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    HP:0002870: Obstructive sleep apnea

    Developed by Shray Alag, The Harker School
    Sections: Correlations, Clinical Trials, and HPO

    Correlations computed by analyzing all clinical trials.

    Navigate: Clinical Trials and HPO

    Correlated Drug Terms (10)

    Name (Synonyms) Correlation
    drug1004 Comparator full face mask 3 Wiki 0.45
    drug1745 Home Sleep Apnea Testing or In-hospital Polysomnography Wiki 0.45
    drug4038 Toffee Full Face Mask Wiki 0.45
    Name (Synonyms) Correlation
    drug1002 Comparator full face mask 1 Wiki 0.45
    drug3642 Skin biopsy Wiki 0.45
    drug684 CBT-OSA Wiki 0.45
    drug3644 Sleep Education Wiki 0.45
    drug1003 Comparator full face mask 2 Wiki 0.45
    drug614 Blood sampling Wiki 0.37
    drug4006 Throat swab Wiki 0.32

    Correlated MeSH Terms (9)

    Name (Synonyms) Correlation
    D020181 Sleep Apnea, Obstructive NIH 1.00
    D012891 Sleep Apnea, NIH 0.80
    D001049 Apnea NIH 0.63
    Name (Synonyms) Correlation
    D009103 Multiple Sclerosis NIH 0.11
    D012598 Scoliosi NIH 0.10
    D040921 Stress Disorders, Traumatic NIH 0.08
    D013313 Stress Disorders, Post-Traumatic NIH 0.07
    D013577 Syndrome NIH 0.04
    D011014 Pneumonia NIH 0.02

    Correlated HPO Terms (3)

    Name (Synonyms) Correlation
    HP:0010535 Sleep apnea HPO 0.80
    HP:0002104 Apnea HPO 0.63
    HP:0002090 Pneumonia HPO 0.02

    Clinical Trials

    Navigate: Correlations   HPO

    There are 5 clinical trials

    1 Cognitive Behavioral Therapy to Increase CPAP Adherence in Veterans With PTSD

    Approximately 20 million Americans suffer from Obstructive Sleep Apnea (OSA) creating risks for major health problems, including dementia, heart attack, and stroke. Obesity, a growing problem for Americans and Veterans alike, is the greatest risk factor for the development of OSA. Male gender and smoking, other OSA risk factors, are common in Veterans. Given the high comorbidity of these risk factors in Veterans, OSA presents a significant health burden to Veterans. The investigators' prior work provides evidence that OSA occurs in up to 69% of Vietnam-era Veterans with PTSD. OSA is easily treated; however, 15-30% of OSA patients are non-compliant with continuous positive airway pressure (CPAP), the standard OSA treatment. The proposed research aims to facilitate adherence to CPAP treatment by testing a novel cognitive-behavioral therapy intervention in Veterans with PTSD. If successful, it may represent an approach that could be applied to the rehabilitation of other chronic conditions with similar barriers to care.

    1. Obstructive Sleep Apnea
    2. PTSD
    3. Posttraumatic Stress Disorder
    1. Behavioral: CBT-OSA
    2. Behavioral: Sleep Education
    MeSH:Sleep Apnea Syndromes Sleep Apnea, Obstructive Stress Disorders, Traumatic Stres Stress Disorders, Post-Traumatic
    HPO:Obstructive sleep apnea Sleep apnea

    Primary Outcomes

    Description: The CPAP machine will measure the number of hours that the CPAP mask is on the participant's face and in use.

    Measure: Time in hours of "mask-on" CPAP usage per night

    Time: 1 year

    Secondary Outcomes

    Description: Effect of CBT on Self-reported Everyday Activities, Mood and Quality of Life. The investigators hypothesize that after initiating CPAP treatment, Veterans in the CBT-OSA group will report more improvement in the ease of performing everyday activities compared to that reported by those in the Education group.

    Measure: Functional Outcomes of Sleep Questionnaire (FOSQ)

    Time: 1 year

    Description: Effect of CBT on Cognitive Outcomes. The CBT-OSA group will have better cognitive outcomes than the Education group over time. The California Verbal Learning Test-II, Delayed Recall Score is the cognitive outcome measure.

    Measure: California Verbal Learning Test, Second Edition (CVLT-II)

    Time: 1 year

    Description: Effect of CBT on PTSD. The CBT-OSA group will have fewer PTSD symptoms than the Education group over time. The PTSD Checklist for DSM-5 (PCL-5) will be the PTSD outcome measure.

    Measure: PTSD Checklist for DSM-5 (PCL-5)

    Time: 1 year
    2 Impact of Obstructive Sleep Apnea on Covid-19 Outcomes (OSACOVID-19 Study): A Prospective Observational Cohort Study

    Covid-19 infection is an on-going pandemic with worse diagnosis in adults with comorbid conditions such as hypertension and cardiopulmonary diseases. Obstructive sleep apnea (OSA) is common in those comorbidities and may contribute to worse prognosis for the Covid-19 cases.

    1. COVID
    2. Obstructive Sleep Apnea
    3. Pneumonia
    1. Diagnostic Test: Home Sleep Apnea Testing or In-hospital Polysomnography
    MeSH:Apnea Sleep Apnea Syndromes Pneumonia Sleep Apnea, Obstructive
    HPO:Apnea Obstructive sleep apnea Pneumonia Sleep apnea

    Primary Outcomes

    Description: Defined as a decline of 2 categories from admission on a 7-category ordinal scale

    Measure: The rate of clinical improvement

    Time: 7 days

    Description: Defined as a decline of 2 categories from admission on a 7-category ordinal scale

    Measure: The rate of clinical improvement

    Time: 14 days

    Description: Defined as a decline of 2 categories from admission on a 7-category ordinal scale

    Measure: The rate of clinical improvement

    Time: 21 days

    Description: Defined as a decline of 2 categories from admission on a 7-category ordinal scale

    Measure: The rate of clinical improvement

    Time: 28 days

    Secondary Outcomes

    Description: Time to hospital discharge, ICU discharge, weaning from intubation, weaning from supplemental oxygen, incident pneumonia, ARDS, in-hospital mortality

    Measure: Clinical status - improvement

    Time: 7, 14, 21, 28 days

    Description: Defined as an increase in category on a 7-category ordinal scale from admission

    Measure: Clinical status - worsening

    Time: 7, 14, 21, 28 days

    Other Outcomes

    Description: Re-analysis of the correlation of obstructive sleep apnea (objectively verified) severity in terms of apnea-hypopnea index and oxygenation levels with the primary and secondary outcomes as described above (the rate of clinical improvement defined as a decline of 2 categories from admission on a 7-category ordinal scale; time to hospital discharge, ICU discharge, weaning from intubation, weaning from supplemental oxygen, incident pneumonia, ARDS, in-hospital mortality as well as with the lung function, CO-diffusion capacity, cardiac function, CT thorax pathologies, biomarkers (cytokines, polymorphisms) and IgG-antibodies after 4 months.

    Measure: Long-term outcomes

    Time: 4-6 months after the initial hospital admission
    3 Evaluation of Physical Activity Level and Sleep Quality in Patients With Obstructive Sleep Apnea Syndrome During Covid-19 Pandemic

    As long as the people stay at home because of the Covid 19 outbreak, the investigators assume that the sleep quality of OUAS patients, like everyone else, and the sleep quality of COVID-19 outbreak are reduced due to anxiety and anxiety in people. In addition, we assume that sleep quality and physical activity level are related to health literacy level and fear of movement (kinesiophobia). In this study; the investigators aimed to determine how patients are affected by this process by evaluating sleep quality, physical activity, fear of movement and health literacy in OSAS patients during our stay in the COVID-19 outbreak.

    1. Obstructive Sleep Apnea-hypopnea Syndrome
    MeSH:Sleep Apnea Syndromes Sleep Apnea, Obstructive Syndrome
    HPO:Obstructive sleep apnea Sleep apnea

    Primary Outcomes

    Description: International Physical Activity Questionnaire/ In activity-specific scoring, walking under the heading of the fields is calculated by the sum of the moderate intensity activity and intensive activity in itself. From these calculations, a score is obtained in MET-minutes. There are 3 categories of physical activity level classification. Physical activity levels are classified as physically inactive (inactive), low level of physical activity (minimally active) and sufficient level of physical activity (very active)

    Measure: Physical Activity

    Time: 1 day

    Description: The Pittsburgh Sleep Quality Index

    Measure: Sleep Quality

    Time: 1 day

    Secondary Outcomes

    Description: In order to measure the general sleepiness of people during the day, it was evaluated with a standard questionnaire, which is defined as Epworth sleepiness scale (EUS) and consists of 8 questions. The answers for each question are scored between 0 and 3 and the total score is obtained. The score obtained above 10 in EUS has high sensitivity and specificity for daytime sleepiness.

    Measure: Daytime Sleepiness

    Time: 1 day

    Description: Tampa Kinesiophobia Scale (TKS)The person gets a total score between 17-68. The high score on the scale indicates that kinesiophobia is also high

    Measure: Fear of movement

    Time: 1 day

    Description: Translated into Turkish TURKEY health literacy SCALE-32 (Tsoy-32) will be used. It was used to evaluate the literacy rates of individuals over the age of 15. 0 indicates the lowest health literacy and 50 indicates the highest health literacy.

    Measure: Health literacy

    Time: 1 day

    Other Outcomes

    Description: In the human circadian rhythm, the Morning Morning-Evening Survey (SAA) form was used, which determined morning and evening types.

    Measure: Circadian rhythm evaluation

    Time: 1 day
    4 Prevalence and Impact of Obstructive Sleep Apnea in Multiple Sclerosis

    This study will evaluate the influence of sleep apnea on clinical and radiological features of MS. Sleep apnea is associated with hypoxemia during sleep, which we believe is detrimental to MS. We will examine clinical data (MRI, lab results, medical history, labs, and sleep studies) of Dr. Sloane's MS patients. This will allow us to study correlations between MRI, clinical data, lab studies and sleep studies. We are specifically interested in the type of sleep apnea associated with MS, and whether MRI or clinical metrics of MS severity correlate with presence or absence of sleep apnea.

    1. Multiple Sclerosis
    2. Obstructive Sleep Apnea
    MeSH:Apnea Sleep Apnea Syndromes Sleep Apnea, Obstructive Multiple Sclerosis Sclerosis
    HPO:Apnea Obstructive sleep apnea Sleep apnea

    Primary Outcomes

    Description: Home Sleep Study Data

    Measure: Home Sleep Study Data

    Time: 1 year

    Secondary Outcomes

    Description: sleep quality, quality of life, depression and anxiety scales

    Measure: Questionnaire data

    Time: 1 year
    5 F&P Toffee Full Face Mask Clinical Trial, NZ, 2020

    This will be a prospective, multi-arm, randomized, and non-blinded clinical trial designed to evaluate the performance, comfort, and usability of the Toffee full face mask amongst participants who have been prescribed PAP therapy by a physician. This clinical trial will take place across three investigation sites with a sample of 45 participants.

    1. Positive Airway Pressure Therapy
    2. Obstructive Sleep Apnea
    1. Device: Comparator full face mask 1
    2. Device: Comparator full face mask 2
    3. Device: Comparator full face mask 3
    4. Device: Toffee Full Face Mask
    MeSH:Sleep Apnea, Obstructive
    HPO:Obstructive sleep apnea

    Primary Outcomes

    Description: To assess the comfort of the mask as experienced by the participant. Comfort will be measured on a 5 point likert type scale from Very Uncomfortable to Very Comfortable. Different aspects of the mask such as cushion comfort, headgear comfort and overall comfort will be assessed using the same scale. Questions will be asked on a questionnaire and further qualitative responses will be captured during an interview.

    Measure: Comfort

    Time: Assessed 2 weeks after mask fitting

    Description: To assess the ease of use of the mask as experienced by the participant. Questions regarding the ease of assembly, disassembly and mask fitting will be asked using a 5 point likert type scale with responses ranging from Very Easy to Very Difficult. Questions will be asked via a questionnaire with additional qualitative responses captured during an interview.

    Measure: Usability

    Time: Assessed 2 weeks after mask fitting

    Description: To assess the long term reliability and durability of the mask when used in a home. environment over an extended period of time. Open ended questions during a semi-structured interview will be asked to participants who will provide qualitative information on their experience using the mask with specific regard to broken or degraded parts and components.

    Measure: Reliability and Durability

    Time: Assessed 4 months after mask fitting

    HPO Nodes


    Data processed on September 26, 2020.

    An HTML report was created for each of the unique drugs, MeSH, and HPO terms associated with COVID-19 clinical trials. Each report contains a list of either the drug, the MeSH terms, or the HPO terms. All of the terms in a category are displayed on the left-hand side of the report to enable easy navigation, and the reports contain a list of correlated drugs, MeSH, and HPO terms. Further, all reports contain the details of the clinical trials in which the term is referenced. Every clinical trial report shows the mapped HPO and MeSH terms, which are also hyperlinked. Related HPO terms, with their associated genes, protein mutations, and SNPs are also referenced in the report.

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