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    HP:0000405: Conductive hearing impairment

    Developed by Shray Alag, The Harker School
    Sections: Correlations, Clinical Trials, and HPO

    Correlations computed by analyzing all clinical trials.

    Navigate: Clinical Trials and HPO


    Correlated Drug Terms (2)


    Name (Synonyms) Correlation
    drug624 Bone conduction headphones Wiki 1.00
    drug4473 ensoETM device Wiki 1.00

    Correlated MeSH Terms (4)


    Name (Synonyms) Correlation
    D003638 Deafness NIH 1.00
    D010034 Otitis Media with Effusion NIH 1.00
    D034381 Hearing Loss NIH 1.00
    Name (Synonyms) Correlation
    D006314 Hearing Loss, Conductive NIH 1.00

    Correlated HPO Terms (2)


    Name (Synonyms) Correlation
    HP:0040262 Glue ear HPO 1.00
    HP:0000365 Hearing impairment HPO 0.71

    Clinical Trials

    Navigate: Correlations   HPO

    There is one clinical trial.


    1 Exploring Interventions for Children With Chronic Otitis Media With Effusion ('Glue Ear') When Services Are Reduced During Covid-19

    During the Coronavirus pandemic children's hearing services are closed or reduced and grommet operations are part of the lowest priority group. In the absence of management options, this research study aims to see if bone conduction headphones either paired (via bluetooth) to a microphone or an app will help children with a hearing loss during this period of waiting. The child's quality of life is measured with validated questionnaires The study is over 3 months, and delivered remotely, with the product being sent to the family home and support offered via telephone/ video consulattion.

    NCT04427631
    Conditions
    1. Hearing Impaired Children
    2. Glue Ear
    3. Hearing Loss, Conductive
    Interventions
    1. Device: Bone conduction headphones
    MeSH:Hearing Loss Deafness Otitis Media with Effusion Hearing Loss, Conductive
    HPO:Conductive hearing impairment Glue ear Hearing impairment

    Primary Outcomes

    Description: questionnaire based accpetability question. A higher acceptability score will be positive for the intervention.

    Measure: acceptability of management strategy, questionnaire

    Time: Acceptability will be measured on a Likert scale pre-assessment and the end of 3 months of using the intervention

    Secondary Outcomes

    Description: validated questionnaire assessing quality of life in children with glue ear. The questionnaire assess disease- related hearing difficulty and treatment-related improvements in hearing. Improved (lower) scores will indicate a more positive response from the intervention.

    Measure: quality of life questionnaire OMQ-14

    Time: Questionnaires at beginning of study (as a baseline assessment and after 3 months of using the intervention. The sc

    HPO Nodes


    HP:0000405: Conductive hearing impairment
    Genes 430
    NR2E3 GAS8 GRHL3 RSPH4A FAT4 DNAH9 ANKRD11 PGM3 PRPF4 RP2 ERCC8 SALL4 PDE6B TOPORS GP1BB COL2A1 ARL2BP FGF9 DNAAF2 NOTCH2 RET SEC24C PROM1 EDNRA CPLX1 EYA1 BMP2 C8ORF37 ODAD4 BBS2 OFD1 RLIM FGFR3 TP63 CFAP300 NSD2 SNRPB SLC25A24 HOXA2 RPS23 DNAAF6 TCTN3 TCF20 JMJD1C UFD1 ODAD1 ZMIZ1 CREBBP FBXW11 FREM2 PDE6A USH2A CCDC65 ANKH NSD1 EFTUD2 PCARE NFIX DHODH RET TNFRSF11A ALX3 SDHB CCBE1 TCOF1 MAN2B1 FLNA ZNF469 DNMT3A RPGR SEMA3E PIK3C2A RPE65 REEP6 SPECC1L TWIST1 RLBP1 FGFR2 LRRC56 POLR1C HYDIN GATA1 RPS28 POMGNT1 FKBP14 SAG KMT2A FAM149B1 RAD21 SEMA4A ANKH DDX6 ALX3 DVL1 FANCI CDHR1 RERE VHL SPAG1 EYA1 GJB6 DNAAF5 FGFR2 ROM1 MYCN KIF7 ZNF513 WDFY3 SRCAP RP1 FGFR3 DNAJB13 CCDC39 NIPBL POU3F4 TULP1 CPLANE1 CREBBP SPATA7 LETM1 GNPTAB MDH2 CA4 NIPBL PRDM5 STAC3 RP9 DCHS1 ZBTB20 MERTK GJA1 FGFR3 PGM3 PRPF6 LMNA RAI1 TP63 NF1 RPGR NME8 PAX1 NOG GJB2 DNAAF4 RAB23 CHD7 GUCA1B FAT4 HDAC8 KMT2E TNFRSF11A LONP1 KIAA1549 FOXJ1 CDH1 NEK1 DOCK3 POLR1D STK36 CCBE1 DLX4 SDHD CPLANE1 TFAP2A PCGF2 DDR2 ZMYND10 SKI TRMT1 ACVR1 SNRNP200 SC5D SMC1A TBX22 CNGB1 CLRN1 FGFR2 STAC3 TTC8 FLNB FRAS1 SOST CNOT3 SDHD TMEM216 PRPH2 CHRNG ZMPSTE24 DNAH1 OSTM1 KMT2D TRAPPC4 DHDDS GMNN MAP3K7 ALX1 COL1A2 MCIDAS NOTCH3 IDH3B IRF6 NECTIN1 CFAP300 GDF5 RSPH3 DHODH CNGA1 GJA1 GAS8 DNAL1 NTNG1 CCDC40 MASP1 MYCN SMCHD1 ARL3 TUB GJA1 EDN1 PRRX1 SDHAF2 SIX1 NEK2 PRPF3 RDH12 IFT172 FBN1 NOG POLR1C TP63 SETD2 CFAP221 ARHGEF18 AMER1 SPEF2 RREB1 COL2A1 POU3F4 NOG ABCA4 MSX1 KIAA0753 LRAT ARVCF GALNT2 CDCA7 TBX1 BEST1 RECQL4 SETD5 DRC1 CDH11 POR FH RECQL4 SCAPER DNAH5 ZNF408 MAN2B1 AMMECR1 SGMS2 ACTL6A BMP4 WHCR MAP3K7 FGFR2 DNAAF3 MED13 GAS2L2 CCDC103 AFF4 PRCD DHX38 MEOX1 EXT1 SLC7A14 SIX1 OFD1 FAM161A FLNB ACTL6B DNAH11 CCNO DLG1 NOTCH3 UBB PAX1 POLR1B TP63 TMEM127 KIZ PORCN DNAI1 FAM20C MYT1L RAI1 TSR2 MYT1L MAP3K7 ARID2 SNRPB CTNND1 SLC25A11 PSMD12 FGFR3 TRPS1 FGF10 EYA1 GABRD EP300 EFTUD2 LRP5 KCNAB2 PSMD12 HDAC4 PDE6D GDF6 IMPG2 NOG MAP3K7 ODAD3 ERCC6 AGBL5 SLITRK6 AMER1 BPTF SLC25A24 SKI AHR SDHC TTC12 CRX TXNL4A CRB1 BPTF GSC TFAP2A SDHA SIX1 COMT TBX1 IMPDH1 MYH3 DNAI2 PRPF31 KLHL7 DEAF1 SKI PIGL MAX ADAMTS3 SMC3 ODAD2 POLR1D DLST FLII NRL TCOF1 PDE6G GRIP1 RBP3 CDH1 KDM6A EYA1 APC2 TCTN3 COL2A1 ELMO2 FLNA HGSNAT CERKL FLNB LRRC6 RPS26 BCORL1 TSHZ1 FRAS1 DNAI1 RHO IDH3A RP1L1 CTBP1 NSD1 SDHD CNOT1 DNAAF1 EYS FGFRL1 CHRNG SDHB TMEM67 SF3B4 DCHS1 IFT88 ARHGAP29 ARL6 FGFR2 AHI1 FAT4 PRPF8 MAK CREB3L1 NEK10 EPAS1 FLNA OFD1 GJA1 B3GLCT RGR FSCN2 RSPH9 HIRA RSPH1 CFAP298 KIF1B VHL IQSEC2 SVBP IRF6 NECTIN1 COL11A2 MSX1 EYA1 ERF TELO2 PRDM16 IFT140 COL2A1 TANC2 PTPN22
    Protein Mutations 0
    SNP 0

    HPO

    Alphabetical listing of all HPO terms. Navigate: Correlations   Clinical Trials


    HPO Nodes


    HP:0000405: Conductive hearing impairment
    Genes 430
    NR2E3 GAS8 GRHL3 RSPH4A FAT4 DNAH9 ANKRD11 PGM3 PRPF4 RP2 ERCC8 SALL4 PDE6B TOPORS GP1BB COL2A1 ARL2BP FGF9 DNAAF2 NOTCH2 RET SEC24C PROM1 EDNRA CPLX1 EYA1 BMP2 C8ORF37 ODAD4 BBS2 OFD1 RLIM FGFR3 TP63 CFAP300 NSD2 SNRPB SLC25A24 HOXA2 RPS23 DNAAF6 TCTN3 TCF20 JMJD1C UFD1 ODAD1 ZMIZ1 CREBBP FBXW11 FREM2 PDE6A USH2A CCDC65 ANKH NSD1 EFTUD2 PCARE NFIX DHODH RET TNFRSF11A ALX3 SDHB CCBE1 TCOF1 MAN2B1 FLNA ZNF469 DNMT3A RPGR SEMA3E PIK3C2A RPE65 REEP6 SPECC1L TWIST1 RLBP1 FGFR2 LRRC56 POLR1C HYDIN GATA1 RPS28 POMGNT1 FKBP14 SAG KMT2A FAM149B1 RAD21 SEMA4A ANKH DDX6 ALX3 DVL1 FANCI CDHR1 RERE VHL SPAG1 EYA1 GJB6 DNAAF5 FGFR2 ROM1 MYCN KIF7 ZNF513 WDFY3 SRCAP RP1 FGFR3 DNAJB13 CCDC39 NIPBL POU3F4 TULP1 CPLANE1 CREBBP SPATA7 LETM1 GNPTAB MDH2 CA4 NIPBL PRDM5 STAC3 RP9 DCHS1 ZBTB20 MERTK GJA1 FGFR3 PGM3 PRPF6 LMNA RAI1 TP63 NF1 RPGR NME8 PAX1 NOG GJB2 DNAAF4 RAB23 CHD7 GUCA1B FAT4 HDAC8 KMT2E TNFRSF11A LONP1 KIAA1549 FOXJ1 CDH1 NEK1 DOCK3 POLR1D STK36 CCBE1 DLX4 SDHD CPLANE1 TFAP2A PCGF2 DDR2 ZMYND10 SKI TRMT1 ACVR1 SNRNP200 SC5D SMC1A TBX22 CNGB1 CLRN1 FGFR2 STAC3 TTC8 FLNB FRAS1 SOST CNOT3 SDHD TMEM216 PRPH2 CHRNG ZMPSTE24 DNAH1 OSTM1 KMT2D TRAPPC4 DHDDS GMNN MAP3K7 ALX1 COL1A2 MCIDAS NOTCH3 IDH3B IRF6 NECTIN1 CFAP300 GDF5 RSPH3 DHODH CNGA1 GJA1 GAS8 DNAL1 NTNG1 CCDC40 MASP1 MYCN SMCHD1 ARL3 TUB GJA1 EDN1 PRRX1 SDHAF2 SIX1 NEK2 PRPF3 RDH12 IFT172 FBN1 NOG POLR1C TP63 SETD2 CFAP221 ARHGEF18 AMER1 SPEF2 RREB1 COL2A1 POU3F4 NOG ABCA4 MSX1 KIAA0753 LRAT ARVCF GALNT2 CDCA7 TBX1 BEST1 RECQL4 SETD5 DRC1 CDH11 POR FH RECQL4 SCAPER DNAH5 ZNF408 MAN2B1 AMMECR1 SGMS2 ACTL6A BMP4 WHCR MAP3K7 FGFR2 DNAAF3 MED13 GAS2L2 CCDC103 AFF4 PRCD DHX38 MEOX1 EXT1 SLC7A14 SIX1 OFD1 FAM161A FLNB ACTL6B DNAH11 CCNO DLG1 NOTCH3 UBB PAX1 POLR1B TP63 TMEM127 KIZ PORCN DNAI1 FAM20C MYT1L RAI1 TSR2 MYT1L MAP3K7 ARID2 SNRPB CTNND1 SLC25A11 PSMD12 FGFR3 TRPS1 FGF10 EYA1 GABRD EP300 EFTUD2 LRP5 KCNAB2 PSMD12 HDAC4 PDE6D GDF6 IMPG2 NOG MAP3K7 ODAD3 ERCC6 AGBL5 SLITRK6 AMER1 BPTF SLC25A24 SKI AHR SDHC TTC12 CRX TXNL4A CRB1 BPTF GSC TFAP2A SDHA SIX1 COMT TBX1 IMPDH1 MYH3 DNAI2 PRPF31 KLHL7 DEAF1 SKI PIGL MAX ADAMTS3 SMC3 ODAD2 POLR1D DLST FLII NRL TCOF1 PDE6G GRIP1 RBP3 CDH1 KDM6A EYA1 APC2 TCTN3 COL2A1 ELMO2 FLNA HGSNAT CERKL FLNB LRRC6 RPS26 BCORL1 TSHZ1 FRAS1 DNAI1 RHO IDH3A RP1L1 CTBP1 NSD1 SDHD CNOT1 DNAAF1 EYS FGFRL1 CHRNG SDHB TMEM67 SF3B4 DCHS1 IFT88 ARHGAP29 ARL6 FGFR2 AHI1 FAT4 PRPF8 MAK CREB3L1 NEK10 EPAS1 FLNA OFD1 GJA1 B3GLCT RGR FSCN2 RSPH9 HIRA RSPH1 CFAP298 KIF1B VHL IQSEC2 SVBP IRF6 NECTIN1 COL11A2 MSX1 EYA1 ERF TELO2 PRDM16 IFT140 COL2A1 TANC2 PTPN22
    Protein Mutations 0
    SNP 0

    Reports

    Data processed on September 26, 2020.

    An HTML report was created for each of the unique drugs, MeSH, and HPO terms associated with COVID-19 clinical trials. Each report contains a list of either the drug, the MeSH terms, or the HPO terms. All of the terms in a category are displayed on the left-hand side of the report to enable easy navigation, and the reports contain a list of correlated drugs, MeSH, and HPO terms. Further, all reports contain the details of the clinical trials in which the term is referenced. Every clinical trial report shows the mapped HPO and MeSH terms, which are also hyperlinked. Related HPO terms, with their associated genes, protein mutations, and SNPs are also referenced in the report.

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