CovidResearchTrials by Shray Alag


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Generic Response Training Control InterventionWiki

Developed by Shray Alag
Clinical Trial MeSH HPO Drug Gene SNP Protein Mutation


Correlated Drug Terms (1)


Name (Synonyms) Correlation
drug626 Computer Based Response Training Weight Loss Intervention Wiki 1.00

Correlated MeSH Terms (3)


Name (Synonyms) Correlation
D006963 Hyperphagia NIH 0.71
D001068 Feeding and Eating Disorders NIH 0.50
D009765 Obesity NIH 0.41

Correlated HPO Terms (2)


Name (Synonyms) Correlation
HP:0002591 Polyphagia HPO 0.71
HP:0001513 Obesity HPO 0.41

There is one clinical trial.

Clinical Trials


1 Translational Neuroscience: Response Training for Obesity Treatment

This project will test whether a food response training intervention produces lasting body fat loss, use objective brain imaging to examine the mechanism of effect of this treatment and investigate the generalizability of the training to non-training foods, and examine factors that should amplify intervention effects to provide a test of the intervention theory. This novel treatment represents a bottom-up implicit training intervention that does not rely on executive control, prolonged caloric deprivation, and expensive clinicians to deliver, like behavioral weight loss treatments that have not produced lasting weight loss. If this computer-based response training intervention produces sustained body fat loss in overweight individuals, it could be easily implemented very broadly at almost no expense, addressing a leading public health problem.

NCT03375853 Obesity Hyperphagia Feeding and Eating Disorders Behavioral: Computer Based Response Training Weight Loss Intervention Behavioral: Generic Response Training Control Intervention
MeSH:Obesity Hyperphagia Feeding and Eating Disorders
HPO:Obesity Polyphagia

Primary Outcomes

Description: Change in participant's body fat percentage

Measure: Body Fat Change

Time: Baseline, 1 month, 3 months, 6 months, 12 months

Secondary Outcomes

Description: Eating disorder symptoms as measured with the Eating Disorder Diagnostic Interview

Measure: Change in Eating Disorder Symptoms

Time: Baseline, 1 month, 3 months, 6 months, 12 months

Description: Change in Dietary Restraint, Emotional Eating, and External Eating (aggregate score) as measured by the Dutch Eating Behavior Questionnaire

Measure: Dietary Restraint, Emotional Eating, and External Eating

Time: Baseline, 1 month, 3 months, 6 months, 12 months

Description: Chang in Disinhibited Eating as measured by the Three Factor Eating Questionnaire

Measure: Change in Disinhibited Eating Behavior

Time: Baseline, 1 month, 3 months, 6 months, 12 months

Description: Change in Eating When Not Hungry as measured by the Eating in the Absence of Hunger Questionnaire

Measure: Change in Eating in the Absence of Hunger Behavior

Time: Baseline, 1 month, 3 months, 6 months, 12 months

Description: Change in Problematic eating patterns associated with symptoms of addictive behaviors as measured by the Yale Food Addiction Scale

Measure: Change in Food Addiction Behavior

Time: Baseline, 1 month, 3 months, 6 months, 12 months

Description: Change in Physical Activity as measured by the Paffenberger Questionnaire

Measure: Change in Physical Activity

Time: Baseline, 1 month, 3 months, 6 months, 12 months

Description: Change in Substance use frequency (i.e., number of times per day) for alcohol of participants as measured by the Daily Drinking Questionnaire

Measure: Change in Alcohol Use Behavior

Time: Baseline, 1 month, 3 months, 6 months, 12 months

Description: Change in Substance use frequency (i.e., number of times per day) for common recreational drugs of participants as measured by the Daily Drug Taking Questionnaire

Measure: Change in Substance Use Behavior

Time: Baseline, 1 month, 3 months, 6 months, 12 months

Description: Change in Participant behavioral response to food pictures, and subjective palatability rating

Measure: Change in Participant Ratings of Unhealthy Food Palatability

Time: Baseline, 1 month

Description: Change in Participant behavioral response to food pictures, and willingness to pay given dollar amounts (aggregate score) for the pictured food

Measure: Change in Participant Ratings of Food Monetary Value

Time: Baseline, 1 month

Description: Change Participant food craving behaviors as measured by the Food Craving and Liking Scale

Measure: Change in Food Craving and Liking Behavior

Time: Baseline, 1 month, 3 months, 6 months, 12 months

Description: Change in Participant BMI using standard methods of calculation

Measure: Change in Body Mass Index

Time: Baseline, 1 month, 3 months, 6 months, 12 months

Description: Change in mean R-Peak Amplitude measured using three-lead ECG using PowerLab 8 Diagnostic Suite

Measure: Change in mean R-Peak Amplitude

Time: Baseline, 1 month, 3 months, 6 months, 12 months

Description: Change in Heart Rate Variability measured using three-lead ECG using PowerLab 8 Diagnostic Suite

Measure: Change in Heart Rate Variability

Time: Baseline, 1 month, 3 months, 6 months, 12 months


Related HPO nodes (Using clinical trials)


HP:0001513: Obesity
Genes 477
SHOX HACE1 THOC2 LIMK1 FMR1 SOX3 PHF6 CLCN4 IFT172 TNFSF4 PDX1 KCNAB2 AGRP GNAS ADCY3 HLA-DRB1 AFF4 REEP6 PRPF6 KLF11 KIAA1549 ARL6 ELN MKS1 PWAR1 IFT27 SDC3 LIPE SYNE2 RAB39B FGF8 ARHGEF6 RDH12 ZNF408 BRAF SH2B1 BPTF HLA-DQB1 ANOS1 LMNA TRIM32 ARX AKT1 KIF7 TRIP12 SLC7A7 IL1RAPL1 SHANK3 INS EGF RAI1 SYNE1 GNAS ATP6AP2 XRCC4 SLC7A14 GNAS HDAC8 BBS2 HSD11B1 MC4R AGBL5 KMT2D ACADVL BBS4 MEGF8 CYP7A1 RAD21 ARVCF BEST1 RPS6KA3 ZNF365 ADRB3 CRX MID2 ATRX NDN UCP3 IQSEC2 SKI RBP3 CNGB1 RAB23 ZNF513 SLC25A4 FLRT3 KISS1R CCDC141 IFT140 TSPAN7 CCDC141 ARMC5 TRAF3IP1 LZTFL1 SUFU OFD1 MAGEL2 SMC1A AKT2 GNAS ARL6 GTF2IRD1 UFD1 TRIM32 CDHR1 NF2 MEGF8 SNORD115-1 WT1 HACE1 SH2B1 CNGA1 DHDDS RFC2 PSMD12 SMO KIZ NTRK2 BBS10 DCC PRPF8 EP300 SOX10 POU3F4 BAP1 TMEM43 NEK2 DEAF1 GNAS-AS1 BBS9 SIN3A SNRPN MAK FGFR1 PHF6 CLIP2 BBS2 COMT BBS2 HESX1 HESX1 GNAS JMJD1C TCF20 MCM3AP NEUROD1 LZTFL1 ARL6 ABCA4 C8ORF37 GHR TMEM67 USP8 HIRA LEP IQSEC2 CERKL NRL PAX6 TBX1 SRY H6PD CREBBP PRKAR1A PROM1 ZNF41 PCSK1 PCSK1 EHMT1 IMPDH1 CNNM2 RNPC3 C8ORF37 ZNF711 LEPR TTC8 ALMS1 PRCD PROKR2 ELN PNPLA6 PAX4 MKKS GATA4 SYP VPS13B FGF17 PRPF4 HNF1A CA4 GDI1 TUB POMC AIP TTC8 ENPP1 KIDINS220 SLC9A7 CEP164 NSD1 NR2E3 TBX1 HNF4A PWRN1 MC3R KIDINS220 KMT2A BDNF MTTP PCARE ARL6 POMC P2RY11 IQSEC2 BBS10 RAB23 KCNJ18 PDE4D BBS9 HDAC4 TUB XYLT1 SEC24C PDSS1 HGSNAT EIF2S3 IGF1R MAGEL2 IPW FTO GCK SPRY4 PRMT7 ARHGEF18 DYRK1B XYLT1 RP1 GNAS CLRN1 AHR MED12 HDAC8 CTSH TTC8 PNKP IFT172 FGFR1 SIM1 MKKS FTSJ1 MAPK8IP3 ALB IFT74 ALMS1 GUCA1B UPF3B ATRX PDE6G CTNNB1 CCDC28B SETD2 SLC10A7 APOE NIPBL BBS7 RAI1 HCFC1 PRDM16 TOPORS WDR11 BBS5 IDH3B PIK3CA SCAPER ARL2BP SPG11 CXORF56 ADRB2 HS6ST1 RREB1 LAS1L PDE6B BLK IL17RD ADNP TBX3 NPAP1 P4HTM EIF2S3 PRPF3 CARTPT SMC3 POMC SPATA7 SH3KBP1 MECP2 CYP19A1 BBS12 MKS1 NKAP HDAC8 RERE PRKAR1A TAF1 UBE3A MLXIPL KCNJ11 INPP5E HCRT IGF1 RPGR APC2 CNKSR2 BLK PRMT7 MC4R PPARG RPS6KA3 HUWE1 BAZ1B PDGFB PROKR2 NIN AHI1 RBMX SOX2 SAG MECP2 TRAF7 WDPCP HERC2 ABCC8 GP1BB TRAPPC9 BBS12 CEP290 ADNP MKRN3-AS1 PTCHD1 ACSL4 CUL4B BAP1 NR0B2 PROK2 TERT PCNT PCNT EYS WT1 FGFR3 IFT27 RGR GTF2I ZNF711 SDCCAG8 EMD LAS1L CACNA1S GNAS DHX38 IDH3A USP27X DYNC2I2 PIGT PDE4D TACR3 LEPR RHO POGZ MRAP2 EXOC6B BBS5 ZBTB20 FOXP1 RP9 BBS7 SH2B1 KLHL7 EHMT1 DNMT3A ARMC5 RLBP1 ALG13 AGTR2 MYT1L VPS13B CDH23 PAX6 PAK3 SMARCB1 LEP BBS4 ARL13B DUSP6 MKRN3 TRAPPC9 AFF4 SDCCAG8 TBX1 GHRL BBS1 STX16 BBIP1 USH2A MOG LMNA PROK2 OFD1 SIM1 FLII RP2 SETD5 MOG FRMPD4 DPYD IFT172 APPL1 ARNT2 SNORD116-1 NSMF BBS1 DLG3 FAM161A RPE65 PDE4D PRPH2 ROM1 TBL2 OTX2 FHL1 ERMARD C8ORF37 NPHP1 CEP19 DMD SEMA4A ARL3 PHIP CEL MAN1B1 LRAT CANT1 GABRD TULP1 SNRNP200 IFT88 MTFMT AKT2 FSCN2 CEP290 MERTK SEMA3A BBIP1 PDE11A CHD7 IMPG2 POMGNT1 SMARCE1 SMAD4 IFT172 MAN1B1 CUL4B USP9X PRPF31 PTEN KDM6A IGFALS WNT4 SETD2 GNAS TBX3 PDE6A FEZF1 USP8 CRB1 ZNF81 GABRA3
Protein Mutations 3
G20210A P12A W64R