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  • HP:0002621: Atherosclerosis
  • Pneumonia (359) Respiratory tract infection (38) Neoplasm (36) Abnormality of the cardiovascular system (34) Diabetes mellitus (33) Depressivity (29) Acute kidney injury (27) Hypoxemia (26) Hypertension (24) Abnormal lung morphology (24) Thromboembolism (22) Anosmia (20) Myocardial infarction (20) Arthritis (19) Type II diabetes mellitus (18) Stroke (16) Pulmonary embolism (16) Mental deterioration (15) Abnormality of coagulation (15) Pulmonary fibrosis (15) Chronic pulmonary obstruction (15) Abnormality of the kidney (14) Autistic behavior (14) Rheumatoid arthritis (14) Leukemia (14) Interstitial pneumonitis (14) Pulmonary obstruction (14) Asthma (13) Chronic pain (13) Congestive heart failure (12) Deep venous thrombosis (12) Neoplasm of the lung (12) Autism (11) Obesity (11) Respiratory distress (11) Colitis (11) Ulcerative colitis (11) Crohn's disease (11) Type I diabetes mellitus (10) Abnormality of the liver (9) Coronary artery atherosclerosis (9) Inflammation of the large intestine (9) Pulmonary insufficiency (9) Chronic kidney disease (9) Myocarditis (9) Behavioral abnormality (8) Psychosis (8) Dementia (8) Alzheimer disease (8) Carcinoma (8) Low levels of vitamin D (8) Sepsis (8) Infertility (7) Peripheral arterial stenosis (7) Renal insufficiency (6) Lymphopenia (6) Dysphagia (6) Lymphoma (6) Systemic lupus erythematosus (6) Osteoarthritis (6) Breast carcinoma (6) Psoriasiform dermatitis (6) Abnormality of the gastrointestinal tract (6) Fatigue (6) Encephalopathy (5) Premature birth (5) Bronchiectasis (5) Difficulty walking (5) Gastroparesis (5) Immunodeficiency (5) Obstructive sleep apnea (5) Autoimmunity (5) Knee osteoarthritis (5) Sleep apnea (5) Prostate cancer (5) Allergy (5) Non-small cell lung carcinoma (5) Schizophrenia (5) Neoplasm of the large intestine (5) Seizure (4) Hepatic fibrosis (4) Cardiac arrest (4) Weight loss (4) Migraine (4) Pulmonary arterial hypertension (4) Abnormal intestine morphology (4) Neoplasm of the pancreas (4) Colon 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    HP:0002621: Atherosclerosis

    Developed by Shray Alag, The Harker School
    Sections: Correlations, Clinical Trials, and HPO

    Correlations computed by analyzing all clinical trials.

    Navigate: Clinical Trials and HPO

    Correlated Drug Terms (5)

    Name (Synonyms) Correlation
    drug2358 Metformin XR Wiki 0.71
    drug738 COVID-19 Antibody testing Wiki 0.71
    drug737 COVID-19 Androgen Sensitivity Test (CoVAST) Wiki 0.71
    Name (Synonyms) Correlation
    drug1880 Icosapent ethyl Wiki 0.50
    drug2916 Placebo Wiki 0.03

    Correlated MeSH Terms (4)

    Name (Synonyms) Correlation
    D050197 Atherosclerosis NIH 1.00
    D011236 Prediabetic State NIH 0.35
    D002318 Cardiovascular Diseases NIH 0.12
    Name (Synonyms) Correlation
    D012141 Respiratory Tract Infections NIH 0.11

    Correlated HPO Terms (2)

    Name (Synonyms) Correlation
    HP:0001626 Abnormality of the cardiovascular system HPO 0.12
    HP:0011947 Respiratory tract infection HPO 0.11

    Clinical Trials

    Navigate: Correlations   HPO

    There are 2 clinical trials

    1 CSP #2002 - Investigation of Metformin in Pre-Diabetes on Atherosclerotic Cardiovascular OuTcomes (VA-IMPACT)

    This research will help us to learn if the medicine called metformin reduces the risk of death, heart attacks, and/or strokes in patients who have pre-diabetes and heart or blood vessel problems.

    1. Prediabetic State
    2. Atherosclerosis
    3. Metformin
    1. Drug: Metformin XR
    2. Drug: Placebo
    MeSH:Atherosclerosis Prediabetic State
    HPO:Atherosclerosis Type IV atherosclerotic lesion

    Primary Outcomes

    Description: The primary outcome measure is the time to first occurrence of death, non-fatal myocardial infarction or stroke, hospitalization for unstable angina with objective evidence of acute myocardial ischemia, or coronary revascularization driven by acute or progressive symptoms.

    Measure: Time in days to death, non-fatal myocardial infarction, stroke, hospitalization for unstable angina, or symptom-driven coronary revascularization

    Time: through study completion, an average of 4.5 years

    Secondary Outcomes

    Description: Time to first occurrence of death, myocardial infarction, or stroke Time to first occurrence of a primary endpoint event, peripheral arterial disease event, or hospitalization for congestive heart failure Cumulative incidence of all components of the primary endpoint, including recurrent or multiple events in the same participant Cumulative incidence and time to first occurrence of each component of the primary outcome measure, peripheral arterial disease events, and hospitalization for congestive heart failure

    Measure: Time in days to Cardiovascular Outcomes

    Time: through study completion, an average of 4.5 years

    Description: Time to new or recurrent diagnosis of a malignancy or death from a malignancy

    Measure: Time in days to Oncologic Outcome

    Time: through study completion, an average of 4.5 years

    Description: Time to new diagnosis of type 2 diabetes (ADA criteria)

    Measure: Time in days to Diabetes Outcome

    Time: through study completion, an average of 4.5 years
    2 A Pragmatic Randomized Trial of Icosapent Ethyl for High-Cardiovascular Risk Adults (MITIGATE)

    MITIGATE is a prospective, open-label, parallel-group, randomized, pragmatic clinical trial. The MITIGATE Study has been designed to evaluate the real-world clinical effectiveness of pre-treatment with icosapent ethyl (IPE), also known as Vascepa®, compared to usual standard of care to prevent and reduce the sequelae of laboratory-confirmed viral upper respiratory infection (URI)-related (i.e., COVID-19, influenza, and other known viral respiratory pathogens) morbidity and mortality in a high-risk cohort of adults with established atherosclerotic cardiovascular disease (ASCVD).

    1. Covid19
    2. Atherosclerosis
    3. Cardiovascular Diseases
    4. Upper Respiratory Tract Infections
    1. Drug: Icosapent ethyl
    MeSH:Respiratory Tract Infections Cardiovascular Diseases Atherosclerosis
    HPO:Abnormality of the cardiovascular system Atherosclerosis Respiratory tract infection Type IV atherosclerotic lesion

    Primary Outcomes

    Description: Confirmed viral URIs (i.e., including recurrent events) (i.e., COVID-19, influenza, and other known viral respiratory pathogens) based on laboratory testing (i.e., FDA or locally-approved testing modalities) with an oxygen saturation <94% on room air and/or requiring any form of supplemental oxygen.

    Measure: Percentage of patients with moderate or severe confirmed viral URIs

    Time: 0-12 months

    Description: At any point in time based on a 7-point ordinal scale (i.e., 1 = death, 2 = mechanically ventilated/extracorporeal membrane oxygenation, 3 = high flow supplemental oxygen, 4 = low flow supplemental oxygen, 5 = hospitalized with no supplemental oxygen requirements, 6 = urgent care or emergency department visit not leading to hospitalization, and 7 = no relevant clinical encounters)

    Measure: Worst clinical status due to a confirmed viral URI

    Time: 0-12 months

    Other Outcomes

    Measure: Percentage of participants who die due to any cause

    Time: 0-12 months

    Description: Death due to any cause, hospitalization for myocardial infarction, or hospitalization for ischemic stroke

    Measure: Percentage of participants experiencing a major adverse cardiovascular event

    Time: 0-12 months

    Description: Major adverse cardiovascular events, hospitalization for acute coronary syndrome, and coronary revascularization (i.e., percutaneous coronary intervention and/or coronary artery bypass graft)

    Measure: Percentage of participants experiencing an expanded major adverse cardiovascular event

    Time: 0-12 months

    Measure: Percentage of participants who are hospitalized for heart failure

    Time: 0-12 months

    Measure: Percentage of participants who are hospitalized for any reason

    Time: 0-12 months

    Measure: Percentage of participants who have an emergency department visit for any reason

    Time: 0-12 months

    HPO Nodes


    Data processed on September 26, 2020.

    An HTML report was created for each of the unique drugs, MeSH, and HPO terms associated with COVID-19 clinical trials. Each report contains a list of either the drug, the MeSH terms, or the HPO terms. All of the terms in a category are displayed on the left-hand side of the report to enable easy navigation, and the reports contain a list of correlated drugs, MeSH, and HPO terms. Further, all reports contain the details of the clinical trials in which the term is referenced. Every clinical trial report shows the mapped HPO and MeSH terms, which are also hyperlinked. Related HPO terms, with their associated genes, protein mutations, and SNPs are also referenced in the report.

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    263 reports on HPO terms

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