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    HP:0002414: Spina bifida

    Developed by Shray Alag, The Harker School
    Sections: Correlations, Clinical Trials, and HPO

    Correlations computed by analyzing all clinical trials.

    Navigate: Clinical Trials and HPO

    Correlated Drug Terms (3)

    Name (Synonyms) Correlation
    drug4466 eM2M Wiki 1.00
    drug912 Chloroquine phosphate Wiki 0.58
    drug3928 Telemedicine Wiki 0.50

    Correlated MeSH Terms (8)

    Name (Synonyms) Correlation
    D016135 Spinal Dysraphism NIH 1.00
    D002547 Cerebral Palsy NIH 0.58
    D013119 Spinal Cord Injuries NIH 0.38
    Name (Synonyms) Correlation
    D000070642 Brain Injuries, Traumatic NIH 0.33
    D010300 Parkinsonian NIH 0.33
    D001930 Brain Injuries, NIH 0.28
    D009103 Multiple Sclerosis NIH 0.24
    D014947 Wounds and Injuries NIH 0.17

    Correlated HPO Terms (1)

    Name (Synonyms) Correlation
    HP:0001264 Spastic diplegia HPO 0.58

    Clinical Trials

    Navigate: Correlations   HPO

    There is one clinical trial.

    1 The M2M LEADERS Project: Lakeshore Examination of Activity, Disability, and Exercise Response Study (LEADERS)

    The purpose of this study is to test the effects of an innovative exercise program referred to as movement-2-music (M2M) on health and fitness outcomes in adults with physical/mobility disabilities. One hundred and eight participants with physical/mobility disabilities will be recruited and randomly enrolled into one of two groups: a) M2M or b) waitlist control. The primary aim of this study is to determine the effects of a 12-week M2M program on health and fitness in participants with physical/mobility disabilities who are in one of three functional mobility groups: 1) Group I - only able to exercise while sitting, 2) Group II - able to exercise sitting and standing with/without support, and 3) Group III - able to exercise one side of the body more than the other side. The second aim is to compare the observed effects of the program in this study to a previous M2M study that groups participants based on disability type. The third aim of this study is to test whether adherence (defined as attendance to the 12-week program) affects the effects of M2M in participants with physical/mobility disabilities. The potential influences of different functional mobility and disabilities of participants on how the program affects participants' health and fitness outcomes will also be tested. **In response to COVID-19, the 12-week M2M intervention and all assessments have been modified from being delivered in-person at Lakeshore Foundation to being delivered remotely in real-time through videoconferencing technology.**

    1. Spinal Cord Injuries
    2. Traumatic Brain Injury
    3. Spina Bifida
    4. Cerebral Palsy
    5. Stroke
    6. Parkinson Disease
    7. Multiple Sclerosis
    1. Other: eM2M
    MeSH:Parkinson Disease Multiple Sclerosis Brain Injuries Spinal Cord Injuries Brain Injuries, Traumatic Cerebral Palsy Spinal Dysraphism Wounds and Injuries
    HPO:Athetoid cerebral palsy Cerebral palsy Spastic diplegia Spina bifida

    Primary Outcomes

    Description: The cardiorespiratory fitness is measured using a heart rate recovery test

    Measure: Change from baseline cardiorespiratory fitness at 3 months

    Time: Baseline and post 12-week intervention

    Description: Muscle strength is measured with grip strength using a hand-held dynamometer.

    Measure: Change from baseline muscle strength at 3 months

    Time: Baseline and post 12-week intervention

    Secondary Outcomes

    Description: Lower extremity function is assessed using the Short Physical Performance Battery (SPPB)

    Measure: Change from baseline lower extremity function at 3 months

    Time: Baseline and post 12-week intervention

    Description: Lower extremity function will be assessed using the Timed Up and Go (TUG) test.

    Measure: Change from baseline lower extremity function at 3 months

    Time: Baseline and post 12-week intervention

    Description: Health-related quality of life is measured using the National Institutes of Health Patient-Reported Outcomes Measurement Information System (PROMIS) Global-10 Health Items. The instrument is a 10-item measure with the response scores ranging from 1 (very severe) to 5 (none). Two summary scores, a global physical health score and a global mental health score, can be calculated from this scale, with each score ranging from 4 to 20. Higher scores indicate better health. The total raw score is translated into a T-score for each participant for analysis.

    Measure: Change from baseline health-related quality of life at 3 months

    Time: Baseline and post 12-week intervention

    Description: Social participation is measured using the National Institutes of Health Patient-Reported Outcomes Measurement Information System (PROMIS) Ability to Participate in Social Roles and Activities. The instrument is a 8-item measure with the response scores ranging from 1 (always) to 5 (never). The lowest possible total raw score is 8 and the highest possible score is 40. Higher scores indicate better ability to participate in social roles and activities. The total raw score is translated into a T-score for each participant for analysis.

    Measure: Change from baseline social participation at 3 months

    Time: Baseline and post 12-week intervention

    Description: Physical activity is measured using the Godin Leisure Time Exercise Questionnaire. The questionnaire contains two questions. The first question asks participants to report weekly frequencies of activities they perform at different intensities. A total weekly leisure activity is a sum of activity scores calculated by multiplying the weekly frequencies of strenuous, moderate, and light activities by 9, 5, and 3, respectively. The second question asks participants the frequency of weekly leisure-time activities performed that are long enough to work up a sweat.

    Measure: Change from baseline physical activity at 3 months

    Time: Baseline and post 12-week intervention

    Other Outcomes

    Description: Barriers in physical activity will be assessed using the Barriers in Physical Activity Questionnaire. The instrument contains 43 items. Each item is responded with either no (1) or yes (2). If response is yes, a follow-up response that ranges from 1 (very small) to 5 (very large) is selected. There are 8 domains, which include personal health, attitudes/beliefs towards physical activity, friends, family, fitness center built environment, policy/programs/staff, community built environment, and safety. Each domain score is calculated by summing the item responses with its respective item weight. Higher domain scores indicate greater perceived barriers to physical activity.

    Measure: Change from baseline barriers in physical activity at 3 months

    Time: Baseline and post 12-week intervention

    Description: Exercise self-efficacy will be assessed using the Exercise Self-Efficacy Scale. The scale contains 8 items, with response options of each item ranging from 0% (not at all confident) to 100% (highly confident). All items are summed and a mean score is calculated. Higher scores indicate higher levels of self-efficacy.

    Measure: Change from baseline exercise self-efficacy at 3 months

    Time: Baseline and post 12-week intervention

    Description: Exercise goal-setting will be measured using the Exercise Goal-Setting Scale. The instrument contains 10 items with response options ranging from 1 (does not describe) to 5 (describes completely). A mean score is calculated. A higher mean score indicate better goal-setting and self-monitoring for exercise.

    Measure: Change from baseline exercise goal-setting at 3 months

    Time: Baseline and post 12-week intervention

    Description: Outcome expectations for exercise will be assessed using the Multidimensional Outcome Expectations for Exercise Scale. The instrument contains 15 items, with the response options ranging from 1 (strongly disagree) to 5 (strongly agree). Three domains of outcome expectations for exercise are assessed, which include physical outcome expectations (6 items), social outcome expectations (4 items), and self-evaluative outcome expectations (5 items). Each dimension is scored by summing the item responses. Higher scores indicate higher levels of outcome expectations for exercise.

    Measure: Change from baseline outcome expectations for exercise at 3 months

    Time: Baseline and post 12-week intervention

    Description: Social support will be assessed using the Social Provision Scale. The instrument contains 24 items, with the response options ranging from 1 (strongly disagree) to 4 (strongly agree). A total score is calculated by summing scores from all items. A higher score indicates a greater degree of perceived support.

    Measure: Change from baseline social support at 3 months

    Time: Baseline and post 12-week intervention

    HPO Nodes


    Data processed on September 26, 2020.

    An HTML report was created for each of the unique drugs, MeSH, and HPO terms associated with COVID-19 clinical trials. Each report contains a list of either the drug, the MeSH terms, or the HPO terms. All of the terms in a category are displayed on the left-hand side of the report to enable easy navigation, and the reports contain a list of correlated drugs, MeSH, and HPO terms. Further, all reports contain the details of the clinical trials in which the term is referenced. Every clinical trial report shows the mapped HPO and MeSH terms, which are also hyperlinked. Related HPO terms, with their associated genes, protein mutations, and SNPs are also referenced in the report.

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