Developed by Shray Alag, The Harker School
Sections: Correlations,
Clinical Trials, and HPO
Navigate: Clinical Trials and HPO
| Name (Synonyms) | Correlation | |
|---|---|---|
| drug1703 | Healthy lifestyle advise Wiki | 0.71 |
| drug634 | Breastfeeding self-efficacy (BSE) Wiki | 0.71 |
| drug1446 | Exercise program Wiki | 0.50 |
| Name (Synonyms) | Correlation | |
|---|---|---|
| D005317 | Fetal Growth Retardation NIH | 0.71 |
| D004461 | Eclampsia NIH | 0.71 |
| D000078064 | Gestational Weight Gain NIH | 0.71 |
| Name (Synonyms) | Correlation | |
|---|---|---|
| HP:0100601 | Eclampsia HPO | 0.71 |
| HP:0004324 | Increased body weight HPO | 0.71 |
| HP:0001511 | Intrauterine growth retardation HPO | 0.71 |
| Name (Synonyms) | Correlation | |
|---|---|---|
| HP:0100603 | Toxemia of pregnancy HPO | 0.50 |
| HP:0000822 | Hypertension HPO | 0.14 |
Navigate: Correlations HPO
There are 2 clinical trials
Historically and traditionally, the recommendations related to physical exercise during pregnancy have been based more on moral or cultural issues than on scientific evidence. During some phases of history, pregnancy has meant a period of seclusion for women (not only physical). One of the adverse consequences has been the common recommendation of rest as a general rule for pregnant women. Scientific evidence from recent years has achieved a better understanding of the process of pregnancy and childbirth as well as maternal and fetal responses to exercise. Currently, both from a scientific and clinical/obstetric point of view, there is no doubt about the benefits of an active pregnancy for entire body of pregnant woman, and even her child. In fact, risks of a sedentary lifestyle are applicable to the pregnancy situation, even more with important associated complications during pregnancy and postpartum period. Unfortunately, the impact of COVID-19 has caused an unprecedented global crisis, in this sense the necessary measures taken by the different administrations, especially in terms of confinement causes (from now on) a large number of complications affecting different populations. In summary a complex situation without established prevention strategies exists. The pregnant population is, due to the nature of the gestation and delivery process, one of the population groups with the highest risk of adverse outcomes and associated complications and whose consequences include the mother, fetus, newborn and even children. According to an important body of scientific literature and based on an epigenetic effect, the intrauterine environment can be a determining factor for the future human being to evolve regardless of complications and pathologies (cardiovascular, metabolic, psychic, emotional). This is demonstrated by numerous recent scientific evidences that confirm the unfortunate association between an adverse intrauterine environment (due to various factors) and observable postnatal pathologies in infants. In addition, current publications report the large number and variety of alterations that the COVID-19 situation causes in pregnant women and that includes the entire female organism. This complex situation does not only affect aspects of a physical or physiological nature, but also psychic and emotional factors. In summary, a new state of confinement or similar situations in the near future (impossibility of groupings, distance between people), avoid during the daily life of pregnant women one of the important and recent recommendations made by the international scientific community: a pregnancy physically active. This is especially relevant, due to the dangerous association between complications of a psychological or emotional nature during pregnancy with pre, peri and postnatal disorders (low birth weights, perinatal complications, altered and prolonged deliveries, etc.), which affect not only to the mother and can determine the health of the future human being. According to the scientific literature and based on an epigenetic effect, the intrauterine environment can be a determining aspect in the health of the future human being and the prevention of complications and pathologies (cardiovascular, metabolic, psychic, emotional). This is demonstrated by numerous and recent scientific evidences that confirm the unfortunate association between an adverse intrauterine environment (due to various factors) and different pathologies during and after pregnancy. It is evident the change that COVID-19 and its effects will generate in the lifestyle of the pregnant population and the increased probability of suffering associated pathologies in the next 24-36 months. No preventive actions have yet been planned in Spain and its public hospitals against the impact of COVID-19 on the quality of life of pregnant women. It is urgent to design and perform an adequate strategy of intervention for its possible prevention. From the scientific point of view, the recommendations are clear and concrete, an aerobic exercise program, designed and supervised by professionals from the Sciences of Physical Activity and Sports, is the best option for pregnant women. In this sense, in the last 30 years, physical exercise has proven to have many benefits for pregnant women, without causing risks or adverse effects on maternal-fetal well-being. This is confirmed by an important body of scientific literature on gestational physical exercise and its effects on pregnancy outcomes.
Description: analyze the increase during pregnancy
Measure: Maternal weight gain Time: 9 monthsDescription: analyze how it varies during pregnancy
Measure: blood pressure Time: 9 monthsDescription: analyze the value and its interrelationship with physical exercise patterns
Measure: OGTT-O'Sullivan test Time: 1 monthDescription: analyze with a questionnaire the value and its interrelationship with physical exercise patterns (different measures in the questionnaire)
Measure: Urinary Incontinence Questionnaire (ICIQ-SF) Time: 9 monthsDescription: analyze with a questionnaire the value and its interrelationship with physical exercise patterns (Likert scale 0-3)
Measure: State-Trait Anxiety Inventory (STAI) Time: 9 monthsDescription: analyze with a questionnaire the variability during pregnancy (Likert scale 0-3)
Measure: depression scale (CES-D) Time: 9 monthsDescription: analyze variability during pregnancy
Measure: Behavior of Fetal Heart Rate Time: 3 monthsDescription: analyze the value and its interrelationship with physical exercise patterns
Measure: gestational age Time: 9 monthsDescription: analyze whether women have had a vaginal, instrumental or cesarean delivery and its interrelationship with physical exercise patterns
Measure: type of delivery (Vaginal, instrumental or cesarean) Time: 1 monthDescription: analyze the value and its interrelationship with physical exercise patterns
Measure: duration of labor Time: 1 monthDescription: analyze the value and its interrelationship with physical exercise patterns
Measure: birthweight Time: 1 monthDescription: analyze the value and its interrelationship with physical exercise patterns during pregnancy
Measure: child's weight Time: 24 monthsDescription: analyze the value and its interrelationship with physical exercise patterns during pregnancy
Measure: child's height Time: 24 monthsDescription: analyze the value and its interrelationship with physical exercise patterns during pregnancy (Likert scale 0-3)
Measure: mental assessment of the child (depression questionnaire adapted to childhood) Time: 24 monthsDescription: analyze the value and its interrelationship with physical exercise patterns
Measure: Maternal pains during pregnancy (headache, back pain, pelvic pain, paravertebral, scapular, etc.) Time: 9 monthsDescription: analyze the value and its interrelationship with physical exercise patterns
Measure: fetal growth and development Time: 9 monthsDescription: analyze the value and its interrelationship with physical exercise patterns
Measure: Delivery tears Time: 1 monthDescription: analyze the appearance (descriptive: yes/no) and its interrelationship with physical exercise patterns
Measure: performing episiotomy during childbirth Time: 1 monthDescription: analyze the value and its interrelationship with physical exercise patterns
Measure: Apgar Score Time: 1 monthDescription: analyze the value and its interrelationship with physical exercise patterns
Measure: length Time: 1 monthDescription: analyze the value and its interrelationship with physical exercise patterns
Measure: cranial perimeter Time: 1 monthDescription: analyze the value and its interrelationship with physical exercise patterns
Measure: Landau reflexes test Time: 1 monthDescription: analyze the number of admissions and its interrelationship with physical exercise patterns
Measure: neonatal intensive care unit (NICU) Time: 1 monthDescription: analyze how it varies during postpartum period
Measure: Postpartum recovery of pre-pregnancy weight Time: 12 monthsDescription: analyze with a questionnaire how it varies during postpartum period (Likert scale 0-3)
Measure: Edinburgh Postpartum Depression Scale (EPDS) Time: 12 monthsDescription: analyze the value and its interrelationship with physical exercise patterns (Likert scale)
Measure: Perception of health status - SF36 health scale Time: 24 monthsDescription: analyze the diameter and thickness of muscles in the perineal area and its interrelationship with physical exercise patterns
Measure: Recovery of pelvic floor muscles ultrasound Time: 6 monthsDescription: analyzewith a questionnaire how it varies during and after pregnancy
Measure: Maternal habits of physical activity - Pregnancy Physical Activity Questionnaire (PPAQ) Time: 12 monthsHypertensive disorders of pregnancy (HDP) are increasingly recognized sex-specific risk factors for premature cardiovascular disease (CVD) in women. HDP, including preeclampsia and gestational hypertension, confer a 2- to 3-fold increase in the risk of chronic hypertension and ischemic heart disease 10-15 years after delivery. Observational data suggest that breastfeeding can lower maternal blood pressure (BP), risk of metabolic syndrome, and other markers of cardiovascular risk in the short term and long term, possibly by helping to re-set the metabolic changes of pregnancy. We recently demonstrated an 11% reduction in the risk of metabolic syndrome among postpartum women with a variety of complications in pregnancy, including HDP, who breastfed for > 6 months, compared to those who did not breastfeed and those who breastfed for shorter durations. An analysis of 622 postpartum women at Kingston General Hospital showed that breastfeeding women had nearly a 6-mmHg lower systolic BP than women who did not breastfeed with an apparent dose-response effect of breastfeeding duration. Women with pregnancy complications including HDP are vulnerable to early weaning. Interactive, multi-modal approaches targeting a mother's breastfeeding self-efficacy (i.e., confidence about breastfeeding) have been effective in healthy postpartum women. However, breastfeeding support interventions have not yet been tested specifically in HDP women, who stand to derive substantial benefit from breastfeeding. This is an important area to study since nurse-led breastfeeding supportive interventions can be widely applied to the postpartum care of women with HDP and can be integrated into comprehensive CVD risk reduction programs for these women. Our primary outcome is postpartum BP, since hypertension is a key mediating factor in women's heart health. We conducted a feasibility study of a breastfeeding self-efficacy intervention to enhance breastfeeding outcomes among women with HDP showing feasibility (achieving pre-defined targets of a recruitment rate of >50% , attrition rates of < 30%), and > 70% participant satisfaction with the intervention, measured at the 6-month time point. Additionally, data showed trends in both systolic and diastolic BP favoring the intervention group. We are now conducting a multi-site open-label randomized trial to assess for a difference in blood pressure and breastfeeding between groups, and to serve as a cohort of HDP women for longitudinal follow-up.
Description: Evaluate whether a nurse-led BSE intervention will result in a lower systolic and/or diastolic BP 12 months postpartum
Measure: Systolic and/or diastolic BP, in mmHg. Time: 12 monthsDescription: Evaluate whether a nurse-led BSE intervention will result in a lower need for antihypertensive therapy
Measure: Use of antihypertensive therapy Time: 12 monthsDescription: Evaluate whether a nurse-led BSE intervention will result in longer duration of exclusive breastfeeding
Measure: Duration of exclusive breastfeeding (weeks) Time: 12 monthsDescription: Evaluate whether a nurse-led BSE intervention will result in higher rates of any continued breastfeeding at 6 months
Measure: The proportion who breastfeed (exclusive or non-exclusive) Time: 12 monthsDescription: Evaluate whether a nurse-led BSE intervention will result in lower metabolic syndrome
Measure: Metabolic syndrome Time: 12 monthsAlphabetical listing of all HPO terms. Navigate: Correlations Clinical Trials
Data processed on September 26, 2020.
An HTML report was created for each of the unique drugs, MeSH, and HPO terms associated with COVID-19 clinical trials. Each report contains a list of either the drug, the MeSH terms, or the HPO terms. All of the terms in a category are displayed on the left-hand side of the report to enable easy navigation, and the reports contain a list of correlated drugs, MeSH, and HPO terms. Further, all reports contain the details of the clinical trials in which the term is referenced. Every clinical trial report shows the mapped HPO and MeSH terms, which are also hyperlinked. Related HPO terms, with their associated genes, protein mutations, and SNPs are also referenced in the report.
Drug Reports MeSH Reports HPO Reports