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Sections: Correlations,
Clinical Trials, and HPO
Navigate: Clinical Trials and HPO
| Name (Synonyms) | Correlation | |
|---|---|---|
| drug3433 | Tezepelumab Wiki | 0.39 |
| drug1206 | Ensifentrine Wiki | 0.39 |
| drug1600 | ION-827359 Wiki | 0.28 |
| Name (Synonyms) | Correlation | |
|---|---|---|
| drug3103 | Serology for Covid-19 Wiki | 0.28 |
| drug3183 | Sputum and blood sampling Wiki | 0.28 |
| drug619 | COVID 19 Diagnostic Test Wiki | 0.28 |
| drug1587 | ID NOW vs. Accula Wiki | 0.28 |
| drug1095 | Drug Isotretinoin (13 cis retinoic acid ) capsules+standard treatment Wiki | 0.28 |
| drug2966 | SARS-CoV-2 rS/Matrix-M1 Adjuvant Wiki | 0.28 |
| drug1601 | IP-10 in CDS protocol Wiki | 0.28 |
| drug94 | ARALAST NP Wiki | 0.28 |
| drug891 | Control swab Wiki | 0.28 |
| drug1236 | Exercise Training Only Wiki | 0.28 |
| drug1237 | Exercise and Cognitive Training Wiki | 0.28 |
| drug2685 | Prototype swab Wiki | 0.28 |
| drug1742 | Isotretinoin(Aerosolized 13 cis retinoic acid) +standard treatment Wiki | 0.28 |
| drug401 | BI 764198 Wiki | 0.20 |
| drug38 | 2D Telemedicine Wiki | 0.20 |
| drug46 | 3D Telemedicine Wiki | 0.16 |
| drug1978 | Matching placebo Wiki | 0.16 |
| drug390 | BCG vaccine Wiki | 0.16 |
| drug464 | Best Practice Wiki | 0.12 |
| drug3257 | Standard treatment Wiki | 0.11 |
| drug2505 | Placebo Wiki | 0.09 |
| drug3485 | Tocilizumab Wiki | 0.05 |
| Name (Synonyms) | Correlation | |
|---|---|---|
| D029424 | Pulmonary Disease, Chronic Obstructive NIH | 0.80 |
| D008171 | Lung Diseases, NIH | 0.42 |
| D029481 | Bronchitis, Chronic NIH | 0.28 |
| Name (Synonyms) | Correlation | |
|---|---|---|
| D001991 | Bronchitis NIH | 0.28 |
| D001982 | Bronchial Diseases NIH | 0.28 |
| D006969 | Hypersensitivity, Immediate NIH | 0.28 |
| D012130 | Respiratory Hypersensitivity NIH | 0.28 |
| D008168 | Pulmonary NIH | 0.28 |
| D018410 | Pneumonia, Bacterial NIH | 0.28 |
| D004646 | Emphysema NIH | 0.20 |
| D000208 | Acute Disease NIH | 0.20 |
| D019896 | Alpha 1-Antitrypsin Deficiency NIH | 0.20 |
| D003139 | Common Cold NIH | 0.16 |
| D005356 | Fibromyalgia NIH | 0.14 |
| D001249 | Asthma NIH | 0.14 |
| D010003 | Osteoarthritis, NIH | 0.12 |
| D006967 | Hypersensitivity, NIH | 0.12 |
| D012140 | Respiratory Tract Diseases NIH | 0.12 |
| D007154 | Immune System Diseases NIH | 0.11 |
| D007676 | Kidney Failure, Chronic NIH | 0.10 |
| D003327 | Coronary Disease NIH | 0.10 |
| D003324 | Coronary Artery Disease NIH | 0.10 |
| D006331 | Heart Diseases NIH | 0.08 |
| D012120 | Respiration Disorders NIH | 0.07 |
| D020521 | Stroke NIH | 0.07 |
| D011024 | Pneumonia, Viral NIH | 0.06 |
| D006973 | Hypertension NIH | 0.06 |
| D002318 | Cardiovascular Diseases NIH | 0.05 |
| D007249 | Inflammation NIH | 0.05 |
| D009369 | Neoplasms, NIH | 0.05 |
| D012141 | Respiratory Tract Infections NIH | 0.05 |
| D007239 | Infection NIH | 0.04 |
| D045169 | Severe Acute Respiratory Syndrome NIH | 0.04 |
| D018352 | Coronavirus Infections NIH | 0.03 |
| D011014 | Pneumonia NIH | 0.03 |
| D014777 | Virus Diseases NIH | 0.03 |
| D003141 | Communicable Diseases NIH | 0.02 |
| Name (Synonyms) | Correlation | |
|---|---|---|
| HP:0006536 | Pulmonary obstruction HPO | 0.88 |
| HP:0006510 | Chronic pulmonary obstruction HPO | 0.65 |
| HP:0002088 | Abnormal lung morphology HPO | 0.38 |
| Name (Synonyms) | Correlation | |
|---|---|---|
| HP:0012387 | Bronchitis HPO | 0.28 |
| HP:0004469 | Chronic bronchitis HPO | 0.28 |
| HP:0002099 | Asthma HPO | 0.14 |
| HP:0012393 | Allergy HPO | 0.12 |
| HP:0001677 | Coronary artery atherosclerosis HPO | 0.11 |
| HP:0001297 | Stroke HPO | 0.08 |
| HP:0011947 | Respiratory tract infection HPO | 0.05 |
| HP:0002664 | Neoplasm HPO | 0.05 |
| HP:0001626 | Abnormality of the cardiovascular system HPO | 0.05 |
| HP:0002090 | Pneumonia HPO | 0.03 |
Navigate: Correlations HPO
There are 13 clinical trials
Since the infectious aetiology of AECOPD has been suggested to vary according to geographical region, the primary purpose of this study (which will be conducted in several countries in Asia Pacific) is to evaluate the occurrence of bacterial and viral pathogens in the sputum of stable COPD patients and at the time of AECOPD. Given the increasing and projected burden of COPD in the Asia Pacific region, this study will also evaluate the frequency, severity and duration of AECOPD, as well as the impact of AECOPD on health-related quality of life (HRQOL), healthcare utilisation and lung function.
Description: Bacterial pathogens, as identified by bacteriological methods, including (but not necessarily limited to) Haemophilus influenzae, Moraxella catarrhalis, Streptococcus pneumoniae, Staphylococcus aureus, Pseudomonas aeruginosa, Klebsiella pneumoniae and Acinetobacter baumannii.
Measure: Occurrence of potential bacterial in sputum of stable COPD patients. Time: Over the course of 1 yearDescription: Bacterial pathogens, as identified by bacteriological methods, including (but not necessarily limited to) Haemophilus influenzae, Moraxella catarrhalis, Streptococcus pneumoniae, Staphylococcus aureus, Pseudomonas aeruginosa, Klebsiella pneumoniae and Acinetobacter baumannii.
Measure: Occurrence of potential bacterial in sputum during AECOPD. Time: Over the course of 1 yearDescription: Viral pathogens, as identified by PCR, including (but not necessarily limited to) Respiratory syncytial virus (RSV), parainfluenza virus, enterovirus/ rhinovirus, metapneumovirus, influenza virus, adenovirus, bocavirus and coronavirus and by rhinovirus quantitative RT-PCR.
Measure: Occurrence of viral pathogens in sputum of stable COPD patients. Time: Over the course of 1 yearDescription: Viral pathogens, as identified by PCR, including (but not necessarily limited to) Respiratory syncytial virus (RSV), parainfluenza virus, enterovirus/ rhinovirus, metapneumovirus, influenza virus, adenovirus, bocavirus and coronavirus and by rhinovirus quantitative RT-PCR.
Measure: Occurrence of viral pathogens in sputum during AECOPD. Time: Over the course of 1 yearDescription: Including (but not necessarily limited to) H. influenzae, M. catarrhalis, S. pneumoniae, S. aureus and P. aeruginosa. The proportion of sputum samples obtained at each confirmed stable/AECOPD visit and positive for specific bacterial pathogens by PCR will be computed with 95% confidence intervals.
Measure: Occurrence of potential bacterial pathogens in sputum of stable COPD patients and during AECOPD, as measured by real-time qualitative PCR/ quantitative PCR and compared to data from bacteriological methods. Time: Over the course of 1 yearDescription: The proportion of sputum samples obtained at each AECOPD visit and positive for specific bacterial/viral pathogens by bacteriological methods and PCR, respectively (overall and by bacterial/viral species) will be computed with 95% confidence intervals by any severity (mild, moderate and severe).
Measure: Occurrence of potential bacterial and viral pathogens (overall and by species) in sputum during AECOPD by severity of AECOPD. Time: Over the course of 1 yearDescription: The proportion of sputum samples obtained at each confirmed stable visit and positive for bacterial/viral pathogens by bacteriological methods and PCR, respectively (overall and by bacterial / viral species) will be computed with 95% confidence intervals by Gold grade at enrolment.
Measure: Occurrence of potential bacterial and viral pathogens (overall and by species) in sputum of stable COPD patients by GOLD grade. Time: Over the course of 1 yearDescription: The following incidence rates will be computed, with 95% confidence intervals (CI): All-cause AECOPD. AECOPD having sputum containing bacterial pathogens found by PCR or by bacteriological methods or by both methods (overall and by, but not limited to, the following bacterial species: H. influenzae, M. catarrhalis, S. pneumoniae, S. aureus, and P. aeruginosa). The 95% CI of the incidence rate will be computed using a model which accounts for repeated events. The incidence rates described above will also be computed for mild, moderate severe AECOPD and by GOLD grade at enrolment.
Measure: Incident rate (per subject per year) of any AECOPD overall and by GOLD grade. Time: Over the course of 1 yearDescription: Classification of severity according to the intensity of medical intervention required: mild: controlled with an increase in dosage of regular medications; moderate: requires treatment with systemic corticosteroids and/ or antibiotics; severe: requires hospitalisation.
Measure: Number of mild, moderate or severe AECOPD overall and by GOLD grade. Time: Over the course of 1 yearDescription: Descriptive statistics (median, mean, range, standard deviation, first and third quartiles) on the number of days of AECOPD episodes will be presented.
Measure: Number of days of AECOPD episodes overall and by AECOPD severity. Time: Over the course of 1 yearDescription: Descriptive statistics (median, mean, range, standard deviation, first and third quartiles) on the CAT scores will be tabulated at each respective visit.
Measure: COPD assessment test (CAT) score in stable COPD patients and during AECOPD. Time: Over the course of 1 yearDescription: Descriptive statistics (median, mean, range, standard deviation, first and third quartiles) on the SGRQ-C scores will be tabulated at each respective visit.
Measure: St. George's Respiratory Questionnaire (SGRQ-C) score in stable COPD patients. Time: Over the course of 1 yearDescription: The spirometric classification of airflow limitation in COPD patients is based on post-bronchodilator FEV1. Summary statistics (mean, median, standard deviation, maximum and minimum) on post bronchodilator FEV1% of predicted normal value will be tabulated at each respective visit.
Measure: Forced expiratory volume in 1 second (FEV1%) of predicted normal value in stable COPD patients. Time: At Pre-Month 0 and Month 12Description: Healthcare use for each COPD patient will be obtained through review of the subject's medical record (aided by subject self-reporting). Healthcare utilisation includes all unscheduled visits to a physician office, visits to urgent care, visits to emergency department, and hospitalizations.
Measure: Assessment of the Healthcare utilization. Time: Over the course of 1 yearA phase 2, multicentre, randomized, double-blind, placebo-controlled, parallel group study to evaluate the effect of tezepelumab on airway inflammation in adults with inadequately controlled asthma.
Description: The change from baseline in number of airway submucosal inflammatory cells/mm2 of bronchoscopic biopsies.
Measure: The change from baseline in number of airway submucosal inflammatory cells/mm2 of bronchoscopic biopsies. Time: Baseline, End of Treatment (EoT). The EoT will be performed at Week 28 for the majority of subjects but may be performed at later timepoints for some subjects (Week 32, etc.) due to up to 6 additional doses added during the Covid-19 pandemic.Description: The change in reticular basement membrane (RBM) thickness from baseline, determined by microscopic evaluation of bronchoscopic biopsies
Measure: The change in reticular basement membrane (RBM) thickness from baseline, determined by microscopic evaluation of bronchoscopic biopsies Time: Baseline, End of Treatment (EoT). The EoT will be performed at Week 28 for the majority of subjects but may be performed at later timepoints for some subjects (Week 32, etc.) due to up to 6 additional doses added during the Covid-19 pandemic.Description: The change in % airway epithelial integrity from baseline determined by microscopic evaluation of bronchoscopic biopsies
Measure: The change in % airway epithelial integrity from baseline determined by microscopic evaluation of bronchoscopic biopsies Time: Baseline, End of Treatment (EoT). The EoT will be performed at Week 28 for the majority of subjects but may be performed at later timepoints for some subjects (Week 32, etc.) due to up to 6 additional doses added during the Covid-19 pandemic.Description: The change in number of airway submucosal inflammatory cells per mm2 from baseline, across the spectrum of T2 status, determined by microscopic evaluation of bronchoscopic biopsies
Measure: The change in number of airway submucosal inflammatory cells per mm2 from baseline, across the spectrum of T2 status, determined by microscopic evaluation of bronchoscopic biopsies Time: Baseline, End of Treatment (EoT). The EoT will be performed at Week 28 for the majority of subjects but may be performed at later timepoints for some subjects (Week 32, etc.) due to up to 6 additional doses added during the Covid-19 pandemic.A Multicenter, Randomized, Double-blind, Placebo-controlled, Parallel Group, Phase 2a Study to Explore the Efficacy and Safety of Tezepelumab in Adults with Moderate to Very Severe Chronic Obstructive Pulmonary Disease (COPD)
Description: The exacerbation rate is based on exacerbations reported by the investigator over 52 weeks.
Measure: Moderate or severe COPD exacerbation rate ratio (tezepelumab vs placebo) Time: Over 52 WeeksDescription: Time to first occurrence of moderate/severe exacerbation post randomization. Outcome measures: Hazard ratio
Measure: Time to first moderate or severe COPD exacerbation Time: By Week 52Description: Proportion of subjects with at least one moderate/severe exacerbation reported by the Investigator over 52 weeks Outcome measure: Odds Ratio
Measure: Proportion with at least one moderate/severe COPD exacerbation Time: Over 52 WeeksDescription: The severe exacerbation rate is based on severe exacerbations reported by the Investigator over 52 weeks.
Measure: Severe COPD exacerbation rate ratio (tezepelumab vs. placebo) Time: Over 52 WeeksDescription: Difference in change from baseline in pre-BD forced expiratory volume in 1 second (FEV1) in tezepelumab arm as compared to placebo at Week 52. FEV1 is defined as the volume of air exhaled from the lungs in the first second of forced expiration.
Measure: Change from baseline in pre-bronchodilator (pre-BD) forced expiratory volume in 1 second (FEV1) Time: Baseline, Week 52Description: Proportion of subjects achieving a decrease of 4 units or more in the St. George's Respiratory Questionnaire (SGRQ) total score at Week 52, i.e. minimum clinically important difference (MCID). Outcome measure: odds ratio
Measure: Change in respiratory health status/health-related quality of life Time: Baseline, Week 52Description: Difference (tezepelumab vs. placebo) in SGRQ from baseline at Week 52. SGRQ is a 50-item patient reported outcome questionnaire. The SGRQ total score is expressed as a percentage of overall impairment, in which 100% means the worst possible health status and 0% indicates the best possible health status. Likewise, the domain scores range from 0 to 100, with higher scores indicative of greater impairment. Decrease of 4 units is associated with a minimum clinically important difference (MCID).
Measure: Change from baseline in St. George's Respiratory Questionnaire (SGRQ) Total Score Time: Baseline, Week 52Description: Difference (tezepelumab vs. placebo) in COPD assessment tool (CAT) from baseline at Week 52. CAT is an 8-item patient reported outcome questionnaire developed to measure the impact of COPD on health status. The instrument uses semantic differential six-point response scales. A CAT total score is the sum of item responses. The score ranges from 0 to 40, with higher scores indicating greater COPD impact on health status.
Measure: Change from baseline in the COPD Assessment Test (CAT) Total Score Time: Baseline, Week 52Description: Serum trough concentration of tezepelumab
Measure: Evaluate pharmacokinetics of tezepelumab Time: Weeks 0, 4, 12, 24, 36, 52, 64Description: Incidence of anti-drug antibodies (ADA)
Measure: Evaluate immunogenicity of tezepelumab Time: Over 52 weeksIt has been reported that nearly half of the patients who are hospitalized for Covid-19 pneumonia have on admission old age or comorbidities. In particular, hypertension was present in 30% of the cases, diabetes in 19%, coronary heart disease in 8% and chronic obstructive lung disease in 3% of the patients. Amazingly, in the two major studies published in the Lancet (Zhou F et al Lancet 2020) and in the New England Journal of Medicine (Guan W et al 2020), the weight of the subjects as well their body mass index (BMI) were omitted. However, obesity, alone or in association with diabetes, can be a major predisposition factor for Covid-19 infection. The primary end-point of our prospective, observational study is to assess the recovery rate in patients with diagnosis of Covid-19 pneumonia. Among the other secondary end-points, we intend to find the predictors of the time to clinical improvement or hospital discharge in patients affected by Covid-19 pneumonia.
Description: mean rate of recovery in patients with diagnosis of Covid-19 pneumonia, who present with complications at the time of hospital admission (such as diabetes, obesity, cardiovascular disease, hypertension or respiratory failure), with the mean recovery rate in patients without any of the above-mentioned complications.
Measure: rate of recovery Time: 3 weeksDescription: comparison of the survival curves (times to improvement) in the two groups (patients with and without complications) and among patients presenting with different types of complications
Measure: time to improvement Time: 3 weeksDescription: the efficacy of different pharmaceutical treatment against Covid-19
Measure: efficacy of treatments Time: 3 weeksDescription: liver, kidney or multiorgan failure, cardiac failure
Measure: organ failure Time: 3 weeksAn open access study that will define and collect digital measures of coughing in multiple populations and public spaces using various means of audio data collection.
Description: Size of collected audio dataset measured as number of collected cough sounds, targeting ≥10,000 identified coughs.
Measure: Dataset size Time: 14 daysDescription: Identification of cough sounds by the existing mathematical model with ≥ 99% specificity and ≥ 60% sensitivity
Measure: Cough sound identification Time: 14 daysDescription: Increase in the sensitivity of the mathematical model to cough sounds to ≥ 70% while retaining the specificity of ≥ 99%
Measure: Improvement of the existing model Time: 14 daysDescription: Determination of the level of acceptance and satisfaction of the solution by patients by means of a Standard Usability Questionnaire to provide feedback. The score ranges from 10 to 50, higher score indicating a better usability.
Measure: Evaluate the usability of the application Time: 14 daysThis phase III trial compares the effect of adding tocilizumab to standard of care versus standard of care alone in treating cytokine release syndrome (CRS) in patients with SARS-CoV-2 infection. CRS is a potentially serious disorder caused by the release of an excessive amount of substance that is made by cells of the immune system (cytokines) as a response to viral infection. Tocilizumab is used to decrease the body's immune response. Adding tocilizumab to standard of care may work better in treating CRS in patients with SARS-CoV-2 infection compared to standard of care alone.
Description: The 7-day length of invasive MV for each arm will be estimated with 95% confidence intervals (CIs) using the exact binomial distribution. Their difference by the arms will be tested by Cochran-Mantel-Haenszel (CMH) test stratified by the age group and Sequential Organ Failure Assessment (SOFA) score at significance level of 0.05.
Measure: 7-day length of invasive mechanical ventilation (MV) Time: Up to 7 daysDescription: Defined as death within 30-day after randomization. The 30-day mortality rate for each arm will be estimated with 95% CIs using the exact binomial distribution. Their difference by the arms will be tested CMH test stratified by the age group and SOFA score at significance level of 0.05.
Measure: 30-day mortality rate Time: Up to 30-day after randomizationDescription: The rate of ICU transfer for each arm will be estimated with 95% CIs using the exact binomial distribution. Their difference by the arms will be tested CMH test stratified by the age group and SOFA score at significance level of 0.05.
Measure: Rate of intensive care (ICU) transfer Time: Up to 2 yearsDescription: The rate of invasive mechanical ventilation for each arm will be estimated with 95% CIs using the exact binomial distribution. Their difference by the arms will be tested CMH test stratified by the age group and SOFA score at significance level of 0.05.
Measure: Rate of invasive mechanical ventilation Time: Up to 2 yearsDescription: The rate of tracheostomy for each arm will be estimated with 95% CIs using the exact binomial distribution. Their difference by the arms will be tested CMH test stratified by the age group and SOFA score at significance level of 0.05.
Measure: Rate of tracheostomy Time: Up to 2 yearsDescription: Will first be described by median and inter-quartile, and then compared between two arms by Wilcoxon Sum-Rank test
Measure: Length of ICU stay Time: Up to 2 yearsMolecular testing (e.g PCR) of respiratory tract samples is the recommended method for the identification and laboratory confirmation of COVID-19 cases. Recent evidence reported that the diagnostic accuracy of many of the available RT-PCR tests for detecting SARS-CoV2 may be lower than optimal. Of course, the economical and clinical implications of diagnostic errors are of foremost significance and in case of infectious outbreaks, namely pandemics, the repercussions are amplified. False positives and false-negative results may jeopardize the health of a single patient and may affect the efficacy of containment of the outbreak and of public health policies. In particular, false-negative results contribute to the ongoing of the infection causing further spread of the virus within the community, masking also other potentially infected people.
Description: assess if inpatients who presented with pneumonia but had a negative test for Covid-19 are positive at the serology for SARS-CoV-2.
Measure: Serology Time: 3 weeksDescription: to find if the combination of CT scan and serology could help us in the identification of those patients who were initially negative at laboratory testing alone.
Measure: Efficacy of CT scan and Serology Time: 3 weeksDescription: the efficacy of different pharmaceutical treatments against Covid-19
Measure: Efficacy of different pharmaceutical treatments Time: 3 weeksBased on findings of the interim analysis of the ACTIVATE study showing 53% decrease of the incidence of all new infections with BCG vaccination, a new trial is designed aiming to validate if BCG can protect against COVID-19 (Corona Virus Disease-19).The aim of the study is to demonstrate in a double-blind, placebo-controlled approach if vaccination of participants susceptible to COVID-19 with BCG vaccine may modulate their disease susceptibility for COVID-19. This will be validated using both clinical and immunological criteria. At the same time, a sub-study will be conducted and the mechanism of benefit from BCG vaccination by assessing its effect on vascular endothelial function and mononuclear blood cells will be studied
Description: This is set on visit 3 (90 ± 5 days from the date of visit 1). The two groups of vaccination are compared for the primary endpoints which is composite. Patients who meet any of the following will be considered to meet the primary endpoint: Positive for the respiratory questionnaire endpoint when at least one of the following combination is met either at visit 2 and/or at visit 3: One situation definitively related to COVID-19 All four questions of symptoms possibly related to COVID-19 At least two questions of symptoms possibly related to COVID-19 as well as need for admission at the emergency department of any hospital and/or need for intake of antibiotics At least four questions of symptoms probably related to COVID-19 one of which is "need for admission at the emergency department of any hospital and/or need for intake of antibiotics" Positive IgG or IgM antibodies against SARS-CoV-2
Measure: Positive for the respiratory questionnaire consisted of questions concerning the appearance of symptoms possibly, probably and/or definitively related to COVID-19 on visit 3. Time: Visit 3 (90 +/- 5 days)Description: The two groups of vaccination are compared for the primary endpoints which is composite (as defined at primary study endpoint) and meet a positive respiratory questionnaire endpoint on visit 4
Measure: Positive respiratory questionnaire endpoint consisted of questions concerning the appearance of symptoms possibly, probably and/or definitively related to COVID-19 on visit 4 Time: Visit 4 (135 +/- 5 days)Description: The two groups of vaccination are compared for the primary endpoints which is composite (as defined at primary study endpoint) and meet a positive respiratory questionnaire endpoint (as defined at primary study endpoint) on visit 5
Measure: Positive respiratory questionnaire endpoint consisted of questions concerning the appearance of symptoms possibly, probably and/or definitively related to COVID-19 on visit 5 Time: Visit 5 (180 +/- 5 days)Description: Prevalence of IgG/IgM against SARS-CoV-2 will be measured among the patients who failed the eligibility procedure and the patients that were eligible and were enrolled
Measure: Prevalence of IgG/IgM against SARS-CoV-2 Time: Screening Visit and Visit 3 (90 +/- 5 days)Description: Itemized analysis of each of the components of the respiratory questionnaire on each study visit
Measure: Analysis of each of the components of the respiratory questionnaire consisted of questions concerning the appearance of symptoms possibly, probably and/or definitively related to COVID-19. Time: Visit 2 (45 +/- 5 days), Visit 3 (90 +/- 5 days), Visit 4 (135 +/- 5 days), Visit 5 (180 +/- 5 days)Description: The impact of new cardiovascular events between the two study groups (placebo and BCG) will be analyzed, though the collection of any cardiovascular events occured to the enrolled patients.
Measure: The impact of new cardiovascular events between the two study groups Time: Visit 2 (45 +/- 5 days), Visit 3 (90 +/- 5 days), Visit 4 (135 +/- 5 days), Visit 5 (180 +/- 5 days)Description: Differences in repeated measurements of arterial stiffness in visit 3 between the two sub-study groups (placebo or BCG) will be analyzed through the speed of the pulse wave velocity. Pulse wave velocity is measured in m/sec.
Measure: Differences in repeated measurements of angiometric parameters (arterial hardness) between the two sub-study groups in Visit 3 Time: Visit 1 (Day 0), Visit 3 (90 +/- 5 days)Description: Differences in repeated measurements of central arterial pressures and reflected waves in visit 3 between the two sub-study groups (placebo or BCG) will be measured non-invasively by pulse wave analysis. Central arterial pressure is measured in mmHg.
Measure: Differences in repeated measurements of angiometric parameters (central arterial pressures and reflected waves) between the two sub-study groups in Visit 3 Time: Visit 1 (Day 0), Visit 3 (90 +/- 5 days)Description: Differences in repeated measurements of endothelial function in visit 3 between the two sub-study groups (placebo or BCG) will be measured by ultrasound measurement of endothelium-dependent flow-mediated dilatation and by nitrate-mediated dialatation. Endothelial function will be assessed by Flow Mediated Dilatation (FMD). Endothelium-dependent: diameter of the artery prior and after temporary ischemia in is measured in mm, nitrate-mediated: diameter of the artery prior and after nitrate administration is measured in mm
Measure: Differences in repeated measurements of angiometric parameters (endothelial function) between the two sub-study groups in Visit 3 Time: Visit 1 (Day 0), Visit 3 (90 +/- 5 days)Description: Differences in repeated measurements of thickness of the medial carotid sheath in visit 3 between the two sub-study groups (placebo or BCG) will be measured by B-mode ultrasound examination. Intima-Media Thickness is measured in mm
Measure: Differences in repeated measurements of angiometric parameters (thickness of the medial carotid sheath) between the two sub-study groups in Visit 3 Time: Visit 1 (Day 0), Visit 3 (90 +/- 5 days)Description: Differences in repeated measurements of arterial stiffness in visit 5 between the two sub-study groups (placebo or BCG) will be analyzed through the speed of the pulse wave velocity. Pulse wave velocity is measured in m/sec.
Measure: Differences in repeated measurements of angiometric parameters (arterial hardness) between the two sub-study groups in Visit 5 Time: Visit 1 (Day 0), Visit 3 (90 +/- 5 days), Visit 5 (180 +/- 5 days)Description: Differences in repeated measurements of central arterial pressures and reflected waves in visit 5 between the two sub-study groups (placebo or BCG) will be measured non-invasively by pulse wave analysis. Central arterial pressure is measured in mmHg.
Measure: Differences in repeated measurements of angiometric parameters (central arterial pressures and reflected waves) between the two sub-study groups in Visit 5 Time: Visit 1 (Day 0), Visit 3 (90 +/- 5 days), Visit 5 (180 +/- 5 days)Description: Differences in repeated measurements of thickness of the medial carotid sheath in visit 5 between the two sub-study groups (placebo or BCG) will be measured by B-mode ultrasound examination. Intima-Media Thickness is measured in mm
Measure: Differences in repeated measurements of angiometric parameters (thickness of the medial carotid sheath) between the two sub-study groups in Visit 5 Time: Visit 1 (Day 0), Visit 3 (90 +/- 5 days), Visit 5 (180 +/- 5 days)Description: Differences in repeated measurements of endothelial function in visit 5 between the two sub-study groups (placebo or BCG) will be measured by ultrasound measurement of endothelium-dependent flow-mediated dilatation and by nitrate-mediated dialatation. Endothelial function will be assessed by Flow Mediated Dilatation (FMD). Endothelium-dependent: diameter of the artery prior and after temporary ischemia in is measured in mm, nitrate-mediated: diameter of the artery prior and after nitrate administration is measured in mm
Measure: Differences in repeated measurements of angiometric parameters (endothelial function) between the two sub-study groups in Visit 5 Time: Visit 1 (Day 0), Visit 3 (90 +/- 5 days), Visit 5 (180 +/- 5 days)Description: Differences in cardiac ultrasound at visit 5 between the two sub-study groups (placebo or BCG) will be assessed using standard measurements from 2-D and Doppler echocardiography.
Measure: Differences in cardiac ultrasound at visit 5 between the two sub-study groups Time: Visit 1 (Day 0), Visit 3 (90 +/- 5 days), Visit 5 (180 +/- 5 days)Description: Changes in the release of cytokines from blood mononuclear cells at visit 3 between the two sub-study groups (placebo or BCG) will be analyzed
Measure: Changes in the release of cytokines from blood mononuclear cells at visit 3 between the two sub-study groups Time: Visit 1 (Day 0), Visit 3 (90 +/- 5 days)The purpose of this study is to evaluate the efficacy of ARALAST NP A1PI augmentation therapy 120 milligrams per kilogram (mg/kg) body weight (BW)/week compared with an external placebo comparator on the loss of emphysematous lung tissue measured by lung density change in participants with A1PI deficiency and COPD-E.
Description: Annual rate of the physiologically adjusted lung density change will be measured as the 15th percentile of the lung density measurements (PD15) as assessed by Computed Tomography (CT) densitometry at total lung capacity (TLC). CT lung density at the 15th percentile (PD15) is the threshold below which 15 percentage (%) of the voxels have lower densities and is used as the parameter for estimating the rate of lung density decline. Annual rate of the physiologically adjusted lung density change will be tested in a fixed comparision sequence 1. ARALAST NP 120 mg/kg BW/week group versus (vs) external placebo group, 2. ARALAST NP120 mg/kg BW/week vs 60 mg/kg BW/week, 3. ARALAST NP 60 mg/kg BW/week group vs external placebo group.
Measure: Annual Rate of the Physiologically Adjusted Lung Density Change Time: Baseline, up to Week 104Description: COPD exacerbations are defined as an acute worsening of respiratory symptoms that results in additional therapy and will be assessed according to the classification in GOLD criteria (2020) as follows: Moderate (treated with short acting bronchodilators [SABDs] plus antibiotics and/or oral corticosteroids) and Severe (required hospitalizations or a visit to the emergency room).
Measure: Number of Moderate or Severe Exacerbations of Chronic Obstructive Pulmonary Disease (COPD) Time: Baseline, up to Week 104Description: Annual rate of change in post-bronchodilator FEV1 will be assessed.
Measure: Annual Rate of Change in Post-Bronchodilator Forced Expiratory Volume in 1 Second (FEV1) Time: Baseline, up to Week 104Description: An adverse event (AE) is any untoward medical occurrence in a clinical investigation participant administered a pharmaceutical product and that does not necessarily have a causal relationship with this IP or medicinal product. A TEAE is defined as any event emerging or manifesting at or after the initiation of treatment with an IP or medicinal product or any existing event that worsens in either intensity or frequency following exposure to the IP or medicinal product. TEAE's will include related, serious adverse events (SAEs), suspected adverse reactions plus adverse reactions of interest, temporally-associated adverse events (AEs) with onset during infusion or within 24 hours following the end of IP infusion, and AEs resulting in changes to infusion dose.
Measure: Number of Participants with Treatment-Emergent Adverse Events (TEAE's) Time: From Start of the study drug administration up to End of the study (up to Week 105)Description: Number of participants who develop anti- A1PI antibodies following treatment with ARALAST NP will be assessed.
Measure: Number of Participants Who Develop Anti-A1PI Antibodies Following Treatment With ARALAST NP Time: From Start of the study drug administration up to End of the study (up to Week 105)Description: Plasma trough level of antigenic and functional A1PI for ARALAST NP at each dose level (ARALAST NP 60 mg/kg BW/week, ARALAST NP 120 mg/kg BW/week) will be assessed.
Measure: Plasma Trough Level of Antigenic and Functional A1PI for ARALAST NP at each dose Level Time: Pre-dose, Weeks 4, 13, 28, 52, 78, 91, 104, 105The purpose of this study is to evaluate the effect of ION-827359 on forced expiratory volume in 1 second (FEV1) in patients with mild to moderate COPD with CB.
Description: The EXACT (E-RS) scale is a participant-reported outcome (PRO) designed to measure the symptoms of participants with COPD. The E-RS utilizes 11 respiratory symptom items from the existing and validated 14-item EXACT, which measures symptoms of exacerbation. The E-RS total score quantifies respiratory symptom severity, and 3 domains assess breathlessness, cough and sputum, and chest symptoms. The E-RS will be collected on the daily e-diary, which will include all 14 items from the EXACT questionnaire.
Measure: Change From Baseline in the EXACT Respiratory Symptoms (E-RS) Daily Symptom Diary to the Primary Time Point Time: One week prior to first dose through one week after the last dose.Description: The CAT is an eight-item questionnaire that will be completed by the participant and is designed to quantify the impact of COPD symptoms on the health status of participants. The CAT provides a score of 0-40 to indicate the impact of the disease.
Measure: Change From Baseline in the COPD Assessment Test (CAT) to the Week 14 Time Point Time: From Baseline up to Week 14Description: The SGRQ is a participant completed, a disease-specific instrument designed to measure impact on overall health, daily life, and perceived well-being in participants with obstructive airway disease. Scores of the SGRQ-C range from 0 to 100, with higher scores indicating more limitations.
Measure: Change From Baseline in St. George's Respiratory Questionnaire (SGRQ) to the Week 14 Time Point Time: From Baseline up to Week 14The overarching aim of this project is to implement and evaluate a proven cognitive training regimen in combination with a community exercise program among older adults who attend wellness exercise programs at the YMCA. To support this aim, the investigators have developed a collaboration with the YMCA of Kitchener-Waterloo, which offer exercise programs targeted to older adults. The specific objectives are: (1) to evaluate the feasibility of a combined exercise and cognitive training in a community-setting among older adults; and (2) to conduct a preliminary evaluation and comparison of changes in cognitive function, physical function, well-being and self-efficacy with 12-weeks of combined exercise and cognitive training versus exercise alone. The hypothesis for each objective are as follows: (1) It is anticipated that this program will be feasible to implement and will be well accepted by the participants and exercise providers. (2) The investigators may not have the power to find statistically significant differences between the control and experimental groups for physical and cognitive function. However, the investigators expect to observe positive changes between the pre- and post-assessments, suggesting improved cognitive function and mobility as a result of the 12-week program.
Description: Total number of people enrolled divided by the total number of people invited to participate (multiplied by 100 to calculate a percentage)
Measure: Recruitment Rate Time: Pre-program (baseline)Description: Percentage of people who completed the full program and all assessments
Measure: Completion Rate Time: Through study completion, 12 weeksDescription: Percentage of people who attended program sessions (exercise and cognitive training components)
Measure: Attendance Time: Throughout entire intervention (12 weeks, 2 sessions/week per group)Description: Participant and instructors rating of program components and overall program (via hand-written questionnaire). Participants and instructors must rate their level of agreement (1 = strongly disagree, 2 = disagree, 3 = no opinion, 4 = agree, 5 = strongly agree) with various statements. The higher the rating, the greater the satisfaction. They also must rate if the difficulty of the program was optimal, somewhat easy or hard, or too easy or hard. They must also specify how much money they would be willing to spend on the program. They are also given an opportunity to record optional additional comments/recommendation.
Measure: Change in Participant and Instructor Rating of experience, satisfaction, and feasibility of program Time: Mid-point (6 weeks) and post-program (12 weeks)Description: Financial cost of running program (equipment purchased for study - cognitive training tablet and stands - and YMCA staff pay) as reported by researcher and YMCA staff
Measure: Cost of program Time: Post-program (12 weeks)Description: Self-reported biological sex (at birth) using basic demographics questionnaire
Measure: Sex Time: Pre-program (baseline)Description: One-on-one interview with researcher, answering broad questions about their experience in the program and study
Measure: Participant and Instructor perceived program experience and satisfaction Time: Post-program (at 12 weeks)Description: Experience of participants and instructors will also be observed by the researcher (observational notes will be taken by the researcher during each class). No names of participants and instructors will be recorded.
Measure: Participant and Instructor observer-perceived program experience and satisfaction Time: Throughout entire intervention (12 weeks, 2 sessions/week per group)Description: Self-reported years of formal education and training (training years for instructors only) using basic demographics questionnaire
Measure: Education Time: Pre-program (baseline)Description: Self-reported previous and current occupations using basic demographics questionnaire
Measure: Occupation Time: Pre-program (baseline)Description: Self-reported previous and current medical conditions using basic demographics questionnaire
Measure: Medical Condition Time: Pre-program (baseline)Description: Self-reported previous and current medications using basic demographics questionnaire
Measure: Medications Time: Pre-program (baseline)Description: Using the Montreal Cognitive Assessments (brief clinical tool) to assess visual/spatial abilities, working memory, executive functioning, language, abstraction, and orientation). Will be used to describe participants' baseline cognitive status (a score out of 30 is measured).
Measure: Montreal Cognitive Assessment (global cognitive function) Time: Pre-program (baseline)Description: Using the International Physical Activities Questionnaire (IPAQ) to assess physical activity level based on self-reported frequency and duration of job-related, house work-related, transportation-related, and leisure-related physical activities done in the past week. METS-minutes/week will be calculated and reported (i.e. take the number of minutes doing an activity in the past week and multiply by the appropriate metabolic equivalent, which will vary based on the intensity of the physical activity).
Measure: Physical Activity Level Time: Pre-program (baseline)Description: Using a cognitive activity scale (score of 0-4 per activity) that requires participants to self-report how often they typically engage in a variety of mentally stimulating activities (i.e. playing card games, reading, cooking, etc.) The more frequently they engage in the activity, the higher the score.
Measure: Participant cognitive activity Time: Pre-program (baseline)Description: Using a scale (score of 0-3 per group) that requires participants to self-report how often they typically interact (face-to-face or virtually) with different groups of people (i.e. their spouse, family, friends, co-workers, etc.). The more frequently they interact with the group, the higher the score.
Measure: Participant social activity Time: Pre-program (baseline)Description: Self-reported years of age using basic demographics questionnaire
Measure: Participant and Instructor Age Time: Pre-program (baseline)Description: STROOP task which assesses the length of time (seconds) it takes for a participant to correctly name a coloured square (test 1), read the name of a colour (test 2), and say the name of the colour that a word is printed in (test 3). Number of corrected and uncorrected errors are also recorded.
Measure: Change in Stroop Task Performance Time: Pre-program (baseline) and post-program (12 weeks)Description: Trails Making Test Part A and B. Part A assesses visual search (participants must connect numbered circles in ascending numerical order (1-2-3-etc). Part B assesses working memory and task-switching (participants must connect circles in ascending numerical and alphabetical order (1-A-2-B- etc.). Time to complete the tests (second) and errors (number) made during the tests are recorded.
Measure: Change in Trail Making Task Performance Time: Pre-program (baseline) and post-program (12 weeks)Description: Resting (seated) heart rate (beats per minute) using an automatic blood pressure cuff
Measure: Change in Resting Heart Rate Time: Pre-program (baseline) and post-program (12 weeks)Description: Resting (seated) blood pressure (millimeters of mercury) using an automatic blood pressure cuff
Measure: Change in Resting Systolic and Diastolic Blood Pressure Time: Pre-program (baseline) and post-program (12 weeks)Description: Using hand dynamometer (assessing grip strength in lbs) for right and left hand (two trials per hand)
Measure: Change in Grip Strength Time: Pre-program (baseline) and post-program (12 weeks)Description: Weight (using automatic scale to measure in lbs, converted to kg) and height (measured in feet and inches, converted to meters) measured and combined to provide BMI (kg/m^2)
Measure: Change in Body Mass Index (BMI) Time: Pre-program (baseline) and post-program (12 weeks)Description: Divide waist circumference (cm) by hip circumference (cm) to get ratio calculation
Measure: Change in Hip-to-Waist Circumference Ratio Time: Pre-program (baseline) and post-program (12 weeks)Description: Agility and functional balance will be assessed using the Timed Up-and-Go (participants stand up from a chair, walk 6 meters, turn around an object, walk back to chair, and sit down). Time to complete test is measured (seconds) and assessor's observational notes of performance are taken.
Measure: Change in Timed Up-and-Go Performance Time: Pre-program (baseline) and post-program (12 weeks)Description: Agility and functional balance will be assessed using the Four Square Step Test (participants must step over lines that are set up in a cross formation, creating 4 quadrants. They must step forward, backward, and side to side in a specific pattern (i.e. from quadrant 1 to quadrant 2, to quadrant 3, to quadrant 4). Time to complete test is recorded in seconds.
Measure: Change in Four Square Step Test Performance Time: Pre-program (baseline) and post-program (12 weeks)Description: Lower body strength will be assessed using the 5 Time Sit-to-Stand (participants must complete 5 sit-to-stands from a chair as fast as they can). Time to complete all 5 is recorded in seconds.
Measure: Change in Sit-to-Stand Performance Time: Pre-program (baseline) and post-program (12 weeks)Description: Functional fitness will be assessed using the 6 minute walk (participants walk along indoor track for 6 minutes). The number of laps achieved in 6 minutes is recorded. Assessor's observational notes of walking performance is also recorded.
Measure: Change in 6-minute walk test Performance Time: Pre-program (baseline) and post-program (12 weeks)Description: Well-being will be self-reported using the "Vitality-Plus Scale" (self-reported general health questionnaire - rating of sleep quality, appetite, general energy level, etc.). Participants rate their degree of health on a scale from 1 - 5 (the higher the rating, the better their perceived overall well-being).
Measure: Change in Overall Well-being Time: Pre-program (baseline) and post-program (12 weeks)Description: Bandura Scale (named after the researcher who developed it) - self-reported rating of confidence (0 - 100%) to continue exercising routinely in various hypothetical situations (i.e. if one is sick, if the weather is poor, etc). The greater the confidence, the higher the score
Measure: Change in Exercise-related Self-Efficacy Time: Pre-program (baseline) and post-program (12 weeks)The purpose of this study is to determine if ensifentrine is safe and effective for the treatment of patients with moderate to severe Chronic Obstructive Pulmonary Disease (COPD).
Description: Change from baseline of Average forced expiratory volume in 1 second (FEV1) area under the curve (AUC)0-12h
Measure: Average forced expiratory volume in 1 second (FEV1) area under the curve (AUC)0-12h Time: 12 weeksDescription: Change from baseline of Average FEV1 AUC0-4h post-dose at Week 12
Measure: Average FEV1 AUC0-4h post-dose at Week 12 Time: 12 weeksDescription: Change from baseline in Peak FEV1 over 4 hours post dose at Week 12
Measure: Peak FEV1 over 4 hours post dose at Week 12 Time: 12 weeksDescription: Change from baseline as a weekly average of Evaluating-Respiratory Symptoms (E-RS) Total Score at Week 24
Measure: Weekly average of Evaluating-Respiratory Symptoms (E-RS) Total Score at Week 24 Time: 24 weeksDescription: Change from baseline of SGRQ total score at Week 24
Measure: St. George's Respiratory Questionnaire (SGRQ) total score at Week 24 Time: 24 weeksDescription: Change from baseline of Morning trough FEV1 at Week 12
Measure: Morning trough FEV1 at Week 12 Time: 12 weeksDescription: The proportion of St. George's Respiratory Questionnaire (SGRQ) responders at Week 24.
Measure: St. George's Respiratory Questionnaire (SGRQ) Time: 24 weeksDescription: Change from baseline of Rescue medication use at Week 24
Measure: Rescue medication use at Week 24 Time: 24 weeksDescription: Transitional Dyspnea Index (TDI) at Week 24
Measure: Transitional Dyspnea Index (TDI) at Week 24 Time: 24 weeksDescription: Change from baseline Evening trough FEV1 at Week 12
Measure: Evening trough FEV1 at Week 12 Time: 12 weeksDescription: Change from baseline Peak FEV1
Measure: Peak FEV1 at Week 6 and Week 24 Time: 6 and 24 weeksDescription: Change from baseline morning trough FEV1
Measure: Morning trough FEV1 at Week 6 and Week 24 Time: 6 and 24 weeksDescription: Change from baseline evening trough FEV1
Measure: Evening trough FEV1 at Week 6 and Week 24 Time: 6 and 24 weeksDescription: Change from baseline FEV1 AUC0-4h
Measure: FEV1 AUC0-4h at Week 6 and Week 24 Time: 6 and 24 weeksDescription: Change from baseline E-RS Total Score
Measure: Evaluating-Respiratory Symptoms (E-RS) Total Score at Week 6 and Week 12 Time: 6 and 12 weeksDescription: Change from baseline SGRQ responder analysis
Measure: St. George's Respiratory Questionnaire (SGRQ) responder analysis at Week 6 and Week 12 Time: 6 and 12 weeksDescription: Change from baseline TDI
Measure: TDI at Week 6 and Week 12 Time: 6 and 12 WeeksDescription: Change from baseline of SGRQ total score at Weeks 6 and 12
Measure: St. George's Respiratory Questionnaire (SGRQ) total score at Weeks 6 and 12 Time: 6 Weeks and 12 weeksDescription: Change from baseline of Rescue medication use at Weeks 6 and 12
Measure: Rescue medication use at Weeks 6 and 12 Time: 12 weeksThe purpose of this study is to determine if ensifentrine is safe and effective for the treatment of patients with moderate to severe Chronic Obstructive Pulmonary Disease (COPD).
Description: Change from baseline of Average forced expiratory volume in 1 second (FEV1) area under the curve (AUC)0-12h
Measure: Average forced expiratory volume in 1 second (FEV1) area under the curve (AUC)0-12h Time: 12 weeksDescription: Change from baseline of Average FEV1 AUC0-4h post-dose at Week 12
Measure: Average FEV1 AUC0-4h post-dose at Week 12 Time: 12 weeksDescription: Change from baseline of Peak FEV1 over 4 hours post-dose at Week 12
Measure: Peak FEV1 over 4 hours post-dose at Week 12 Time: 12 weeksDescription: Change from baseline as a weekly average of Evaluating-Respiratory Symptoms (E-RS) Total Score at Week 24
Measure: Evaluating-Respiratory Symptoms (E-RS) Total Score at Week 24 Time: 24 weeksDescription: Change from baseline of SGRQ total score at Week 24
Measure: St. George's Respiratory Questionnaire (SGRQ) total score at Week 24 Time: 24 weeksDescription: Change from baseline of Morning trough FEV1 at Week 12
Measure: Morning trough FEV1 at Week 12 Time: 12 weeksDescription: The proportion of St. George's Respiratory Questionnaire (SGRQ) responders at Week 24.
Measure: St. George's Respiratory Questionnaire (SGRQ) responders at Week 24 Time: 24 weeksDescription: Change from baseline of Rescue medication use at Week 24
Measure: Rescue medication use at Week 24 Time: 24 weeksDescription: Transitional Dyspnea Index (TDI) at Week 24
Measure: Transitional Dyspnea Index (TDI) at Week 24 Time: 24 weeksDescription: Change from baseline Evening trough FEV1 at Week 12
Measure: Evening trough FEV1 at Week 12 Time: 12 weeksDescription: Change from baseline Peak FEV1
Measure: Peak FEV1 at Week 6 and Week 24 Time: 6 or 24 weeksDescription: Change from baseline morning trough FEV1
Measure: Morning trough FEV1 at Week 6 and Week 24 Time: 6 or 24 weeksDescription: Change from baseline evening trough FEV1
Measure: Evening trough FEV1 at Week 6 and Week 24 Time: 6 or 24 weeksDescription: Change from baseline FEV1 AUC0-4h
Measure: FEV1 AUC0-4h at Week 6 and Week 24 Time: 6 or 24 weeksDescription: Change from baseline E-RS Total Score
Measure: Evaluating-Respiratory Symptoms (E-RS) Total Score at Week 6 and Week 12 Time: 6 or 12 weeksDescription: Change from baseline SGRQ responder analysis
Measure: SGRQ responder analysis at Week 6 and Week 12 Time: 6 or 12 weeksDescription: Change from baseline TDI
Measure: TDI at Week 6 and Week 12 Time: 6 or 12 weeksDescription: Change from baseline of SGRQ total score
Measure: St. George's Respiratory Questionnaire (SGRQ) total score at Weeks 6 and 12 Time: 6 or 12 weeksDescription: Change from baseline of Rescue medication use
Measure: Rescue medication use at Weeks 6 and 12 Time: 6 or 12 weeksAlphabetical listing of all HPO terms. Navigate: Correlations Clinical Trials
Data processed on September 26, 2020.
An HTML report was created for each of the unique drugs, MeSH, and HPO terms associated with COVID-19 clinical trials. Each report contains a list of either the drug, the MeSH terms, or the HPO terms. All of the terms in a category are displayed on the left-hand side of the report to enable easy navigation, and the reports contain a list of correlated drugs, MeSH, and HPO terms. Further, all reports contain the details of the clinical trials in which the term is referenced. Every clinical trial report shows the mapped HPO and MeSH terms, which are also hyperlinked. Related HPO terms, with their associated genes, protein mutations, and SNPs are also referenced in the report.
Drug Reports MeSH Reports HPO Reports