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  • HP:0002072: Chorea
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    HP:0002072: Chorea

    Developed by Shray Alag, The Harker School
    Sections: Correlations, Clinical Trials, and HPO

    Correlations computed by analyzing all clinical trials.

    Navigate: Clinical Trials and HPO


    Correlated Drug Terms (2)


    Name (Synonyms) Correlation
    drug4195 Valbenazine Wiki 1.00
    drug1114 Customized questionnaire Wiki 1.00

    Correlated MeSH Terms (2)


    Name (Synonyms) Correlation
    D002819 Chorea NIH 1.00
    D006816 Huntington Disease NIH 0.58

    Correlated HPO Terms (0)


    Name (Synonyms) Correlation

    Clinical Trials

    Navigate: Correlations   HPO

    There is one clinical trial.


    1 Open-Label Rollover Study for Continuing Valbenazine Administration for the Treatment of Chorea Associated With Huntington Disease

    This is a Phase 3, open-label study to evaluate the long-term safety and tolerability of valbenazine, and to provide subjects continued access to valbenazine for the treatment of chorea associated with Huntington disease.

    NCT04400331
    Conditions
    1. Chorea, Huntington
    Interventions
    1. Drug: Valbenazine
    MeSH:Huntington Disease Chorea
    HPO:Chorea Paroxysmal dyskinesia

    Primary Outcomes

    Measure: Number of Participants with Treatment-Emergent Adverse Events (TEAEs)

    Time: Up to 104 weeks

    Secondary Outcomes

    Description: The TMC is part of the motor assessment of the UHDRS and measures chorea in 7 different body parts including the face, oral-buccal-lingual region, trunk and each limb independently. The TMC score is the sum of the individual scores and ranges from 0 to 28. A decrease in score indicates improvement in chorea.

    Measure: Change from Baseline in the Unified Huntington's Disease Rating Scale (UHDRS) Total Maximal Chorea (TMC) Score

    Time: Up to 104 weeks

    HPO Nodes


    HP:0002072: Chorea
    Genes 267
    LMAN2L CACNA1B GRIK2 PRNP ND4 ARX TBP SLC25A22 PIGP AIMP1 RHOBTB2 SPR PRRT2 MECP2 LINS1 UBTF ERCC6 NUP62 FTL SEPSECS MECR SYT1 MRPS34 STXBP1 CRADD GRIN2B HTT DHX30 SLC2A1 PRNP SLC2A1 CHMP1A GPR88 HPRT1 SCO2 SYT1 MED25 ATP5MD NDST1 PTS PANK2 PNPT1 CRBN PIGC FBXL4 ADCY5 GCH1 ATP1A2 MECP2 FXN FBXO31 RSRC1 DLAT PRSS12 MMUT GCDH TRNL1 MAN1B1 PDGFRB FRRS1L SETX TUSC3 TUBB4A NUP62 GCDH PDGFB SCN2A TBP C12ORF4 SLC6A3 PLA2G6 IRF2BPL FOXG1 PRRT2 SLC2A1 KCNA1 ZNF142 ATP6 DMXL2 SLC2A1 PDGFB TAF1 ADAR JPH3 MED23 GRIA4 TRIM8 TSEN2 GABRA2 ARSA JPH3 HNMT GRIA2 KCNMA1 ERCC2 DCAF17 GM2A GNAO1 MBOAT7 KIF5A PNKD GNAO1 GTPBP2 SPOP HSPD1 SLC6A8 NDUFAF5 VAMP2 ADA2 TAF1 DYSF NKX2-1 POU3F3 PITX3 POLG NAXD ND6 CP TSEN34 WASHC4 GUF1 SLC2A1 PRNP PNPT1 MYORG MICOS13 ST3GAL5 XPA FMN2 SLC20A2 KDM5B ATXN7 PLP1 NDUFB8 SLC2A1 GRIN1 CARS2 ND5 AARS1 AP1S2 ATN1 ATM MICU1 HTT PDHA1 PRRT2 XPR1 GM2A SURF1 CLCN4 ATXN1 PSAP ND1 FOXG1 KCNA1 SUOX PRRT2 ELP2 NADK2 PNKD NDUFS2 PANK2 C9ORF72 PDE10A CTDP1 NEUROD2 CASK GAMT ATP1A3 NDUFA9 ATP7A SETX GNAS IQSEC1 CP NDUFA1 SLC45A1 NGLY1 NSUN2 TREM2 B3GALNT2 OPA3 IREB2 EZR TRNV MICU1 QDPR PRRT2 TRAPPC11 SIK1 CDKL5 VPS13A TRAPPC11 DCAF17 ATN1 UGDH TRAPPC11 VPS13A NGLY1 DCPS AP2M1 TYROBP KCNA1 CLIP1 ST3GAL3 MRE11 SLC25A42 ACP5 CACNA2D2 ATXN2 KIF1C TNIK TRNW MRM2 METTL23 OPA3 HTT SCN1B TRNK SLC30A9 EIF2AK2 SCN8A CC2D1A SLC2A3 PGAP1 ATXN1 TRAPPC9 PIK3R5 ARX HSD17B10 ND2 NDUFAF3 GJC2 PDE10A NDUFA13 SARS1 APTX EDC3 FTL TECR HCFC1 NADK2 UBTF MMUT NKX2-1 PIGQ GRIN2B NKX2-1 PNKP DDC ATP6 ARSA ACAT2 FRRS1L ZC3H14 SLC6A3 MRE11 ADCY5 PUM1 PDE10A PTS CLPB PRRT2 PDE10A GNAO1 PIGN ND3
    Protein Mutations 0
    SNP 0

    HPO

    Alphabetical listing of all HPO terms. Navigate: Correlations   Clinical Trials


    HPO Nodes


    HP:0002072: Chorea
    Genes 267
    LMAN2L CACNA1B GRIK2 PRNP ND4 ARX TBP SLC25A22 PIGP AIMP1 RHOBTB2 SPR PRRT2 MECP2 LINS1 UBTF ERCC6 NUP62 FTL SEPSECS MECR SYT1 MRPS34 STXBP1 CRADD GRIN2B HTT DHX30 SLC2A1 PRNP SLC2A1 CHMP1A GPR88 HPRT1 SCO2 SYT1 MED25 ATP5MD NDST1 PTS PANK2 PNPT1 CRBN PIGC FBXL4 ADCY5 GCH1 ATP1A2 MECP2 FXN FBXO31 RSRC1 DLAT PRSS12 MMUT GCDH TRNL1 MAN1B1 PDGFRB FRRS1L SETX TUSC3 TUBB4A NUP62 GCDH PDGFB SCN2A TBP C12ORF4 SLC6A3 PLA2G6 IRF2BPL FOXG1 PRRT2 SLC2A1 KCNA1 ZNF142 ATP6 DMXL2 SLC2A1 PDGFB TAF1 ADAR JPH3 MED23 GRIA4 TRIM8 TSEN2 GABRA2 ARSA JPH3 HNMT GRIA2 KCNMA1 ERCC2 DCAF17 GM2A GNAO1 MBOAT7 KIF5A PNKD GNAO1 GTPBP2 SPOP HSPD1 SLC6A8 NDUFAF5 VAMP2 ADA2 TAF1 DYSF NKX2-1 POU3F3 PITX3 POLG NAXD ND6 CP TSEN34 WASHC4 GUF1 SLC2A1 PRNP PNPT1 MYORG MICOS13 ST3GAL5 XPA FMN2 SLC20A2 KDM5B ATXN7 PLP1 NDUFB8 SLC2A1 GRIN1 CARS2 ND5 AARS1 AP1S2 ATN1 ATM MICU1 HTT PDHA1 PRRT2 XPR1 GM2A SURF1 CLCN4 ATXN1 PSAP ND1 FOXG1 KCNA1 SUOX PRRT2 ELP2 NADK2 PNKD NDUFS2 PANK2 C9ORF72 PDE10A CTDP1 NEUROD2 CASK GAMT ATP1A3 NDUFA9 ATP7A SETX GNAS IQSEC1 CP NDUFA1 SLC45A1 NGLY1 NSUN2 TREM2 B3GALNT2 OPA3 IREB2 EZR TRNV MICU1 QDPR PRRT2 TRAPPC11 SIK1 CDKL5 VPS13A TRAPPC11 DCAF17 ATN1 UGDH TRAPPC11 VPS13A NGLY1 DCPS AP2M1 TYROBP KCNA1 CLIP1 ST3GAL3 MRE11 SLC25A42 ACP5 CACNA2D2 ATXN2 KIF1C TNIK TRNW MRM2 METTL23 OPA3 HTT SCN1B TRNK SLC30A9 EIF2AK2 SCN8A CC2D1A SLC2A3 PGAP1 ATXN1 TRAPPC9 PIK3R5 ARX HSD17B10 ND2 NDUFAF3 GJC2 PDE10A NDUFA13 SARS1 APTX EDC3 FTL TECR HCFC1 NADK2 UBTF MMUT NKX2-1 PIGQ GRIN2B NKX2-1 PNKP DDC ATP6 ARSA ACAT2 FRRS1L ZC3H14 SLC6A3 MRE11 ADCY5 PUM1 PDE10A PTS CLPB PRRT2 PDE10A GNAO1 PIGN ND3
    Protein Mutations 0
    SNP 0

    Reports

    Data processed on September 26, 2020.

    An HTML report was created for each of the unique drugs, MeSH, and HPO terms associated with COVID-19 clinical trials. Each report contains a list of either the drug, the MeSH terms, or the HPO terms. All of the terms in a category are displayed on the left-hand side of the report to enable easy navigation, and the reports contain a list of correlated drugs, MeSH, and HPO terms. Further, all reports contain the details of the clinical trials in which the term is referenced. Every clinical trial report shows the mapped HPO and MeSH terms, which are also hyperlinked. Related HPO terms, with their associated genes, protein mutations, and SNPs are also referenced in the report.

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    263 reports on HPO terms

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