Name (Synonyms) | Correlation | |
---|---|---|
drug616 | Community Referral as appropriate Wiki | 0.71 |
drug2065 | Relaxation Therapy Wiki | 0.71 |
drug1196 | Inflammatory cytokines and chemokines profiles of patients with dexmedetomidine administration Wiki | 0.71 |
drug315 | Baricitinib Wiki | 0.27 |
drug2067 | Remdesivir Wiki | 0.18 |
drug1822 | Placebo Wiki | 0.04 |
Name (Synonyms) | Correlation | |
---|---|---|
D009771 | Obsessive-Compulsive Disorder NIH | 0.71 |
D001010 | Anxiety, Separation NIH | 0.71 |
D000072861 | Phobia, Social NIH | 0.71 |
D003193 | Compulsive Personality Disorder NIH | 0.71 |
D003192 | Compulsive Behavior NIH | 0.71 |
D016584 | Panic Disorder NIH | 0.71 |
D000379 | Agoraphobia NIH | 0.71 |
D010698 | Phobic Disorders NIH | 0.50 |
D004194 | Disease NIH | 0.13 |
D001008 | Anxiety Disorders NIH | 0.12 |
Name (Synonyms) | Correlation | |
---|---|---|
HP:0000756 | Agoraphobia HPO | 0.71 |
HP:0000722 | Obsessive-compulsive behavior HPO | 0.50 |
There are 2 clinical trials
Anxiety is among the most prevalent, costly and disabling illnesses and tends emerge early in childhood. Cognitive behavioral therapy (CBT) is the first-line treatment for early life anxiety, but as many as 40% of young patients who receive CBT fail to get better. The proposed study will examine brain changes marking positive response to CBT for anxiety and how these changes may differ in children compared adolescents. By helping us to understand how CBT works, this study will pave the way for new treatments to stop anxiety early.
Description: Pre- to post-CBT changes in functional, connectivity and structural MRI measures of brain networks relevant for anxiety. Brain regions include the amygdala, anterior insula, dorsal anterior cingulate cortex (dACC) and ventrolateral prefrontal cortex (vlPFC). Functional activation and connectivity of these brain regions are assessed using simple computer tasks performed during MRI scanning. Tasks engage threat reactivity, self-regulatory control and the interaction of these processes. Structural connections between regions will be measured using a MRI technique that measures water diffusion in the brain.
Measure: Brain function/structure as assessed by Magnetic Resonance Imaging scans Time: Baseline and 12-weeksDescription: The Pediatric Anxiety Rating Scale (PARS) is a clinician-administered assessment to rate the severity of anxiety symptoms associated with common DSM-V anxiety disorders (social phobia, separation anxiety disorder, and generalized anxiety disorder) in children. The investigators are looking for decreases in anxiety severity ratings from pre- to post-treatment.
Measure: Pediatric Anxiety Rating Scale Time: weeks 0, 3, 6, 9, 12This study will use magnetic resonance imaging (MRI) to assess the function and structure of overlapping task control circuits in children with a range of Obsessive-Compulsive symptoms (OCS). The functioning of task control circuits will be assessed using the well-validated Multisource interference task (MSIT). This study will also assess functional and anatomical connectivity within task control circuits in the same children, and determine whether disturbances in these overlapping circuits are associated with Obsessive-Compulsive Disorder (OCD) symptom severity. Behavioral measures will be administered to further assess regulatory, learning and memory functions. Children with OCD will then be offered a standard course of cognitive behavioral therapy (CBT) before rescanning (along with age-and gender-matched control participants) in order to assess how these circuits may change with treatment. Children with subclinical OC symptoms will be offered referral for treatment on an as-needed basis. In addition, de-identified data may be used in the future to conduct secondary data analyses. As more about OC symptoms and neurobiological mechanisms of interest in the current study are understood, data may be used to answer questions beyond those described in this protocol. All study procedures will be conducted on-site at Columbia University/the New York State Psychiatric Institute (New York, NY) and the University of Michigan's outpatient Child and Adolescent Psychiatry (Ann Arbor, Michigan).
Description: Child Yale-Brown Obsessive Compulsive Scale (CYBOCS) is scored on a scale of 0 to 40, with 40 being the most severe.
Measure: Child Yale-Brown Obsessive Compulsive Scale Time: approximately 1 hour