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  • HP:0005523: Lymphoproliferative disorder
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    HP:0005523: Lymphoproliferative disorder

    Developed by Shray Alag, The Harker School
    Sections: Correlations, Clinical Trials, and HPO

    Correlations computed by analyzing all clinical trials.

    Navigate: Clinical Trials and HPO


    Correlated Drug Terms (1)


    Name (Synonyms) Correlation
    drug4135 tabelecleucel Wiki 1.00

    Correlated MeSH Terms (1)


    Name (Synonyms) Correlation
    D008232 Lymphoproliferative Disorders NIH 1.00

    Correlated HPO Terms (0)


    Name (Synonyms) Correlation

    Clinical Trials

    Navigate: Correlations   HPO

    There are 2 clinical trials


    1 Multicenter, Open-Label, Phase 3 Study of Tabelecleucel for Allogeneic Hematopoietic Cell Transplant Subjects With Epstein-Barr Virus-Associated Post-Transplant Lymphoproliferative Disease After Failure of Rituximab

    This is a multicenter, open label, single-arm, phase 3 study to assess the efficacy and safety of tabelecleucel for the treatment of Epstein-Barr virus-associated post-transplant lymphoproliferative disease (EBV+ PTLD) in the setting of allogeneic hematopoietic cell transplant (HCT) after failure of rituximab.

    NCT03392142
    Conditions
    1. Epstein-Barr Virus-Associated Post-Transplant Lymphoproliferative Disease (EBV+ PTLD)
    2. Stem Cell Transplant Complications
    3. Lymphoproliferative Disorders
    Interventions
    1. Biological: tabelecleucel
    MeSH:Lymphoproliferative Disorders
    HPO:Lymphoproliferative disorder

    Primary Outcomes

    Measure: Objective response rate (ORR)

    Time: 2 years

    Secondary Outcomes

    Measure: Overall survival (OS)

    Time: 5 years

    Measure: Duration of response (DOR)

    Time: 2 years

    Measure: PTLD progression-free survival (PFS) following best response

    Time: 2 years

    Measure: Rate of durable response

    Time: 2 years

    Measure: Time to progression

    Time: 2 years

    Measure: Patient reported outcome: EQ-5D

    Time: 2 years

    Measure: Patient reported outcome: Functional Assessment of Cancer Therapy Lymphoma (FACT-Lym)

    Time: 2 years

    Measure: Incidence of related and unrelated adverse events (AE), including AEs of special interest

    Time: 2 years
    2 Multicenter, Open Label, Phase 3 Study of Tabelecleucel for Solid Organ or Allogeneic Hematopoietic Cell Transplant Subjects With Epstein-Barr Virus-Associated Post-Transplant Lymphoproliferative Disease After Failure of Rituximab or Rituximab and Chemotherapy

    The purpose of this study is to determine the clinical benefit and characterize the safety profile of tabelecleucel for the treatment of Epstein-Barr virus-associated post-transplant lymphoproliferative disease (EBV+ PTLD) in the setting of (1) solid organ transplant (SOT) after failure of rituximab and rituximab plus chemotherapy or (2) allogeneic hematopoietic cell transplant (HCT) after failure of rituximab.

    NCT03394365
    Conditions
    1. Epstein-Barr Virus+ Associated Post-transplant Lymphoproliferative Disease (EBV+ PTLD)
    2. Solid Organ Transplant Complications
    3. Lymphoproliferative Disorders
    4. Allogeneic Hematopoietic Cell Transplant
    5. Stem Cell Transplant Complications
    Interventions
    1. Biological: tabelecleucel
    MeSH:Lymphoproliferative Disorders
    HPO:Lymphoproliferative disorder

    Primary Outcomes

    Measure: Objective response rate (ORR) in the SOT or HCT cohort

    Time: 2 years

    Secondary Outcomes

    Measure: Duration of response (DOR) in SOT and HCT cohorts separately

    Time: 2 years

    Measure: ORR and DOR in SOT and HCT cohorts combined

    Time: 2 years

    Measure: Rates of complete response (CR) and partial response (PR)

    Time: 2 years

    Measure: Time to response

    Time: 2 years

    Measure: Time to best response

    Time: 2 years

    Measure: Overall survival (OS)

    Time: 2 years

    Measure: Rates of allograft loss or rejection episodes (SOT cohort)

    Time: 2 years

    HPO Nodes


    HPO

    Alphabetical listing of all HPO terms. Navigate: Correlations   Clinical Trials

    Reports

    Data processed on September 26, 2020.

    An HTML report was created for each of the unique drugs, MeSH, and HPO terms associated with COVID-19 clinical trials. Each report contains a list of either the drug, the MeSH terms, or the HPO terms. All of the terms in a category are displayed on the left-hand side of the report to enable easy navigation, and the reports contain a list of correlated drugs, MeSH, and HPO terms. Further, all reports contain the details of the clinical trials in which the term is referenced. Every clinical trial report shows the mapped HPO and MeSH terms, which are also hyperlinked. Related HPO terms, with their associated genes, protein mutations, and SNPs are also referenced in the report.

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    Interventions

    4,180 reports on interventions/drugs

    MeSH

    691 reports on MeSH terms

    HPO

    263 reports on HPO terms

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    Alphabetical index of all Terms

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