Developed by Shray Alag, The Harker School
Sections: Correlations,
Clinical Trials, and HPO
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Navigate: Correlations HPO
There is one clinical trial.
Post-COVID-19 syndrome is an assembly of symptoms, following an infection with COVID-19. The syndrome is characterized by cognitive impairment, fatigue, sleep disorders, smell and taste disorders, pain and more. This long-term sequela can last for months after recovering from the virus, and no treatment is known to date. The aim of this study is to compare the effect of HBOT vs. Sham on post COVID-19 syndrome
Description: Memory, attention and information process will be evaluated using the NeuroTrax computerized cognitive evaluation battery.
Measure: Cognitive health assessment (NeuroTrax) Time: Baseline, 2 monthsDescription: Cerebral blood volume and flow will be measured using perfusion MRI protocol Dynamic susceptibility contrast (DSC).
Measure: Brain perfusion Time: Baseline, 2 monthsDescription: Fractional anisotropy (FA) and Mean diffusivity (MD) will be evaluated using diffusion tensor imaging (DTI) MRI protocol
Measure: Brain microstructure Brain microstructure Time: Baseline, 2 monthsDescription: Resting state fMRI (rsfMRI), and task based fmri will evaluate brain function during a working memory task
Measure: Brain function imaging Time: Baseline, 2 monthsDescription: Self-reported questionnaire covers the most common symptoms related to post-COVID19 disease
Measure: Post-COVID-19 symptom Time: Baseline, 2 monthsDescription: SF-36 questionnaire for self reporting qulity of life
Measure: Quality of Life SF-36 Time: Baseline, 2 monthsDescription: The Pittsburgh Sleep Quality Index (PSQI) is a self-report questionnaire that assesses sleep quality
Measure: The Pittsburgh Sleep Quality Index PSQI Time: Baseline, 2 monthsDescription: The BSI-18 will be used to evaluate psychological distress. The BSI-18 is an 18 item self-report questionnaire which generates a summary scale, the global stress index (GSI), and three subscales: depression, anxiety, and somatization
Measure: The Brief Symptom Inventory - 18 (BSI-18) Time: Baseline, 2 monthsDescription: The BPI is a short, self-administered questionnaire. It contains 15 items, which include 2 multi-item scales measuring pain intensity and the impact of pain on functioning and well-being.
Measure: BPI - Brief pain inventory (short form) Time: Baseline, 2 monthsDescription: Static balance will be assessed by the Balance Error Scoring System (BESS); Dynamic balance and risk of falling will be assessed by the Timed Up and Go test (TUG) and 10-meter walk (10MW). Muscle function will be assessed by the sit to stand (STS) test for the leg strength and endurance and hand-held dynamometry (HHD) for the isometric grip strength. The sub-maximal aerobic capacity and endurance will be assessed by the 6-minute walk test (6MWT).
Measure: Neuro-physical evaluation Time: Baseline, 2 monthsDescription: The neurological exam will include tests of the cranial nerves, motor, sensory and cerebellar function and gait
Measure: Neurological evaluation Time: Baseline, 2 monthsDescription: Smell will be tested through smell identification kits to test for odour detection, discrimination and threshold. The kit is standardized for age and gender, and available in different languages (Sniffin' sticks). Taste will be tested on bilateral anterior and posterior parts of the tongue by four tastes: bitter, sour, salt and sweet ("The Taste Strip Test").
Measure: Smell and taste evaluations. Time: Baseline, 2 monthsDescription: The cardiopulmonary exercise test (CPET) is a non-invasive measurement of the cardiovascular system, respiratory system and muscles.
Measure: Cardiopulmonary exercise test Time: Baseline, 2 monthsDescription: Conventional echocardiography evaluation, linear, volumetric and Doppler measurements will be performed to assess cardiac functions.
Measure: Echocardiography Time: Baseline, 2 monthsDescription: Measurements of pulmonary functions will be performed using the MiniSpir testing apparatus.
Measure: Lung functions test Time: Baseline, 2 monthsDescription: Blood tests will evaluate immune system including cytokines, CRP and COVID-19 antibodies
Measure: Immune system Time: Baseline, 2 monthsAlphabetical listing of all HPO terms. Navigate: Correlations Clinical Trials
Data processed on January 01, 2021.
An HTML report was created for each of the unique drugs, MeSH, and HPO terms associated with COVID-19 clinical trials. Each report contains a list of either the drug, the MeSH terms, or the HPO terms. All of the terms in a category are displayed on the left-hand side of the report to enable easy navigation, and the reports contain a list of correlated drugs, MeSH, and HPO terms. Further, all reports contain the details of the clinical trials in which the term is referenced. Every clinical trial report shows the mapped HPO and MeSH terms, which are also hyperlinked. Related HPO terms, with their associated genes, protein mutations, and SNPs are also referenced in the report.
Drug Reports MeSH Reports HPO Reports