Correlated Drug Terms (0)

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	Name (Synonyms)	Correlation

Correlated MeSH Terms (1)

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	Name (Synonyms)	Correlation
D014947	Wounds and Injuries NIH	0.22

Correlated HPO Terms (0)

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	Name (Synonyms)	Correlation

Primary Outcomes

Description: Number of intrusive memories of traumatic event recorded by participants in a diary daily (morning, afternoon, evening and night) for one week during the baseline phase and each week during the intervention phase (week 1-6) and during one week at one month follow-up and three month follow-up.

Measure: Change in the number of intrusive memories of trauma

Time: Baseline week 1; Intervention week 1-6; 1 month follow-up and 3 month follow-up

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Secondary Outcomes

Description: How often did you manage to play Tetris after you experienced an intrusive memory? (11-point scale; 0 = not at all; 10 = every time).

Measure: Self-guided intervention adherence - usage of the gameplay intervention in daily life

Time: Intervention week 2-6

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Description: Feasibility and Acceptability of the intervention assessed with two self-rated items, "Would you recommend playing Tetris to a friend?" and "Do you consider gameplay to be an acceptable way to reduce the daily frequency of intrusive memories?". Scores could range from 0 - 10 with higher scores indicating greater acceptability/feasibility.

Measure: Feasibility and acceptability ratings for using a smartphone game-play intervention

Time: Post intervention up to week 7

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Description: Two open-ended questions: 1. "How did you feel about playing Tetris after you had an intrusive memory?" 2. "Did you find the intervention helpful? If yes, how?"

Measure: Feasibility and acceptability - open ended questions

Time: Post intervention up to week 7

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Description: Six self-rated items to assess the impact of intrusive memories on concentration, sleep, and stress in the past week. 2 items assessing concentration difficulties in general and due to intrusive memories (11-point scale; high scores indicating more difficulties). 2 items assessing sleep disturbances due to intrusive memories (11-point scale; higher scores indicating more sleep disturbance); and 1 item assessing to what degree intrusive memories affected stress levels (0 = not at all; 10 = affected very much).

Measure: Impact of intrusive memories on concentration, sleep and stress - ratings

Time: Baseline week 1; Post intervention up to week 7; 1 month follow-up and 3 month follow-up

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Description: 1 item assessing for how long intrusive memories disrupted concentration on average on a 6-point scale (0 = <1 minute - 6 = > 60 minutes)

Measure: Rating of how long intrusive memories disrupted concentration on average

Time: Baseline week 1; Post intervention up to week 7; 1 month follow-up and 3 month follow-up

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Description: Two items both rated on an 11-point scale: 1. "During the last week, how distressing were your intrusive memories (0 = not at all; 10 = very distressing). 2. During the last week, how vivid were your intrusive memories (0 = not at all; 10= very vivid)

Measure: General impact of intrusive memories - ratings

Time: Baseline week 1; Intervention week 1-6; 1 month follow-up and 3 month follow-up

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Description: Adherence to the intrusion diary assessed with 1 item: "How accurately did you fill out the diary?" (0= not at all; 10 = very accurately)

Measure: Intrusion diary adherence

Time: Baseline phase week 1; Intervention week 1-6; 1 month follow-up and 3 month follow-up

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Description: The PCL-5 is a short 20-item self-report scale used to assess the severity of PTSD symptoms corresponding to the DSM-5 criteria for PTSD. Symptoms are rated from 0-4. Higher scores indicate greater severity.

Measure: The Posttraumatic Stress Disorder Checklist 5 (PCL-5)

Time: Baseline week 1; Post intervention up to week 7; 1 month follow-up and 3 month follow-up

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Description: The PHQ-9 is a 9-item self-report measure of depression symptoms and the severity of those symptoms. Each item can be scored from 0 (i.e., not at all) to 3 (i.e., nearly every day).

Measure: The Patient Health Questionnaire-9 (PHQ-9)

Time: Baseline week 1; Post intervention up to week 7; 1 month follow-up and 3 month follow-up

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Description: The GAD-7 is a brief self-report questionnaire designed as a screening tool for symptoms of general anxiety disorder and their severity. Each item can be scored from 0 (i.e., not at all) to 3 (i.e., nearly every day).

Measure: The Generalized Anxiety Disorder-7 scale (GAD-7)

Time: Baseline week 1; Post intervention up to week 7; 1 month follow-up and 3 month follow-up

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Description: The SDS is a self-report questionnaire which is designed to assess functional impairment across three domains: (1) Work/school, (2) social, and (3) family life. These domains are measured on an 11-point scale which ranges from 0 (i.e., not at all) to 10 (i.e., extremely). The scale will be adjusted to assess impairment associated with intrusive memories.

Measure: The Sheehan Disability Scale (SDS)

Time: Baseline week 1; Post intervention up to week 7; 1 month follow-up and 3 month follow-up

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Description: Two questions assessing the impact intrusive memories have on functioning in daily life. One question is open-ended: "Have the intrusive memories affected your ability to function in your daily life in the past week? If yes, how?" and one question is self-rated: "Have the intrusive memories affected your ability to function in your daily life?" (11-point scale, higher score indicate greater impact on functioning.)

Measure: Impact of intrusive memories on functioning

Time: Baseline week 1; Post intervention up to week 7, 1 month follow-up and 3 month follow-up

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