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  • HP:0004944: Dilatation of the cerebral artery
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    HP:0004944: Dilatation of the cerebral artery

    Developed by Shray Alag, The Harker School
    Sections: Correlations, Clinical Trials, and HPO

    Correlations computed by analyzing all clinical trials.

    Navigate: Clinical Trials and HPO


    Correlated Drug Terms (2)


    Name (Synonyms) Correlation
    drug2912 Pipeline™ Flex Embolization Device with Shield Technology™ Wiki 1.00
    drug513 Bariatric surgery Wiki 1.00

    Correlated MeSH Terms (4)


    Name (Synonyms) Correlation
    D017542 Aneurysm, Ruptured NIH 1.00
    D002532 Intracranial Aneurysm NIH 1.00
    D000783 Aneurysm, NIH 1.00
    Name (Synonyms) Correlation
    D012421 Rupture NIH 0.71

    Correlated HPO Terms (1)


    Name (Synonyms) Correlation
    HP:0002617 Dilatation HPO 1.00

    Clinical Trials

    Navigate: Correlations   HPO

    There is one clinical trial.


    1 EvaLuate EndoVascular Treatment of Acutely Ruptured Shallow Intradural Aneurysms With the Pipeline™ Flex Embolization Device With Shield TEchnology™ (ELEVATE)

    The purpose of the study is to assess the safety and effectiveness of the Pipeline™ Flex Embolization Device with Shield Technology™ in the treatment with acutely ruptured intracranial aneurysms.

    NCT04391803
    Conditions
    1. Intracranial Aneurysm
    2. Ruptured Aneurysm
    Interventions
    1. Device: Pipeline™ Flex Embolization Device with Shield Technology™
    MeSH:Intracranial Aneurysm Aneurysm Aneurysm, Ruptured Rupture
    HPO:Cerebral berry aneurysm Dilatation Dilatation of the cerebral artery

    Primary Outcomes

    Description: Occlusion is measured by the Raymond Roy Scale. Significant stenosis is classified as >50%.

    Measure: Incidence of complete angiographic occlusion without significant stenosis, and no rebleeding or retreatment of the target aneurysm

    Time: at 180-day

    Description: Disabling stroke is defined as any post-procedural ischemic or hemorrhagic event that results in poor functional outcome (i.e. mRS ≥ 3 points) assessed at 90 days post stroke event through 180 day follow-up.

    Measure: Incidence of neurological death or disabling stroke post-procedure.

    Time: at 180-day

    Secondary Outcomes

    Measure: Pipeline™ Flex Device Deployment Success Rate

    Time: Day 0 During Procedure

    Measure: Incidence of rebleed of target aneurysm

    Time: through 180-day and 365-day post procedure

    Measure: Incidence of neurological hemorrhagic serious adverse events

    Time: through 180-day and 365-day post procedure

    Measure: Incidence of ipsilateral major stroke post-procedure after 30 days

    Time: through 180-day and 365-day post procedure

    Measure: Incidence of any ipsilateral stroke post-procedure after 30 days

    Time: through 180-day and 365-day post procedure

    Description: Scale for measuring general neurologic function: 0- No symptoms at all No significant disability despite symptoms; able to carry out all usual duties and activities Slight disability; unable to carry out all previous activities, but able to look after own affairs without assistance Moderate disability; requiring some help, but able to walk without assistance Moderately severe disability; unable to walk without assistance and unable to attend to own bodily needs without assistance Severe disability; bedridden, incontinent and requiring constant nursing care and attention Dead

    Measure: Good clinical outcome (modified Rankin Scale (mRS) 0-2)

    Time: at 30-day, 180-day and 365-day post procedure

    Measure: Incidence of parent artery thrombosis

    Time: through 365-day post procedure

    Measure: Incidence of in-construct stenosis > 50%

    Time: through 365-day post procedure

    Measure: Incidence of retreatment

    Time: through 180-day and 365-day post procedure

    Measure: Incidence of peri-/post-procedural serious adverse events related to the device, procedure or antiplatelet therapy

    Time: through 180-day and 365-day post procedure

    Measure: Incidence of neurological death or disabling stroke

    Time: through 365-day post procedure

    Measure: Incidence of complete angiographic occlusion without significant stenosis (≤ 50%), and no rebleeding or retreatment of the target aneurysm

    Time: through 365-day post procedure

    HPO Nodes


    Reports

    Data processed on September 26, 2020.

    An HTML report was created for each of the unique drugs, MeSH, and HPO terms associated with COVID-19 clinical trials. Each report contains a list of either the drug, the MeSH terms, or the HPO terms. All of the terms in a category are displayed on the left-hand side of the report to enable easy navigation, and the reports contain a list of correlated drugs, MeSH, and HPO terms. Further, all reports contain the details of the clinical trials in which the term is referenced. Every clinical trial report shows the mapped HPO and MeSH terms, which are also hyperlinked. Related HPO terms, with their associated genes, protein mutations, and SNPs are also referenced in the report.

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