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  • HP:0002143: Abnormality of the spinal cord
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    HP:0002143: Abnormality of the spinal cord

    Developed by Shray Alag, The Harker School
    Sections: Correlations, Clinical Trials, and HPO

    Correlations computed by analyzing all clinical trials.

    Navigate: Clinical Trials and HPO


    Correlated Drug Terms (2)


    Name (Synonyms) Correlation
    drug3359 Reverse-transcription polymerase chain reaction (RT-PCR) Wiki 1.00
    drug897 Chest computed tomography (CT) Wiki 1.00

    Correlated MeSH Terms (2)


    Name (Synonyms) Correlation
    D001855 Bone Marrow Diseases NIH 1.00
    D013118 Spinal Cord Diseases NIH 1.00

    Correlated HPO Terms (1)


    Name (Synonyms) Correlation
    HP:0005561 Abnormality of bone marrow cell morphology HPO 1.00

    Clinical Trials

    Navigate: Correlations   HPO

    There is one clinical trial.


    1 Study of Postural Stability in Subjects With Myelopathy Using a Portable Virtual Reality Balance Protocol

    Veterans are at heightened risk of developing cervical spondylotic myelopathy (CSM) from rigors of military service. Balance and posturography are negatively affected in CSM, but require expensive equipment, and extensive training of personnel for data acquisition and interpretation. The Virtual Environment TBI Screen (VETS) is a simple and inexpensive construct that could be implemented as an aid in diagnosis and as an objective means to compare treatment modalities and track recovery. The goal for the SPiRE is to generate the critical data to support rigorous Merit studies of posturography for assessments of clinical course in the treatment and rehabilitation of CSM. The investigators' ultimate goal, if the SPiRE is successful, is to phase in objective posturography assessments as VA standard of care in CSM.

    NCT03810781
    Conditions
    1. Cervical Spondylotic Myelopathy
    MeSH:Spinal Cord Diseases Bone Marrow Diseases
    HPO:Abnormality of bone marrow cell morphology Abnormality of the spinal cord Myelopathy

    Primary Outcomes

    Description: The postural stability task involves six conditions during which veterans are instructed to look straight ahead and maintain an upright stance as stably as possible. Veterans are barefooted with feet comfortably placed ~25 cm apart. The six conditions are (1) Eyes Open (EO) Firm (2) Eyes Closed (EC) Firm, (3) Dynamic Scene (DYN) Firm, (4) EO Foam, (5) EC Foam, and (6) DYN Foam. Each condition is tested three times with the average center of pressure (COP) sway area used as a index of stability for that condition.

    Measure: Virtual Environment TBI System (VETS) assessment of Static Posturography

    Time: PreSurgery compared to otherwise healthy veterans

    Description: It is expected that posturography, especially that from FOAM and EC conditions will be improved be surgical relief. This is a within comparison of veterans with CSM and receiving surgical relief through widening of the chord.

    Measure: Change in Posturography

    Time: Presurgery compared to 2 weeks, 6 weeks, and 6 months post-surgery. The Post-surgery endpoints are normally scheduled clinical follow ups.

    Secondary Outcomes

    Description: The Nurick scale is a 6-grade ordinal scale assessing gait impairment, with grades ranging from 0 (signs and symptoms of root involvement but no evidence of spinal cord disease) to 5 (chair bound or bedridden). The aggregate value of the Nurick scale will be related to posturography.

    Measure: Nurick Scale

    Time: PreSurgery compared to otherwise healthy veterans

    Description: The NDI is a 10-item questionnaire addressing function activities (personal care, lifting, reading, work, driving, sleeping, and recreation), pain intensity, concentration, and headache. For each item, patients make their ratings on a 6-point Likert scale with values 0 = no disability and 5 = complete disability. Summed scores for each category are multiplied by 2 to give a total NDI score ranging from 0-100. NDI will be related to VETS posturography to determine the sensitivity of standing posture to degree of disability.

    Measure: Neck Disability Index (NDI)

    Time: PreSurgery compared to otherwise healthy veterans

    Description: The SF-36v2 is a general health survey that includes mental and physical component scores to measure functional status and overall quality of life. The instrument includes 8 scales: physical functioning, role limitations physical pain, bodily pain, general health perceptions, vitality, social functioning, role limitations, emotional health, and mental health. The higher the score the more limitations. The total scale will be used to determine the sensitivity of VETS posturography to quality of life.

    Measure: Short Form-36 version 2 (SF-36v2)

    Time: PreSurgery compared to otherwise healthy veterans

    Description: From the VETS, a ratio corresponding to the Rhomberg ratio of COP sway will be used to determine the degree static posture depends on visual input.

    Measure: EC FIRM/EO FIRM ratio

    Time: PreSurgery

    Description: From the VETS, a ratio of COP sway will be used to determine the degree static posture is affected by reduced proprioception.

    Measure: EO FOAM/EO FIRM

    Time: PreSurgery compared to otherwise healthy veterans

    Description: From the VETS, a ratio of COP sway will be used to determine the degree loss of visual information compounds reduced proprioception in static balance.

    Measure: EC FOAM/EO FOAM ratio

    Time: PreSurgery compared to otherwise healthy veterans

    Description: From the VETS, a ratio of COP sway to determine the roll vection is induced by loss of proprioception.

    Measure: DYN FOAM/DYN FIRM ratio

    Time: PreSurgery compared to otherwise healthy veterans

    Description: From the VETS, a ration of COP sway to determine the degree roll vection is induced.

    Measure: DYN FIRM/ EO FIRM ratio

    Time: PreSurgery compared to otherwise healthy veterans

    HPO Nodes


    HP:0002143: Abnormality of the spinal cord
    Genes 340
    MFAP5 SMARCA4 LIG4 ELN EXT1 HES7 MASP1 MAN2B1 FOXF1 NOTCH2 CCND1 PNPLA6 IRF6 B3GALT6 TRAF7 SH2B1 GNPTAB TMEM216 MTHFR LIMK1 DACT1 PDCD10 NF2 VANGL1 FBN1 SMARCB1 HFE PSAT1 COL2A1 TGFB3 GP1BB FANCI GLI3 FA2H WNT7A SLC25A19 NSD2 SEC24C DKK1 LZTR1 NELFA AMER1 CPLX1 C11ORF95 RREB1 BMP2 FBN1 CHN1 RAD51C ARVCF NEK9 FBLN1 DPF2 FKRP NEPRO TDP1 CLIP2 TBX1 NSD2 SLX4 RNASEH1 LOX FKTN SUFU MSX2 FANCF KCNH1 KIAA0586 RECQL4 ELN IKBKG FXN BAZ1B AKT1 WHCR FOXC2 GJB1 RELA FANCD2 BMS1 KIF1B RAD51 JMJD1C PIK3CA UFD1 ERCC4 CREBBP GMPPB FREM2 RMRP GALNS DNAJC3 COLEC10 RFC2 PTPN11 RUNX2 GTF2I XRCC2 POLA1 POMT1 RIPPLY2 ARID1A SIN3A FANCL SMARCB1 SOX4 ALX4 RORA MYH3 PHGDH RUNX2 KRIT1 TWNK TNFRSF11A BRIP1 FLI1 PTCH1 ATXN3 NOTCH3 MASP1 COMP MTHFD1 TBC1D24 DNA2 MYLK DARS2 PUF60 PORCN PAX3 GDF3 LYST PRKG1 HES7 NFIA H19 GLRX5 MPO COL2A1 VHL SNRPB TGFB2 PLP1 ALDH18A1 LETM1 MAT2A FANCE SLC26A2 MNX1 PHGDH HBB ZIC1 ACY1 ARID2 EP300 GDF6 ATXN2 APC ZSWIM6 SLC33A1 BRCA1 CEP290 LMNB1 FANCM ACTA2 TBX6 TGFB2 POMGNT1 FANCC SMARCE1 GDF6 NF2 ATXN3 DLL4 UBE2T NRAS PRPS1 APOE ENG SOX11 FUZ MAP3K7 ARSB WASHC5 AMER1 HMGA2 IDUA RTN2 SPG7 FLNA CREBBP SETX CREBBP MYH11 HABP2 LETM1 GJB2 SALL4 DDR2 FANCG TBX6 APP COMT VANGL1 TBXT TBX1 MAFB ATXN3 GCLC GTF2IRD1 ACVRL1 MYH3 DACT1 CCL2 GNAS CCNQ FOXE3 FLI1 EXTL3 TGFBR2 CCM2 POMT2 PTPN11 A2M FOXE1 RAI1 CCT5 SMAD3 EXT2 RAB23 COL2A1 GRIP1 NF1 MORC2 PHEX RBM8A ITGB4 ALDH18A1 KDM1A IGF2 PUF60 PTCH2 FANCA SMAD4 SMARCC2 MAD2L2 ARID1B MTRR FLVCR1 TWNK SC5D ATXN3 RAF1 FLNA OFD1 CSPP1 CCBE1 ATXN2 RFWD3 POLG PALB2 BMPER SMARCD1 CCND1 FLNB COLEC11 PORCN TRIM36 PNPLA6 SMAD3 FRAS1 HAAO ABCA1 EP300 CTBP1 FBN1 TGFBR1 SC5D PRMT7 INPP5E BRCA2 ATXN1 FGFRL1 CCNQ ZIC1 LFNG CUL7 FRAS1 CCT5 PLEC MTR SETD2 CREBBP MEOX1 NF1 B3GALNT2 COL2A1 ARID1B FANCB KCNQ1OT1 CHRNG NAXE BRAF TNXB LMX1B RRM2B GCLC POLG PLAU TBL2 B3GLCT WNT7A VANGL2 LEMD3 NOTCH2NLC ACTB CTNNB1 PRPS1 HIRA NOS3 GTF2E2 NOTCH3 CYP7B1 MTHFR NSUN2 SALL4 FANCB MFN2 GLB1 LARGE1 RMRP KIF22 MESP2 PAX3 SMAD3 IDS TRPV4 DLL3 MINPP1 FIBP LOX
    Protein Mutations 0
    SNP 0

    HPO

    Alphabetical listing of all HPO terms. Navigate: Correlations   Clinical Trials


    HPO Nodes


    HP:0002143: Abnormality of the spinal cord
    Genes 340
    MFAP5 SMARCA4 LIG4 ELN EXT1 HES7 MASP1 MAN2B1 FOXF1 NOTCH2 CCND1 PNPLA6 IRF6 B3GALT6 TRAF7 SH2B1 GNPTAB TMEM216 MTHFR LIMK1 DACT1 PDCD10 NF2 VANGL1 FBN1 SMARCB1 HFE PSAT1 COL2A1 TGFB3 GP1BB FANCI GLI3 FA2H WNT7A SLC25A19 NSD2 SEC24C DKK1 LZTR1 NELFA AMER1 CPLX1 C11ORF95 RREB1 BMP2 FBN1 CHN1 RAD51C ARVCF NEK9 FBLN1 DPF2 FKRP NEPRO TDP1 CLIP2 TBX1 NSD2 SLX4 RNASEH1 LOX FKTN SUFU MSX2 FANCF KCNH1 KIAA0586 RECQL4 ELN IKBKG FXN BAZ1B AKT1 WHCR FOXC2 GJB1 RELA FANCD2 BMS1 KIF1B RAD51 JMJD1C PIK3CA UFD1 ERCC4 CREBBP GMPPB FREM2 RMRP GALNS DNAJC3 COLEC10 RFC2 PTPN11 RUNX2 GTF2I XRCC2 POLA1 POMT1 RIPPLY2 ARID1A SIN3A FANCL SMARCB1 SOX4 ALX4 RORA MYH3 PHGDH RUNX2 KRIT1 TWNK TNFRSF11A BRIP1 FLI1 PTCH1 ATXN3 NOTCH3 MASP1 COMP MTHFD1 TBC1D24 DNA2 MYLK DARS2 PUF60 PORCN PAX3 GDF3 LYST PRKG1 HES7 NFIA H19 GLRX5 MPO COL2A1 VHL SNRPB TGFB2 PLP1 ALDH18A1 LETM1 MAT2A FANCE SLC26A2 MNX1 PHGDH HBB ZIC1 ACY1 ARID2 EP300 GDF6 ATXN2 APC ZSWIM6 SLC33A1 BRCA1 CEP290 LMNB1 FANCM ACTA2 TBX6 TGFB2 POMGNT1 FANCC SMARCE1 GDF6 NF2 ATXN3 DLL4 UBE2T NRAS PRPS1 APOE ENG SOX11 FUZ MAP3K7 ARSB WASHC5 AMER1 HMGA2 IDUA RTN2 SPG7 FLNA CREBBP SETX CREBBP MYH11 HABP2 LETM1 GJB2 SALL4 DDR2 FANCG TBX6 APP COMT VANGL1 TBXT TBX1 MAFB ATXN3 GCLC GTF2IRD1 ACVRL1 MYH3 DACT1 CCL2 GNAS CCNQ FOXE3 FLI1 EXTL3 TGFBR2 CCM2 POMT2 PTPN11 A2M FOXE1 RAI1 CCT5 SMAD3 EXT2 RAB23 COL2A1 GRIP1 NF1 MORC2 PHEX RBM8A ITGB4 ALDH18A1 KDM1A IGF2 PUF60 PTCH2 FANCA SMAD4 SMARCC2 MAD2L2 ARID1B MTRR FLVCR1 TWNK SC5D ATXN3 RAF1 FLNA OFD1 CSPP1 CCBE1 ATXN2 RFWD3 POLG PALB2 BMPER SMARCD1 CCND1 FLNB COLEC11 PORCN TRIM36 PNPLA6 SMAD3 FRAS1 HAAO ABCA1 EP300 CTBP1 FBN1 TGFBR1 SC5D PRMT7 INPP5E BRCA2 ATXN1 FGFRL1 CCNQ ZIC1 LFNG CUL7 FRAS1 CCT5 PLEC MTR SETD2 CREBBP MEOX1 NF1 B3GALNT2 COL2A1 ARID1B FANCB KCNQ1OT1 CHRNG NAXE BRAF TNXB LMX1B RRM2B GCLC POLG PLAU TBL2 B3GLCT WNT7A VANGL2 LEMD3 NOTCH2NLC ACTB CTNNB1 PRPS1 HIRA NOS3 GTF2E2 NOTCH3 CYP7B1 MTHFR NSUN2 SALL4 FANCB MFN2 GLB1 LARGE1 RMRP KIF22 MESP2 PAX3 SMAD3 IDS TRPV4 DLL3 MINPP1 FIBP LOX
    Protein Mutations 0
    SNP 0

    Reports

    Data processed on September 26, 2020.

    An HTML report was created for each of the unique drugs, MeSH, and HPO terms associated with COVID-19 clinical trials. Each report contains a list of either the drug, the MeSH terms, or the HPO terms. All of the terms in a category are displayed on the left-hand side of the report to enable easy navigation, and the reports contain a list of correlated drugs, MeSH, and HPO terms. Further, all reports contain the details of the clinical trials in which the term is referenced. Every clinical trial report shows the mapped HPO and MeSH terms, which are also hyperlinked. Related HPO terms, with their associated genes, protein mutations, and SNPs are also referenced in the report.

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