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  • HP:0001397: Hepatic steatosis
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    HP:0001397: Hepatic steatosis

    Developed by Shray Alag, The Harker School
    Sections: Correlations, Clinical Trials, and HPO

    Correlations computed by analyzing all clinical trials.

    Navigate: Clinical Trials and HPO


    Correlated Drug Terms (2)


    Name (Synonyms) Correlation
    drug3355 TERN-101 Wiki 1.00
    drug2505 Placebo Wiki 0.05

    Correlated MeSH Terms (2)


    Name (Synonyms) Correlation
    D065626 Non-alcoholic Fatty Liver Disease NIH 1.00
    D005234 Fatty Liver NIH 1.00

    Correlated HPO Terms (0)


    Name (Synonyms) Correlation

    Clinical Trials

    Navigate: Correlations   HPO

    There is one clinical trial.


    1 A Multicenter, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, Phase 2a Clinical Trial to Evaluate the Safety, Tolerability, Efficacy, and Pharmacokinetics of Orally Administered TERN-101 Tablets in Adult Patients With Presumed Non-Cirrhotic Non-Alcoholic Steatohepatitis (NASH)

    This is a Phase 2, randomized, double-blind, placebo-controlled study designed to evaluate the safety, tolerability, efficacy, and pharmacokinetics (PK) of TERN-101 in non-cirrhotic NASH patients.

    NCT04328077
    Conditions
    1. NASH - Nonalcoholic Steatohepatitis
    Interventions
    1. Drug: TERN-101
    2. Other: Placebo
    MeSH:Fatty Liver Non-alcoholic Fatty Liver Disease
    HPO:Hepatic steatosis

    Primary Outcomes

    Measure: Subject incidence of adverse events for TERN-101 versus placebo

    Time: 16 weeks

    Secondary Outcomes

    Measure: Percent change from baseline in ALT for TERN-101 versus placebo at 12 weeks

    Time: 12 weeks

    Description: Area under the curve

    Measure: Plasma concentration of TERN-101 - AUC

    Time: 12 weeks

    Description: Maximum observed concentration

    Measure: Plasma concentration of TERN-101 - Cmax

    Time: 12 weeks

    Description: Time to reach maximum measured plasma concentration

    Measure: Plasma concentration of TERN-101 - Tmax

    Time: 12 weeks

    Description: Determination of half-life

    Measure: Plasma concentration of TERN-101 - t1/2

    Time: 12 weeks

    HPO Nodes


    Reports

    Data processed on September 26, 2020.

    An HTML report was created for each of the unique drugs, MeSH, and HPO terms associated with COVID-19 clinical trials. Each report contains a list of either the drug, the MeSH terms, or the HPO terms. All of the terms in a category are displayed on the left-hand side of the report to enable easy navigation, and the reports contain a list of correlated drugs, MeSH, and HPO terms. Further, all reports contain the details of the clinical trials in which the term is referenced. Every clinical trial report shows the mapped HPO and MeSH terms, which are also hyperlinked. Related HPO terms, with their associated genes, protein mutations, and SNPs are also referenced in the report.

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