Name (Synonyms) | Correlation | |
---|---|---|
drug1362 | ION-827359 Wiki | 1.00 |
drug35 | 2D Telemedicine Wiki | 0.71 |
drug44 | 3D Telemedicine Wiki | 0.58 |
drug2122 | Placebo Wiki | 0.05 |
Name (Synonyms) | Correlation | |
---|---|---|
D029481 | Bronchitis, Chronic NIH | 1.00 |
D000208 | Acute Disease NIH | 0.71 |
D029424 | Pulmonary Disease, Chronic Obstructive NIH | 0.35 |
D008173 | Lung Diseases, Obstructive NIH | 0.33 |
D008171 | Lung Diseases, NIH | 0.24 |
Name (Synonyms) | Correlation | |
---|---|---|
HP:0012387 | Bronchitis HPO | 1.00 |
HP:0004469 | Chronic bronchitis HPO | 1.00 |
HP:0006510 | Chronic pulmonary obstruction HPO | 0.35 |
HP:0006536 | Pulmonary obstruction HPO | 0.33 |
HP:0002088 | Abnormal lung morphology HPO | 0.24 |
There is one clinical trial.
The purpose of this study is to evaluate the effect of ION-827359 on forced expiratory volume in 1 second (FEV1) in patients with mild to moderate COPD with CB.
Description: The EXACT (E-RS) scale is a participant-reported outcome (PRO) designed to measure the symptoms of participants with COPD. The E-RS utilizes 11 respiratory symptom items from the existing and validated 14-item EXACT, which measures symptoms of exacerbation. The E-RS total score quantifies respiratory symptom severity, and 3 domains assess breathlessness, cough and sputum, and chest symptoms. The E-RS will be collected on the daily e-diary, which will include all 14 items from the EXACT questionnaire.
Measure: Change From Baseline in the EXACT Respiratory Symptoms (E-RS) Daily Symptom Diary to the Primary Time Point Time: One week prior to first dose through one week after the last dose.Description: The CAT is an eight-item questionnaire that will be completed by the participant and is designed to quantify the impact of COPD symptoms on the health status of participants. The CAT provides a score of 0-40 to indicate the impact of the disease.
Measure: Change From Baseline in the COPD Assessment Test (CAT) to the Week 14 Time Point Time: From Baseline up to Week 14Description: The SGRQ is a participant completed, a disease-specific instrument designed to measure impact on overall health, daily life, and perceived well-being in participants with obstructive airway disease. Scores of the SGRQ-C range from 0 to 100, with higher scores indicating more limitations.
Measure: Change From Baseline in St. George's Respiratory Questionnaire (SGRQ) to the Week 14 Time Point Time: From Baseline up to Week 14