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  • HP:0012387: Bronchitis
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    HP:0012387: Bronchitis

    Developed by Shray Alag, The Harker School
    Sections: Correlations, Clinical Trials, and HPO

    Correlations computed by analyzing all clinical trials.

    Navigate: Clinical Trials and HPO

    Correlated Drug Terms (4)

    Name (Synonyms) Correlation
    drug1600 ION-827359 Wiki 1.00
    drug38 2D Telemedicine Wiki 0.71
    drug46 3D Telemedicine Wiki 0.58
    Name (Synonyms) Correlation
    drug2505 Placebo Wiki 0.05

    Correlated MeSH Terms (6)

    Name (Synonyms) Correlation
    D029481 Bronchitis, Chronic NIH 1.00
    D001991 Bronchitis NIH 1.00
    D000208 Acute Disease NIH 0.71
    Name (Synonyms) Correlation
    D029424 Pulmonary Disease, Chronic Obstructive NIH 0.29
    D008173 Lung Diseases, Obstructive NIH 0.28
    D008171 Lung Diseases, NIH 0.22

    Correlated HPO Terms (4)

    Name (Synonyms) Correlation
    HP:0004469 Chronic bronchitis HPO 1.00
    HP:0006510 Chronic pulmonary obstruction HPO 0.33
    HP:0006536 Pulmonary obstruction HPO 0.32
    Name (Synonyms) Correlation
    HP:0002088 Abnormal lung morphology HPO 0.23

    Clinical Trials

    Navigate: Correlations   HPO

    There is one clinical trial.

    1 A Double-Blind, Placebo-Controlled, Phase 2a Study to Assess the Safety, Tolerability, and Efficacy of ION-827359 in Patients With Mild to Moderate COPD With Chronic Bronchitis

    The purpose of this study is to evaluate the effect of ION-827359 on forced expiratory volume in 1 second (FEV1) in patients with mild to moderate COPD with CB.

    1. Chronic Bronchitis
    2. Chronic Obstructive Pulmonary Disease
    1. Drug: ION-827359
    2. Drug: Placebo
    MeSH:Lung Diseases Lung Diseases, Obstructive Pulmonary Disease, Chronic Obstructive Bronchitis Bronchitis, Chronic Acute Disease
    HPO:Abnormal lung morphology Bronchitis Chronic bronchitis Chronic pulmonary obstruction Pulmonary obstruction

    Primary Outcomes

    Measure: Change From Baseline to the Primary Time Point in Forced Expiratory Volume in 1 Second (FEV1) Compared to Placebo

    Time: From Baseline up to average of Weeks 13 and 14

    Secondary Outcomes

    Description: The EXACT (E-RS) scale is a participant-reported outcome (PRO) designed to measure the symptoms of participants with COPD. The E-RS utilizes 11 respiratory symptom items from the existing and validated 14-item EXACT, which measures symptoms of exacerbation. The E-RS total score quantifies respiratory symptom severity, and 3 domains assess breathlessness, cough and sputum, and chest symptoms. The E-RS will be collected on the daily e-diary, which will include all 14 items from the EXACT questionnaire.

    Measure: Change From Baseline in the EXACT Respiratory Symptoms (E-RS) Daily Symptom Diary to the Primary Time Point

    Time: One week prior to first dose through one week after the last dose.

    Description: The CAT is an eight-item questionnaire that will be completed by the participant and is designed to quantify the impact of COPD symptoms on the health status of participants. The CAT provides a score of 0-40 to indicate the impact of the disease.

    Measure: Change From Baseline in the COPD Assessment Test (CAT) to the Week 14 Time Point

    Time: From Baseline up to Week 14

    Description: The SGRQ is a participant completed, a disease-specific instrument designed to measure impact on overall health, daily life, and perceived well-being in participants with obstructive airway disease. Scores of the SGRQ-C range from 0 to 100, with higher scores indicating more limitations.

    Measure: Change From Baseline in St. George's Respiratory Questionnaire (SGRQ) to the Week 14 Time Point

    Time: From Baseline up to Week 14

    Measure: Change from Baseline in Post-Bronchodilator FEV1

    Time: From Baseline up to average of Weeks 13 and 14

    Measure: Cmax: Maximum Observed Plasma Concentration for ION-827359

    Time: Up to Week 24

    Measure: Tmax: Time to Reach the Maximum Plasma Concentration for ION-827359

    Time: Up to Week 24

    Measure: AUC[0-t]: Area Under the Plasma Concentration-Time Curve from Time Zero to t for ION-827359

    Time: Up to Week 24

    Measure: Incidence of Participants With at Least One Treatment-Emergent Adverse Event (TEAE), Graded by Severity

    Time: Up to Week 24

    Measure: Number of Participants With Abnormal Laboratory Values

    Time: Up to Week 24

    Measure: Number of Participants With Abnormal Vital Signs Measurements

    Time: Up to Week 24

    HPO Nodes


    Data processed on September 26, 2020.

    An HTML report was created for each of the unique drugs, MeSH, and HPO terms associated with COVID-19 clinical trials. Each report contains a list of either the drug, the MeSH terms, or the HPO terms. All of the terms in a category are displayed on the left-hand side of the report to enable easy navigation, and the reports contain a list of correlated drugs, MeSH, and HPO terms. Further, all reports contain the details of the clinical trials in which the term is referenced. Every clinical trial report shows the mapped HPO and MeSH terms, which are also hyperlinked. Related HPO terms, with their associated genes, protein mutations, and SNPs are also referenced in the report.

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