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  • HP:0100614: Myositis
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    HP:0100614: Myositis

    Developed by Shray Alag, The Harker School
    Sections: Correlations, Clinical Trials, and HPO

    Correlations computed by analyzing all clinical trials.

    Navigate: Clinical Trials and HPO


    Correlated Drug Terms (4)


    Name (Synonyms) Correlation
    drug3981 muscle ultrasound Wiki 1.00
    drug3936 laboratory biomarkers Wiki 1.00
    drug2400 PLX-PAD Wiki 1.00
    Name (Synonyms) Correlation
    drug2505 Placebo Wiki 0.05

    Correlated MeSH Terms (5)


    Name (Synonyms) Correlation
    D009220 Myositis NIH 0.71
    D009205 Myocarditis NIH 0.33
    D007239 Infection NIH 0.05
    Name (Synonyms) Correlation
    D045169 Severe Acute Respiratory Syndrome NIH 0.04
    D018352 Coronavirus Infections NIH 0.04

    Correlated HPO Terms (1)


    Name (Synonyms) Correlation
    HP:0012819 Myocarditis HPO 0.35

    Clinical Trials

    Navigate: Correlations   HPO

    There is one clinical trial.


    1 Prospective Registry for Multimodal Assessment of Neuromuscular Pathology Associated With Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection

    Prospective registry for multimodal assessment of neuromuscular pathology associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, enrolling consecutive patients with corona virus disease 2019 (Covid-19), who are admitted to the intensive care unit of the department of anesthesiology and intensive care medicine, or the department of neurology at Tübingen University Hospital.

    NCT04367350
    Conditions
    1. COVID
    2. Sars-CoV2
    3. Corona Virus Infection
    4. Myositis
    5. Myocarditis
    Interventions
    1. Diagnostic Test: laboratory biomarkers
    2. Diagnostic Test: muscle ultrasound
    MeSH:Infection Coronavirus Infections Severe Acute Respiratory Syndrome Myositis Myocarditis
    HPO:Inflammatory myopathy Myocarditis Myositis

    Primary Outcomes

    Description: Elevation of creatine kinase during hyperacute phase of corona virus disease 2019 (Covid-19)

    Measure: Rate of elevated creatine kinase in hyperacute phase

    Time: 1 week

    Secondary Outcomes

    Description: Elevation of creatine kinase during hyperacute, acute, subacute and chronic phase of corona virus disease 2019 (Covid-19)

    Measure: Rate of elevated creatine kinase

    Time: 24 months

    Description: Two-peak elevation of creatine kinase during acute phase of corona virus disease 2019 (Covid-19)

    Measure: Rate of two-peak elevation of creatine kinase during acute phase

    Time: 30 days

    Description: Presence of myositis-specific antibodies on admission, at two weeks, and at end of follow-up

    Measure: Rate of myositis-specific antibodies

    Time: 24 months

    Description: Presence of antimyocardial antibodies on admission, at two weeks, and at end of follow-up

    Measure: Rate of antimyocardial antibodies

    Time: 24 months

    Description: Level of creatine kinase elevation in the hyperacute, acute, subacute and chronic phase of corona virus disease 2019 (Covid-19) assessed by the area under the curve (AUC)

    Measure: Area under the curve (AUC) of elevated creatine kinase

    Time: 24 months

    Description: Maximal value of creatine kinase elevation in the hyperacute, acute, subacute and chronic phase of corona virus disease 2019 (Covid-19)

    Measure: Peak-levels of elevated creatine kinase

    Time: 24 months

    Description: Maximal value of troponin in the acute phase of corona virus disease 2019 (Covid-19)

    Measure: Peak-levels of troponin

    Time: 30 days

    Description: Maximal value of urine myoglobin in the acute of corona virus disease 2019 (Covid-19)

    Measure: Peak-levels of urine myoglobin

    Time: 30 days

    Description: Muscle hyperechogenicity in the upper and lower extremities, the accessory respiratory serratus anterior muscle, and abdominal wall according to qualitative ultrasound assessment (Heckmatt score) during the hyperacute, acute, subacute and chronic phase of corona virus disease 2019 (Covid-19)

    Measure: Rate of muscle hyperechogenicity

    Time: 24 months

    Description: Peak-muscle hyperechogenicity in the upper and lower extremities, the accessory respiratory serratus anterior muscle, and abdominal wall according to qualitative ultrasound assessment (Heckmatt score) during the hyperacute, acute, subacute and chronic phase of corona virus disease 2019 (Covid-19)

    Measure: Peak-muscle hyperechogenicity

    Time: 24 months

    HPO Nodes


    Reports

    Data processed on September 26, 2020.

    An HTML report was created for each of the unique drugs, MeSH, and HPO terms associated with COVID-19 clinical trials. Each report contains a list of either the drug, the MeSH terms, or the HPO terms. All of the terms in a category are displayed on the left-hand side of the report to enable easy navigation, and the reports contain a list of correlated drugs, MeSH, and HPO terms. Further, all reports contain the details of the clinical trials in which the term is referenced. Every clinical trial report shows the mapped HPO and MeSH terms, which are also hyperlinked. Related HPO terms, with their associated genes, protein mutations, and SNPs are also referenced in the report.

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    4,180 reports on interventions/drugs

    MeSH

    691 reports on MeSH terms

    HPO

    263 reports on HPO terms

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