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  • HP:0005145: Coronary artery stenosis
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    HP:0005145: Coronary artery stenosis

    Developed by Shray Alag, The Harker School
    Sections: Correlations, Clinical Trials, and HPO

    Correlations computed by analyzing all clinical trials.

    Navigate: Clinical Trials and HPO


    Correlated Drug Terms (4)


    Name (Synonyms) Correlation
    drug2719 QFR Wiki 1.00
    drug1583 IC14 Wiki 1.00
    drug243 Angiography Wiki 1.00
    Name (Synonyms) Correlation
    drug2505 Placebo Wiki 0.05

    Correlated MeSH Terms (5)


    Name (Synonyms) Correlation
    D023921 Coronary Stenosis NIH 1.00
    D007511 Ischemia NIH 0.41
    D003327 Coronary Disease NIH 0.38
    Name (Synonyms) Correlation
    D003324 Coronary Artery Disease NIH 0.38
    D009203 Myocardial Ischemia NIH 0.24

    Correlated HPO Terms (2)


    Name (Synonyms) Correlation
    HP:0001677 Coronary artery atherosclerosis HPO 0.41
    HP:0001658 Myocardial infarction HPO 0.27

    Clinical Trials

    Navigate: Correlations   HPO

    There is one clinical trial.


    1 Comparison of Quantitative Flow Ratio Guided and Angiography Guided Percutaneous InterVention in Patients With cORonary Artery Disease (The FAVOR III China Study)

    The overall purpose of the FAVOR III China trial is to investigate if a strategy of quantitative flow ratio (QFR)-guided percutaneous coronary intervention (PCI) yields superior clinical outcome and cost-effectiveness compared to a strategy of standard coronary angiography-guided PCI in evaluation of patients with coronary artery disease.

    NCT03656848
    Conditions
    1. Coronary Artery Disease
    2. Myocardial Ischaemia
    3. Coronary Circulation
    4. Coronary Stenosis
    5. Percutaneous Coronary Intervention
    Interventions
    1. Diagnostic Test: QFR
    2. Diagnostic Test: Angiography
    MeSH:Coronary Artery Disease Myocardial Ischemia Coronary Disease Coronary Stenosis Ischemia
    HPO:Coronary artery atherosclerosis Coronary artery stenosis Myocardial infarction

    Primary Outcomes

    Description: A composite of all-cause mortality, any myocardial infarction and any ischemia-driven revascularization

    Measure: MACE

    Time: 1 year

    Secondary Outcomes

    Description: all-cause mortality, any spontaneous myocardial infarction and any ischemia-driven revascularization

    Measure: MACE excluding peri-procedural MI (Major secondary endpoint)

    Time: 1 year

    Description: Cardiovascular, non-cardiovascular and undetermined death

    Measure: Death

    Time: 1 month, 6 months, 1 year, 2 years and 3 years

    Description: Target vessel related and non-target vessel related MI

    Measure: MI

    Time: 1 month, 6 months, 1 year, 2 years and 3 years

    Description: The ischemia driven and non-ischemia driven TVR

    Measure: Target vessel revascularization (TVR)

    Time: 1 month, 6 months, 1 year, 2 years and 3 years

    Description: The The ischemia driven and non-ischemia driven Revascularization

    Measure: Any coronary artery revascularization

    Time: 1 month, 6 months, 1 year, 2 years and 3 years

    Description: Definite and probable stent thrombosis during acute, sub-acute, late, and very late phase according to the Academic Research Consortium (ARC)-2

    Measure: Definite or probable stent thrombosis

    Time: 1 month, 6 months, 1 year, 2 years and 3 years

    Description: PCI strategy changes following QFR and three-dimension quantitative coronary angiography (3D-QCA)

    Measure: The PCI strategy changes based on the QFR and 3D-QCA

    Time: During the procedure

    Description: Costs include direct clinical costs during the initial hospitalization and other resources used, main cardiovascular medication expenses, and outpatient and/or hospitalization expenses associated with MACE.

    Measure: Cost during 1-year follow-up

    Time: 1 month, 6 months, 1 year

    Description: QALYs determined using EuroQol five dimensions questionnaire (EQ-5D) in official Chinese version, to assess the quality of life.

    Measure: Quality-adjusted-life-years (QALYs) index

    Time: 1 month, 6 months, 1 year

    HPO Nodes


    HPO

    Alphabetical listing of all HPO terms. Navigate: Correlations   Clinical Trials

    Reports

    Data processed on September 26, 2020.

    An HTML report was created for each of the unique drugs, MeSH, and HPO terms associated with COVID-19 clinical trials. Each report contains a list of either the drug, the MeSH terms, or the HPO terms. All of the terms in a category are displayed on the left-hand side of the report to enable easy navigation, and the reports contain a list of correlated drugs, MeSH, and HPO terms. Further, all reports contain the details of the clinical trials in which the term is referenced. Every clinical trial report shows the mapped HPO and MeSH terms, which are also hyperlinked. Related HPO terms, with their associated genes, protein mutations, and SNPs are also referenced in the report.

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    Interventions

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    MeSH

    691 reports on MeSH terms

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    263 reports on HPO terms

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