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    HP:0002871: Central apnea

    Developed by Shray Alag, The Harker School
    Sections: Correlations, Clinical Trials, and HPO

    Correlations computed by analyzing all clinical trials.

    Navigate: Clinical Trials and HPO


    Correlated Drug Terms (3)


    Name (Synonyms) Correlation
    drug573 Buspirone + PAP therapy Wiki 1.00
    drug3759 Zolpidem + PAP therapy Wiki 1.00
    drug162 Acetazolamide + supplemental oxygen + PAP therapy Wiki 1.00

    Correlated MeSH Terms (3)


    Name (Synonyms) Correlation
    D020182 Sleep Apnea, Central NIH 1.00
    D012891 Sleep Apnea, NIH 0.50
    D053120 Respiratory Aspiration NIH 0.29

    Correlated HPO Terms (1)


    Name (Synonyms) Correlation
    HP:0010535 Sleep apnea HPO 0.50

    Clinical Trials

    Navigate: Correlations   HPO

    There is one clinical trial.


    1 Central Sleep Apnea: Physiologic Mechanisms to Inform Treatment

    Central sleep apnea (CSA) is common in patients with heart failure and those using opioid analgesics. Unfortunately, effective treatment of central apnea remains elusive, pressure therapy given the modest efficiency of positive airway pressure therapy. The focus of this proposal is to identify mechanistic pathways to guide future therapeutic interventions for central sleep apnea based on the strong premise that multi-modality therapy will normalize respiration and hence mitigate adverse long-term consequences of CSA. The investigators' proposed studies will test combination therapies, including positive airway pressure (PAP) plus a pharmacological agent who have heart failure or are using opioid analgesics. The investigators anticipate that findings will inform future clinical trials to improve care and quality of life among Veterans suffering from central sleep apnea, which remains difficult to treat using existing approaches.

    NCT04118387
    Conditions
    1. Sleep Disordered Breathing
    2. Able Bodied
    Interventions
    1. Drug: Acetazolamide + supplemental oxygen + PAP therapy
    2. Drug: Zolpidem + PAP therapy
    3. Drug: Buspirone + PAP therapy
    MeSH:Sleep Apnea Syndromes Respiratory Aspiration Sleep Apnea, Central
    HPO:Central apnea Central sleep apnea Sleep apnea

    Primary Outcomes

    Description: CO2 reserve is the requisite change to induce central apnea is referred to as the CO2 reserve, which can be positive or negative.

    Measure: CO2 reserve

    Time: 120 days

    Description: Central apnea indices is used to indicate the severity of central sleep apnea

    Measure: Central apnea indices

    Time: 120 days

    Secondary Outcomes

    Description: Controller gain is a ventilatory response to changes in end-tidal PCO2

    Measure: Controller gain

    Time: 120 days

    Description: Plant gain is blood gas response to a change in ventilation. This measure represents the effectiveness of the "plant" in eliminating CO2.

    Measure: Plant gain

    Time: 120 days

    Description: This measure represents the activity of the carotid bodies. It is measured by the decrease in ventilation in response to a single breath of 100% oxygen.

    Measure: Carotid body function

    Time: 120 days

    Description: Peripheral chemoreflex sensitivity is measured either via brief hypoxia or a single breath of CO2.

    Measure: Peripheral chemoreflex sensitivity

    Time: 120 days

    Description: The nadir pressure in the upper airway (supra-glottic pressure) prior to the occurrence of an arousal.

    Measure: Respiratory arousal threshold

    Time: 120 days

    Description: To assess breathing stability, the investigators will measure % stable breathing using minute ventilation (VE) and tidal volume (VT) coefficient of variation as indices of breathing instability.

    Measure: % stable breathing

    Time: 120 days

    HPO Nodes


    HPO

    Alphabetical listing of all HPO terms. Navigate: Correlations   Clinical Trials

    Reports

    Data processed on September 26, 2020.

    An HTML report was created for each of the unique drugs, MeSH, and HPO terms associated with COVID-19 clinical trials. Each report contains a list of either the drug, the MeSH terms, or the HPO terms. All of the terms in a category are displayed on the left-hand side of the report to enable easy navigation, and the reports contain a list of correlated drugs, MeSH, and HPO terms. Further, all reports contain the details of the clinical trials in which the term is referenced. Every clinical trial report shows the mapped HPO and MeSH terms, which are also hyperlinked. Related HPO terms, with their associated genes, protein mutations, and SNPs are also referenced in the report.

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