures with web-based questionnaires, 5 times (every 3 months), over one year. Outcome measures: Musculoskeletal pain will be measured with the The Nordic Musculoskeletal Questionnaire (NMQ). The NMQ measure musculoskeletal symptoms, and pain intensity in nine body areas: neck, shoulder, elbow, wrists/hands, upper back, lower back, hips/thighs/buttocks, knees, ankle/feet. The questions were modified to assess previous month rather than the previous 12 months as per the original NMQ. No symptoms = a pain score of 0, while the participants who report musculoskeletal symptoms also report average pain intensity over the last month, on a scale from 0 (no complaints), to 9 (pain 'worst possible'). Weekly text messages measure levels of pain.

Measure: Pain

Time: 2019-2022

Description: Repeated measures with web-based questionnaires, 5 times (every 3 months), over one year. Outcome measures: Depression Anxiety Stress Scale-21(DASS-21). DASS-21 includes three subscales (range 0-3, score 0-63, higher scores = more symptoms) to measure depression, anxiety and stress symptoms in nonclinical populations. Weekly text messages measure levels anxiety and depression.

Measure: Mental health problems

Time: 2019-2022

Secondary Outcomes

Description: Web-based questionnaires comparing students entering the study before the Covid-19 pandemic and after. Outcome measures: Musculoskeletal pain will be measured with the The Nordic Musculoskeletal Questionnaire (NMQ). The NMQ measure musculoskeletal symptoms, and pain intensity in nine body areas: neck, shoulder, elbow, wrists/hands, upper back, lower back, hips/thighs/buttocks, knees, ankle/feet. The questions were modified to assess previous month rather than the previous 12 months as per the original NMQ. No symptoms = a pain score of 0, while the participants who report musculoskeletal symptoms also report average pain intensity over the last month, on a scale from 0 (no complaints), to 9 (pain 'worst possible'). Weekly text messages measure levels of pain.

Measure: Pain related to the Covid-19 pandemic.

Time: 2019-2020

Description: Web-based questionnaires comparing students entering the study before the Covid-19 pandemic and after. Outcome measures: Depression Anxiety Stress Scale-21(DASS-21). DASS-21 (3 subscales, range 0-3, score 0-63, higher scores = more symptoms) to measure depression, anxiety and stress symptoms in nonclinical populations. Weekly text messages measure levels of anxiety and depression.

Measure: Mental health problems related to the Covid-19 pandemic.

Time: 2019-2020

4 Effect of Tele-Yoga Therapy on Patients With Chronic Musculoskeletal Pain During Covid-19 Lockdown: Randomized Clinical Trial

Covid-19 outbreak and lockdown measures raised significant concerns over clinical management of chronic pain patients around the world. Patients with chronic musculoskeletal pain (CMSP) are at high risk of physical disability, psychological distress, and poor quality of life. Analgesic medications were main management during lockdown, but opioid-related concerns have prompted to find immediate alternatives. Present study was undertaken to determine whether patients randomized to tele-yoga therapy would experience less pain, disability and improved global health, adherence and satisfaction, compared with patients assigned to usual care.

NCT04466605 Chronic Musculoskeletal Pain Other: Tele-yoga therapy Other: Primary care
MeSH:Musculoskeletal Pain

Primary Outcomes

Description: Pain was assessed using the Brief Pain Inventory (BPI), which rates the severity of pain on 4 items (current, worst, least, and average pain in past week)

Measure: Severity of pain

Time: From baseline to 6-week post intervention

Description: Interference of pain in 7 areas (mood, physical activity, work, social activity, relations with others, sleep, enjoyment of life) were reported using BPI

Measure: Interference of pain

Time: From baseline to 6-week post intervention

Secondary Outcomes

Description: 7-point global rating of pain change was used to assess change in pain

Measure: Global rating of change in pain

Time: From baseline to 6-week post interventiona

Description: 10 point scale was used to assess intervention-specific satisfaction

Measure: Intervention specific satisfaction

Time: From baseline to 6-week post interventiona

5 Emotion- and Relationship-Focused Therapeutic Interview for Chronic Musculoskeletal Pain: A Randomized Trial

The goal of the study is to determine whether a brief, therapeutic interview can help patients improve their pain and health by addressing psychological issues that are known to drive chronic musculoskeletal pain. This randomized, controlled trial tests the efficacy of a brief, one-session therapeutic interview for patients with chronic musculoskeletal pain and histories of childhood adversity. Adults with chronic musculoskeletal pain will be randomized to either a therapeutic interview condition or a waitlist control condition. The therapeutic interview will be 90-minute session during which participants will be encouraged to disclose stressful experiences, express important emotions, and identify connections between their life stress and their pain, which we hope will increase their psychological attributions for pain and reduce their pain, interpersonal problems, and psychological distress. The study will compare the therapeutic interview condition to a delayed interview condition and will follow patients for 5 weeks to identify changes in response to the interview. Participants in the therapeutic interview condition are expected to show more improvement on pain severity, pain interference, psychological distress, interpersonal function, and psychological attitudes toward pain at follow-up, relative to participants in the delayed interview condition.

NCT04498663 Musculoskeletal Pain Behavioral: Emotion- and Relationship-Focused Therapeutic Interview
MeSH:Musculoskeletal Pain

Primary Outcomes

Description: Brief Pain Inventory pain severity scale (0 - 10; higher values = greater pain severity)

Measure: Change in pain severity from baseline to 5-week follow-up

Time: 5-week follow-up

Description: Brief Pain Inventory pain interference scale (0 - 10; higher values = greater pain interference)

Measure: Change in pain interference from baseline to 5-week follow-up

Time: 5-week follow-up

Description: PROMIS anxiety scale (0 to 4; higher values = greater anxiety)

Measure: Change in anxiety from baseline to 5-week follow-up

Time: 5-week follow-up

Description: PROMIS depression scale (0 to 4; higher values = greater depression)

Measure: Change in depression from baseline to 5-week follow-up

Time: 5-week follow-up

Description: PROMIS anger scale (0 to 4; higher values = greater anger)

Measure: Change in anger from baseline to 5-week follow-up

Time: 5-week follow-up

Description: Rathus Assertiveness Schedule short form (- 3 to + 3; higher values = greater assertion)

Measure: Change in assertiveness from baseline to 5-week follow-up

Time: 5-week follow-up

Description: Affect Phobia Test (1 to 5; lower values = affect phobia)

Measure: Change in affect phobia from baseline to 5-week follow-up

Time: 5-week follow-up

Description: Pain attributions psychological subscale (0 to 4; higher values = greater psychological attribution)

Measure: Change in pain attributions to psychological processes from baseline to 5-week follow-up

Time: 5-week follow-up

Description: Pain attributions brain subscale (0 to 4; higher values = greater brain attributions)

Measure: Change in pain attributions to brain processes from baseline to 5-week follow-up

Time: 5-week follow-up

Description: Alcohol use item (1 to 7; higher = greater alcohol use)

Measure: Change in alcohol use frequency from baseline to 5-week follow-up

Time: 5-week follow-up

Description: Item assessing pain medication use (1 to 5; higher = greater medication use)

Measure: Change in pain medication use from baseline to 5-week follow-up

Time: 5-week follow-up


HPO Nodes