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  • HP:0001287: Meningitis
  • Pneumonia (359) Respiratory tract infection (38) Neoplasm (36) Abnormality of the cardiovascular system (34) Diabetes mellitus (33) Depressivity (29) Acute kidney injury (27) Hypoxemia (26) Hypertension (24) Abnormal lung morphology (24) Thromboembolism (22) Anosmia (20) Myocardial infarction (20) Arthritis (19) Type II diabetes mellitus (18) Stroke (16) Pulmonary embolism (16) Mental deterioration (15) Abnormality of coagulation (15) Pulmonary fibrosis (15) Chronic pulmonary obstruction (15) Abnormality of the kidney (14) Autistic behavior (14) Rheumatoid arthritis (14) Leukemia (14) Interstitial pneumonitis (14) Pulmonary obstruction (14) Asthma (13) Chronic pain (13) Congestive heart failure (12) Deep venous thrombosis (12) Neoplasm of the lung (12) Autism (11) Obesity (11) Respiratory distress (11) Colitis (11) Ulcerative colitis (11) Crohn's disease (11) Type I diabetes mellitus (10) Abnormality of the liver (9) Coronary artery atherosclerosis (9) Inflammation of the large 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Jaundice (2) Lymphedema (2) Spasticity (2) Meningitis (2) Abnormal joint morphology (2) Hepatic steatosis (2) Hepatic failure (2) Tachycardia (2) Angina pectoris (2) Pancreatitis (2) Abnormality of blood and blood-forming tissues (2) Thrombocytopenia (2) Autoimmune thrombocytopenia (2) Gout (2) Diarrhea (2) Gastroesophageal reflux (2) Apnea (2) Neurodegeneration (2) Alopecia of scalp (2) Mutism (2) Transient ischemic attack (2) Hyperkinetic movements (2) Polyphagia (2) Hypotension (2) Atherosclerosis (2) Hypoventilation (2) Squamous cell carcinoma (2) Myelodysplasia (2) Back pain (2) Low back pain (2) Muscular dystrophy (2) Stillbirth (2) Acute myeloid leukemia (2) Lymphoproliferative disorder (2) Myeloproliferative disorder (2) Multiple myeloma (2) Intervertebral disc degeneration (2) Stridor (2) Postprandial hyperglycemia (2) Hemeralopia (2) Arteritis (2) Hepatitis (2) Glioblastoma multiforme (2) Cervix cancer (2) Small cell lung carcinoma (2) Endocarditis (2) Toxemia of pregnancy 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Spina bifida (1) Language impairment (1) Waddling gait (1) Increased intracranial pressure (1) Biliary cirrhosis (1) Dilatation (1) Osteomyelitis (1) Central apnea (1) Hypokalemia (1) Hyponatremia (1) Hyperphosphatemia (1) Skeletal muscle atrophy (1) Male infertility (1) Spondylolisthesis (1) Myalgia (1) Bruxism (1) Neonatal death (1) Increased body weight (1) Intermittent claudication (1) Thrombophlebitis (1) Chronic bronchitis (1) Ventricular tachycardia (1) Acute myelomonocytic leukemia (1) Dilatation of the cerebral artery (1) Coronary artery stenosis (1) Venous insufficiency (1) Chronic lymphatic leukemia (1) Abnormality of bone marrow cell morphology (1) Hypersensitivity pneumonitis (1) Intraalveolar phospholipid accumulation (1) Neoplasm of the genitourinary tract (1) Neoplasm of the skin (1) Female infertility (1) Benign prostatic hyperplasia (1) Hip osteoarthritis (1) Bladder neoplasm (1) Stomatitis (1) Uterine neoplasm (1) Intestinal atresia (1) Placental abruption (1) Sinus 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    HP:0001287: Meningitis

    Developed by Shray Alag, The Harker School
    Sections: Correlations, Clinical Trials, and HPO

    Correlations computed by analyzing all clinical trials.

    Navigate: Clinical Trials and HPO

    Correlated Drug Terms (3)

    Name (Synonyms) Correlation
    drug4206 Venepuncture Wiki 0.71
    drug2724 Oral fluid swab Wiki 0.71
    drug1795 Hydroxychloroquine Sulfate Wiki 0.20

    Correlated MeSH Terms (8)

    Name (Synonyms) Correlation
    D008585 Meningitis, Meningococcal NIH 1.00
    D008581 Meningitis, Mening NIH 1.00
    D004165 Diphtheria NIH 0.71
    Name (Synonyms) Correlation
    D008589 Meningococcal Infections NIH 0.71
    D007249 Inflammation NIH 0.12
    D003141 Communicable Diseases NIH 0.05
    D011014 Pneumonia NIH 0.04
    D007239 Infection NIH 0.03

    Correlated HPO Terms (1)

    Name (Synonyms) Correlation
    HP:0002090 Pneumonia HPO 0.04

    Clinical Trials

    Navigate: Correlations   HPO

    There are 2 clinical trials

    1 Serum Testing of Representative Youngsters: Sero- Epidemiological Survey of England in 2019/2020

    This is a pilot study to assess the feasibility of establishing a national sero-epidemiological survey in England in individuals aged 0-24 years, focusing on assessing humoral immunity against diphtheria, Group C invasive meningococcus and SARS-CoV-2. The investigators will recruit 2800 to 3500 individuals, divided into two groups: Group one (N= 2300): This will include all age groups (0-24years), with recruitment restricted by postcodes provided by Public Health England (PHE) to recruit a representative population for the region as assessed by the IMD (Index of Multiple Deprivation scores). Group two (N= up to 1200): This group has been added following additional funding to enhance the sample size in response to the COVID-19 pandemic. This will recruit 0-19 year olds and will not be restricted by post code sampling. Instead recruitment will be by public promotion within the normal recruiting regions for each site.

    1. Serogroup C Meningococcal Meningitis
    2. Diphtheria
    3. COVID-19
    1. Procedure: Venepuncture
    2. Procedure: Oral fluid swab
    MeSH:Diphtheria Meningitis, Meningococcal Meningitis

    Primary Outcomes

    Description: Measure the representativeness of participants as compared to the census data for the study region.

    Measure: Feasibility of developing an England based sero-epidemiological programme in 0-24 year olds

    Time: 11months

    Description: Test serological markers of immunity for vaccine preventable diseases starting with diphtheria.

    Measure: Feasibility of developing an England based sero epidemiological survey in 0-24 year olds

    Time: 11 months

    Description: Test serological markers of immunity for vaccine preventable diseases including Invasive Meningococcal type C.

    Measure: Feasibility of developing an England based sero epidemiological survey in 0-24 year olds

    Time: 11 months

    Description: Test serological markers to determine the true number of infections with SARS-CoV-2 in the population.

    Measure: Feasibility of developing an England based sero epidemiological survey in 0-24 year olds

    Time: 11 months

    Secondary Outcomes

    Description: Recruitment rate per month, recruitment rates as percentage of potential participants contacted

    Measure: Recruitment rate

    Time: 11 Months

    Description: Cost per sample obtained of 'disease specific correlates of protection/markers of immunity, e.g. Anti-Diphtheria Toxoid IgG concentrations and Capsular Group C meningococcal Serum bactericidal activity (SBA) titres and Serum IgG to SARS-CoV-2 antigens, including spike protein (as measured by ELISA and/or neutralising assay)

    Measure: Cost

    Time: 12 months

    Description: IgG to COVID-19 spike protein

    Measure: To assess, in relevant age groups, antibody concentrations against infections and vaccine preventable diseases

    Time: 11 months

    Description: A collection of anonymised sera from participants with appropriate consent and known demographic details and immunisation history. Serum IgG to SARS-CoV-2 antigens, including spike protein (as measured by ELISA and/or neutralising assay)

    Measure: Sera collection

    Time: 11 months

    Description: • Representativeness of participants sampled, in terms of the local population's ethnicity, community identity, migrant population and socioeconomic background in group 1 and group 2. Differences in immunological read outs PCR for SARS-CoV-2 on saliva samples this will be stored and processed at the end of the study. IgA to SARS-CoV-2 in saliva paired with serum samples.

    Measure: Exploratory

    Time: 11 months

    Description: • T cell responses to SARS-CoV-2 antigens including, but not limited to S, M and N proteins, as measured by techniques including, but not limited to ELISpot ICS Proliferation assay

    Measure: Exploratory

    Time: 6 months

    Description: • Antigen specific IgG and T cells against non-SARS-CoV-2 coronaviruses (e.g. NL62 and 229E)

    Measure: Exploratory

    Time: 6 months
    2 Evaluation of Post Infectious Inflammatory Reaction (PIIR) in a Retrospective Study Concerning Children After Streptococcus Pneumoniae, Streptococcus Pyogenes and Neisseria Meningococcus Invasive Infection

    As Covid 19 manifestations that have been recently described, inflammatory manifestation have major impact in infectious disease lesions. Some of them are delayed and provide Post infectious inflammatory reaction (PIIR), they are challenging for diagnosis and for management. Clinician have to avoid unnecessary antibiotic thearapy and in if necessary have to give immunosuppressive therapy. Except for rheumatic disease for group A streptococcus (GAS) infections there are not stanrdized diagnostic criteria and therapeutic protocol, and PIIR have probably a suboptimal management. In this context the investigators aim to explore PIIR in the 3 most frequent bacterial invasive infection in France, by a retrospective monocentric study. The investigators include all children betwwen 2012 and 2018 hospitalized for infections by Streptococcus pneumoniae (SP), Neisseria meningitidis (NM), and GAS invasive infections.

    1. Streptococcus Pneumonia
    2. Streptococcus Pyogenes Infection
    3. Neisseria Meningitides Meningiti
    4. Neisseria Meningitides Meningitis
    MeSH:Infection Communicable Diseases Meningococcal Infections Meningitis, Meningococcal Pneumonia Meningitis Inflammation
    HPO:Meningitis Pneumonia

    Primary Outcomes

    Description: Describe the frequency PIIRs following invasive pneumococcal, meningococcal, or group A Streptococcal infection

    Measure: Describe the frequency PIIRs

    Time: 1 day

    Secondary Outcomes

    Description: Describe the characteristics PIIRs following invasive pneumococcal, meningococcal, or group A Streptococcal infection

    Measure: Characteristics PIIRs following invasive pneumococcal, meningococcal, or group A Streptococcal infection

    Time: 1 day

    Other Outcomes

    Description: Identified the predictors of PIIRs in order to find warning symptoms

    Measure: Predictors of PIIRs

    Time: 1 day

    HPO Nodes


    Data processed on September 26, 2020.

    An HTML report was created for each of the unique drugs, MeSH, and HPO terms associated with COVID-19 clinical trials. Each report contains a list of either the drug, the MeSH terms, or the HPO terms. All of the terms in a category are displayed on the left-hand side of the report to enable easy navigation, and the reports contain a list of correlated drugs, MeSH, and HPO terms. Further, all reports contain the details of the clinical trials in which the term is referenced. Every clinical trial report shows the mapped HPO and MeSH terms, which are also hyperlinked. Related HPO terms, with their associated genes, protein mutations, and SNPs are also referenced in the report.

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