Developed by Shray Alag, The Harker School
Sections: Correlations,
Clinical Trials, and HPO
Navigate: Clinical Trials and HPO
Name (Synonyms) | Correlation |
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Navigate: Correlations HPO
There is one clinical trial.
SARS-CoV-2 is causing an unprecedented stress on healthcare systems around the world, due to its high rate of infection and the high morbidity and mortality. The COVID-19 infection triggers an inflammatory cascade with cytokine synthesis, prompting the immune response. Low dose radiotherapy (LD-RT) (≤ 100 cGy) induces an anti-inflammatory response, lowering levels of pro-inflammatory cytokines such as IL-1β or inhibit leukocyte recruitment. LD-RT has been used historically for the pneumonia treatment reporting a rapid clinical improvement (within the first week), as well as a reduced mortality (from around 30% to 10%). Considering these results, LD-RT can potentially afford a therapeutic benefit against SARS-CoV-2. The study purpose is to evaluate prospectively the safety and efficacy of LD-RT for SARS-CoV-2.
Description: Radiological results: Radiological worsening, improvement or without significant changes
Measure: Radiological response Time: 3 days after low dose radiationDescription: Radiological results: Radiological worsening, improvement or without significant changes
Measure: Radiological response Time: 7 days after low dose radiationDescription: Remission of respiratory symptoms
Measure: Remission of respiratory symptoms Time: up to 6 monthsDescription: Time to SPO2>94% or PaO2/FiO2 >350mmHg without oxygen
Measure: SPO2 and PaO2/FiO2 Time: 7 daysDescription: Occurrence and grade of CTCAE 5.0 adverse events
Measure: Adverse events Time: 1 yearDescription: Duration of hospitalization
Measure: Hospitalization Time: 3 monthsDescription: Overall survival
Measure: Overall survival Time: 1 monthDescription: ferritin value (ng/mL)
Measure: Ferritin value Time: 1 day after low dose radiationDescription: ferritin value (ng/mL)
Measure: Ferritin value Time: 2 days after low dose radiationDescription: ferritin value (ng/mL)
Measure: Ferritin value Time: 3 days after low dose radiationDescription: blood cell count (unit/L)
Measure: blood cell count Time: 1 day after low dose radiationDescription: blood cell count (unit/L)
Measure: blood cell count Time: 2 days after low dose radiationDescription: blood cell count (unit/L)
Measure: blood cell count Time: 3 days after low dose radiationDescription: C-reactive protein (mg/dl)
Measure: C-reactive protein Time: 1 day after low dose radiationDescription: C-reactive protein (mg/dl)
Measure: C-reactive protein Time: 2 days after low dose radiationDescription: C-reactive protein (mg/dl)
Measure: C-reactive protein Time: 3 days after low dose radiationDescription: D-dimer (ng/ml)
Measure: D-dimer Time: 1 day after low dose radiationDescription: D-dimer (ng/ml)
Measure: D-dimer Time: 2 days after low dose radiationDescription: D-dimer (ng/ml)
Measure: D-dimer Time: 3 days after low dose radiationDescription: LDH levels (UI/L)
Measure: LDH levels Time: 1 day after low dose radiationDescription: LDH levels (UI/L)
Measure: LDH levels Time: 2 days after low dose radiationDescription: LDH levels (UI/L)
Measure: LDH levels Time: 3 days after low dose radiationAlphabetical listing of all HPO terms. Navigate: Correlations Clinical Trials
Data processed on January 01, 2021.
An HTML report was created for each of the unique drugs, MeSH, and HPO terms associated with COVID-19 clinical trials. Each report contains a list of either the drug, the MeSH terms, or the HPO terms. All of the terms in a category are displayed on the left-hand side of the report to enable easy navigation, and the reports contain a list of correlated drugs, MeSH, and HPO terms. Further, all reports contain the details of the clinical trials in which the term is referenced. Every clinical trial report shows the mapped HPO and MeSH terms, which are also hyperlinked. Related HPO terms, with their associated genes, protein mutations, and SNPs are also referenced in the report.
Drug Reports MeSH Reports HPO Reports