Name (Synonyms) | Correlation | |
---|---|---|
drug1925 | Norovirus Bivalent (GI.1 / GII.4) Vaccine(high) Wiki | 0.71 |
drug1926 | Norovirus Bivalent (GI.1 / GII.4) Vaccine(low) Wiki | 0.71 |
drug2550 | Saliva Wiki | 0.71 |
drug184 | Aluminum adjuvant Wiki | 0.71 |
drug1927 | Norovirus Bivalent (GI.1 / GII.4) Vaccine(middle) Wiki | 0.71 |
drug934 | Duodenal biopsy Wiki | 0.71 |
drug1922 | Normal saline Wiki | 0.32 |
drug752 | Convalescent Plasma Wiki | 0.29 |
drug2707 | Standard of care Wiki | 0.16 |
drug2698 | Standard of Care Wiki | 0.13 |
Name (Synonyms) | Correlation | |
---|---|---|
D005759 | Gastroenteritis NIH | 0.50 |
D003141 | Communicable Diseases NIH | 0.06 |
D007239 | Infection NIH | 0.04 |
Name (Synonyms) | Correlation |
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There are 2 clinical trials
The primary objective in this study is to establish a list of host cellular proteins that mediate norovirus infection. Norovirus is one of the most common pathogens attributed to diarrheal diseases from unsafe food. It is also the primary cause of mortality among young children and adults in foodborne infections. Norovirus is not just a foodborne burden. In a recent meta-analysis, norovirus accounts for nearly one-fifth of all causes of (including person-to-person transmission) acute gastroenteritis in both sporadic and outbreak settings and affects all age groups. Undoubtedly, norovirus is of paramount public health concern in both developed and developing countries. Research efforts to better understand norovirus pathobiology will be necessary for targeted intervention. From Middle East respiratory syndrome coronavirus to Zika virus, efforts to identify host factors important for mediating virus infection has always been a research priority. Such information will shed light on potential therapeutic targets in antiviral intervention. Norovirus virus-host interaction studies have been hampered by the lack of a robust cell culture model in the past 20 years. In 2016, norovirus has finally been successfully cultivated in a stem cell-derived three-dimensional human gut-like structure called enteroid or mini-gut. In this study, intestinal stem cells will be isolated from duodenal biopsies collected from participants, followed by differentiation into mini-guts. Genome-wide genetic screening for host essential and restrictive factors will be performed on infected mini-guts by knockout CRISPR and gain-of-function CRISPR SAM, respectively. Shortlisted candidates will undergo preliminary functional validation in cell lines. These data will provide insights into potential therapeutic targets against norovirus infection.
Description: Viability of enteroids as determined by microscopy
Measure: Establishment of human intestinal stem cell-derived enteroids Time: An average of three monthsA total of 450 subjects were enrolled, divided into four age groups, including 18-59 years, 6-17 years, 3-5 years, and 6-35 months. There are three types of the test vaccine component in each age group. A total of 30 people in each dose group were vaccinated with the test vaccine or placebo 1 or placebo 2, respectively, in a ratio of 3: 1: 1. The 18-59-year-old, 6-17-year-old, and 3-5-year-old age groups were vaccinated 2 times at a time interval of 28 days. The 6-35 month age group is divided into two groups, Group 1 is inoculated with 2 doses interval of 28 days each, and Group 2 is inoculated with 3 doses interval of 28 days.
Description: Active AE: Local and systemic adverse reactions occurring within 0-7 days after each dose of vaccination
Measure: All active AEs within 0-7 days after each dose Time: 7 daysDescription: Adverse events other than active AE include solicitation adverse events reported in addition to the specified solicitation time window
Measure: All non-active collection AEs within 0-28(30) days after each dose Time: 28(30) days