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  • HP:0002104: Apnea
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    HP:0002104: Apnea

    Developed by Shray Alag, The Harker School
    Sections: Correlations, Clinical Trials, and HPO

    Correlations computed by analyzing all clinical trials.

    Navigate: Clinical Trials and HPO


    Correlated Drug Terms (4)


    Name (Synonyms) Correlation
    drug1745 Home Sleep Apnea Testing or In-hospital Polysomnography Wiki 0.71
    drug3642 Skin biopsy Wiki 0.71
    drug614 Blood sampling Wiki 0.58
    Name (Synonyms) Correlation
    drug4006 Throat swab Wiki 0.50

    Correlated MeSH Terms (6)


    Name (Synonyms) Correlation
    D001049 Apnea NIH 1.00
    D020181 Sleep Apnea, Obstructive NIH 0.63
    D012891 Sleep Apnea, NIH 0.63
    Name (Synonyms) Correlation
    D009103 Multiple Sclerosis NIH 0.17
    D012598 Scoliosi NIH 0.16
    D011014 Pneumonia NIH 0.04

    Correlated HPO Terms (3)


    Name (Synonyms) Correlation
    HP:0002870 Obstructive sleep apnea HPO 0.63
    HP:0010535 Sleep apnea HPO 0.63
    HP:0002090 Pneumonia HPO 0.04

    Clinical Trials

    Navigate: Correlations   HPO

    There are 2 clinical trials


    1 Impact of Obstructive Sleep Apnea on Covid-19 Outcomes (OSACOVID-19 Study): A Prospective Observational Cohort Study

    Covid-19 infection is an on-going pandemic with worse diagnosis in adults with comorbid conditions such as hypertension and cardiopulmonary diseases. Obstructive sleep apnea (OSA) is common in those comorbidities and may contribute to worse prognosis for the Covid-19 cases.

    NCT04363333
    Conditions
    1. COVID
    2. Obstructive Sleep Apnea
    3. Pneumonia
    Interventions
    1. Diagnostic Test: Home Sleep Apnea Testing or In-hospital Polysomnography
    MeSH:Apnea Sleep Apnea Syndromes Pneumonia Sleep Apnea, Obstructive
    HPO:Apnea Obstructive sleep apnea Pneumonia Sleep apnea

    Primary Outcomes

    Description: Defined as a decline of 2 categories from admission on a 7-category ordinal scale

    Measure: The rate of clinical improvement

    Time: 7 days

    Description: Defined as a decline of 2 categories from admission on a 7-category ordinal scale

    Measure: The rate of clinical improvement

    Time: 14 days

    Description: Defined as a decline of 2 categories from admission on a 7-category ordinal scale

    Measure: The rate of clinical improvement

    Time: 21 days

    Description: Defined as a decline of 2 categories from admission on a 7-category ordinal scale

    Measure: The rate of clinical improvement

    Time: 28 days

    Secondary Outcomes

    Description: Time to hospital discharge, ICU discharge, weaning from intubation, weaning from supplemental oxygen, incident pneumonia, ARDS, in-hospital mortality

    Measure: Clinical status - improvement

    Time: 7, 14, 21, 28 days

    Description: Defined as an increase in category on a 7-category ordinal scale from admission

    Measure: Clinical status - worsening

    Time: 7, 14, 21, 28 days

    Other Outcomes

    Description: Re-analysis of the correlation of obstructive sleep apnea (objectively verified) severity in terms of apnea-hypopnea index and oxygenation levels with the primary and secondary outcomes as described above (the rate of clinical improvement defined as a decline of 2 categories from admission on a 7-category ordinal scale; time to hospital discharge, ICU discharge, weaning from intubation, weaning from supplemental oxygen, incident pneumonia, ARDS, in-hospital mortality as well as with the lung function, CO-diffusion capacity, cardiac function, CT thorax pathologies, biomarkers (cytokines, polymorphisms) and IgG-antibodies after 4 months.

    Measure: Long-term outcomes

    Time: 4-6 months after the initial hospital admission
    2 Prevalence and Impact of Obstructive Sleep Apnea in Multiple Sclerosis

    This study will evaluate the influence of sleep apnea on clinical and radiological features of MS. Sleep apnea is associated with hypoxemia during sleep, which we believe is detrimental to MS. We will examine clinical data (MRI, lab results, medical history, labs, and sleep studies) of Dr. Sloane's MS patients. This will allow us to study correlations between MRI, clinical data, lab studies and sleep studies. We are specifically interested in the type of sleep apnea associated with MS, and whether MRI or clinical metrics of MS severity correlate with presence or absence of sleep apnea.

    NCT04603196
    Conditions
    1. Multiple Sclerosis
    2. Obstructive Sleep Apnea
    MeSH:Apnea Sleep Apnea Syndromes Sleep Apnea, Obstructive Multiple Sclerosis Sclerosis
    HPO:Apnea Obstructive sleep apnea Sleep apnea

    Primary Outcomes

    Description: Home Sleep Study Data

    Measure: Home Sleep Study Data

    Time: 1 year

    Secondary Outcomes

    Description: sleep quality, quality of life, depression and anxiety scales

    Measure: Questionnaire data

    Time: 1 year

    HPO Nodes


    HP:0002104: Apnea
    Genes 406
    ZIC2 SH3BP2 SNX10 ND4 POGZ NDUFA10 GPR101 NODAL PRNP CTNNB1 FGFR3 NDUFA2 SIX3 SYT1 FGFR3 NDUFS1 DKK1 FGFR3 SYT1 BMP2 RNF125 TSEN54 TRIP13 DISP1 GAS1 FOXH1 TCTN3 BTD MAGEL2 ASCL1 PTF1A TRNL1 CREBBP TNFSF11 HYLS1 CPLANE1 DLL1 AHDC1 SLC25A20 KIAA0586 SIX3 AHDC1 BTD PLPBP MCCC1 NACC1 SCN5A LTBP3 DCTN1 ATP5F1A PRPS1 FOXH1 ATP6 CDON LAMB2 TOE1 TCF4 GNAI3 HERC2 TMEM67 INPP5E LIFR GAS1 FBP1 PWAR1 SOX9 KIF5A TWIST1 TMEM216 TMEM67 SPOP NODAL PEX13 SCN4A VAMP1 TCTN1 SHH FAM149B1 DISP1 MECP2 ECHS1 ND6 RBM10 SCN2A NDUFV1 AIP GLI2 TMEM107 NPAP1 DISP1 TSPYL1 ACADSB PLCB4 SLC18A3 SNORD116-1 SRPX2 FGF8 KCNQ2 TDGF1 KIF7 NPHP1 NDUFA13 LIPT1 GLI2 FGF8 STXBP1 RPGRIP1L CEP41 OPA1 MYO9A IDUA ARMC9 PDHA1 AHI1 IDUA RARS2 SURF1 MECP2 FGFR1 CREBBP NDUFAF2 ARL13B ND1 GNPTAB ABCA3 GABBR2 MKRN3 SCN4A SNORD115-1 WFS1 SRPX2 ATN1 CSPP1 GBA CDON PLCB4 PLAA STAG2 SIX3 CEP104 GNE NGLY1 DST RAI1 TRNV GNAI3 SCN2A RERE PLAA ZIC2 KCNQ2 NDUFS7 NEK1 USP7 FGF8 TMEM231 STAT2 CSPP1 SHH TSPYL1 SURF1 SLC6A9 RET CPLANE1 STAG2 PCGF2 KCNQ3 NODAL SKI BUB1B PTCH1 ZIC2 PRMT7 MTFMT PIBF1 FGFR2 GAS1 PSAP NDUFS3 HMGCL NDUFA11 NDUFAF3 RPS6KA3 HTRA2 NDN NDUFA12 NDUFA9 FLCN TMEM216 CDON TECPR2 NDUFA4 ARL3 SLC6A5 PTCH1 GABBR2 GLI2 MKRN3-AS1 CRYAB EDN1 CCDC47 TCF4 NDUFV2 SLC25A1 MTHFR COQ2 AHI1 ARCN1 FXR1 COX15 PRRT2 NDUFA2 COL13A1 SNRPN DPH1 BUB3 ND3 SMC1A NALCN LARP7 CHAT PCCA SLC18A3 ASCL1 NDUFAF6 PHOX2B TMEM237 GDNF FBN1 TMEM138 TCIRG1 KCNQ2 CDKL5 SLC5A7 SCO2 AMER1 TMEM216 CEP57 NDUFS1 KIAA0753 ZNF423 GPHN CEP41 PIGT DPAGT1 NDUFS2 KIAA0586 NDUFS8 SIM1 BRAT1 CEP120 BRAF D2HGDH P4HTM KATNIP AFF4 LIAS SIX3 SFTPB TDGF1 KAT6B RUNX2 OFD1 USP7 SOD1 KCNQ3 SLC39A8 SLC2A1 HRAS KIAA0586 CTSD B9D1 CDON ADGRG1 TBR1 PDHA1 MAGEL2 CEP290 AHI1 CC2D2A PIBF1 BCHE CHRNE ZIC2 PI4KA FXR1 HSPD1 NONO FOXH1 NDUFAF5 NFIX FGFR3 ECHS1 NDUFS4 SCN8A FGF8 PHOX2B MAGEL2 ACY1 EP300 GLRA1 DNA2 TGIF1 NDUFB8 SDHA NDUFV1 CSPP1 PDE6D TERT ND5 PTCH1 FBP1 FOXRED1 AGRN TDGF1 VPS51 COLQ SNAP25 SHH CC2D2A C2CD3 GLI2 ARMC9 GAS1 INPP5E NDUFS2 SLC19A3 GNE INPP5E TGIF1 NEB MKS1 LIFR TRPV4 SLC5A7 DNA2 SKI NDUFS8 GABRG2 PTCH1 CHAT FOXH1 GBA TMEM237 TGIF1 CLCN7 TECPR2 IPW TCTN2 NGLY1 NEFH BRAT1 TACO1 GLUL ALPL RPGRIP1L PET100 TDGF1 FARS2 TRNW DLL1 SHH RET TGIF1 EP300 RPGRIP1L TRNK CEP120 HSPG2 INPP5E PWRN1 GRIN2A FGFR1 MYO9A TMEM237 BUB1 ND2 FGFR2 CREBBP PCCB NDUFAF2 CEP290 NADK2 NTNG1 CISD2 NODAL MECP2 SYT2 EDN3 DLL1 COQ2 GSN CPT2 DMPK ZC4H2 PEX5 GPR101 COL3A1 PCK1 DLL1 PRPH IDS CEP57 MKS1 UNC80 DISP1

    HPO

    Alphabetical listing of all HPO terms. Navigate: Correlations   Clinical Trials


    HPO Nodes


    HP:0002104: Apnea
    Genes 406
    ZIC2 SH3BP2 SNX10 ND4 POGZ NDUFA10 GPR101 NODAL PRNP CTNNB1 FGFR3 NDUFA2 SIX3 SYT1 FGFR3 NDUFS1 DKK1 FGFR3 SYT1 BMP2 RNF125 TSEN54 TRIP13 DISP1 GAS1 FOXH1 TCTN3 BTD MAGEL2 ASCL1 PTF1A TRNL1 CREBBP TNFSF11 HYLS1 CPLANE1 DLL1 AHDC1 SLC25A20 KIAA0586 SIX3 AHDC1 BTD PLPBP MCCC1 NACC1 SCN5A LTBP3 DCTN1 ATP5F1A PRPS1 FOXH1 ATP6 CDON LAMB2 TOE1 TCF4 GNAI3 HERC2 TMEM67 INPP5E LIFR GAS1 FBP1 PWAR1 SOX9 KIF5A TWIST1 TMEM216 TMEM67 SPOP NODAL PEX13 SCN4A VAMP1 TCTN1 SHH FAM149B1 DISP1 MECP2 ECHS1 ND6 RBM10 SCN2A NDUFV1 AIP GLI2 TMEM107 NPAP1 DISP1 TSPYL1 ACADSB PLCB4 SLC18A3 SNORD116-1 SRPX2 FGF8 KCNQ2 TDGF1 KIF7 NPHP1 NDUFA13 LIPT1 GLI2 FGF8 STXBP1 RPGRIP1L CEP41 OPA1 MYO9A IDUA ARMC9 PDHA1 AHI1 IDUA RARS2 SURF1 MECP2 FGFR1 CREBBP NDUFAF2 ARL13B ND1 GNPTAB ABCA3 GABBR2 MKRN3 SCN4A SNORD115-1 WFS1 SRPX2 ATN1 CSPP1 GBA CDON PLCB4 PLAA STAG2 SIX3 CEP104 GNE NGLY1 DST RAI1 TRNV GNAI3 SCN2A RERE PLAA ZIC2 KCNQ2 NDUFS7 NEK1 USP7 FGF8 TMEM231 STAT2 CSPP1 SHH TSPYL1 SURF1 SLC6A9 RET CPLANE1 STAG2 PCGF2 KCNQ3 NODAL SKI BUB1B PTCH1 ZIC2 PRMT7 MTFMT PIBF1 FGFR2 GAS1 PSAP NDUFS3 HMGCL NDUFA11 NDUFAF3 RPS6KA3 HTRA2 NDN NDUFA12 NDUFA9 FLCN TMEM216 CDON TECPR2 NDUFA4 ARL3 SLC6A5 PTCH1 GABBR2 GLI2 MKRN3-AS1 CRYAB EDN1 CCDC47 TCF4 NDUFV2 SLC25A1 MTHFR COQ2 AHI1 ARCN1 FXR1 COX15 PRRT2 NDUFA2 COL13A1 SNRPN DPH1 BUB3 ND3 SMC1A NALCN LARP7 CHAT PCCA SLC18A3 ASCL1 NDUFAF6 PHOX2B TMEM237 GDNF FBN1 TMEM138 TCIRG1 KCNQ2 CDKL5 SLC5A7 SCO2 AMER1 TMEM216 CEP57 NDUFS1 KIAA0753 ZNF423 GPHN CEP41 PIGT DPAGT1 NDUFS2 KIAA0586 NDUFS8 SIM1 BRAT1 CEP120 BRAF D2HGDH P4HTM KATNIP AFF4 LIAS SIX3 SFTPB TDGF1 KAT6B RUNX2 OFD1 USP7 SOD1 KCNQ3 SLC39A8 SLC2A1 HRAS KIAA0586 CTSD B9D1 CDON ADGRG1 TBR1 PDHA1 MAGEL2 CEP290 AHI1 CC2D2A PIBF1 BCHE CHRNE ZIC2 PI4KA FXR1 HSPD1 NONO FOXH1 NDUFAF5 NFIX FGFR3 ECHS1 NDUFS4 SCN8A FGF8 PHOX2B MAGEL2 ACY1 EP300 GLRA1 DNA2 TGIF1 NDUFB8 SDHA NDUFV1 CSPP1 PDE6D TERT ND5 PTCH1 FBP1 FOXRED1 AGRN TDGF1 VPS51 COLQ SNAP25 SHH CC2D2A C2CD3 GLI2 ARMC9 GAS1 INPP5E NDUFS2 SLC19A3 GNE INPP5E TGIF1 NEB MKS1 LIFR TRPV4 SLC5A7 DNA2 SKI NDUFS8 GABRG2 PTCH1 CHAT FOXH1 GBA TMEM237 TGIF1 CLCN7 TECPR2 IPW TCTN2 NGLY1 NEFH BRAT1 TACO1 GLUL ALPL RPGRIP1L PET100 TDGF1 FARS2 TRNW DLL1 SHH RET TGIF1 EP300 RPGRIP1L TRNK CEP120 HSPG2 INPP5E PWRN1 GRIN2A FGFR1 MYO9A TMEM237 BUB1 ND2 FGFR2 CREBBP PCCB NDUFAF2 CEP290 NADK2 NTNG1 CISD2 NODAL MECP2 SYT2 EDN3 DLL1 COQ2 GSN CPT2 DMPK ZC4H2 PEX5 GPR101 COL3A1 PCK1 DLL1 PRPH IDS CEP57 MKS1 UNC80 DISP1

    Reports

    Data processed on September 26, 2020.

    An HTML report was created for each of the unique drugs, MeSH, and HPO terms associated with COVID-19 clinical trials. Each report contains a list of either the drug, the MeSH terms, or the HPO terms. All of the terms in a category are displayed on the left-hand side of the report to enable easy navigation, and the reports contain a list of correlated drugs, MeSH, and HPO terms. Further, all reports contain the details of the clinical trials in which the term is referenced. Every clinical trial report shows the mapped HPO and MeSH terms, which are also hyperlinked. Related HPO terms, with their associated genes, protein mutations, and SNPs are also referenced in the report.

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