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    HP:0004324: Increased body weight

    Developed by Shray Alag, The Harker School
    Sections: Correlations, Clinical Trials, and HPO

    Correlations computed by analyzing all clinical trials.

    Navigate: Clinical Trials and HPO


    Correlated Drug Terms (2)


    Name (Synonyms) Correlation
    drug1703 Healthy lifestyle advise Wiki 1.00
    drug1446 Exercise program Wiki 0.71

    Correlated MeSH Terms (5)


    Name (Synonyms) Correlation
    D005317 Fetal Growth Retardation NIH 1.00
    D000078064 Gestational Weight Gain NIH 1.00
    D015430 Weight Gain NIH 1.00
    Name (Synonyms) Correlation
    D046110 Hypertension, Pregnancy-Induced NIH 0.71
    D011248 Pregnancy Complications NIH 0.32

    Correlated HPO Terms (1)


    Name (Synonyms) Correlation
    HP:0001511 Intrauterine growth retardation HPO 1.00

    Clinical Trials

    Navigate: Correlations   HPO

    There is one clinical trial.


    1 Active Pregnancy, Prevention Against the Effects of COVID-19

    Historically and traditionally, the recommendations related to physical exercise during pregnancy have been based more on moral or cultural issues than on scientific evidence. During some phases of history, pregnancy has meant a period of seclusion for women (not only physical). One of the adverse consequences has been the common recommendation of rest as a general rule for pregnant women. Scientific evidence from recent years has achieved a better understanding of the process of pregnancy and childbirth as well as maternal and fetal responses to exercise. Currently, both from a scientific and clinical/obstetric point of view, there is no doubt about the benefits of an active pregnancy for entire body of pregnant woman, and even her child. In fact, risks of a sedentary lifestyle are applicable to the pregnancy situation, even more with important associated complications during pregnancy and postpartum period. Unfortunately, the impact of COVID-19 has caused an unprecedented global crisis, in this sense the necessary measures taken by the different administrations, especially in terms of confinement causes (from now on) a large number of complications affecting different populations. In summary a complex situation without established prevention strategies exists. The pregnant population is, due to the nature of the gestation and delivery process, one of the population groups with the highest risk of adverse outcomes and associated complications and whose consequences include the mother, fetus, newborn and even children. According to an important body of scientific literature and based on an epigenetic effect, the intrauterine environment can be a determining factor for the future human being to evolve regardless of complications and pathologies (cardiovascular, metabolic, psychic, emotional). This is demonstrated by numerous recent scientific evidences that confirm the unfortunate association between an adverse intrauterine environment (due to various factors) and observable postnatal pathologies in infants. In addition, current publications report the large number and variety of alterations that the COVID-19 situation causes in pregnant women and that includes the entire female organism. This complex situation does not only affect aspects of a physical or physiological nature, but also psychic and emotional factors. In summary, a new state of confinement or similar situations in the near future (impossibility of groupings, distance between people), avoid during the daily life of pregnant women one of the important and recent recommendations made by the international scientific community: a pregnancy physically active. This is especially relevant, due to the dangerous association between complications of a psychological or emotional nature during pregnancy with pre, peri and postnatal disorders (low birth weights, perinatal complications, altered and prolonged deliveries, etc.), which affect not only to the mother and can determine the health of the future human being. According to the scientific literature and based on an epigenetic effect, the intrauterine environment can be a determining aspect in the health of the future human being and the prevention of complications and pathologies (cardiovascular, metabolic, psychic, emotional). This is demonstrated by numerous and recent scientific evidences that confirm the unfortunate association between an adverse intrauterine environment (due to various factors) and different pathologies during and after pregnancy. It is evident the change that COVID-19 and its effects will generate in the lifestyle of the pregnant population and the increased probability of suffering associated pathologies in the next 24-36 months. No preventive actions have yet been planned in Spain and its public hospitals against the impact of COVID-19 on the quality of life of pregnant women. It is urgent to design and perform an adequate strategy of intervention for its possible prevention. From the scientific point of view, the recommendations are clear and concrete, an aerobic exercise program, designed and supervised by professionals from the Sciences of Physical Activity and Sports, is the best option for pregnant women. In this sense, in the last 30 years, physical exercise has proven to have many benefits for pregnant women, without causing risks or adverse effects on maternal-fetal well-being. This is confirmed by an important body of scientific literature on gestational physical exercise and its effects on pregnancy outcomes.

    NCT04563065
    Conditions
    1. Pregnancy Complications
    2. Pregnancy, High Risk
    3. Pregnancy Induced Hypertension
    4. Newborn Morbidity
    5. Fetal Growth Retardation
    6. Fetus Disorder
    7. Weight Gain, Maternal
    8. Maternal-Fetal Relations
    Interventions
    1. Other: Exercise program
    2. Other: Healthy lifestyle advise
    MeSH:Pregnancy Complications Fetal Growth Retardation Hypertension, Pregnancy-Induced Weight Gain Gestational Weight Gain
    HPO:Increased body weight Intrauterine growth retardation

    Primary Outcomes

    Description: analyze the increase during pregnancy

    Measure: Maternal weight gain

    Time: 9 months

    Description: analyze how it varies during pregnancy

    Measure: blood pressure

    Time: 9 months

    Description: analyze the value and its interrelationship with physical exercise patterns

    Measure: OGTT-O'Sullivan test

    Time: 1 month

    Description: analyze with a questionnaire the value and its interrelationship with physical exercise patterns (different measures in the questionnaire)

    Measure: Urinary Incontinence Questionnaire (ICIQ-SF)

    Time: 9 months

    Description: analyze with a questionnaire the value and its interrelationship with physical exercise patterns (Likert scale 0-3)

    Measure: State-Trait Anxiety Inventory (STAI)

    Time: 9 months

    Description: analyze with a questionnaire the variability during pregnancy (Likert scale 0-3)

    Measure: depression scale (CES-D)

    Time: 9 months

    Description: analyze variability during pregnancy

    Measure: Behavior of Fetal Heart Rate

    Time: 3 months

    Description: analyze the value and its interrelationship with physical exercise patterns

    Measure: gestational age

    Time: 9 months

    Description: analyze whether women have had a vaginal, instrumental or cesarean delivery and its interrelationship with physical exercise patterns

    Measure: type of delivery (Vaginal, instrumental or cesarean)

    Time: 1 month

    Description: analyze the value and its interrelationship with physical exercise patterns

    Measure: duration of labor

    Time: 1 month

    Description: analyze the value and its interrelationship with physical exercise patterns

    Measure: birthweight

    Time: 1 month

    Description: analyze the value and its interrelationship with physical exercise patterns during pregnancy

    Measure: child's weight

    Time: 24 months

    Description: analyze the value and its interrelationship with physical exercise patterns during pregnancy

    Measure: child's height

    Time: 24 months

    Description: analyze the value and its interrelationship with physical exercise patterns during pregnancy (Likert scale 0-3)

    Measure: mental assessment of the child (depression questionnaire adapted to childhood)

    Time: 24 months

    Secondary Outcomes

    Description: analyze the value and its interrelationship with physical exercise patterns

    Measure: Maternal pains during pregnancy (headache, back pain, pelvic pain, paravertebral, scapular, etc.)

    Time: 9 months

    Description: analyze the value and its interrelationship with physical exercise patterns

    Measure: fetal growth and development

    Time: 9 months

    Description: analyze the value and its interrelationship with physical exercise patterns

    Measure: Delivery tears

    Time: 1 month

    Description: analyze the appearance (descriptive: yes/no) and its interrelationship with physical exercise patterns

    Measure: performing episiotomy during childbirth

    Time: 1 month

    Description: analyze the value and its interrelationship with physical exercise patterns

    Measure: Apgar Score

    Time: 1 month

    Description: analyze the value and its interrelationship with physical exercise patterns

    Measure: length

    Time: 1 month

    Description: analyze the value and its interrelationship with physical exercise patterns

    Measure: cranial perimeter

    Time: 1 month

    Description: analyze the value and its interrelationship with physical exercise patterns

    Measure: Landau reflexes test

    Time: 1 month

    Description: analyze the number of admissions and its interrelationship with physical exercise patterns

    Measure: neonatal intensive care unit (NICU)

    Time: 1 month

    Description: analyze how it varies during postpartum period

    Measure: Postpartum recovery of pre-pregnancy weight

    Time: 12 months

    Description: analyze with a questionnaire how it varies during postpartum period (Likert scale 0-3)

    Measure: Edinburgh Postpartum Depression Scale (EPDS)

    Time: 12 months

    Other Outcomes

    Description: analyze the value and its interrelationship with physical exercise patterns (Likert scale)

    Measure: Perception of health status - SF36 health scale

    Time: 24 months

    Description: analyze the diameter and thickness of muscles in the perineal area and its interrelationship with physical exercise patterns

    Measure: Recovery of pelvic floor muscles ultrasound

    Time: 6 months

    Description: analyzewith a questionnaire how it varies during and after pregnancy

    Measure: Maternal habits of physical activity - Pregnancy Physical Activity Questionnaire (PPAQ)

    Time: 12 months

    HPO Nodes


    HP:0004324: Increased body weight
    Genes 543
    NR2E3 WT1 LMNA TBX3 POGZ PROK2 DCC MID2 SDCCAG8 ZNF41 RAB39B LIMK1 CNKSR2 PRPF4 PDE11A RP2 USP27X BBS10 CTNNB1 KIDINS220 FGFR3 XYLT1 PDE6B TOPORS GP1BB BBS7 GATA4 ARL2BP MTOR KCNJ11 MLXIPL HS6ST1 CEP290 GHRL EGF TAF1 PRKAR1A SEC24C PROM1 BBS12 POMC NPHP1 CARTPT ABCC8 PIGA C8ORF37 APOE RYR1 DMD ZBTB20 AP4E1 BBS2 SYNE2 BLK THRA UBE3A CCDC141 TMEM43 FTSJ1 HCFC1 FEZF1 SOX2 CACNA1S CDH23 BBS7 EMD ELN IFT172 CEL MAGEL2 TMEM67 JMJD1C UFD1 NIN ARMC5 CREBBP MKKS PDE6A BAP1 FHL1 GTF2I NEUROD1 USH2A SIN3A KIF7 RBMX PCARE CXORF56 EXOC6B MCM3AP HERC1 PTCH1 LEP HNF4A TBX1 HERC2 MED12 PDX1 OTX2 USP9X ARL6 LZTFL1 PWAR1 ADRB3 BBS9 RPE65 REEP6 RLBP1 HNF1A TRIP4 ERMARD TTC8 POMGNT1 INPP5E WDPCP CUL4B SAG SDCCAG8 MYF6 SDC3 HESX1 KMT2A BLK RAD21 SEMA4A MOG ATP6AP2 CEP164 ARL6 BBS12 POMC MAN1B1 CTSH ALMS1 HNF4A HSD11B1 NPAP1 CDHR1 RERE BLM HCRT ARNT2 FLRT3 BBS4 ROM1 SNORD116-1 ARHGEF6 AP4M1 ZNF711 ZNF513 GDI1 GNAS VPS13B RP1 FTO PRKACA DDX6 PCNT POU3F4 AP4B1 TULP1 DUSP6 MC4R PNPLA6 RNF135 SYP CREBBP SPATA7 LMNA GABRA3 H6PD CA4 NIPBL GNAS MKRN3 FMR1 SNORD115-1 RP9 MC3R MKS1 BBS2 PHF6 FIBP SUFU GNAS-AS1 WDR11 TSPAN7 MERTK GNAS MTTP PRPF6 NR0B2 GNAS BAP1 PRKAR1A MYT1L HNF4A RAI1 DYNC2I2 RPGR TMCO1 BBS9 ABCC8 SMARCB1 NKAP RAB23 GUCA1B LAS1L ZNF365 ALMS1 PAX6 HDAC8 ATRX TRAF3IP1 HDAC8 KIAA1549 CNNM2 HELLPAR PROKR2 MOG SEMA3A BBS5 KCNJ11 IGSF1 PAX6 LEPR LZTFL1 MTOR SYNE1 SNRNP200 MKKS SMC1A PRMT7 CNGB1 MEGF8 CLRN1 TTC8 MAPK8IP3 TRAF7 AKT2 SETD2 IQSEC2 PCNT PPARG P2RY11 HESX1 BBS10 NDN POMC RAB23 MECP2 SOX10 PRPH2 PTCHD1 DNM2 KCNJ18 BBS2 INS ACADVL LIPE KMT2D DHDDS WNT4 HLA-DQB1 MKRN3-AS1 KLF11 IDH3B UCP2 TUB BBIP1 CCDC141 FRMPD4 CNGA1 ARL13B ADCY3 GLI3 ACSL4 SNRPN PHF21A THOC2 PIGN GNAS GNAS TBX3 CFH STX16 ARL3 SH2B1 TUB ANK3 SMO HUWE1 SHOX CYP7A1 NEK2 PRPF3 PAK3 RDH12 TCF20 USP8 IFT172 BBIP1 FGF8 ADNP IFT27 CYP19A1 ARHGEF18 RREB1 ABCA4 SLC10A7 PDGFB LRAT ARVCF PKDCC IQSEC2 MTFMT CLIP2 C8ORF37 SIM1 TBX1 BEST1 PIGT PIGT SETD5 KCNJ11 PDSS1 EHMT1 SPG11 SCAPER ODC1 ZNF408 RPS6KA3 SIM1 SH2B1 BAZ1B BRAF SLC25A4 P4HTM CEP290 C8ORF37 RAI1 APPL1 UPF3B ENPP1 TRIM32 AFF4 SMARCE1 RFC2 AIP RNPC3 PRCD DHX38 UCP3 IFT172 BBS5 SLC7A14 UBE2A PDE4D ATRX USP7 WT1 FAM161A ANOS1 SHANK3 IFT172 FGFR1 ZNF711 MC4R LEP DLG3 NSMF PNKP GNAS MAGEL2 RPS6KA3 KIZ SLC7A7 DIS3L2 HNF1A CD46 ADRB2 RAI1 MEGF8 AFF4 HDAC8 FXR1 SUFU GNAS CLCN4 PSMD12 PHF6 OFD1 PAX4 TRIP12 MAGEL2 GABRD EP300 TRAPPC9 SOX3 PHIP PTEN KCNAB2 WAC NDNF FGF17 ARMC5 HDAC4 SH3KBP1 IMPG2 LARS2 HACE1 ADNP MEN1 AGRP LEPR PROK2 IL17RD AGBL5 USP8 TERT BPTF THOC2 PIK3CA SKI AHR TRAPPC9 CRX CRB1 PRMT7 AP4S1 KISS1R NF2 COMT TBX1 IMPDH1 SMAD4 BBS1 GTF2IRD1 EIF2S3 BBS1 BRAF PRPF31 PCSK1 KLHL7 DEAF1 COL10A1 AKT2 PIGL EDNRB SMC3 TP53 CCDC28B CUL4B ABCC8 FLII DPYD PDE4D NRL PDE6G RBP3 MRAP2 AGTR2 VPS13B KDM6A IPW IGFALS PROKR2 MECP2 XRCC4 TRIM32 FGFR1 SPRY4 MKS1 ALG13 ABCC9 HGSNAT CERKL AKT1 RHO IDH3A RP1L1 EHMT1 EP300 PWRN1 IGF1 FOXP1 TACR3 SIN3A EYS EIF2S3 BBS4 IL1RAPL1 LAS1L MTMR14 IFT88 ARL6 CREBBP AHI1 ATP7B CHD7 ELN CEP19 ARL6 PRPF8 SLC9A7 PCSK1 MAK SRY DNMT3A HACE1 HLA-DRB1 TTC8 TNFSF4 DYRK1B BIN1 CFI FOXP1 KIDINS220 OFD1 TBL2 BDNF RGR FSCN2 HIRA GHR NTRK2 IQSEC2 IFT74 ZNF81 XYLT1 ALB PRDM16 IFT140 IFT27 MAN1B1 ARX PDE4D SIM1 GCK FIBP IGF1R CANT1 SH2B1

    HPO

    Alphabetical listing of all HPO terms. Navigate: Correlations   Clinical Trials


    HPO Nodes


    HP:0004324: Increased body weight
    Genes 543
    NR2E3 WT1 LMNA TBX3 POGZ PROK2 DCC MID2 SDCCAG8 ZNF41 RAB39B LIMK1 CNKSR2 PRPF4 PDE11A RP2 USP27X BBS10 CTNNB1 KIDINS220 FGFR3 XYLT1 PDE6B TOPORS GP1BB BBS7 GATA4 ARL2BP MTOR KCNJ11 MLXIPL HS6ST1 CEP290 GHRL EGF TAF1 PRKAR1A SEC24C PROM1 BBS12 POMC NPHP1 CARTPT ABCC8 PIGA C8ORF37 APOE RYR1 DMD ZBTB20 AP4E1 BBS2 SYNE2 BLK THRA UBE3A CCDC141 TMEM43 FTSJ1 HCFC1 FEZF1 SOX2 CACNA1S CDH23 BBS7 EMD ELN IFT172 CEL MAGEL2 TMEM67 JMJD1C UFD1 NIN ARMC5 CREBBP MKKS PDE6A BAP1 FHL1 GTF2I NEUROD1 USH2A SIN3A KIF7 RBMX PCARE CXORF56 EXOC6B MCM3AP HERC1 PTCH1 LEP HNF4A TBX1 HERC2 MED12 PDX1 OTX2 USP9X ARL6 LZTFL1 PWAR1 ADRB3 BBS9 RPE65 REEP6 RLBP1 HNF1A TRIP4 ERMARD TTC8 POMGNT1 INPP5E WDPCP CUL4B SAG SDCCAG8 MYF6 SDC3 HESX1 KMT2A BLK RAD21 SEMA4A MOG ATP6AP2 CEP164 ARL6 BBS12 POMC MAN1B1 CTSH ALMS1 HNF4A HSD11B1 NPAP1 CDHR1 RERE BLM HCRT ARNT2 FLRT3 BBS4 ROM1 SNORD116-1 ARHGEF6 AP4M1 ZNF711 ZNF513 GDI1 GNAS VPS13B RP1 FTO PRKACA DDX6 PCNT POU3F4 AP4B1 TULP1 DUSP6 MC4R PNPLA6 RNF135 SYP CREBBP SPATA7 LMNA GABRA3 H6PD CA4 NIPBL GNAS MKRN3 FMR1 SNORD115-1 RP9 MC3R MKS1 BBS2 PHF6 FIBP SUFU GNAS-AS1 WDR11 TSPAN7 MERTK GNAS MTTP PRPF6 NR0B2 GNAS BAP1 PRKAR1A MYT1L HNF4A RAI1 DYNC2I2 RPGR TMCO1 BBS9 ABCC8 SMARCB1 NKAP RAB23 GUCA1B LAS1L ZNF365 ALMS1 PAX6 HDAC8 ATRX TRAF3IP1 HDAC8 KIAA1549 CNNM2 HELLPAR PROKR2 MOG SEMA3A BBS5 KCNJ11 IGSF1 PAX6 LEPR LZTFL1 MTOR SYNE1 SNRNP200 MKKS SMC1A PRMT7 CNGB1 MEGF8 CLRN1 TTC8 MAPK8IP3 TRAF7 AKT2 SETD2 IQSEC2 PCNT PPARG P2RY11 HESX1 BBS10 NDN POMC RAB23 MECP2 SOX10 PRPH2 PTCHD1 DNM2 KCNJ18 BBS2 INS ACADVL LIPE KMT2D DHDDS WNT4 HLA-DQB1 MKRN3-AS1 KLF11 IDH3B UCP2 TUB BBIP1 CCDC141 FRMPD4 CNGA1 ARL13B ADCY3 GLI3 ACSL4 SNRPN PHF21A THOC2 PIGN GNAS GNAS TBX3 CFH STX16 ARL3 SH2B1 TUB ANK3 SMO HUWE1 SHOX CYP7A1 NEK2 PRPF3 PAK3 RDH12 TCF20 USP8 IFT172 BBIP1 FGF8 ADNP IFT27 CYP19A1 ARHGEF18 RREB1 ABCA4 SLC10A7 PDGFB LRAT ARVCF PKDCC IQSEC2 MTFMT CLIP2 C8ORF37 SIM1 TBX1 BEST1 PIGT PIGT SETD5 KCNJ11 PDSS1 EHMT1 SPG11 SCAPER ODC1 ZNF408 RPS6KA3 SIM1 SH2B1 BAZ1B BRAF SLC25A4 P4HTM CEP290 C8ORF37 RAI1 APPL1 UPF3B ENPP1 TRIM32 AFF4 SMARCE1 RFC2 AIP RNPC3 PRCD DHX38 UCP3 IFT172 BBS5 SLC7A14 UBE2A PDE4D ATRX USP7 WT1 FAM161A ANOS1 SHANK3 IFT172 FGFR1 ZNF711 MC4R LEP DLG3 NSMF PNKP GNAS MAGEL2 RPS6KA3 KIZ SLC7A7 DIS3L2 HNF1A CD46 ADRB2 RAI1 MEGF8 AFF4 HDAC8 FXR1 SUFU GNAS CLCN4 PSMD12 PHF6 OFD1 PAX4 TRIP12 MAGEL2 GABRD EP300 TRAPPC9 SOX3 PHIP PTEN KCNAB2 WAC NDNF FGF17 ARMC5 HDAC4 SH3KBP1 IMPG2 LARS2 HACE1 ADNP MEN1 AGRP LEPR PROK2 IL17RD AGBL5 USP8 TERT BPTF THOC2 PIK3CA SKI AHR TRAPPC9 CRX CRB1 PRMT7 AP4S1 KISS1R NF2 COMT TBX1 IMPDH1 SMAD4 BBS1 GTF2IRD1 EIF2S3 BBS1 BRAF PRPF31 PCSK1 KLHL7 DEAF1 COL10A1 AKT2 PIGL EDNRB SMC3 TP53 CCDC28B CUL4B ABCC8 FLII DPYD PDE4D NRL PDE6G RBP3 MRAP2 AGTR2 VPS13B KDM6A IPW IGFALS PROKR2 MECP2 XRCC4 TRIM32 FGFR1 SPRY4 MKS1 ALG13 ABCC9 HGSNAT CERKL AKT1 RHO IDH3A RP1L1 EHMT1 EP300 PWRN1 IGF1 FOXP1 TACR3 SIN3A EYS EIF2S3 BBS4 IL1RAPL1 LAS1L MTMR14 IFT88 ARL6 CREBBP AHI1 ATP7B CHD7 ELN CEP19 ARL6 PRPF8 SLC9A7 PCSK1 MAK SRY DNMT3A HACE1 HLA-DRB1 TTC8 TNFSF4 DYRK1B BIN1 CFI FOXP1 KIDINS220 OFD1 TBL2 BDNF RGR FSCN2 HIRA GHR NTRK2 IQSEC2 IFT74 ZNF81 XYLT1 ALB PRDM16 IFT140 IFT27 MAN1B1 ARX PDE4D SIM1 GCK FIBP IGF1R CANT1 SH2B1

    Reports

    Data processed on September 26, 2020.

    An HTML report was created for each of the unique drugs, MeSH, and HPO terms associated with COVID-19 clinical trials. Each report contains a list of either the drug, the MeSH terms, or the HPO terms. All of the terms in a category are displayed on the left-hand side of the report to enable easy navigation, and the reports contain a list of correlated drugs, MeSH, and HPO terms. Further, all reports contain the details of the clinical trials in which the term is referenced. Every clinical trial report shows the mapped HPO and MeSH terms, which are also hyperlinked. Related HPO terms, with their associated genes, protein mutations, and SNPs are also referenced in the report.

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    4,180 reports on interventions/drugs

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    691 reports on MeSH terms

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