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  • HP:0005561: Abnormality of bone marrow cell morphology
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    HP:0005561: Abnormality of bone marrow cell morphology

    Developed by Shray Alag, The Harker School
    Sections: Correlations, Clinical Trials, and HPO

    Correlations computed by analyzing all clinical trials.

    Navigate: Clinical Trials and HPO

    Correlated Drug Terms (2)

    Name (Synonyms) Correlation
    drug3359 Reverse-transcription polymerase chain reaction (RT-PCR) Wiki 1.00
    drug897 Chest computed tomography (CT) Wiki 1.00

    Correlated MeSH Terms (2)

    Name (Synonyms) Correlation
    D001855 Bone Marrow Diseases NIH 1.00
    D013118 Spinal Cord Diseases NIH 1.00

    Correlated HPO Terms (1)

    Name (Synonyms) Correlation
    HP:0002143 Abnormality of the spinal cord HPO 1.00

    Clinical Trials

    Navigate: Correlations   HPO

    There is one clinical trial.

    1 Study of Postural Stability in Subjects With Myelopathy Using a Portable Virtual Reality Balance Protocol

    Veterans are at heightened risk of developing cervical spondylotic myelopathy (CSM) from rigors of military service. Balance and posturography are negatively affected in CSM, but require expensive equipment, and extensive training of personnel for data acquisition and interpretation. The Virtual Environment TBI Screen (VETS) is a simple and inexpensive construct that could be implemented as an aid in diagnosis and as an objective means to compare treatment modalities and track recovery. The goal for the SPiRE is to generate the critical data to support rigorous Merit studies of posturography for assessments of clinical course in the treatment and rehabilitation of CSM. The investigators' ultimate goal, if the SPiRE is successful, is to phase in objective posturography assessments as VA standard of care in CSM.

    1. Cervical Spondylotic Myelopathy
    MeSH:Spinal Cord Diseases Bone Marrow Diseases
    HPO:Abnormality of bone marrow cell morphology Abnormality of the spinal cord Myelopathy

    Primary Outcomes

    Description: The postural stability task involves six conditions during which veterans are instructed to look straight ahead and maintain an upright stance as stably as possible. Veterans are barefooted with feet comfortably placed ~25 cm apart. The six conditions are (1) Eyes Open (EO) Firm (2) Eyes Closed (EC) Firm, (3) Dynamic Scene (DYN) Firm, (4) EO Foam, (5) EC Foam, and (6) DYN Foam. Each condition is tested three times with the average center of pressure (COP) sway area used as a index of stability for that condition.

    Measure: Virtual Environment TBI System (VETS) assessment of Static Posturography

    Time: PreSurgery compared to otherwise healthy veterans

    Description: It is expected that posturography, especially that from FOAM and EC conditions will be improved be surgical relief. This is a within comparison of veterans with CSM and receiving surgical relief through widening of the chord.

    Measure: Change in Posturography

    Time: Presurgery compared to 2 weeks, 6 weeks, and 6 months post-surgery. The Post-surgery endpoints are normally scheduled clinical follow ups.

    Secondary Outcomes

    Description: The Nurick scale is a 6-grade ordinal scale assessing gait impairment, with grades ranging from 0 (signs and symptoms of root involvement but no evidence of spinal cord disease) to 5 (chair bound or bedridden). The aggregate value of the Nurick scale will be related to posturography.

    Measure: Nurick Scale

    Time: PreSurgery compared to otherwise healthy veterans

    Description: The NDI is a 10-item questionnaire addressing function activities (personal care, lifting, reading, work, driving, sleeping, and recreation), pain intensity, concentration, and headache. For each item, patients make their ratings on a 6-point Likert scale with values 0 = no disability and 5 = complete disability. Summed scores for each category are multiplied by 2 to give a total NDI score ranging from 0-100. NDI will be related to VETS posturography to determine the sensitivity of standing posture to degree of disability.

    Measure: Neck Disability Index (NDI)

    Time: PreSurgery compared to otherwise healthy veterans

    Description: The SF-36v2 is a general health survey that includes mental and physical component scores to measure functional status and overall quality of life. The instrument includes 8 scales: physical functioning, role limitations physical pain, bodily pain, general health perceptions, vitality, social functioning, role limitations, emotional health, and mental health. The higher the score the more limitations. The total scale will be used to determine the sensitivity of VETS posturography to quality of life.

    Measure: Short Form-36 version 2 (SF-36v2)

    Time: PreSurgery compared to otherwise healthy veterans

    Description: From the VETS, a ratio corresponding to the Rhomberg ratio of COP sway will be used to determine the degree static posture depends on visual input.

    Measure: EC FIRM/EO FIRM ratio

    Time: PreSurgery

    Description: From the VETS, a ratio of COP sway will be used to determine the degree static posture is affected by reduced proprioception.

    Measure: EO FOAM/EO FIRM

    Time: PreSurgery compared to otherwise healthy veterans

    Description: From the VETS, a ratio of COP sway will be used to determine the degree loss of visual information compounds reduced proprioception in static balance.

    Measure: EC FOAM/EO FOAM ratio

    Time: PreSurgery compared to otherwise healthy veterans

    Description: From the VETS, a ratio of COP sway to determine the roll vection is induced by loss of proprioception.

    Measure: DYN FOAM/DYN FIRM ratio

    Time: PreSurgery compared to otherwise healthy veterans

    Description: From the VETS, a ration of COP sway to determine the degree roll vection is induced.

    Measure: DYN FIRM/ EO FIRM ratio

    Time: PreSurgery compared to otherwise healthy veterans

    HPO Nodes


    Alphabetical listing of all HPO terms. Navigate: Correlations   Clinical Trials

    HPO Nodes


    Data processed on September 26, 2020.

    An HTML report was created for each of the unique drugs, MeSH, and HPO terms associated with COVID-19 clinical trials. Each report contains a list of either the drug, the MeSH terms, or the HPO terms. All of the terms in a category are displayed on the left-hand side of the report to enable easy navigation, and the reports contain a list of correlated drugs, MeSH, and HPO terms. Further, all reports contain the details of the clinical trials in which the term is referenced. Every clinical trial report shows the mapped HPO and MeSH terms, which are also hyperlinked. Related HPO terms, with their associated genes, protein mutations, and SNPs are also referenced in the report.

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