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  • HP:0002860: Squamous cell carcinoma
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    HP:0002860: Squamous cell carcinoma

    Developed by Shray Alag, The Harker School
    Sections: Correlations, Clinical Trials, and HPO

    Correlations computed by analyzing all clinical trials.

    Navigate: Clinical Trials and HPO


    Correlated Drug Terms (9)


    Name (Synonyms) Correlation
    drug796 Cisplatin Wiki 1.00
    drug2683 Proton Therapy Wiki 1.00
    drug3744 Yoga group Wiki 1.00
    Name (Synonyms) Correlation
    drug39 30 Gy over 3 weeks Wiki 1.00
    drug846 Combination Wiki 1.00
    drug54 5Fluorouracil Wiki 1.00
    drug1271 F-FMISO PET/CT Scan Wiki 1.00
    drug1475 High Intensity Interval Training group Wiki 1.00
    drug729 Carboplatin Wiki 0.71

    Correlated MeSH Terms (2)


    Name (Synonyms) Correlation
    D002294 Carcinoma, Squamous Cell NIH 1.00
    D002277 Carcinoma NIH 0.35

    Correlated HPO Terms (1)


    Name (Synonyms) Correlation
    HP:0030731 Carcinoma HPO 0.35

    Clinical Trials

    Navigate: Correlations   HPO

    There is one clinical trial.


    1 A Prospective Single Arm Non-inferiority Trial of Major Radiation Dose De-Escalation Concurrent With Chemotherapy for Human Papilloma Virus Associated Oropharyngeal Carcinoma (Major De-escalation to 30Gy for Select Human Papillomavirus Associated Oropharyngeal Carcinoma)

    The purpose of this study is to demonstrate that participants with HPV positive and hypoxia negative T1-2, N1-2c (AJCC, 7th ed.) oropharyngeal squamous cell carcinoma receiving a major de-escalated radiation therapy with 2 cycles of standard chemotherapy is not inferior to comparable subjects treated with the current standard chemoradiation. Given the restrictions of surgery during the COVID19 pandemic, we will start enrolling patients on Cohort B where surgery is not required. Once the COVI19 pandemic is over, we will resume and complete enrollment on Cohort A where surgery is required, prior to continuing enrolling patients on Cohort B. During the COVID-19 pandemic, the research MRIs are optional.

    NCT03323463
    Conditions
    1. HPV-Associated Oropharyngeal Squamous Cell Carcinoma
    2. Squamous Cell Carcinoma of the Neck
    Interventions
    1. Diagnostic Test: F-FMISO PET/CT Scan
    2. Radiation: 30 Gy over 3 weeks
    3. Drug: Cisplatin
    4. Drug: Carboplatin
    5. Drug: 5Fluorouracil
    6. Radiation: Proton Therapy
    MeSH:Carcinoma Carcinoma, Squamous Cell
    HPO:Carcinoma Squamous cell carcinoma

    Primary Outcomes

    Measure: Effectiveness of study treatment for participants receiving de-escalated radiation therapy radiation therapy, comparable to participants treated with the current standard of care chemoradiation by standard CT (or MRI) or tumor site and PET scan

    Time: 2 years (+/- 3 months)

    HPO Nodes


    Reports

    Data processed on September 26, 2020.

    An HTML report was created for each of the unique drugs, MeSH, and HPO terms associated with COVID-19 clinical trials. Each report contains a list of either the drug, the MeSH terms, or the HPO terms. All of the terms in a category are displayed on the left-hand side of the report to enable easy navigation, and the reports contain a list of correlated drugs, MeSH, and HPO terms. Further, all reports contain the details of the clinical trials in which the term is referenced. Every clinical trial report shows the mapped HPO and MeSH terms, which are also hyperlinked. Related HPO terms, with their associated genes, protein mutations, and SNPs are also referenced in the report.

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