CovidResearchTrials by Shray Alag


CovidResearchTrials Covid 19 Research using Clinical Trials (Home Page)


Cognitive Behavioral TherapyWiki

Developed by Shray Alag
Clinical Trial MeSH HPO Drug Gene SNP Protein Mutation


Correlated Drug Terms (6)


Name (Synonyms) Correlation
drug616 Community Referral as appropriate Wiki 0.71
drug2065 Relaxation Therapy Wiki 0.71
drug1196 Inflammatory cytokines and chemokines profiles of patients with dexmedetomidine administration Wiki 0.71
drug315 Baricitinib Wiki 0.27
drug2067 Remdesivir Wiki 0.18
drug1822 Placebo Wiki 0.04

Correlated MeSH Terms (10)


Name (Synonyms) Correlation
D009771 Obsessive-Compulsive Disorder NIH 0.71
D001010 Anxiety, Separation NIH 0.71
D000072861 Phobia, Social NIH 0.71
D003193 Compulsive Personality Disorder NIH 0.71
D003192 Compulsive Behavior NIH 0.71
D016584 Panic Disorder NIH 0.71
D000379 Agoraphobia NIH 0.71
D010698 Phobic Disorders NIH 0.50
D004194 Disease NIH 0.13
D001008 Anxiety Disorders NIH 0.12

Correlated HPO Terms (2)


Name (Synonyms) Correlation
HP:0000756 Agoraphobia HPO 0.71
HP:0000722 Obsessive-compulsive behavior HPO 0.50

There are 2 clinical trials

Clinical Trials


1 Dimensional Brain Behavior Predictors of CBT Outcomes in Pediatric Anxiety

Anxiety is among the most prevalent, costly and disabling illnesses and tends emerge early in childhood. Cognitive behavioral therapy (CBT) is the first-line treatment for early life anxiety, but as many as 40% of young patients who receive CBT fail to get better. The proposed study will examine brain changes marking positive response to CBT for anxiety and how these changes may differ in children compared adolescents. By helping us to understand how CBT works, this study will pave the way for new treatments to stop anxiety early.

NCT02810171 Anxiety Disorders Social Anxiety Disorder Social Phobia Generalized Anxiety Disorder Separation Anxiety Disorder Specific Phobia Phobia Agoraphobia Panic Disorder Panic Attack Anxiety Behavioral: Cognitive Behavioral Therapy Behavioral: Relaxation Therapy
MeSH:Disease Anxiety Disorders Phobic Disorders Panic Disorder Phobia, Social Agoraphobia Anxiety, Separation
HPO:Agoraphobia

Primary Outcomes

Description: Pre- to post-CBT changes in functional, connectivity and structural MRI measures of brain networks relevant for anxiety. Brain regions include the amygdala, anterior insula, dorsal anterior cingulate cortex (dACC) and ventrolateral prefrontal cortex (vlPFC). Functional activation and connectivity of these brain regions are assessed using simple computer tasks performed during MRI scanning. Tasks engage threat reactivity, self-regulatory control and the interaction of these processes. Structural connections between regions will be measured using a MRI technique that measures water diffusion in the brain.

Measure: Brain function/structure as assessed by Magnetic Resonance Imaging scans

Time: Baseline and 12-weeks

Secondary Outcomes

Description: The Pediatric Anxiety Rating Scale (PARS) is a clinician-administered assessment to rate the severity of anxiety symptoms associated with common DSM-V anxiety disorders (social phobia, separation anxiety disorder, and generalized anxiety disorder) in children. The investigators are looking for decreases in anxiety severity ratings from pre- to post-treatment.

Measure: Pediatric Anxiety Rating Scale

Time: weeks 0, 3, 6, 9, 12

2 Task Control Circuit Targets for Obsessive Compulsive Behaviors in Children

This study will use magnetic resonance imaging (MRI) to assess the function and structure of overlapping task control circuits in children with a range of Obsessive-Compulsive symptoms (OCS). The functioning of task control circuits will be assessed using the well-validated Multisource interference task (MSIT). This study will also assess functional and anatomical connectivity within task control circuits in the same children, and determine whether disturbances in these overlapping circuits are associated with Obsessive-Compulsive Disorder (OCD) symptom severity. Behavioral measures will be administered to further assess regulatory, learning and memory functions. Children with OCD will then be offered a standard course of cognitive behavioral therapy (CBT) before rescanning (along with age-and gender-matched control participants) in order to assess how these circuits may change with treatment. Children with subclinical OC symptoms will be offered referral for treatment on an as-needed basis. In addition, de-identified data may be used in the future to conduct secondary data analyses. As more about OC symptoms and neurobiological mechanisms of interest in the current study are understood, data may be used to answer questions beyond those described in this protocol. All study procedures will be conducted on-site at Columbia University/the New York State Psychiatric Institute (New York, NY) and the University of Michigan's outpatient Child and Adolescent Psychiatry (Ann Arbor, Michigan).

NCT03584945 Obsessive-compulsive Disorders and Symptoms in Children Behavioral: Cognitive Behavioral Therapy Other: Community Referral as appropriate
MeSH:Compulsive Personality Disorder Obsessive-Compulsive Disorder Compulsive Behavior
HPO:Obsessive-compulsive behavior

Primary Outcomes

Measure: Blood oxygen-level dependent (BOLD) functional MRI signal during a cognitive conflict task

Time: approximately 15-20 minutes

Description: Child Yale-Brown Obsessive Compulsive Scale (CYBOCS) is scored on a scale of 0 to 40, with 40 being the most severe.

Measure: Child Yale-Brown Obsessive Compulsive Scale

Time: approximately 1 hour

Secondary Outcomes

Measure: Blood oxygen-level dependent (BOLD) functional connectivity MRI of task control circuits

Time: approximately 10 minutes

Measure: Diffusion tensor imaging (fractional anisotropy, FA) in task control circuit regions

Time: approximately 10 minutes


Related HPO nodes (Using clinical trials)


Protein Mutations 0
SNP 0