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  • HP:0010280: Stomatitis
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    HP:0010280: Stomatitis

    Developed by Shray Alag, The Harker School
    Sections: Correlations, Clinical Trials, and HPO

    Correlations computed by analyzing all clinical trials.

    Navigate: Clinical Trials and HPO


    Correlated Drug Terms (2)


    Name (Synonyms) Correlation
    drug2487 Photobiomodulation Wiki 1.00
    drug2925 Routine Oral Care and Analgesia Wiki 1.00

    Correlated MeSH Terms (5)


    Name (Synonyms) Correlation
    D013280 Stomatitis NIH 1.00
    D052016 Mucositis NIH 1.00
    D005892 Gingivitis, Necrotizing Ulcerative NIH 1.00
    Name (Synonyms) Correlation
    D006258 Head and Neck Neoplasms NIH 0.50
    D014456 Ulcer NIH 0.33

    Correlated HPO Terms (1)


    Name (Synonyms) Correlation
    HP:0012288 Neoplasm of head and neck HPO 0.50

    Clinical Trials

    Navigate: Correlations   HPO

    There is one clinical trial.


    1 Photobiomodulation Therapy Using the MuReva Phototherapy System to Demonstrate Safety and Reduce the Incidence of Oral Mucositis in Adult Patients With Head and Neck Cancer Receiving Concurrent Radiation and Chemotherapy

    The overall purpose of this clinical study is to evaluate safety and efficacy of the MuReva Phototherapy System with a light delivery mouthpiece to reduce the incidence of severe oral mucositis (OM) in adult patients with squamous cell carcinoma of the oral cavity, oropharynx, tonsils and base of tongue receiving concurrent radiation and chemotherapy.

    NCT03972527
    Conditions
    1. Oral Mucositis (Ulcerative)
    2. Oral Mucositis (Ulcerative) Due to Radiation
    3. Oral Mucositis (Ulcerative) Due to Antineoplastic Therapy
    4. Head and Neck Cancer
    Interventions
    1. Device: Photobiomodulation
    2. Other: Routine Oral Care and Analgesia
    MeSH:Gingivitis, Necrotizing Ulcerative Head and Neck Neoplasms Mucositis Stomatitis Ulce Ulcer
    HPO:Neoplasm of head and neck Stomatitis

    Primary Outcomes

    Description: The primary effectiveness endpoint of the study is the proportion of patients who have severe oral mucositis (Grade 3 or 4) at week 6 of treatment according to the World Health Organization (WHO) Oral Toxicity Scale.

    Measure: Incidence of severe oral mucositis (WHO grade 3 and 4) at week 6 of chemoradiation therapy.

    Time: 6-8 weeks of photobiomodulation and chemoradiation therapy

    Secondary Outcomes

    Description: Radiation therapy oncology group scale (RTOG) 0 (Normal)- 4 (necrosis/hemorrhage), 5= death

    Measure: Oral Mucositis (OM) Grade and Incidence,

    Time: 6-8 weeks, evaluated once per week

    Description: World Health Organization scale (WHO) 0 (Normal)- 4 (oral alimentation not possible), 5= death

    Measure: Oral Mucositis (OM) Grade and Incidence,

    Time: 6-8 weeks, evaluated once per week

    Description: World Health Organization (WHO) analgesic ladder Steps 1-3: 1= non opioid, 2= weak opioid, 3= strong opioid

    Measure: Analgesic Usage

    Time: 6-8 weeks, evaluated daily

    HPO Nodes


    Reports

    Data processed on September 26, 2020.

    An HTML report was created for each of the unique drugs, MeSH, and HPO terms associated with COVID-19 clinical trials. Each report contains a list of either the drug, the MeSH terms, or the HPO terms. All of the terms in a category are displayed on the left-hand side of the report to enable easy navigation, and the reports contain a list of correlated drugs, MeSH, and HPO terms. Further, all reports contain the details of the clinical trials in which the term is referenced. Every clinical trial report shows the mapped HPO and MeSH terms, which are also hyperlinked. Related HPO terms, with their associated genes, protein mutations, and SNPs are also referenced in the report.

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