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  • HP:0100615: Ovarian neoplasm
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    HP:0100615: Ovarian neoplasm

    Developed by Shray Alag, The Harker School
    Sections: Correlations, Clinical Trials, and HPO

    Correlations computed by analyzing all clinical trials.

    Navigate: Clinical Trials and HPO

    Correlated Drug Terms (5)

    Name (Synonyms) Correlation
    drug1011 Deep Breathing training Wiki 0.71
    drug859 Compassion focused intervention Wiki 0.71
    drug3971 modification of the planned therapeutic management Wiki 0.71
    Name (Synonyms) Correlation
    drug2799 Radspherin Wiki 0.71
    drug789 Choices and judgements Wiki 0.71

    Correlated MeSH Terms (10)

    Name (Synonyms) Correlation
    D010051 Ovarian Neoplasms NIH 0.82
    D000077216 Carcinoma, Ovarian Epithelial NIH 0.71
    D014594 Uterine Neoplasms NIH 0.71
    Name (Synonyms) Correlation
    D014625 Vaginal Neoplasms NIH 0.71
    D014846 Vulvar Neoplasms NIH 0.71
    D010534 Peritoneal Neoplasms NIH 0.71
    D002583 Uterine Cervical Neoplasms NIH 0.50
    D001943 Breast Neoplasms NIH 0.32
    D002277 Carcinoma NIH 0.25
    D009369 Neoplasms, NIH 0.13

    Correlated HPO Terms (7)

    Name (Synonyms) Correlation
    HP:0100650 Vaginal neoplasm HPO 0.71
    HP:0030416 Vulvar neoplasm HPO 0.71
    HP:0010784 Uterine neoplasm HPO 0.71
    Name (Synonyms) Correlation
    HP:0030079 Cervix cancer HPO 0.50
    HP:0003002 Breast carcinoma HPO 0.32
    HP:0030731 Carcinoma HPO 0.25
    HP:0002664 Neoplasm HPO 0.14

    Clinical Trials

    Navigate: Correlations   HPO

    There are 2 clinical trials

    1 A Phase 1 Study to Evaluate the Dose, Safety and Tolerability of an Intraperitoneal α-emitting Radionuclide Therapy (Radspherin®) in Patients With Platinum Sensitive Recurrent Epithelial Ovarian, Fallopian Tube or Primary Peritoneal Carcinoma With Peritoneal Carcinomatosis Following CRS

    RAD-18-001 is a First-In-Man, Dose Escaltion study conducted at 2 sites. The dose escalation will be performed based on a 3 + 3 design. Increasing dose levels starting at 1 MBq will be followed by 2, 4 and 7 MBq. If the highest dose level of 7 MBq is reached without Dose Limiting Toxicicities (which will stop the dose escalation), this will be the recommended dose for further exploration. Acceptability of up to 7 MBq gives the opportunity to explore the doses of the dose escalation split into two administrations, and given as two separate injections 1 week apart. Split doses of 1, 2 and 3.5 MBq will be administered as two injections. Each subject will be followed until disease progression (in the abdominal cavity), or for 12 months after the administration of Radspherin® (whichever comes first).

    1. Peritoneal Carcinomatosis
    2. Ovarian Cancer
    1. Drug: Radspherin
    MeSH:Ovarian Neoplasms Carcinoma, Ovarian Epithelial Carcinoma Peritoneal Neoplasms
    HPO:Carcinoma Ovarian neoplasm

    Primary Outcomes

    Description: To investigate safety and toxicity of Radspherin®

    Measure: Number of participants with Dose Limiting Toxicities as assessed by CTCAE v5.0.

    Time: 12 months

    Description: To determine the MTD of Radspherin®, among the four suggested doses 1, 2, 4 and 7 MBq, as a single intraperitoneal (IP) injection and two repeated IP injections following cytoreductive surgery (CRS)

    Measure: Maximum Tolerated Dose (MTD)

    Time: 21 days
    2 Impact of the COVID-19 Pandemic on Changes in Therapeutic Strategies in Gynecological Oncology

    The current infection with the Coronavirus SARS-CoV-2 (COVID-19) is an exceptional health situation which requires an adaptation of our management practices in gynecological oncology. Data from the literature suggest that infection with Coronavirus is serious in subjects with cancer with a risk of severe form 5 times higher than that of the population without cancer and a risk of death multiplied by 8. In addition, the risk of infection would be 3 times greater in case of cancer. Faced with the COVID-19 epidemic, the investigator must organize themselves to ensure continuity in the treatment of patients with gynecological cancer but also adapt our practices in the management (CPR, teleconsultation, adaptation of treatment or even postponement of treatment). The objective of the High Council of Public Health is to be able to ensure adequate oncological care avoiding any potential loss of chance concerning the care of cancer: people affected must, despite the pandemic, have care allowing the same level of curability (localized cancers) or the same life expectancy (advanced cancers). This must be done by limiting as much as possible the impact on the organization of the service, the organization of patient follow-up and the psychological impact that these possible modifications could have. The hypotheses of our study are that the exceptional health situation linked to this pandemic leads to a change in the care of patients with gynecological cancer associated with a psychological impact and increased anxiety of patients during their care. Despite the extent of the pandemic, very little existing data makes it possible to define recommendations with a sufficient level of evidence.

    1. Gynecologic Cancer
    2. Breast Neoplasm Female
    3. Uterine Neoplasms
    4. Ovarian Neoplasms
    5. Uterine Cervical Neoplasms
    6. Vulvar Neoplasms
    7. Vaginal Neoplasms
    1. Other: modification of the planned therapeutic management
    MeSH:Neoplasms Breast Neoplasms Ovarian Ovarian Neoplasms Uterine Cervical Neoplasms Uterine Neoplasms Vulvar Neoplasms Vaginal Neoplasms
    HPO:Breast carcinoma Cervical polyp Cervix cancer Neoplasm Neoplasm of the breast Ovarian neoplasm Uterine neoplasm Vaginal neoplasm Vulvar neoplasm

    Primary Outcomes

    Description: modification of the planned therapeutic management

    Measure: percentage of patients with a change in the planned therapeutic management (surgery, chemotherapy, radiotherapy, hormone therapy)

    Time: Day O

    HPO Nodes


    Data processed on September 26, 2020.

    An HTML report was created for each of the unique drugs, MeSH, and HPO terms associated with COVID-19 clinical trials. Each report contains a list of either the drug, the MeSH terms, or the HPO terms. All of the terms in a category are displayed on the left-hand side of the report to enable easy navigation, and the reports contain a list of correlated drugs, MeSH, and HPO terms. Further, all reports contain the details of the clinical trials in which the term is referenced. Every clinical trial report shows the mapped HPO and MeSH terms, which are also hyperlinked. Related HPO terms, with their associated genes, protein mutations, and SNPs are also referenced in the report.

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