Developed by Shray Alag, The Harker School
Sections: Correlations,
Clinical Trials, and HPO
Navigate: Clinical Trials and HPO
| Name (Synonyms) | Correlation | |
|---|---|---|
| drug3390 | Robot Assisted Percutaneous Cardiovascular Intervention Wiki | 0.71 |
| drug738 | COVID-19 Antibody testing Wiki | 0.71 |
| Name (Synonyms) | Correlation | |
|---|---|---|
| D050197 | Atherosclerosis NIH | 0.50 |
| D003327 | Coronary Disease NIH | 0.27 |
| D003324 | Coronary Artery Disease NIH | 0.24 |
| Name (Synonyms) | Correlation | |
|---|---|---|
| HP:0002621 | Atherosclerosis HPO | 0.50 |
| HP:0001677 | Coronary artery atherosclerosis HPO | 0.24 |
| HP:0001658 | Myocardial infarction HPO | 0.16 |
| Name (Synonyms) | Correlation | |
|---|---|---|
| HP:0001626 | Abnormality of the cardiovascular system HPO | 0.12 |
| HP:0011947 | Respiratory tract infection HPO | 0.11 |
Navigate: Correlations HPO
There are 2 clinical trials
This is a 14-day long prospective, multi-site, two-armed, randomized, open-label study that will enroll approximately 100 adult outpatients in Canada who have received a positive SARS-CoV-2 test result within the preceding 72 hours. Participants will be randomized (1:1) to receive either icosapent ethyl (4 g BID for 3 days, then 2 g BID for the subsequent 11 days) or usual care. Blood samples will be collected to determine if icosapent ethyl use lowers circulating pro-inflammatory biomarkers.
Description: Response options will be along one of the following formats: (i) 5-point Likert scale with answers ranging from (a) "Not at all" to "Very much" and (b) "Never" to "Always" (ii) Quantitative with answers ranging from "0 times" or "4 or more times" (iii) Binary response format (Yes or No)
Measure: Change in FLU-PRO scores from the screening visit to the Day 14 visit Time: 14 daysDescription: Response options will range from 0 to 6 with a higher value indicating a worse outcome
Measure: World Health Organization Symptom Severity Scale Time: 14 daysMITIGATE is a prospective, open-label, parallel-group, randomized, pragmatic clinical trial. The MITIGATE Study has been designed to evaluate the real-world clinical effectiveness of pre-treatment with icosapent ethyl (IPE), also known as Vascepa®, compared to usual standard of care to prevent and reduce the sequelae of laboratory-confirmed viral upper respiratory infection (URI)-related (i.e., COVID-19, influenza, and other known viral respiratory pathogens) morbidity and mortality in a high-risk cohort of adults with established atherosclerotic cardiovascular disease (ASCVD).
Description: Confirmed viral URIs (i.e., including recurrent events) (i.e., COVID-19, influenza, and other known viral respiratory pathogens) based on laboratory testing (i.e., FDA or locally-approved testing modalities) with an oxygen saturation <94% on room air and/or requiring any form of supplemental oxygen.
Measure: Percentage of patients with moderate or severe confirmed viral URIs Time: 0-12 monthsDescription: At any point in time based on a 7-point ordinal scale (i.e., 1 = death, 2 = mechanically ventilated/extracorporeal membrane oxygenation, 3 = high flow supplemental oxygen, 4 = low flow supplemental oxygen, 5 = hospitalized with no supplemental oxygen requirements, 6 = urgent care or emergency department visit not leading to hospitalization, and 7 = no relevant clinical encounters)
Measure: Worst clinical status due to a confirmed viral URI Time: 0-12 monthsDescription: Death due to any cause, hospitalization for myocardial infarction, or hospitalization for ischemic stroke
Measure: Percentage of participants experiencing a major adverse cardiovascular event Time: 0-12 monthsDescription: Major adverse cardiovascular events, hospitalization for acute coronary syndrome, and coronary revascularization (i.e., percutaneous coronary intervention and/or coronary artery bypass graft)
Measure: Percentage of participants experiencing an expanded major adverse cardiovascular event Time: 0-12 monthsAlphabetical listing of all HPO terms. Navigate: Correlations Clinical Trials
Data processed on September 26, 2020.
An HTML report was created for each of the unique drugs, MeSH, and HPO terms associated with COVID-19 clinical trials. Each report contains a list of either the drug, the MeSH terms, or the HPO terms. All of the terms in a category are displayed on the left-hand side of the report to enable easy navigation, and the reports contain a list of correlated drugs, MeSH, and HPO terms. Further, all reports contain the details of the clinical trials in which the term is referenced. Every clinical trial report shows the mapped HPO and MeSH terms, which are also hyperlinked. Related HPO terms, with their associated genes, protein mutations, and SNPs are also referenced in the report.
Drug Reports MeSH Reports HPO Reports