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D003324: Coronary Artery Disease

Developed by Shray Alag, The Harker School
Sections: Correlations, Clinical Trials, and HPO

Correlations computed by analyzing all clinical trials.

Navigate: Clinical Trials and HPO


Correlated Drug Terms (19)


Name (Synonyms) Correlation
drug2874 Resolute Onyx Wiki 0.38
drug1113 DynamX Bioadaptor Wiki 0.38
drug179 Ad5FGF-4 Wiki 0.38
Name (Synonyms) Correlation
drug1587 ID NOW vs. Accula Wiki 0.38
drug3386 Tele-medicine platform Wiki 0.38
drug2719 QFR Wiki 0.38
drug999 Data collection and rhinopharyngeal swab Wiki 0.38
drug252 Anthocyanins Wiki 0.38
drug2918 Robot Assisted Percutaneous Cardiovascular Intervention Wiki 0.38
drug17 14C-lazertinib Wiki 0.38
drug1583 IC14 Wiki 0.38
drug427 BRII-198 Wiki 0.38
drug1594 INC424 / Ruxolitinib Wiki 0.38
drug243 Angiography Wiki 0.38
drug1592 IMU-838 Wiki 0.27
drug464 Best Practice Wiki 0.17
drug2351 Oseltamivir Wiki 0.14
drug3485 Tocilizumab Wiki 0.06
drug2505 Placebo Wiki 0.05

Correlated MeSH Terms (22)


Name (Synonyms) Correlation
D000787 Angina Pectoris NIH 0.53
D009203 Myocardial Ischemia NIH 0.46
D003327 Coronary Disease NIH 0.43
Name (Synonyms) Correlation
D003331 Coronary Artery NIH 0.38
D023921 Coronary Stenosis NIH 0.38
D060050 Angina, Stable NIH 0.38
D007511 Ischemia NIH 0.31
D054143 Heart Failure, Systolic NIH 0.27
D054058 Acute Coronary Syndrome NIH 0.17
D003704 Dementia NIH 0.14
D007676 Kidney Failure, Chronic NIH 0.14
D006333 Heart Failure NIH 0.12
D006331 Heart Diseases NIH 0.11
D029424 Pulmonary Disease, Chronic Obstructive NIH 0.11
D060825 Cognitive Dysfunction NIH 0.11
D008173 Lung Diseases, Obstructive NIH 0.10
D020521 Stroke NIH 0.09
D002318 Cardiovascular Diseases NIH 0.07
D007249 Inflammation NIH 0.07
D009369 Neoplasms, NIH 0.07
D013577 Syndrome NIH 0.04
D007239 Infection NIH 0.02

Correlated HPO Terms (12)


Name (Synonyms) Correlation
HP:0001677 Coronary artery atherosclerosis HPO 0.93
HP:0001681 Angina pectoris HPO 0.53
HP:0001658 Myocardial infarction HPO 0.40
Name (Synonyms) Correlation
HP:0005145 Coronary artery stenosis HPO 0.38
HP:0000726 Dementia HPO 0.14
HP:0001635 Congestive heart failure HPO 0.13
HP:0006510 Chronic pulmonary obstruction HPO 0.13
HP:0006536 Pulmonary obstruction HPO 0.12
HP:0001268 Mental deterioration HPO 0.11
HP:0001297 Stroke HPO 0.10
HP:0002664 Neoplasm HPO 0.07
HP:0001626 Abnormality of the cardiovascular system HPO 0.07

Clinical Trials

Navigate: Correlations   HPO

There are 7 clinical trials


1 A Randomized, Double-Blind, Placebo-Controlled, Parallel Group, Multicenter, Phase 3 Study to Evaluate the Safety and Efficacy of Ad5FGF-4 in Patients With Refractory Angina Due to Myocardial Ischemia

The purpose of this study is to determine whether a single intracoronary infusion of an adenovirus serotype 5 virus expressing the gene for human fibroblast growth factor-4 (Ad5FGF-4) is effective in improving angina-limited exercise duration, angina functional class, frequency of angina attacks, frequency of nitroglycerin usage, and quality of life. Half of the study participants will receive Ad5FGF-4, and half will receive placebo. The primary endpoint is the change from baseline to Month 6 in Exercise Tolerance Test (ETT) duration. Long-term safety of Ad5FGF-4 will also be assessed.

NCT02928094
Conditions
  1. Angina, Stable
Interventions
  1. Biological: Ad5FGF-4
  2. Biological: Placebo
MeSH:Angina Pectoris Myocardial Ischemia Coronary Artery Disease Angina, Stable Ischemia
HPO:Angina pectoris Coronary artery atherosclerosis Myocardial infarction

Primary Outcomes

Description: Modified Bruce Protocol with exercise duration limited by angina or angina equivalent

Measure: Change in Exercise Tolerance Test (ETT) duration

Time: Baseline and Month 6

Secondary Outcomes

Description: Canadian Cardiovascular Society (CCS) angina classification

Measure: Change in patient functional status (CCS class)

Time: Baseline and Month 6

Description: Average weekly angina episodes

Measure: Change in weekly angina frequency

Time: Baseline and Month 6

Description: Average weekly nitroglycerin usage

Measure: Change in weekly nitroglycerin usage

Time: Baseline and Month 6

Description: Seattle Angina Questionnaire

Measure: Change in quality of life

Time: Baseline and Month 6

Description: Adverse events and clinical laboratory testing

Measure: Safety of Ad5FGF-4

Time: Through Month 6

Description: Occurrence of clinically significant events

Measure: Long-term safety of Ad5FGF-4

Time: Through Month 60
2 A Randomized, 24-week Parallel-group Placebo-controlled Multicenter (Phase 2) Study of Anthocyanins in People at Risk for Dementia

The aim of this project is to study the safety and efficacy of anthocyanins in improving key dementia-related mechanisms and cognitive functioning in older people at risk for dementia. Secondary analyses will include a variety of biological measures, including biochemistry, imaging and cardiovascular measures.

NCT03419039
Conditions
  1. Dementia
  2. Inflammation
  3. Mild Cognitive Impairment
  4. Coronary Artery Disease
Interventions
  1. Dietary Supplement: Anthocyanins
  2. Dietary Supplement: Placebo
MeSH:Dementia Coronary Artery Coronary Artery Disease Inflammation Cognitive Dysfunction
HPO:Cognitive impairment Coronary artery atherosclerosis Dementia Mental deterioration

Primary Outcomes

Description: A composite measure from the CogTrack battery

Measure: Quality of episodic memory.

Time: Baseline to 24 weeks

Secondary Outcomes

Description: CogTrack evaluates attentional intensity index, sustained intensity index, cognitive reaction time, attentional fluctuation index, quality of working memory, quality of episodic memory and speed of memory retrieval.

Measure: Secondary endpoints from CogTrack

Time: Baseline to 24 weeks

Description: Lipid profile, fatty acids, cytokines ( among others: IL-1, IL-2, IL-6, TNF-a), plasma antoxidant status and vitamins (lipid peroxidation markers, vitamins E, C, A, total plasma antioxidant capacity, glutathion)., carinthine, blood glucose, HbA1c, anthocyanins and metabolites, mapping of a-beta degradation products.

Measure: Blood outcome analysis

Time: Baseline to 24 weeks

Description: Flow-mediated dilation (FMD), Cardiac-ankle vascular index (CAVI), photoplethysmogram (PPG).

Measure: Cardiovascular parameters

Time: Baseline to 24 weeks

Description: Microbiota

Measure: Fecal analysis

Time: Baseline to 24 weeks

Description: kyrinin

Measure: Urine analysis

Time: Baseline to 24 weeks

Description: anthocyanin metabolites

Measure: CSF measurements

Time: Baseline to 24 weeks

Description: Diagnosing and follow-up of cerebrovascular disease

Measure: MR-imaging/CT

Time: Baseline to 24 weeks
3 Comparison of Quantitative Flow Ratio Guided and Angiography Guided Percutaneous InterVention in Patients With cORonary Artery Disease (The FAVOR III China Study)

The overall purpose of the FAVOR III China trial is to investigate if a strategy of quantitative flow ratio (QFR)-guided percutaneous coronary intervention (PCI) yields superior clinical outcome and cost-effectiveness compared to a strategy of standard coronary angiography-guided PCI in evaluation of patients with coronary artery disease.

NCT03656848
Conditions
  1. Coronary Artery Disease
  2. Myocardial Ischaemia
  3. Coronary Circulation
  4. Coronary Stenosis
  5. Percutaneous Coronary Intervention
Interventions
  1. Diagnostic Test: QFR
  2. Diagnostic Test: Angiography
MeSH:Coronary Artery Disease Myocardial Ischemia Coronary Disease Coronary Stenosis Ischemia
HPO:Coronary artery atherosclerosis Coronary artery stenosis Myocardial infarction

Primary Outcomes

Description: A composite of all-cause mortality, any myocardial infarction and any ischemia-driven revascularization

Measure: MACE

Time: 1 year

Secondary Outcomes

Description: all-cause mortality, any spontaneous myocardial infarction and any ischemia-driven revascularization

Measure: MACE excluding peri-procedural MI (Major secondary endpoint)

Time: 1 year

Description: Cardiovascular, non-cardiovascular and undetermined death

Measure: Death

Time: 1 month, 6 months, 1 year, 2 years and 3 years

Description: Target vessel related and non-target vessel related MI

Measure: MI

Time: 1 month, 6 months, 1 year, 2 years and 3 years

Description: The ischemia driven and non-ischemia driven TVR

Measure: Target vessel revascularization (TVR)

Time: 1 month, 6 months, 1 year, 2 years and 3 years

Description: The The ischemia driven and non-ischemia driven Revascularization

Measure: Any coronary artery revascularization

Time: 1 month, 6 months, 1 year, 2 years and 3 years

Description: Definite and probable stent thrombosis during acute, sub-acute, late, and very late phase according to the Academic Research Consortium (ARC)-2

Measure: Definite or probable stent thrombosis

Time: 1 month, 6 months, 1 year, 2 years and 3 years

Description: PCI strategy changes following QFR and three-dimension quantitative coronary angiography (3D-QCA)

Measure: The PCI strategy changes based on the QFR and 3D-QCA

Time: During the procedure

Description: Costs include direct clinical costs during the initial hospitalization and other resources used, main cardiovascular medication expenses, and outpatient and/or hospitalization expenses associated with MACE.

Measure: Cost during 1-year follow-up

Time: 1 month, 6 months, 1 year

Description: QALYs determined using EuroQol five dimensions questionnaire (EQ-5D) in official Chinese version, to assess the quality of life.

Measure: Quality-adjusted-life-years (QALYs) index

Time: 1 month, 6 months, 1 year
4 Integrated Distance Management Strategy for Patients With Cardiovascular Disease (Ischaemic Coronary Artery Disease, High Blood Pressure, Heart Failure) in the Context of the COVID-19 Pandemic

Management of known patients with cardiovascular disease (in particular the whole spectrum of atherosclerotic ischaemic coronary artery disease, essential hypertension under treatment, and also patients with chronic heart failure under medication) and with other associated chronic pathologies, with obvious effects on the management of the pandemic with modern / distance means (e-Health) of patients at high risk of mortality in contact with coronavirus. Given the Covid-19 Pandemic, all the above complex cardiovascular patients are under the obligation to stay in the house isolated and can no longer come to standard clinical and paraclinical monitoring and control visits. Therefore, a remote management solution (tele-medicine) of these patients must be found. The Investigators endeavour is to create an electronic platform to communicate with these patients and offer solutions for their cardiovascular health issues (including psychological and religious problems due to isolation). The Investigators intend to create this platform for communicating with a patient and stratify their complaints in risk levels. A given specialist will sort and classify their needs on a scale, based on specific algorithms (derived from the clinical European Cardiovascular Guidelines), and generate specific protocols varying from 911 like emergencies to cardiological advices or psychological sessions. These could include medication changing of doses, dietary advices or exercise restrictions. Moreover, in those patients suspected of COVID infection, special assistance should be provided per protocol.

NCT04325867
Conditions
  1. Angina Pectoris
  2. Acute Coronary Syndrome
  3. Coronary Syndrome
  4. Coronary Artery Disease
  5. Angioplasty
  6. Stent Restenosis
  7. Hypertension
  8. Heart Failure, Systolic
  9. Depression, Anxiety
  10. Covid-19
  11. Isolation, Social
Interventions
  1. Other: Tele-medicine platform
MeSH:Heart Failure Cardiovascular Diseases Coronary Artery Disease Myocardial Ischemia Coronary Disease Acute Coronary Syndrome Angina Pectoris Heart Failure, Systolic Syndrome
HPO:Abnormality of the cardiovascular system Angina pectoris Congestive heart failure Coronary artery atherosclerosis Left ventricular dysfunction Myocardial infarction Right ventricular failure

Primary Outcomes

Description: Development of an electronic (e-HEALTH) framework structure for management of patients with known cardiovascular disease in COVID19 pandemic social context

Measure: Providing a special electronic platform (e-health) for remote managing cardiovascular outpatients

Time: 6 months

Description: patients come into direct contact with the case coordinator, who provides ongoing assistance, including for connecting to devices that ensure real-time data transmission and directing to specialist teams that establish stage diagnosis and management / therapy behavior (including adjustment). doses, decisions to discontinue medication or to add medication);

Measure: Number of patients included in this platform

Time: 6 months

Secondary Outcomes

Description: Will be the number of sessions per patient multiplied with the number of patients included

Measure: Number of consultations/sessions given

Time: 6 months
5 Tociluzumab for Cytokine Release Syndrome With SARS-CoV-2: An Open-Labeled, Randomized Phase 3 Trial

This phase III trial compares the effect of adding tocilizumab to standard of care versus standard of care alone in treating cytokine release syndrome (CRS) in patients with SARS-CoV-2 infection. CRS is a potentially serious disorder caused by the release of an excessive amount of substance that is made by cells of the immune system (cytokines) as a response to viral infection. Tocilizumab is used to decrease the body's immune response. Adding tocilizumab to standard of care may work better in treating CRS in patients with SARS-CoV-2 infection compared to standard of care alone.

NCT04361552
Conditions
  1. Cerebrovascular Accident
  2. Chronic Obstructive Pulmonary Disease
  3. Chronic Renal Failure
  4. Coronary Artery Disease
  5. Diabetes Mellitus
  6. Malignant Neoplasm
  7. SARS Coronavirus 2 Infection
Interventions
  1. Other: Best Practice
  2. Biological: Tocilizumab
MeSH:Infection Neoplasms Lung Diseases, Obstructive Pulmonary Disease, Chronic Obstructive Stroke Kidney Failure, Chronic Coronary Artery Disease
HPO:Chronic pulmonary obstruction Coronary artery atherosclerosis Neoplasm Pulmonary obstruction Stroke

Primary Outcomes

Description: The 7-day length of invasive MV for each arm will be estimated with 95% confidence intervals (CIs) using the exact binomial distribution. Their difference by the arms will be tested by Cochran-Mantel-Haenszel (CMH) test stratified by the age group and Sequential Organ Failure Assessment (SOFA) score at significance level of 0.05.

Measure: 7-day length of invasive mechanical ventilation (MV)

Time: Up to 7 days

Description: Defined as death within 30-day after randomization. The 30-day mortality rate for each arm will be estimated with 95% CIs using the exact binomial distribution. Their difference by the arms will be tested CMH test stratified by the age group and SOFA score at significance level of 0.05.

Measure: 30-day mortality rate

Time: Up to 30-day after randomization

Secondary Outcomes

Description: The rate of ICU transfer for each arm will be estimated with 95% CIs using the exact binomial distribution. Their difference by the arms will be tested CMH test stratified by the age group and SOFA score at significance level of 0.05.

Measure: Rate of intensive care (ICU) transfer

Time: Up to 2 years

Description: The rate of invasive mechanical ventilation for each arm will be estimated with 95% CIs using the exact binomial distribution. Their difference by the arms will be tested CMH test stratified by the age group and SOFA score at significance level of 0.05.

Measure: Rate of invasive mechanical ventilation

Time: Up to 2 years

Description: The rate of tracheostomy for each arm will be estimated with 95% CIs using the exact binomial distribution. Their difference by the arms will be tested CMH test stratified by the age group and SOFA score at significance level of 0.05.

Measure: Rate of tracheostomy

Time: Up to 2 years

Description: Will first be described by median and inter-quartile, and then compared between two arms by Wilcoxon Sum-Rank test

Measure: Length of ICU stay

Time: Up to 2 years

Measure: Length of hospital stay

Time: Up 2 years
6 Robot Assisted Percutaneous Cardiovascular Intervention as a Strategy to Reduce or Risk of Intra-Procedure Contamination by COVID-19 and Other Respiratory Viruses

Percutaneous cardiovascular intervention procedures (e.g. coronary angioplasty, peripheral artery angioplasty) must be performed in person, requiring the physical presence of one or more medical, nursing and technical professionals. The control of catheters and interventional materials is performed manually, with the operator positioned next to the patient. This context results in potential for reciprocal exposure to exhaled air, both for the professionals involved and for the patient, with an inherent risk of aerial contamination. It is important to note that interventional procedures are often performed on an urgent or emergency basis (e.g. myocardial infarction), without the possibility of postponement or postponement. The recent robot-assisted cardiovascular intervention makes it possible to modify this scenario by allowing the procedure to be performed effectively and safely in a position far from the patient. In an environment with high potential for contamination, mainly related to the current pandemic caused by the COVID-19 virus, may prove to be a tactic to expand hospital security. It is in this sense that the present pilot proposal is inserted, which, ultimately, aims to evaluate the potential of robotic intervention as a strategy to reduce exposure to exhaled air of patients and professionals during the intervention procedure.

NCT04379453
Conditions
  1. Coronary Artery Disease
Interventions
  1. Procedure: Robot Assisted Percutaneous Cardiovascular Intervention
MeSH:Coronary Artery Disease Myocardial Ischemia Coronary Disease
HPO:Coronary artery atherosclerosis Myocardial infarction

Primary Outcomes

Description: (arterial dilation with residual lesion <50% at angiography and normal anterograde flow)

Measure: Successful cardiovascular intervention

Time: Until the end of the procedure

Measure: Performed with the professional team positioned at> 2 meters from the patient for at least 50% of the duration of the intervention

Time: Until the end of the procedure

Measure: absence of fatal complications caused by the procedure or acute non-fatal vessel occlusion during index admission

Time: Until the end of the procedure
7 Infinity-Swedeheart Study: Registry Based Randomized Clinical Trial (R-RCT) Comparing Long Term Outcomes of the DynamX Bioadaptor to the Resolute Onyx Stent in a More-comer PCI Patient Population

The Infinity-Swedeheart trial is a prospective, multicenter, single-blind, randomized registry-based clinical trial. Eligible patients will be randomized 1:1 (DynamX Bioadaptor : Resolute Onyx).

NCT04562805
Conditions
  1. Coronary Artery Disease
  2. Ischemic Heart Disease
Interventions
  1. Device: DynamX Bioadaptor
  2. Device: Resolute Onyx
MeSH:Coronary Artery Disease Myocardial Ischemia Heart Diseases
HPO:Coronary artery atherosclerosis Myocardial infarction

Primary Outcomes

Description: Device Oriented Clinical Endpoint (DOCE) of target lesion failure (TLF; cardiovascular death, target vessel myocardial infarction (TV-MI), or ischemia-driven target lesion revascularization (ID-TLR))

Measure: Target Lesion Failure (TLF)

Time: 1 year

Secondary Outcomes

Description: Lesion-Level Analysis

Measure: Device Success

Time: During Study Procedure

Description: Patient-Level Analysis

Measure: Procedural Success

Time: In-Hospital, assessed up to 7 days

Description: Composite Device Oriented Clinical Endpoint (DOCE) (TLF; cardiovascular death, TV-MI, ischemia-driven TLR)

Measure: Composite Rate of Device Oriented Clinical Endpoint (DOCE)

Time: 30 days, 6 months, 1-5 years

Description: Composite Patient Oriented Clinical Endpoint (POCE) (all-cause mortality, any stroke, any myocardial infarction (includes non-target vessel territory) and any revascularization). Note: Stroke to be collected and included in the POCE at 1 year and 5 years only.

Measure: Composite Rate of Patient Oriented Clinical Endpoint (POCE)

Time: 30 days, 6 months, 1-5 years

Description: Target vessel failure (TVF; cardiovascular death, target vessel myocardial infarction (TV-MI), or target vessel revascularization (TVR))

Measure: Rate of Target Vessel Failure (TVF)

Time: 30 days, 6 months, 1-5 years

Description: Composite of cardiovascular death, any myocardial infarction and any revascularization

Measure: Composite Rate of cardiovascular death, any myocardial infarction and any revascularization

Time: 30 days, 6 months, 1-5 years

Description: Ischemia driven target lesion revascularization (ID-TLR)

Measure: Rate of Ischemia driven target lesion revascularization (ID-TLR)

Time: 30 days, 6 months, 1-5 years

Description: All Target Lesion Revascularization

Measure: Rate of Target Lesion Revascularization (TLR)

Time: 30 days, 6 months, 1-5 years

Description: All Target Vessel Revascularization

Measure: Rate of Target Vessel Revascularization (TVR)

Time: 30 days, 6 months, 1-5 years

Description: Ischemia driven target vessel revascularization (ID-TVR)

Measure: Rate of Ischemia driven target vessel revascularization (ID-TVR)

Time: 30 days, 6 months, 1-5 years

Description: Ischemia driven non target vessel revascularization (ID-NTVR)

Measure: Rate of Ischemia driven non target vessel revascularization (ID-NTVR)

Time: 30 days, 6 months, 1-5 years

Description: Non target vessel revascularization (NTVR)

Measure: Rate of Non target vessel revascularization (NTVR)

Time: 30 days, 6 months, 1-5 years

Description: All revascularization

Measure: Rate of All revascularization

Time: 30 days, 6 months, 1-5 years

Description: All MI, Q-Wave and Non Q-Wave MI, TV-MI, NTV-MI

Measure: Rate of Myocardial Infarction

Time: 30 days, 6 months, 1-5 years

Description: Cardiovascular Death, All-Cause Death

Measure: Rate of Death

Time: 30 days, 6 months, 1-5 years

Description: Composite: Cardiovascular death or myocardial infarction

Measure: Composite: Cardiovascular death or myocardial infarction

Time: 30 days, 6 months, 1-5 years

Description: Composite: All-cause death or myocardial infarction

Measure: Composite: All-cause death or myocardial infarction

Time: 30 days, 6 months, 1-5 years

Description: Composite: All-cause death, myocardial infarction or target vessel revascularization

Measure: Composite: All-cause death, myocardial infarction or target vessel revascularization

Time: 30 days, 6 months, 1-5 years

Description: Any stroke (collected at 1 year and 5 years only)

Measure: Rate of any stroke

Time: 1 year and 5 years

Description: Anginal Status by Seattle Angina Questionnaire-7 (SAQ-7)

Measure: Anginal Status

Time: 30 days and 1 year

Description: Composite: Probable or definite stent thrombosis Probable Stent Thrombosis Definite Stent Thrombosis

Measure: Rate of Stent Thrombosis

Time: 30 days, 6 months, 1-5 years

HPO Nodes


Reports

Data processed on September 26, 2020.

An HTML report was created for each of the unique drugs, MeSH, and HPO terms associated with COVID-19 clinical trials. Each report contains a list of either the drug, the MeSH terms, or the HPO terms. All of the terms in a category are displayed on the left-hand side of the report to enable easy navigation, and the reports contain a list of correlated drugs, MeSH, and HPO terms. Further, all reports contain the details of the clinical trials in which the term is referenced. Every clinical trial report shows the mapped HPO and MeSH terms, which are also hyperlinked. Related HPO terms, with their associated genes, protein mutations, and SNPs are also referenced in the report.

Drug Reports   MeSH Reports   HPO Reports  

Interventions

4,180 reports on interventions/drugs

MeSH

691 reports on MeSH terms

HPO

263 reports on HPO terms

All Terms

Alphabetical index of all Terms

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