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  • HP:0003302: Spondylolisthesis
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    HP:0003302: Spondylolisthesis

    Developed by Shray Alag, The Harker School
    Sections: Correlations, Clinical Trials, and HPO

    Correlations computed by analyzing all clinical trials.

    Navigate: Clinical Trials and HPO


    Correlated Drug Terms (2)


    Name (Synonyms) Correlation
    drug3684 ViviGen® Cellular Bone Matrix Wiki 1.00
    drug1849 Local Bone Autograft Wiki 1.00

    Correlated MeSH Terms (5)


    Name (Synonyms) Correlation
    D013168 Spondylolisthesis NIH 1.00
    D013130 Spinal Stenosis NIH 1.00
    D011843 Radiculopathy NIH 1.00
    Name (Synonyms) Correlation
    D013122 Spinal Diseases NIH 0.71
    D055959 Intervertebral Disc Degeneration NIH 0.71

    Correlated HPO Terms (1)


    Name (Synonyms) Correlation
    HP:0008419 Intervertebral disc degeneration HPO 0.71

    Clinical Trials

    Navigate: Correlations   HPO

    There is one clinical trial.


    1 Clinical Outcomes Associated With the Use of ViviGen® in Conjunction With Posterolateral Fusion for the Treatment of Lumbar Degenerative Disc Disease

    The objective of this study is to perform a prospective, randomized, controlled clinical trial to compare radiographic fusion rates and patient reported outcomes, including pain and function preoperatively and postoperatively, using Depuy ViviGen® Cellular Bone Matrix mixed with cortical/cancellous allograft in conjunction with an approved Depuy Synthes pedicle screw system compared to autograft mixed with cortical/cancellous allograft in conjunction with the same DePuy Synthes pedicle screw system used for a one or two - level posterolateral lumbar fusion.

    NCT03733626
    Conditions
    1. Lumbar Spondylolisthesis
    2. Degenerative Disc Disease
    3. Degenerative Spondylolisthesis
    4. Lumbar Radiculopathy
    5. Lumbar Spinal Stenosis
    6. Lumbar Disc Disease
    Interventions
    1. Combination Product: ViviGen® Cellular Bone Matrix
    2. Combination Product: Local Bone Autograft
    MeSH:Spinal Stenosis Spinal Diseases Intervertebral Disc Degeneration Spondylolisthesis Radiculopathy
    HPO:Intervertebral disc degeneration Spondylolisthesis

    Primary Outcomes

    Description: Count of participants with successful lumbar bone fusion as measured by CT scan and flexion/extension x-rays at 12-months as evidenced by the following three criteria: bony bridging, no presence of radiolucency and no development of pseudoarthrosis at the treated lumbar level

    Measure: Incidence of successful Lumbar Fusion measured radiographically

    Time: 12 months postoperative

    Secondary Outcomes

    Description: Equal to or greater than a 2-point decrease in patient reported outcomes as measured by Visual Analog Scale for pain (0-10 point scale, 0 = no pain and 10 = severe amount of pain) from baseline to 12-months.

    Measure: Visual Analog Scale for Pain

    Time: 12 months postoperative

    Description: Equal to or greater than 15-point decrease in patient reported outcomes as measured by Oswestry Disability Index (0-100 point scale, 0 = least amount of disability, 100 = most severe disability) from baseline to 12-months.

    Measure: Change in Oswestry Disability Index for Pain and Function

    Time: 12 months postoperative

    Description: Equal to or greater than 15-point increase in patient reported outcomes as measured by SF-36 (0-100 point scale, 0 = low favorable health state and 100 = most favorable health state) from baseline to 12-months.

    Measure: Change in Short Form Health Survey-36 for Quality of Life

    Time: 12 months postoperative

    Description: Count of participants with new or worsening neurological (lumbar motor and sensory) deficit as evaluated by lumbar spine neurological exam from baseline through 12 months.

    Measure: Neurological Deficit per Lumbar Spine Neurological Exam

    Time: 12 months postoperative

    Description: Count of participants with revision surgery by month 12

    Measure: Count of participants with revision surgery by month 12

    Time: 12 months postoperative

    Description: Count of participants developing pseudoarthrosis by month 12

    Measure: Count of participants developing pseudoarthrosis by month 12

    Time: 12 months postoperative

    HPO Nodes


    Reports

    Data processed on September 26, 2020.

    An HTML report was created for each of the unique drugs, MeSH, and HPO terms associated with COVID-19 clinical trials. Each report contains a list of either the drug, the MeSH terms, or the HPO terms. All of the terms in a category are displayed on the left-hand side of the report to enable easy navigation, and the reports contain a list of correlated drugs, MeSH, and HPO terms. Further, all reports contain the details of the clinical trials in which the term is referenced. Every clinical trial report shows the mapped HPO and MeSH terms, which are also hyperlinked. Related HPO terms, with their associated genes, protein mutations, and SNPs are also referenced in the report.

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    MeSH

    691 reports on MeSH terms

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    263 reports on HPO terms

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