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  • HP:0002014: Diarrhea
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    HP:0002014: Diarrhea

    Developed by Shray Alag, The Harker School
    Sections: Correlations, Clinical Trials, and HPO

    Correlations computed by analyzing all clinical trials.

    Navigate: Clinical Trials and HPO


    Correlated Drug Terms (4)


    Name (Synonyms) Correlation
    drug1792 Hydroxychloroquine Pill Wiki 0.71
    drug3638 SivoMixx (200 billion) Wiki 0.50
    drug4510 hydroxychloroquine Wiki 0.32
    Name (Synonyms) Correlation
    drug421 Azithromycin Wiki 0.11

    Correlated MeSH Terms (2)


    Name (Synonyms) Correlation
    D003967 Diarrhea NIH 1.00
    D011014 Pneumonia NIH 0.04

    Correlated HPO Terms (1)


    Name (Synonyms) Correlation
    HP:0002090 Pneumonia HPO 0.04

    Clinical Trials

    Navigate: Correlations   HPO

    There are 2 clinical trials


    1 Evaluation of the Impact of Bacteriotherapy in the Treatment of COVID-19

    In light of its high morbidity and mortality, COronaVIrus Disease 19 (COVID-19) pandemic spread is considered an unprecedented global health challenge. Given the very limited therapeutic options available against Severe Acute Respiratory Syndrome - CoronaVirus-2 (SARS-CoV-2) epidemic at this time, the evaluation of new resources, designed in the first instance for other pathologies but potentially active against COVID-19, represents a priority in clinical research. This is an observational, retrospective, non-profit study on the adjuvant use of bacteriotherapy in the early control of disease progression in patients affected by COVID-19 and treated with the current standard of care on the basis of the interim guidelines of the Italian Society of Infectious and Tropical Diseases. The main purpose of the study is to evaluate the effectiveness of bacteriotherapy in reducing the clinical impact of acute diarrhea, containing the progression of COVID-19 and preventing the need for hospitalization in intensive care units.

    NCT04368351
    Conditions
    1. COVID
    2. Pneumonia
    3. Diarrhea
    Interventions
    1. Dietary Supplement: SivoMixx (200 billion)
    2. Drug: Azithromycin
    3. Drug: hydroxychloroquine
    MeSH:Pneumonia Diarrhea
    HPO:Diarrhea Pneumonia

    Primary Outcomes

    Description: Comparison between the two groups. Acute diarrhea was defined as a stool with increased water content, volume, or frequency that lasts less than 14 days.

    Measure: delta of time of disappearance of acute diarrhea

    Time: 21 days

    Secondary Outcomes

    Description: Comparison between the two groups

    Measure: Delta in the number of patients requiring orotracheal intubation despite treatment

    Time: 21 days

    Description: Comparison between the two groups

    Measure: Delta of crude mortality

    Time: 21 days

    Description: Comparison between the two groups

    Measure: Delta of length of stay for patients in hospital

    Time: 21 days
    2 Corona Virus (COVID-19) Disease Duration and Gastrointestinal Tract (GIT) Manifestations; Can be New Disease Severity Classification. A Pilot Egyptian Single National Center Experience

    The present study conducted to correlate symptoms not only constitutional and respiratory, but GIT as a principle presentation, with laboratory markers and COVID-19 severe acute respiratory syndrome (SARS-COV2) disease outcomes, as the duration of symptoms varies substantially between patients; the investigators undertook this study to determine the optimal time to predict COVID-19 outcomes based on real-time experience.

    NCT04554979
    Conditions
    1. Covid19
    2. Diarrhea
    Interventions
    1. Drug: Hydroxychloroquine Pill
    MeSH:Diarrhea
    HPO:Diarrhea

    Primary Outcomes

    Description: The investigators tried to correlate disease severity with disease duration

    Measure: COVID-19 disease spectrum and duration

    Time: july 2020 to june 2020

    Description: spectrum of GIT manifestations in COVID-19 patients was investigated

    Measure: GIT manifestations among COVID-19 patients

    Time: july 2020 to june 2020

    Secondary Outcomes

    Description: The link between non-communicable disease (including diabetes, hypertension and Hypercholesterolemia) severity and COVID-19 prognosis

    Measure: Non-communicable disease and COVID-19

    Time: july 2020 to june 2020

    Description: the investigators studied the Impact of weather climate on COVID-19 presentations (higher incidence of diarrhea in COVID-19 patients in summer) and outcomes

    Measure: Seasonal change and COVID-19

    Time: july 2020 to june 2020

    Description: The investigators tried to find new Egyptian classification fro COVID-19 disease severity

    Measure: Possible region specific classification for COVID-19 disease

    Time: july 2020 to june 2020

    HPO Nodes


    HP:0002014: Diarrhea
    Genes 392
    AVP TRNL1 MCM6 COG4 ANTXR2 LIPA CD247 HBB WNT2B TYMP MYO5B HMGCS2 DGAT1 IL2RG ALG3 TTR DAXX SERPING1 SLC5A1 BMPR1A EGFR ABCC8 SI PTEN SMARCD2 DBH KRAS BLNK TSHR PRKN LRRK2 PPP2R5D DNAJC6 KIF1B CD247 IKBKB SCNN1B AGA ADA RAG1 RAG1 COX2 TXNRD2 CARMIL2 BTD IL21R ABCB11 ERCC2 ATP8B1 G6PC CYP7B1 NAGLU STX3 IGHM ERCC4 CD79A TLK2 KCNJ1 TRNH FBP1 MPI MRAP SLC46A1 HGSNAT RET TTR TTC37 GINS1 TET2 BTK IL7R TCN2 RNF113A PIK3CD NBN RET ACTG2 IL2RB RAG2 CD19 ACADM HLA-B RFX6 HNF4A ITCH CD40LG ICOS POLG IDUA CFHR3 MPV17 SAA1 FOXP3 MEFV AP1S1 CIITA IGKC ENG TRNS2 TRNS1 RAG2 ZAP70 STAR NOD2 RECQL4 BRCA2 RFXANK IL6 ITGB3 HBB ITGA2 HYOU1 GATA6 ND4 EGFR BRCA1 ELANE SLC19A2 ND5 SPINT2 IL7R SCNN1A TCIRG1 COX1 SMAD4 CYP27A1 SAMD9 RAG1 LIPA SERPING1 IL21 SDHD CD55 BMPR1A TTC37 GUCY2C ATP7A LCT RFX5 SKIV2L DCLRE1C SON HMBS IRAK1 JAK3 CD109 POLA1 RRM2B RAG2 ITGB4 CTLA4 TERT HMGCL ECE1 CIITA SLC25A13 BTK SLC9A3 TRNF NEUROG3 CFHR1 ZAP70 GP1BA FOXP3 KIF23 KNSTRN TYMP NR3C2 TCF3 HEXB UCHL1 ICOS NNT POLG CDKN1A NEUROG3 TNFRSF13B ADA EPCAM CYP11B2 CCDC47 SLC10A2 UCP2 NSUN2 SRP54 PARK7 IGHM IL10RA NRTN GREM1 DCLRE1C RIPK1 LIG4 OPLAH MC2R AK2 CD79A IL2RG CYP27A1 PLEC ACAT1 CDKN1B MEN1 SCNN1G SLC39A4 TNFRSF13C PINK1 STAT1 HMBS SMAD4 DNMT3B CHD7 MVK PERCC1 COG4 STAT4 EDNRB ALDOB LRBA KCNJ11 RFXAP ATRX SYNJ1 TREH CFH CR2 TRNQ HPS1 CD3D SEMA3C DNASE1L3 SMAD4 SGSH WAS CDKN2C PODXL USP7 CDKN2A SPP1 MLYCD IL6ST LRRC8A ACSF3 TKFC NAGS ETHE1 SAR1B ASXL1 GDNF IGLL1 CD79B B2M NCF4 SLC25A13 ALAD CD79B BLNK SLC7A7 EDN3 LCK HNF1A RAG2 CD3E COX3 MGME1 TTC7A NLRC4 CLMP MEN1 ABCB4 RNF168 VPS13C SNCA ND1 NAXD NOD2 MYD88 TP53 BMPR1A PIK3R1 CR2 MTTP SERPING1 APC CASP8 SLC12A3 PKP1 CPT1A ADA AIRE PLVAP IKZF1 DES F5 RFXANK IL2RA CLCNKB IL2RG WDR1 HSD3B7 MGME1 TTC7A ADAM17 OTULIN BTK BACH2 PALLD SRSF2 RUNX1 WIPF1 CD3D MAOA ITGA6 RFX5 C5 DCLRE1C ASAH1 SUGCT PALB2 GLA MEFV ACVRL1 MVK SCN11A BMPR1A COG6 CBL SLC39A4 ITGA2B HADH TSHR ANTXR2 SLC12A1 SP110 TMPRSS15 PPP2R5D PMM2 PIGT ERCC8 TFRC ETHE1 TRNW ARX IFNG TNFRSF1A SCN9A ND6 MYO5B RFXAP ACSF3 RAG1 ALG8 SMAD4 CPOX ENG PCSK1 RMRP WAS MVK PTPRC ELP1 GFI1 AKR1D1 SLC46A1 DDC ADAM17 ERCC6 SLC7A7 SAR1B CDKN2B PIK3R1 PHKB RECQL4 SKIV2L JAK3 DMPK LIG4 IL7R NHLRC2 TGFB1 CDKN1B GALT IFNGR1 SLC26A3 IDS GP1BB EFL1 SEMA3D HTRA2 NBN GNS STAT1
    Protein Mutations 1
    R192G
    SNP 0

    HPO

    Alphabetical listing of all HPO terms. Navigate: Correlations   Clinical Trials


    HPO Nodes


    HP:0002014: Diarrhea
    Genes 392
    AVP TRNL1 MCM6 COG4 ANTXR2 LIPA CD247 HBB WNT2B TYMP MYO5B HMGCS2 DGAT1 IL2RG ALG3 TTR DAXX SERPING1 SLC5A1 BMPR1A EGFR ABCC8 SI PTEN SMARCD2 DBH KRAS BLNK TSHR PRKN LRRK2 PPP2R5D DNAJC6 KIF1B CD247 IKBKB SCNN1B AGA ADA RAG1 RAG1 COX2 TXNRD2 CARMIL2 BTD IL21R ABCB11 ERCC2 ATP8B1 G6PC CYP7B1 NAGLU STX3 IGHM ERCC4 CD79A TLK2 KCNJ1 TRNH FBP1 MPI MRAP SLC46A1 HGSNAT RET TTR TTC37 GINS1 TET2 BTK IL7R TCN2 RNF113A PIK3CD NBN RET ACTG2 IL2RB RAG2 CD19 ACADM HLA-B RFX6 HNF4A ITCH CD40LG ICOS POLG IDUA CFHR3 MPV17 SAA1 FOXP3 MEFV AP1S1 CIITA IGKC ENG TRNS2 TRNS1 RAG2 ZAP70 STAR NOD2 RECQL4 BRCA2 RFXANK IL6 ITGB3 HBB ITGA2 HYOU1 GATA6 ND4 EGFR BRCA1 ELANE SLC19A2 ND5 SPINT2 IL7R SCNN1A TCIRG1 COX1 SMAD4 CYP27A1 SAMD9 RAG1 LIPA SERPING1 IL21 SDHD CD55 BMPR1A TTC37 GUCY2C ATP7A LCT RFX5 SKIV2L DCLRE1C SON HMBS IRAK1 JAK3 CD109 POLA1 RRM2B RAG2 ITGB4 CTLA4 TERT HMGCL ECE1 CIITA SLC25A13 BTK SLC9A3 TRNF NEUROG3 CFHR1 ZAP70 GP1BA FOXP3 KIF23 KNSTRN TYMP NR3C2 TCF3 HEXB UCHL1 ICOS NNT POLG CDKN1A NEUROG3 TNFRSF13B ADA EPCAM CYP11B2 CCDC47 SLC10A2 UCP2 NSUN2 SRP54 PARK7 IGHM IL10RA NRTN GREM1 DCLRE1C RIPK1 LIG4 OPLAH MC2R AK2 CD79A IL2RG CYP27A1 PLEC ACAT1 CDKN1B MEN1 SCNN1G SLC39A4 TNFRSF13C PINK1 STAT1 HMBS SMAD4 DNMT3B CHD7 MVK PERCC1 COG4 STAT4 EDNRB ALDOB LRBA KCNJ11 RFXAP ATRX SYNJ1 TREH CFH CR2 TRNQ HPS1 CD3D SEMA3C DNASE1L3 SMAD4 SGSH WAS CDKN2C PODXL USP7 CDKN2A SPP1 MLYCD IL6ST LRRC8A ACSF3 TKFC NAGS ETHE1 SAR1B ASXL1 GDNF IGLL1 CD79B B2M NCF4 SLC25A13 ALAD CD79B BLNK SLC7A7 EDN3 LCK HNF1A RAG2 CD3E COX3 MGME1 TTC7A NLRC4 CLMP MEN1 ABCB4 RNF168 VPS13C SNCA ND1 NAXD NOD2 MYD88 TP53 BMPR1A PIK3R1 CR2 MTTP SERPING1 APC CASP8 SLC12A3 PKP1 CPT1A ADA AIRE PLVAP IKZF1 DES F5 RFXANK IL2RA CLCNKB IL2RG WDR1 HSD3B7 MGME1 TTC7A ADAM17 OTULIN BTK BACH2 PALLD SRSF2 RUNX1 WIPF1 CD3D MAOA ITGA6 RFX5 C5 DCLRE1C ASAH1 SUGCT PALB2 GLA MEFV ACVRL1 MVK SCN11A BMPR1A COG6 CBL SLC39A4 ITGA2B HADH TSHR ANTXR2 SLC12A1 SP110 TMPRSS15 PPP2R5D PMM2 PIGT ERCC8 TFRC ETHE1 TRNW ARX IFNG TNFRSF1A SCN9A ND6 MYO5B RFXAP ACSF3 RAG1 ALG8 SMAD4 CPOX ENG PCSK1 RMRP WAS MVK PTPRC ELP1 GFI1 AKR1D1 SLC46A1 DDC ADAM17 ERCC6 SLC7A7 SAR1B CDKN2B PIK3R1 PHKB RECQL4 SKIV2L JAK3 DMPK LIG4 IL7R NHLRC2 TGFB1 CDKN1B GALT IFNGR1 SLC26A3 IDS GP1BB EFL1 SEMA3D HTRA2 NBN GNS STAT1
    Protein Mutations 1
    R192G
    SNP 0

    Reports

    Data processed on September 26, 2020.

    An HTML report was created for each of the unique drugs, MeSH, and HPO terms associated with COVID-19 clinical trials. Each report contains a list of either the drug, the MeSH terms, or the HPO terms. All of the terms in a category are displayed on the left-hand side of the report to enable easy navigation, and the reports contain a list of correlated drugs, MeSH, and HPO terms. Further, all reports contain the details of the clinical trials in which the term is referenced. Every clinical trial report shows the mapped HPO and MeSH terms, which are also hyperlinked. Related HPO terms, with their associated genes, protein mutations, and SNPs are also referenced in the report.

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