|drug273||Aprepitant injectable emulsion Wiki||1.00|
|drug2988||Saline Placebo Wiki||0.58|
|D055370||Lung Injury NIH||0.18|
|D012127||Respiratory Distress Syndrome, Newborn NIH||0.08|
There is one clinical trial.
This study assesses the clinical effectiveness of mammalian target of rapamycin (mTOR) inhibition with rapamycin in minimizing or decreasing the severity of acute lung injury/acute respiratory distress syndrome (ALI/ARDS) in participants infected with mild to moderate COVID-19 virus.
Description: The proportion of participants who survive without respiratory failureMeasure: Survival rate Time: 4 weeks
Description: The WHO ordinal scale is a measure of clinical improvement using a scale score of 0-8, where 0 indicates a better outcome and 8 indicates death: Uninfected, no clinical oor virological evidence of infection 0 Ambulatory, no limitation of activities 1 Ambulatory, limitation of activities 2 Hospitalized Mild disease, no oxygen therapy 3 Hospitalized mild disease, oxygen by mask or nasal prongs 4 Hospitalized Severe Disease, non-invasive ventilation 5 Hospitalized severe disease, intubation and mechanical ventilation 6 Hospitalized severe disease, ventilation+organ support 7 Death 8Measure: Change in Clinical Status assessed by the World Health Organization (WHO) scale Time: Baseline to 4 weeks
Description: An ordinal scale for clinical improvement scored from 1 to 8, where 1 represents death and 8 represents recovery to discharge from hospital with no limitation on activities: Death (1) Hospitalized, on invasive mechanical ventilation of extracorporeal membrane oxygenation (ECMO) (2) Hospitalized, on non-invasive ventilation or high flow oxygen devices (3) Hospitalized, requiring supplemental oxygen (4) Hospitalized, not requiring supplemental oxygen or ongoing medical care (6) Not hospitalized, limitation on activities &/or requiring supplemental home oxygen (7) Not hospitalized, no limitation on activities (8)Measure: Change in Clinical Status assessed by the National Institute of Allergy and Infectious Disease (NIAID) scale Time: Baseline to 4 weeks
Description: Total number of deaths during the study periodMeasure: All cause mortality Time: 4 weeks
Description: Number of days on ECMOMeasure: Duration of ECMO Time: Up to 4 weeks
Description: Number of days participants are on supplemental oxygenMeasure: Duration of supplemental oxygen Time: Up to 4 weeks
Description: Days of hospitalizationMeasure: Length of hospital stay Time: Up to 4 weeks
Description: Number of days until there is a negative response to the reverse transcriptase-polymerase chain reaction test (RT-PCR)Measure: Length of time to SARS-CoV2 negativity Time: Up to 4 weeks
Data processed on January 01, 2021.
An HTML report was created for each of the unique drugs, MeSH, and HPO terms associated with COVID-19 clinical trials. Each report contains a list of either the drug, the MeSH terms, or the HPO terms. All of the terms in a category are displayed on the left-hand side of the report to enable easy navigation, and the reports contain a list of correlated drugs, MeSH, and HPO terms. Further, all reports contain the details of the clinical trials in which the term is referenced. Every clinical trial report shows the mapped HPO and MeSH terms, which are also hyperlinked. Related HPO terms, with their associated genes, protein mutations, and SNPs are also referenced in the report.Drug Reports MeSH Reports HPO Reports